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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Species-specific treatment effects of helminth/HIV-1 co-infection: a systematic review and meta-analysis</title><author><name sortKey="Sangare, Laura R" sort="Sangare, Laura R" uniqKey="Sangare L" first="Laura R." last="Sangaré">Laura R. Sangaré</name></author><author><name sortKey="Herrin, Bradely R" sort="Herrin, Bradely R" uniqKey="Herrin B" first="Bradely R." last="Herrin">Bradely R. Herrin</name></author><author><name sortKey="John Stewart, Grace" sort="John Stewart, Grace" uniqKey="John Stewart G" first="Grace" last="John-Stewart">Grace John-Stewart</name></author><author><name sortKey="Walson, Judd L" sort="Walson, Judd L" uniqKey="Walson J" first="Judd L." last="Walson">Judd L. Walson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21729353</idno><idno type="pmc">3387276</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387276</idno><idno type="RBID">PMC:3387276</idno><idno type="doi">10.1017/S0031182011000357</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001859</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001859</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Species-specific treatment effects of helminth/HIV-1 co-infection: a systematic review and meta-analysis</title><author><name sortKey="Sangare, Laura R" sort="Sangare, Laura R" uniqKey="Sangare L" first="Laura R." last="Sangaré">Laura R. Sangaré</name></author><author><name sortKey="Herrin, Bradely R" sort="Herrin, Bradely R" uniqKey="Herrin B" first="Bradely R." last="Herrin">Bradely R. Herrin</name></author><author><name sortKey="John Stewart, Grace" sort="John Stewart, Grace" uniqKey="John Stewart G" first="Grace" last="John-Stewart">Grace John-Stewart</name></author><author><name sortKey="Walson, Judd L" sort="Walson, Judd L" uniqKey="Walson J" first="Judd L." last="Walson">Judd L. Walson</name></author></analytic><series><title level="j">Parasitology</title><idno type="ISSN">0031-1820</idno><idno type="eISSN">1469-8161</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SUMMARY</title><p id="P2">In sub-Saharan Africa, over 22 million people are estimated to be co-infected with both helminths and HIV-1. Several studies have suggested that de-worming individuals with HIV-1 may delay HIV-1 disease progression, and that the benefit of de-worming may vary by individual helminth species. We conducted a systematic review and meta-analysis of the published literature to determine the effect of treatment of individual helminth infections on markers of HIV-1 progression (CD4 count and HIV viral load). There was a trend towards an association between treatment for <italic>Schistosoma mansoni</italic> and a decrease in HIV viral load (Weighted mean difference (WMD)=−0·10; 95% Confidence interval (CI): −0·24, 0·03), although this association was not seen for <italic>Ascaris lumbricoides</italic>, hookworm or <italic>Trichuris trichiura</italic>. Treatment of <italic>A. lumbricoides, S. mansoni</italic>, hookworm or <italic>T. trichiura</italic> was not associated with a change in CD4 count. While pooled data from randomized trials suggested clinical benefit of de-worming for individual helminth species, these effects decreased when observational data were included in the pooled analysis. While further trials are needed to confirm the role of anthelmintic treatment in HIV-1 co-infected individuals, providing anthelmintics to individuals with HIV-1 may be a safe, inexpensive and practical intervention to slow progression of HIV-1.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0401121</journal-id><journal-id journal-id-type="pubmed-jr-id">6357</journal-id><journal-id journal-id-type="nlm-ta">Parasitology</journal-id><journal-id journal-id-type="iso-abbrev">Parasitology</journal-id><journal-title-group><journal-title>Parasitology</journal-title></journal-title-group><issn pub-type="ppub">0031-1820</issn><issn pub-type="epub">1469-8161</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21729353</article-id><article-id pub-id-type="pmc">3387276</article-id><article-id pub-id-type="doi">10.1017/S0031182011000357</article-id><article-id pub-id-type="manuscript">NIHMS358755</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Species-specific treatment effects of helminth/HIV-1 co-infection: a systematic review and meta-analysis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>SANGARÉ</surname><given-names>LAURA R.</given-names></name></contrib><contrib contrib-type="author"><name><surname>HERRIN</surname><given-names>BRADELY R.</given-names></name></contrib><contrib contrib-type="author"><name><surname>JOHN-STEWART</surname><given-names>GRACE</given-names></name></contrib><contrib contrib-type="author"><name><surname>WALSON</surname><given-names>JUDD L.</given-names></name></contrib><aff id="A1">University of Washington, Department of Global Health, Box 359909, 325 Ninth Avenue Seattle, WA 98104, USA</aff></contrib-group><author-notes><corresp id="FN1">Corresponding author: Judd L. Walson, MD, MPH Departments of Global Health, Medicine, Pediatrics and Epidemiology, University of Washington, Box 359909, 325 Ninth Avenue Seattle, WA 98104, Tel: (206) 744-3695, Fax: (206) 543-4818, <email>walson@u.washington.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>12</day><month>6</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>18</day><month>5</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>29</day><month>6</month><year>2012</year></pub-date><volume>138</volume><issue>12</issue><fpage>1546</fpage><lpage>1558</lpage><permissions><copyright-statement>© Cambridge University Press 2011</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><title>SUMMARY</title><p id="P2">In sub-Saharan Africa, over 22 million people are estimated to be co-infected with both helminths and HIV-1. Several studies have suggested that de-worming individuals with HIV-1 may delay HIV-1 disease progression, and that the benefit of de-worming may vary by individual helminth species. We conducted a systematic review and meta-analysis of the published literature to determine the effect of treatment of individual helminth infections on markers of HIV-1 progression (CD4 count and HIV viral load). There was a trend towards an association between treatment for <italic>Schistosoma mansoni</italic> and a decrease in HIV viral load (Weighted mean difference (WMD)=−0·10; 95% Confidence interval (CI): −0·24, 0·03), although this association was not seen for <italic>Ascaris lumbricoides</italic>, hookworm or <italic>Trichuris trichiura</italic>. Treatment of <italic>A. lumbricoides, S. mansoni</italic>, hookworm or <italic>T. trichiura</italic> was not associated with a change in CD4 count. While pooled data from randomized trials suggested clinical benefit of de-worming for individual helminth species, these effects decreased when observational data were included in the pooled analysis. While further trials are needed to confirm the role of anthelmintic treatment in HIV-1 co-infected individuals, providing anthelmintics to individuals with HIV-1 may be a safe, inexpensive and practical intervention to slow progression of HIV-1.</p></abstract><kwd-group><kwd>Helminth</kwd><kwd>HIV-1</kwd><kwd>co-infection</kwd><kwd>meta-analysis</kwd><kwd>Kenya</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source><award-id>P30 AI027757-14 || AI</award-id></award-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source><award-id>P30 AI027757 || AI</award-id></award-group><award-group><funding-source country="United States">National Institute of Child Health & Human Development : NICHD</funding-source><award-id>K24 HD054314 || HD</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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