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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neonatal Mortality in HIV-Exposed Infants Born to Women Receiving Combination Antiretroviral Therapy in Rural Uganda</title>
<author><name sortKey="Ades, Veronica" sort="Ades, Veronica" uniqKey="Ades V" first="Veronica" last="Ades">Veronica Ades</name>
<affiliation><nlm:aff id="fmt044-AFF1">Department of Obstetrics and Gynecology, New York University, New York, NY 10016, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mwesigwa, Julia" sort="Mwesigwa, Julia" uniqKey="Mwesigwa J" first="Julia" last="Mwesigwa">Julia Mwesigwa</name>
<affiliation><nlm:aff id="fmt044-AFF2">Infectious Diseases Research Collaboration, Kampala, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Natureeba, Paul" sort="Natureeba, Paul" uniqKey="Natureeba P" first="Paul" last="Natureeba">Paul Natureeba</name>
<affiliation><nlm:aff id="fmt044-AFF2">Infectious Diseases Research Collaboration, Kampala, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Clark, Tamara D" sort="Clark, Tamara D" uniqKey="Clark T" first="Tamara D." last="Clark">Tamara D. Clark</name>
<affiliation><nlm:aff id="fmt044-AFF3">Department of Medicine, University of California, San Francisco, CA 94143, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Plenty, Albert" sort="Plenty, Albert" uniqKey="Plenty A" first="Albert" last="Plenty">Albert Plenty</name>
<affiliation><nlm:aff id="fmt044-AFF3">Department of Medicine, University of California, San Francisco, CA 94143, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Charlebois, Edwin" sort="Charlebois, Edwin" uniqKey="Charlebois E" first="Edwin" last="Charlebois">Edwin Charlebois</name>
<affiliation><nlm:aff id="fmt044-AFF3">Department of Medicine, University of California, San Francisco, CA 94143, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Achan, Jane" sort="Achan, Jane" uniqKey="Achan J" first="Jane" last="Achan">Jane Achan</name>
<affiliation><nlm:aff id="fmt044-AFF4">Department of Pediatrics, Makerere University College of Health Sciences, Kampala, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kamya, Moses R" sort="Kamya, Moses R" uniqKey="Kamya M" first="Moses R." last="Kamya">Moses R. Kamya</name>
<affiliation><nlm:aff id="fmt044-AFF5">Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Havlir, Diane V" sort="Havlir, Diane V" uniqKey="Havlir D" first="Diane V." last="Havlir">Diane V. Havlir</name>
<affiliation><nlm:aff id="fmt044-AFF3">Department of Medicine, University of California, San Francisco, CA 94143, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cohan, Deborah" sort="Cohan, Deborah" uniqKey="Cohan D" first="Deborah" last="Cohan">Deborah Cohan</name>
<affiliation><nlm:aff id="fmt044-AFF6">Obstetrics and Gynecology, University of California, San Francisco, CA 94143, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ruel, Theodore D" sort="Ruel, Theodore D" uniqKey="Ruel T" first="Theodore D." last="Ruel">Theodore D. Ruel</name>
<affiliation><nlm:aff id="fmt044-AFF7">Department of Pediatrics, University of California, San Francisco, CA 94143, USA</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23764539</idno>
<idno type="pmc">3842848</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842848</idno>
<idno type="RBID">PMC:3842848</idno>
<idno type="doi">10.1093/tropej/fmt044</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">001714</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001714</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Neonatal Mortality in HIV-Exposed Infants Born to Women Receiving Combination Antiretroviral Therapy in Rural Uganda</title>
<author><name sortKey="Ades, Veronica" sort="Ades, Veronica" uniqKey="Ades V" first="Veronica" last="Ades">Veronica Ades</name>
<affiliation><nlm:aff id="fmt044-AFF1">Department of Obstetrics and Gynecology, New York University, New York, NY 10016, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mwesigwa, Julia" sort="Mwesigwa, Julia" uniqKey="Mwesigwa J" first="Julia" last="Mwesigwa">Julia Mwesigwa</name>
<affiliation><nlm:aff id="fmt044-AFF2">Infectious Diseases Research Collaboration, Kampala, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Natureeba, Paul" sort="Natureeba, Paul" uniqKey="Natureeba P" first="Paul" last="Natureeba">Paul Natureeba</name>
<affiliation><nlm:aff id="fmt044-AFF2">Infectious Diseases Research Collaboration, Kampala, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Clark, Tamara D" sort="Clark, Tamara D" uniqKey="Clark T" first="Tamara D." last="Clark">Tamara D. Clark</name>
<affiliation><nlm:aff id="fmt044-AFF3">Department of Medicine, University of California, San Francisco, CA 94143, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Plenty, Albert" sort="Plenty, Albert" uniqKey="Plenty A" first="Albert" last="Plenty">Albert Plenty</name>
<affiliation><nlm:aff id="fmt044-AFF3">Department of Medicine, University of California, San Francisco, CA 94143, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Charlebois, Edwin" sort="Charlebois, Edwin" uniqKey="Charlebois E" first="Edwin" last="Charlebois">Edwin Charlebois</name>
<affiliation><nlm:aff id="fmt044-AFF3">Department of Medicine, University of California, San Francisco, CA 94143, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Achan, Jane" sort="Achan, Jane" uniqKey="Achan J" first="Jane" last="Achan">Jane Achan</name>
<affiliation><nlm:aff id="fmt044-AFF4">Department of Pediatrics, Makerere University College of Health Sciences, Kampala, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kamya, Moses R" sort="Kamya, Moses R" uniqKey="Kamya M" first="Moses R." last="Kamya">Moses R. Kamya</name>
<affiliation><nlm:aff id="fmt044-AFF5">Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Havlir, Diane V" sort="Havlir, Diane V" uniqKey="Havlir D" first="Diane V." last="Havlir">Diane V. Havlir</name>
<affiliation><nlm:aff id="fmt044-AFF3">Department of Medicine, University of California, San Francisco, CA 94143, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cohan, Deborah" sort="Cohan, Deborah" uniqKey="Cohan D" first="Deborah" last="Cohan">Deborah Cohan</name>
<affiliation><nlm:aff id="fmt044-AFF6">Obstetrics and Gynecology, University of California, San Francisco, CA 94143, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ruel, Theodore D" sort="Ruel, Theodore D" uniqKey="Ruel T" first="Theodore D." last="Ruel">Theodore D. Ruel</name>
<affiliation><nlm:aff id="fmt044-AFF7">Department of Pediatrics, University of California, San Francisco, CA 94143, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Tropical Pediatrics</title>
<idno type="ISSN">0142-6338</idno>
<idno type="eISSN">1465-3664</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>As human immunodeficiency virus (HIV)-infected women gain access to combination antiretroviral therapy throughout sub-Saharan Africa, a growing number of infants are being born HIV-exposed but uninfected. Data about neonatal mortality and the impact of premature delivery, in this population are limited. We describe the 28-day mortality outcomes in a cohort of HIV-exposed infants who had ultrasound-confirmed gestational age in rural Uganda. There were 13 deaths among 351 infants, including 9 deaths in the perinatal period. Premature delivery was a strong predictor of mortality. The prevention of HIV transmission to infants is now possible in rural low-resource settings but the frequency of neonatal death among HIV-exposed infants remains extremely high, calling for new comprehensive interventions to reduce mortality in this growing population.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Trop Pediatr</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Trop. Pediatr</journal-id>
<journal-id journal-id-type="publisher-id">tropej</journal-id>
<journal-id journal-id-type="hwp">tropej</journal-id>
<journal-title-group><journal-title>Journal of Tropical Pediatrics</journal-title>
</journal-title-group>
<issn pub-type="ppub">0142-6338</issn>
<issn pub-type="epub">1465-3664</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23764539</article-id>
<article-id pub-id-type="pmc">3842848</article-id>
<article-id pub-id-type="doi">10.1093/tropej/fmt044</article-id>
<article-id pub-id-type="publisher-id">fmt044</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Papers</subject>
</subj-group>
</article-categories>
<title-group><article-title>Neonatal Mortality in HIV-Exposed Infants Born to Women Receiving Combination Antiretroviral Therapy in Rural Uganda</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Ades</surname>
<given-names>Veronica</given-names>
</name>
<xref ref-type="aff" rid="fmt044-AFF1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mwesigwa</surname>
<given-names>Julia</given-names>
</name>
<xref ref-type="aff" rid="fmt044-AFF2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Natureeba</surname>
<given-names>Paul</given-names>
</name>
<xref ref-type="aff" rid="fmt044-AFF2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Clark</surname>
<given-names>Tamara D.</given-names>
</name>
<xref ref-type="aff" rid="fmt044-AFF3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Plenty</surname>
<given-names>Albert</given-names>
</name>
<xref ref-type="aff" rid="fmt044-AFF3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Charlebois</surname>
<given-names>Edwin</given-names>
</name>
<xref ref-type="aff" rid="fmt044-AFF3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Achan</surname>
<given-names>Jane</given-names>
</name>
<xref ref-type="aff" rid="fmt044-AFF4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kamya</surname>
<given-names>Moses R.</given-names>
</name>
<xref ref-type="aff" rid="fmt044-AFF5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Havlir</surname>
<given-names>Diane V.</given-names>
</name>
<xref ref-type="aff" rid="fmt044-AFF3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cohan</surname>
<given-names>Deborah</given-names>
</name>
<xref ref-type="aff" rid="fmt044-AFF6"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ruel</surname>
<given-names>Theodore D.</given-names>
</name>
<xref ref-type="aff" rid="fmt044-AFF7"><sup>7</sup>
</xref>
</contrib>
</contrib-group>
<aff id="fmt044-AFF1"><sup>1</sup>
Department of Obstetrics and Gynecology, New York University, New York, NY 10016, USA</aff>
<aff id="fmt044-AFF2"><sup>2</sup>
Infectious Diseases Research Collaboration, Kampala, Uganda</aff>
<aff id="fmt044-AFF3"><sup>3</sup>
Department of Medicine, University of California, San Francisco, CA 94143, USA</aff>
<aff id="fmt044-AFF4"><sup>4</sup>
Department of Pediatrics, Makerere University College of Health Sciences, Kampala, Uganda</aff>
<aff id="fmt044-AFF5"><sup>5</sup>
Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda</aff>
<aff id="fmt044-AFF6"><sup>6</sup>
Obstetrics and Gynecology, University of California, San Francisco, CA 94143, USA</aff>
<aff id="fmt044-AFF7"><sup>7</sup>
Department of Pediatrics, University of California, San Francisco, CA 94143, USA</aff>
<author-notes><corresp>Correspondence: Veronica Ades, Department of Obstetrics and Gynecology, New York University, 462 First Avenue, 9th floor, New York, NY 10010, USA. Tel: <phone>(212) 238-7244</phone>
. Fax: <fax>(212) 238-7284</fax>
. E-mail <<email>veronica.ades@nyumc.org</email>
>.</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>12</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>13</day>
<month>6</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>12</month>
<year>2014</year>
</pub-date>
<volume>59</volume>
<issue>6</issue>
<fpage>441</fpage>
<lpage>446</lpage>
<permissions><copyright-statement>© The Author [2013]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<abstract><p>As human immunodeficiency virus (HIV)-infected women gain access to combination antiretroviral therapy throughout sub-Saharan Africa, a growing number of infants are being born HIV-exposed but uninfected. Data about neonatal mortality and the impact of premature delivery, in this population are limited. We describe the 28-day mortality outcomes in a cohort of HIV-exposed infants who had ultrasound-confirmed gestational age in rural Uganda. There were 13 deaths among 351 infants, including 9 deaths in the perinatal period. Premature delivery was a strong predictor of mortality. The prevention of HIV transmission to infants is now possible in rural low-resource settings but the frequency of neonatal death among HIV-exposed infants remains extremely high, calling for new comprehensive interventions to reduce mortality in this growing population.</p>
</abstract>
<kwd-group><kwd>HIV</kwd>
<kwd>neonatal</kwd>
<kwd>mortality</kwd>
<kwd>prematurity</kwd>
<kwd>Africa</kwd>
</kwd-group>
<counts><page-count count="6"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
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