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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antiretroviral therapy restores age-dependent loss of resting memory B cells in young HIV-infected Zambian children</title><author><name sortKey="Rainwater Lovett, K" sort="Rainwater Lovett, K" uniqKey="Rainwater Lovett K" first="K" last="Rainwater-Lovett">K. Rainwater-Lovett</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Current affiliation: Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Nkamba, Hc" sort="Nkamba, Hc" uniqKey="Nkamba H" first="Hc" last="Nkamba">Hc Nkamba</name><affiliation><nlm:aff id="A2">Virology Laboratory, University Teaching Hospital, Lusaka, Zambia</nlm:aff></affiliation></author><author><name sortKey="Mubiana Mbewe, M" sort="Mubiana Mbewe, M" uniqKey="Mubiana Mbewe M" first="M" last="Mubiana-Mbewe">M. Mubiana-Mbewe</name><affiliation><nlm:aff id="A3">Center for Infectious Disease Research-Zambia, Lusaka, Zambia</nlm:aff></affiliation></author><author><name sortKey="Bolton Moore, C" sort="Bolton Moore, C" uniqKey="Bolton Moore C" first="C" last="Bolton Moore">C. Bolton Moore</name><affiliation><nlm:aff id="A3">Center for Infectious Disease Research-Zambia, Lusaka, Zambia</nlm:aff></affiliation><affiliation><nlm:aff id="A4">University of Alabama at Birmingham, Alabama, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Current affiliation: Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Margolick, Jb" sort="Margolick, Jb" uniqKey="Margolick J" first="Jb" last="Margolick">Jb Margolick</name><affiliation><nlm:aff id="A5">W. Harry Feinstone Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Moss, Wj" sort="Moss, Wj" uniqKey="Moss W" first="Wj" last="Moss">Wj Moss</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">W. Harry Feinstone Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24326598</idno><idno type="pmc">3999252</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999252</idno><idno type="RBID">PMC:3999252</idno><idno type="doi">10.1097/QAI.0000000000000074</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001919</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001919</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antiretroviral therapy restores age-dependent loss of resting memory B cells in young HIV-infected Zambian children</title><author><name sortKey="Rainwater Lovett, K" sort="Rainwater Lovett, K" uniqKey="Rainwater Lovett K" first="K" last="Rainwater-Lovett">K. Rainwater-Lovett</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Current affiliation: Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Nkamba, Hc" sort="Nkamba, Hc" uniqKey="Nkamba H" first="Hc" last="Nkamba">Hc Nkamba</name><affiliation><nlm:aff id="A2">Virology Laboratory, University Teaching Hospital, Lusaka, Zambia</nlm:aff></affiliation></author><author><name sortKey="Mubiana Mbewe, M" sort="Mubiana Mbewe, M" uniqKey="Mubiana Mbewe M" first="M" last="Mubiana-Mbewe">M. Mubiana-Mbewe</name><affiliation><nlm:aff id="A3">Center for Infectious Disease Research-Zambia, Lusaka, Zambia</nlm:aff></affiliation></author><author><name sortKey="Bolton Moore, C" sort="Bolton Moore, C" uniqKey="Bolton Moore C" first="C" last="Bolton Moore">C. Bolton Moore</name><affiliation><nlm:aff id="A3">Center for Infectious Disease Research-Zambia, Lusaka, Zambia</nlm:aff></affiliation><affiliation><nlm:aff id="A4">University of Alabama at Birmingham, Alabama, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Current affiliation: Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, North Carolina, USA</nlm:aff></affiliation></author><author><name sortKey="Margolick, Jb" sort="Margolick, Jb" uniqKey="Margolick J" first="Jb" last="Margolick">Jb Margolick</name><affiliation><nlm:aff id="A5">W. Harry Feinstone Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Moss, Wj" sort="Moss, Wj" uniqKey="Moss W" first="Wj" last="Moss">Wj Moss</name><affiliation><nlm:aff id="A1">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">W. Harry Feinstone Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of acquired immune deficiency syndromes (1999)</title><idno type="ISSN">1525-4135</idno><idno type="eISSN">1944-7884</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background:</title><p id="P1">Antiretroviral therapy (ART) is associated with incomplete restoration of resting memory B (RMB) cell percentages in adults infected with human immunodeficiency virus (HIV), but the effects on RMB cells in children are less well defined, in part because changes in RMB cell percentages are confounded by development and maturation of the RMB cell pool. The objective of this study was to assess the effect of age at ART initiation on RMB cell percentages over time in HIV-infected Zambian children.</p></sec><sec id="S2"><title>Methods:</title><p id="P2">RMB cell percentages (CD19+CD21+CD27+) were measured by flow cytometry in 146 HIV-infected Zambian children (9 to 120 months old) at baseline and at 3-month intervals after ART initiation and in 34 control children at a single study visit.</p></sec><sec id="S3"><title>Results:</title><p id="P3">RMB cell percentages among untreated HIV-infected children younger than 24 months did not differ from those of control children (p=0.97). Among HIV-infected children older than 24 months of age, however, each 12-month increase in age at ART initiation was associated with a 1.8% decrease in RMB cell percentage. In contrast, RMB cell percentages in control children up to 48 months old increased 4.4% with each 12-month increase in age. After 12 months of ART, children 24-60 months old had a significant increase in RMB cell percentages that no longer differed from those of control children.</p></sec><sec id="S4"><title>Conclusions:</title><p id="P4">Initiation of ART in two- to five-year-old HIV-infected children resulted in reconstitution of RMB cell percentages to levels similar to control children and may help restore normal development and maintenance of B cell immunity.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100892005</journal-id><journal-id journal-id-type="pubmed-jr-id">21821</journal-id><journal-id journal-id-type="nlm-ta">J Acquir Immune Defic Syndr</journal-id><journal-id journal-id-type="iso-abbrev">J. Acquir. Immune Defic. Syndr.</journal-id><journal-title-group><journal-title>Journal of acquired immune deficiency syndromes (1999)</journal-title></journal-title-group><issn pub-type="ppub">1525-4135</issn><issn pub-type="epub">1944-7884</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24326598</article-id><article-id pub-id-type="pmc">3999252</article-id><article-id pub-id-type="doi">10.1097/QAI.0000000000000074</article-id><article-id pub-id-type="manuscript">NIHMS540909</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Antiretroviral therapy restores age-dependent loss of resting memory B cells in young HIV-infected Zambian children</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rainwater-Lovett</surname><given-names>K</given-names></name><degrees>PhD, MPH</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A6">†</xref></contrib><contrib contrib-type="author"><name><surname>Nkamba</surname><given-names>HC</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Mubiana-Mbewe</surname><given-names>M</given-names></name><degrees>MBChB</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Bolton Moore</surname><given-names>C</given-names></name><degrees>MBBCh, MSc</degrees><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref><xref ref-type="aff" rid="A7">‡</xref></contrib><contrib contrib-type="author"><name><surname>Margolick</surname><given-names>JB</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Moss</surname><given-names>WJ</given-names></name><degrees>MD, MPH</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A5">5</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</aff><aff id="A2"><label>2</label>Virology Laboratory, University Teaching Hospital, Lusaka, Zambia</aff><aff id="A3"><label>3</label>Center for Infectious Disease Research-Zambia, Lusaka, Zambia</aff><aff id="A4"><label>4</label>University of Alabama at Birmingham, Alabama, USA</aff><aff id="A5"><label>5</label>W. Harry Feinstone Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA</aff><aff id="A6"><label>†</label>Current affiliation: Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA</aff><aff id="A7"><label>‡</label>Current affiliation: Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, North Carolina, USA</aff><author-notes><corresp id="CR1"><label>*</label>Corresponding author: 615 N. Wolfe Street, Room E6547, Baltimore, MD, USA 21205, <underline><email>wmoss@jhsph.edu</email></underline>, Phone: +1 (410) 502-1165, Fax: +1 (410) 955-1383</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>23</day><month>12</month><year>2013</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>4</month><year>2015</year></pub-date><volume>65</volume><issue>5</issue><fpage>505</fpage><lpage>509</lpage><pmc-comment>elocation-id from pubmed: 10.1097/QAI.0000000000000074</pmc-comment>
<abstract><sec id="S1"><title>Background:</title><p id="P1">Antiretroviral therapy (ART) is associated with incomplete restoration of resting memory B (RMB) cell percentages in adults infected with human immunodeficiency virus (HIV), but the effects on RMB cells in children are less well defined, in part because changes in RMB cell percentages are confounded by development and maturation of the RMB cell pool. The objective of this study was to assess the effect of age at ART initiation on RMB cell percentages over time in HIV-infected Zambian children.</p></sec><sec id="S2"><title>Methods:</title><p id="P2">RMB cell percentages (CD19+CD21+CD27+) were measured by flow cytometry in 146 HIV-infected Zambian children (9 to 120 months old) at baseline and at 3-month intervals after ART initiation and in 34 control children at a single study visit.</p></sec><sec id="S3"><title>Results:</title><p id="P3">RMB cell percentages among untreated HIV-infected children younger than 24 months did not differ from those of control children (p=0.97). Among HIV-infected children older than 24 months of age, however, each 12-month increase in age at ART initiation was associated with a 1.8% decrease in RMB cell percentage. In contrast, RMB cell percentages in control children up to 48 months old increased 4.4% with each 12-month increase in age. After 12 months of ART, children 24-60 months old had a significant increase in RMB cell percentages that no longer differed from those of control children.</p></sec><sec id="S4"><title>Conclusions:</title><p id="P4">Initiation of ART in two- to five-year-old HIV-infected children resulted in reconstitution of RMB cell percentages to levels similar to control children and may help restore normal development and maintenance of B cell immunity.</p></sec></abstract><kwd-group><kwd>resting memory B cell</kwd><kwd>antiretroviral therapy</kwd><kwd>pediatric HIV</kwd><kwd>immune reconstitution</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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