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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Longitudinal Comparison of Chemokines in Breastmilk Early Postpartum Among HIV-1-Infected and Uninfected Kenyan Women</title><author><name sortKey="Bosire, Rose" sort="Bosire, Rose" uniqKey="Bosire R" first="Rose" last="Bosire">Rose Bosire</name><affiliation><nlm:aff id="A1">Center for Public Health Research, Kenya Medical Research Institute, Nairobi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Guthrie, Brandon L" sort="Guthrie, Brandon L" uniqKey="Guthrie B" first="Brandon L." last="Guthrie">Brandon L. Guthrie</name><affiliation><nlm:aff id="A2">Department of Epidemiology, University of Washington, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Lohman Payne, Barbara" sort="Lohman Payne, Barbara" uniqKey="Lohman Payne B" first="Barbara" last="Lohman-Payne">Barbara Lohman-Payne</name><affiliation><nlm:aff id="A3">Department of Medicine, University of Washington, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Mabuka, Jennifer" sort="Mabuka, Jennifer" uniqKey="Mabuka J" first="Jennifer" last="Mabuka">Jennifer Mabuka</name><affiliation><nlm:aff id="A5">Department of Paediatrics, University of Nairobi, Nairobi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Majiwa, Maxwell" sort="Majiwa, Maxwell" uniqKey="Majiwa M" first="Maxwell" last="Majiwa">Maxwell Majiwa</name><affiliation><nlm:aff id="A5">Department of Paediatrics, University of Nairobi, Nairobi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Wariua, Grace" sort="Wariua, Grace" uniqKey="Wariua G" first="Grace" last="Wariua">Grace Wariua</name><affiliation><nlm:aff id="A5">Department of Paediatrics, University of Nairobi, Nairobi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Mbori Ngacha, Dorothy" sort="Mbori Ngacha, Dorothy" uniqKey="Mbori Ngacha D" first="Dorothy" last="Mbori-Ngacha">Dorothy Mbori-Ngacha</name><affiliation><nlm:aff id="A5">Department of Paediatrics, University of Nairobi, Nairobi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Richardson, Barbra" sort="Richardson, Barbra" uniqKey="Richardson B" first="Barbra" last="Richardson">Barbra Richardson</name><affiliation><nlm:aff id="A4">Department of Biostatistics, University of Washington, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="John Stewart, Grace" sort="John Stewart, Grace" uniqKey="John Stewart G" first="Grace" last="John-Stewart">Grace John-Stewart</name><affiliation><nlm:aff id="A2">Department of Epidemiology, University of Washington, Seattle, Washington</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, University of Washington, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Farquhar, Carey" sort="Farquhar, Carey" uniqKey="Farquhar C" first="Carey" last="Farquhar">Carey Farquhar</name><affiliation><nlm:aff id="A2">Department of Epidemiology, University of Washington, Seattle, Washington</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, University of Washington, Seattle, Washington</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17903098</idno><idno type="pmc">3381953</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381953</idno><idno type="RBID">PMC:3381953</idno><idno type="doi">10.1089/bfm.2007.0009</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">001A37</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001A37</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Longitudinal Comparison of Chemokines in Breastmilk Early Postpartum Among HIV-1-Infected and Uninfected Kenyan Women</title><author><name sortKey="Bosire, Rose" sort="Bosire, Rose" uniqKey="Bosire R" first="Rose" last="Bosire">Rose Bosire</name><affiliation><nlm:aff id="A1">Center for Public Health Research, Kenya Medical Research Institute, Nairobi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Guthrie, Brandon L" sort="Guthrie, Brandon L" uniqKey="Guthrie B" first="Brandon L." last="Guthrie">Brandon L. Guthrie</name><affiliation><nlm:aff id="A2">Department of Epidemiology, University of Washington, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Lohman Payne, Barbara" sort="Lohman Payne, Barbara" uniqKey="Lohman Payne B" first="Barbara" last="Lohman-Payne">Barbara Lohman-Payne</name><affiliation><nlm:aff id="A3">Department of Medicine, University of Washington, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Mabuka, Jennifer" sort="Mabuka, Jennifer" uniqKey="Mabuka J" first="Jennifer" last="Mabuka">Jennifer Mabuka</name><affiliation><nlm:aff id="A5">Department of Paediatrics, University of Nairobi, Nairobi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Majiwa, Maxwell" sort="Majiwa, Maxwell" uniqKey="Majiwa M" first="Maxwell" last="Majiwa">Maxwell Majiwa</name><affiliation><nlm:aff id="A5">Department of Paediatrics, University of Nairobi, Nairobi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Wariua, Grace" sort="Wariua, Grace" uniqKey="Wariua G" first="Grace" last="Wariua">Grace Wariua</name><affiliation><nlm:aff id="A5">Department of Paediatrics, University of Nairobi, Nairobi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Mbori Ngacha, Dorothy" sort="Mbori Ngacha, Dorothy" uniqKey="Mbori Ngacha D" first="Dorothy" last="Mbori-Ngacha">Dorothy Mbori-Ngacha</name><affiliation><nlm:aff id="A5">Department of Paediatrics, University of Nairobi, Nairobi, Kenya</nlm:aff></affiliation></author><author><name sortKey="Richardson, Barbra" sort="Richardson, Barbra" uniqKey="Richardson B" first="Barbra" last="Richardson">Barbra Richardson</name><affiliation><nlm:aff id="A4">Department of Biostatistics, University of Washington, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="John Stewart, Grace" sort="John Stewart, Grace" uniqKey="John Stewart G" first="Grace" last="John-Stewart">Grace John-Stewart</name><affiliation><nlm:aff id="A2">Department of Epidemiology, University of Washington, Seattle, Washington</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, University of Washington, Seattle, Washington</nlm:aff></affiliation></author><author><name sortKey="Farquhar, Carey" sort="Farquhar, Carey" uniqKey="Farquhar C" first="Carey" last="Farquhar">Carey Farquhar</name><affiliation><nlm:aff id="A2">Department of Epidemiology, University of Washington, Seattle, Washington</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Medicine, University of Washington, Seattle, Washington</nlm:aff></affiliation></author></analytic><series><title level="j">Breastfeeding Medicine</title><idno type="ISSN">1556-8253</idno><idno type="eISSN">1556-8342</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Breastmilk chemokines have been associated with increased HIV-1 RNA levels in breastmilk and altered risk of mother-to-child HIV-1 transmission. To characterize CC and CXC chemokines in breastmilk postpartum, we collected breastmilk specimens at regular intervals for 6 months after delivery from women with and without HIV-1 infection and used commercial ELISA kits to measure breastmilk concentrations of MIP-1α, MIP-1β, RANTES, and SDF-1α. Among 54 HIV-1-infected and 26 uninfected women, mean chemokine levels were compared cross-sectionally and longitudinally at days 5 and 10, and months 1 and 3 postpartum. For both HIV-1-infected and uninfected women, breastmilk chemokine levels were highest at day 5 for MIP-1α, MIP-1β, and SDF-1α, and subsequently decreased. RANTES levels remained constant over the follow-up period among HIV-1-uninfected women, and increased moderately among HIV-1-infected women. For MIP-1β and RANTES, breastmilk levels were significantly higher among HIV-1-infected women compared to uninfected women early postpartum. In addition, HIV-1-infected women transmitting HIV-1 to their infant had consistently higher breastmilk RANTES levels than those who did not transmit, with the greatest difference observed at 1 month (2.68 vs. 2.21 log<sub>10</sub> pg/mL, respectively; <italic>p</italic> = 0.007). In summary, all four chemokines were most elevated within the first month postpartum, a period of high transmission risk via breastmilk. MIP-1β and RANTES levels in breastmilk were higher among HIV-1-infected women than among uninfected women, and breastmilk RANTES was positively associated with vertical transmission in this study, consistent with results from our earlier cohort.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101260777</journal-id><journal-id journal-id-type="pubmed-jr-id">33499</journal-id><journal-id journal-id-type="nlm-ta">Breastfeed Med</journal-id><journal-id journal-id-type="iso-abbrev">Breastfeed Med</journal-id><journal-title-group><journal-title>Breastfeeding Medicine</journal-title></journal-title-group><issn pub-type="ppub">1556-8253</issn><issn pub-type="epub">1556-8342</issn></journal-meta><article-meta><article-id pub-id-type="pmid">17903098</article-id><article-id pub-id-type="pmc">3381953</article-id><article-id pub-id-type="doi">10.1089/bfm.2007.0009</article-id><article-id pub-id-type="manuscript">NIHMS359146</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Longitudinal Comparison of Chemokines in Breastmilk Early Postpartum Among HIV-1-Infected and Uninfected Kenyan Women</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bosire</surname><given-names>Rose</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Guthrie</surname><given-names>Brandon L.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lohman-Payne</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Mabuka</surname><given-names>Jennifer</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Majiwa</surname><given-names>Maxwell</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Wariua</surname><given-names>Grace</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Mbori-Ngacha</surname><given-names>Dorothy</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Richardson</surname><given-names>Barbra</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>John-Stewart</surname><given-names>Grace</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Farquhar</surname><given-names>Carey</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Center for Public Health Research, Kenya Medical Research Institute, Nairobi, Kenya</aff><aff id="A2"><label>2</label>Department of Epidemiology, University of Washington, Seattle, Washington</aff><aff id="A3"><label>3</label>Department of Medicine, University of Washington, Seattle, Washington</aff><aff id="A4"><label>4</label>Department of Biostatistics, University of Washington, Seattle, Washington</aff><aff id="A5"><label>5</label>Department of Paediatrics, University of Nairobi, Nairobi, Kenya</aff><author-notes><corresp id="cor1">Address reprint requests to: Carey Farquhar, M.D., MPH, University of Washington, 325 Ninth Avenue, Box 359909, Seattle, WA 98104-2499, <email>cfarq@u.washington.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>8</day><month>6</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2007</year></pub-date><pub-date pub-type="pmc-release"><day>25</day><month>6</month><year>2012</year></pub-date><volume>2</volume><issue>3</issue><fpage>129</fpage><lpage>138</lpage><permissions><copyright-statement>© Mary Ann Liebert, Inc.</copyright-statement></permissions><abstract><p id="P1">Breastmilk chemokines have been associated with increased HIV-1 RNA levels in breastmilk and altered risk of mother-to-child HIV-1 transmission. To characterize CC and CXC chemokines in breastmilk postpartum, we collected breastmilk specimens at regular intervals for 6 months after delivery from women with and without HIV-1 infection and used commercial ELISA kits to measure breastmilk concentrations of MIP-1α, MIP-1β, RANTES, and SDF-1α. Among 54 HIV-1-infected and 26 uninfected women, mean chemokine levels were compared cross-sectionally and longitudinally at days 5 and 10, and months 1 and 3 postpartum. For both HIV-1-infected and uninfected women, breastmilk chemokine levels were highest at day 5 for MIP-1α, MIP-1β, and SDF-1α, and subsequently decreased. RANTES levels remained constant over the follow-up period among HIV-1-uninfected women, and increased moderately among HIV-1-infected women. For MIP-1β and RANTES, breastmilk levels were significantly higher among HIV-1-infected women compared to uninfected women early postpartum. In addition, HIV-1-infected women transmitting HIV-1 to their infant had consistently higher breastmilk RANTES levels than those who did not transmit, with the greatest difference observed at 1 month (2.68 vs. 2.21 log<sub>10</sub> pg/mL, respectively; <italic>p</italic> = 0.007). In summary, all four chemokines were most elevated within the first month postpartum, a period of high transmission risk via breastmilk. MIP-1β and RANTES levels in breastmilk were higher among HIV-1-infected women than among uninfected women, and breastmilk RANTES was positively associated with vertical transmission in this study, consistent with results from our earlier cohort.</p></abstract><funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source><award-id>P30 AI027757-13 || AI</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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