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<title xml:lang="en">Global Perspective on Acute Coronary Syndrome: A Burden on the Young and Poor</title>
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<name sortKey="Vedanthan, Rajesh" sort="Vedanthan, Rajesh" uniqKey="Vedanthan R" first="Rajesh" last="Vedanthan">Rajesh Vedanthan</name>
<affiliation>
<nlm:aff id="A1">Zena and Michael A. Weiner Cardiovascular Institute, and Marie-Josée and Henry R. Kravis Center for Cardiovascular Health; Icahn School of Medicine at Mount Sinai; New York, NY, USA</nlm:aff>
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<name sortKey="Seligman, Benjamin" sort="Seligman, Benjamin" uniqKey="Seligman B" first="Benjamin" last="Seligman">Benjamin Seligman</name>
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<nlm:aff id="A2">Stanford University School of Medicine and Department of Biology; Stanford, CA, USA</nlm:aff>
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<name sortKey="Fuster, Valentin" sort="Fuster, Valentin" uniqKey="Fuster V" first="Valentin" last="Fuster">Valentin Fuster</name>
<affiliation>
<nlm:aff id="A1">Zena and Michael A. Weiner Cardiovascular Institute, and Marie-Josée and Henry R. Kravis Center for Cardiovascular Health; Icahn School of Medicine at Mount Sinai; New York, NY, USA</nlm:aff>
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<affiliation>
<nlm:aff id="A3">Centro Nacional de Investigaciones Cardiovasculares; Madrid, Spain</nlm:aff>
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<title xml:lang="en" level="a" type="main">Global Perspective on Acute Coronary Syndrome: A Burden on the Young and Poor</title>
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<name sortKey="Vedanthan, Rajesh" sort="Vedanthan, Rajesh" uniqKey="Vedanthan R" first="Rajesh" last="Vedanthan">Rajesh Vedanthan</name>
<affiliation>
<nlm:aff id="A1">Zena and Michael A. Weiner Cardiovascular Institute, and Marie-Josée and Henry R. Kravis Center for Cardiovascular Health; Icahn School of Medicine at Mount Sinai; New York, NY, USA</nlm:aff>
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<name sortKey="Seligman, Benjamin" sort="Seligman, Benjamin" uniqKey="Seligman B" first="Benjamin" last="Seligman">Benjamin Seligman</name>
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<nlm:aff id="A2">Stanford University School of Medicine and Department of Biology; Stanford, CA, USA</nlm:aff>
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<author>
<name sortKey="Fuster, Valentin" sort="Fuster, Valentin" uniqKey="Fuster V" first="Valentin" last="Fuster">Valentin Fuster</name>
<affiliation>
<nlm:aff id="A1">Zena and Michael A. Weiner Cardiovascular Institute, and Marie-Josée and Henry R. Kravis Center for Cardiovascular Health; Icahn School of Medicine at Mount Sinai; New York, NY, USA</nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="A3">Centro Nacional de Investigaciones Cardiovasculares; Madrid, Spain</nlm:aff>
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<series>
<title level="j">Circulation research</title>
<idno type="ISSN">0009-7330</idno>
<idno type="eISSN">1524-4571</idno>
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<date when="2014">2014</date>
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<p id="P1">Ischemic heart disease (IHD) is the greatest single cause of mortality and loss of disability-adjusted life years (DALYs) worldwide, and a substantial portion of this burden falls on low- and middle-income countries (LMICs). Deaths from IHD and acute coronary syndrome (ACS) occur, on average, at younger ages in LMICs than in high-income countries, often at economically productive ages, and likewise frequently affect the poor within LMICs. While data regarding ACS in LMICs are limited, there is a growing literature in this area and the research gaps are being steadily filled. In high-income countries, decades of investigation into the risk factors for ACS and development of behavioral programs, medications, interventional procedures, and guidelines have provided us with the tools to prevent and treat events. Although similar tools can be, and in fact have been, implemented in many LMICs, challenges remain in the development and implementation of cardiovascular health promotion activities across the entire life course, as well as in access to treatment for ACS and IHD. Intersectoral policy initiatives and global coordination are critical elements of ACS and IHD control strategies. Addressing the hurdles and scaling successful health promotion, clinical and policy efforts in LMICs are necessary in order to adequately address the global burden of ACS and IHD.</p>
</div>
</front>
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<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<journal-id journal-id-type="nlm-journal-id">0047103</journal-id>
<journal-id journal-id-type="pubmed-jr-id">2974</journal-id>
<journal-id journal-id-type="nlm-ta">Circ Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Circ. Res.</journal-id>
<journal-title-group>
<journal-title>Circulation research</journal-title>
</journal-title-group>
<issn pub-type="ppub">0009-7330</issn>
<issn pub-type="epub">1524-4571</issn>
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<article-id pub-id-type="pmid">24902978</article-id>
<article-id pub-id-type="pmc">4144436</article-id>
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<article-id pub-id-type="manuscript">NIHMS594188</article-id>
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<subject>Article</subject>
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<article-title>Global Perspective on Acute Coronary Syndrome: A Burden on the Young and Poor</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Vedanthan</surname>
<given-names>Rajesh</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Seligman</surname>
<given-names>Benjamin</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Fuster</surname>
<given-names>Valentin</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
</contrib-group>
<aff id="A1">
<label>1</label>
Zena and Michael A. Weiner Cardiovascular Institute, and Marie-Josée and Henry R. Kravis Center for Cardiovascular Health; Icahn School of Medicine at Mount Sinai; New York, NY, USA</aff>
<aff id="A2">
<label>2</label>
Stanford University School of Medicine and Department of Biology; Stanford, CA, USA</aff>
<aff id="A3">
<label>3</label>
Centro Nacional de Investigaciones Cardiovasculares; Madrid, Spain</aff>
<author-notes>
<corresp id="FN1">
<label>*</label>
Corresponding Author: Valentin Fuster, MD PhD, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1030, New York, NY 10029, Telephone: 212-241-3799, Fax: 212-423-9488,
<email>valentin.fuster@mssm.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>16</day>
<month>6</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub">
<day>6</day>
<month>6</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>06</day>
<month>6</month>
<year>2015</year>
</pub-date>
<volume>114</volume>
<issue>12</issue>
<fpage>1959</fpage>
<lpage>1975</lpage>
<pmc-comment>elocation-id from pubmed: 10.1161/CIRCRESAHA.114.302782</pmc-comment>
<abstract>
<p id="P1">Ischemic heart disease (IHD) is the greatest single cause of mortality and loss of disability-adjusted life years (DALYs) worldwide, and a substantial portion of this burden falls on low- and middle-income countries (LMICs). Deaths from IHD and acute coronary syndrome (ACS) occur, on average, at younger ages in LMICs than in high-income countries, often at economically productive ages, and likewise frequently affect the poor within LMICs. While data regarding ACS in LMICs are limited, there is a growing literature in this area and the research gaps are being steadily filled. In high-income countries, decades of investigation into the risk factors for ACS and development of behavioral programs, medications, interventional procedures, and guidelines have provided us with the tools to prevent and treat events. Although similar tools can be, and in fact have been, implemented in many LMICs, challenges remain in the development and implementation of cardiovascular health promotion activities across the entire life course, as well as in access to treatment for ACS and IHD. Intersectoral policy initiatives and global coordination are critical elements of ACS and IHD control strategies. Addressing the hurdles and scaling successful health promotion, clinical and policy efforts in LMICs are necessary in order to adequately address the global burden of ACS and IHD.</p>
</abstract>
<kwd-group>
<kwd>Acute coronary syndrome</kwd>
<kwd>epidemiology</kwd>
<kwd>global health</kwd>
<kwd>low- and middle-income countries</kwd>
<kwd>ischemic heart disease</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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