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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Iron Deficiency and Anemia Predict Mortality in Patients with Tuberculosis<xref ref-type="fn" rid="fn1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn2"><sup>2</sup></xref><xref ref-type="fn" rid="fn3"><sup>3</sup></xref></title><author><name sortKey="Isanaka, Sheila" sort="Isanaka, Sheila" uniqKey="Isanaka S" first="Sheila" last="Isanaka">Sheila Isanaka</name><affiliation><nlm:aff id="aff1">Department of Epidemiology</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Nutrition</nlm:aff></affiliation></author><author><name sortKey="Mugusi, Ferdinand" sort="Mugusi, Ferdinand" uniqKey="Mugusi F" first="Ferdinand" last="Mugusi">Ferdinand Mugusi</name></author><author><name sortKey="Urassa, Willy" sort="Urassa, Willy" uniqKey="Urassa W" first="Willy" last="Urassa">Willy Urassa</name></author><author><name sortKey="Willett, Walter C" sort="Willett, Walter C" uniqKey="Willett W" first="Walter C." last="Willett">Walter C. Willett</name><affiliation><nlm:aff id="aff1">Department of Epidemiology</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Nutrition</nlm:aff></affiliation></author><author><name sortKey="Bosch, Ronald J" sort="Bosch, Ronald J" uniqKey="Bosch R" first="Ronald J." last="Bosch">Ronald J. Bosch</name><affiliation><nlm:aff id="aff3">Department of Biostatistics</nlm:aff></affiliation></author><author><name sortKey="Villamor, Eduardo" sort="Villamor, Eduardo" uniqKey="Villamor E" first="Eduardo" last="Villamor">Eduardo Villamor</name><affiliation><nlm:aff id="aff1">Department of Epidemiology</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Nutrition</nlm:aff></affiliation></author><author><name sortKey="Spiegelman, Donna" sort="Spiegelman, Donna" uniqKey="Spiegelman D" first="Donna" last="Spiegelman">Donna Spiegelman</name><affiliation><nlm:aff id="aff1">Department of Epidemiology</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Department of Biostatistics</nlm:aff></affiliation></author><author><name sortKey="Duggan, Christopher" sort="Duggan, Christopher" uniqKey="Duggan C" first="Christopher" last="Duggan">Christopher Duggan</name><affiliation><nlm:aff id="aff2">Department of Nutrition</nlm:aff></affiliation></author><author><name sortKey="Fawzi, Wafaie W" sort="Fawzi, Wafaie W" uniqKey="Fawzi W" first="Wafaie W." last="Fawzi">Wafaie W. Fawzi</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22190024</idno><idno type="pmc">3260062</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260062</idno><idno type="RBID">PMC:3260062</idno><idno type="doi">10.3945/jn.111.144287</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001701</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001701</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Iron Deficiency and Anemia Predict Mortality in Patients with Tuberculosis<xref ref-type="fn" rid="fn1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn2"><sup>2</sup></xref><xref ref-type="fn" rid="fn3"><sup>3</sup></xref></title><author><name sortKey="Isanaka, Sheila" sort="Isanaka, Sheila" uniqKey="Isanaka S" first="Sheila" last="Isanaka">Sheila Isanaka</name><affiliation><nlm:aff id="aff1">Department of Epidemiology</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Nutrition</nlm:aff></affiliation></author><author><name sortKey="Mugusi, Ferdinand" sort="Mugusi, Ferdinand" uniqKey="Mugusi F" first="Ferdinand" last="Mugusi">Ferdinand Mugusi</name></author><author><name sortKey="Urassa, Willy" sort="Urassa, Willy" uniqKey="Urassa W" first="Willy" last="Urassa">Willy Urassa</name></author><author><name sortKey="Willett, Walter C" sort="Willett, Walter C" uniqKey="Willett W" first="Walter C." last="Willett">Walter C. Willett</name><affiliation><nlm:aff id="aff1">Department of Epidemiology</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Nutrition</nlm:aff></affiliation></author><author><name sortKey="Bosch, Ronald J" sort="Bosch, Ronald J" uniqKey="Bosch R" first="Ronald J." last="Bosch">Ronald J. Bosch</name><affiliation><nlm:aff id="aff3">Department of Biostatistics</nlm:aff></affiliation></author><author><name sortKey="Villamor, Eduardo" sort="Villamor, Eduardo" uniqKey="Villamor E" first="Eduardo" last="Villamor">Eduardo Villamor</name><affiliation><nlm:aff id="aff1">Department of Epidemiology</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Nutrition</nlm:aff></affiliation></author><author><name sortKey="Spiegelman, Donna" sort="Spiegelman, Donna" uniqKey="Spiegelman D" first="Donna" last="Spiegelman">Donna Spiegelman</name><affiliation><nlm:aff id="aff1">Department of Epidemiology</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Department of Biostatistics</nlm:aff></affiliation></author><author><name sortKey="Duggan, Christopher" sort="Duggan, Christopher" uniqKey="Duggan C" first="Christopher" last="Duggan">Christopher Duggan</name><affiliation><nlm:aff id="aff2">Department of Nutrition</nlm:aff></affiliation></author><author><name sortKey="Fawzi, Wafaie W" sort="Fawzi, Wafaie W" uniqKey="Fawzi W" first="Wafaie W." last="Fawzi">Wafaie W. Fawzi</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Nutrition</title><idno type="ISSN">0022-3166</idno><idno type="eISSN">1541-6100</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Many studies have documented a high prevalence of anemia among tuberculosis (TB) patients and anemia at TB diagnosis has been associated with an increased risk of death. However, little is known about the factors contributing to the development of TB-associated anemia and their importance in TB disease progression. Data from a randomized clinical trial of micronutrient supplementation in patients with pulmonary TB in Tanzania were analyzed. Repeated measures of anemia with iron deficiency, anemia without iron deficiency, and iron deficiency without anemia were assessed as risk factors for treatment failure, TB recurrence, and mortality. The prevalence of anemia (hemoglobin < 110 g/L) at baseline was 64%, more than one-half of which was related to iron deficiency (mean corpuscular volume , 80 fL). We found no evidence of an association between anemia (with or without iron deficiency) or iron deficiency without anemia at baseline and the risk of treatment failure at 1 mo after initiation. Anemia without iron deficiency was associated with an independent, 4-fold increased risk of TB recurrence [adjusted RR = 4.10 (95% CI = 1.88, 8.91); <italic>P</italic> < 0.001]. Iron deficiency and anemia (with and without iron deficiency) were associated with a 2- to nearly 3-fold independent increase in the risk of death [adjusted RR for iron deficiency without anemia = 2.89 (95% CI = 1.53, 5.47); <italic>P</italic> = 0.001; anemia without iron deficiency = 2.72 (95% CI = 1.50, 4.93); <italic>P</italic> = 0.001; iron deficiency anemia = 2.13 (95% CI = 1.10, 4.11); <italic>P</italic> = 0.02]. Efforts to identify and address the conditions contributing to TB-associated anemia, including iron deficiency, could play an important role in reducing morbidity and mortality in areas heavily affected by TB.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Nutr</journal-id><journal-id journal-id-type="publisher-id">nutrition</journal-id><journal-id journal-id-type="hwp">nutrition</journal-id><journal-title-group><journal-title>The Journal of Nutrition</journal-title></journal-title-group><issn pub-type="ppub">0022-3166</issn><issn pub-type="epub">1541-6100</issn><publisher><publisher-name>American Society for Nutrition</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22190024</article-id><article-id pub-id-type="pmc">3260062</article-id><article-id pub-id-type="publisher-id">144287</article-id><article-id pub-id-type="doi">10.3945/jn.111.144287</article-id><article-categories><subj-group subj-group-type="heading"><subject>Community and International Nutrition</subject></subj-group></article-categories><title-group><article-title>Iron Deficiency and Anemia Predict Mortality in Patients with Tuberculosis<xref ref-type="fn" rid="fn1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn2"><sup>2</sup></xref><xref ref-type="fn" rid="fn3"><sup>3</sup></xref></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Isanaka</surname><given-names>Sheila</given-names></name><xref ref-type="aff" rid="aff1"><sup>4</sup></xref><xref ref-type="aff" rid="aff2"><sup>5</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mugusi</surname><given-names>Ferdinand</given-names></name><xref ref-type="aff" rid="aff5"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Urassa</surname><given-names>Willy</given-names></name><xref ref-type="aff" rid="aff6"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Willett</surname><given-names>Walter C.</given-names></name><xref ref-type="aff" rid="aff1"><sup>4</sup></xref><xref ref-type="aff" rid="aff2"><sup>5</sup></xref><xref ref-type="aff" rid="aff7"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bosch</surname><given-names>Ronald J.</given-names></name><xref ref-type="aff" rid="aff3"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Villamor</surname><given-names>Eduardo</given-names></name><xref ref-type="aff" rid="aff1"><sup>4</sup></xref><xref ref-type="aff" rid="aff2"><sup>5</sup></xref><xref ref-type="aff" rid="aff8"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Spiegelman</surname><given-names>Donna</given-names></name><xref ref-type="aff" rid="aff1"><sup>4</sup></xref><xref ref-type="aff" rid="aff3"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Duggan</surname><given-names>Christopher</given-names></name><xref ref-type="aff" rid="aff2"><sup>5</sup></xref><xref ref-type="aff" rid="aff9"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Fawzi</surname><given-names>Wafaie W.</given-names></name><xref ref-type="aff" rid="aff1"><sup>4–6</sup></xref><xref ref-type="aff" rid="aff2"></xref><xref ref-type="aff" rid="aff3"></xref></contrib><aff id="aff1"><label>4</label>Department of Epidemiology</aff><aff id="aff2"><label>5</label>Department of Nutrition</aff><aff id="aff3"><label>6</label>Department of Biostatistics</aff><aff><sup>7</sup>Department of Global Health and Population, Harvard School of Public Health, Boston, MA</aff><aff id="aff5"><label>8</label>Department of Internal Medicine</aff><aff id="aff6"><label>9</label>Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania</aff><aff id="aff7"><label>10</label>Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, MA</aff><aff id="aff8"><label>11</label>Departments of Environmental Health Sciences and Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI</aff><aff id="aff9"><label>12</label>Division of Gastroenterology and Nutrition, Children’s Hospital Boston, Boston, MA</aff></contrib-group><author-notes><fn id="fn2" fn-type="conflict"><label>2</label><p>Author disclosures: S. Isanaka, F. Mugusi, W. Urassa, W. C. Willett, R. J. Bosch, E. Villamor, D. Spiegelman, C. Duggan, and W. W. Fawzi, no conflicts of interest.</p></fn><corresp id="cor1"><label>*</label>To whom correspondence should be addressed. E-mail: <email>sisanaka@hsph.harvard.edu</email>.</corresp></author-notes><pub-date pub-type="ppub"><month>2</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>21</day><month>12</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>2</month><year>2013</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>142</volume><issue>2</issue><fpage>350</fpage><lpage>357</lpage><history><date date-type="received"><day>5</day><month>5</month><year>2011</year></date><date date-type="rev-recd"><day>29</day><month>6</month><year>2011</year></date><date date-type="accepted"><day>2</day><month>11</month><year>2011</year></date></history><permissions><copyright-statement>© 2012 American Society for Nutrition</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><p>Many studies have documented a high prevalence of anemia among tuberculosis (TB) patients and anemia at TB diagnosis has been associated with an increased risk of death. However, little is known about the factors contributing to the development of TB-associated anemia and their importance in TB disease progression. Data from a randomized clinical trial of micronutrient supplementation in patients with pulmonary TB in Tanzania were analyzed. Repeated measures of anemia with iron deficiency, anemia without iron deficiency, and iron deficiency without anemia were assessed as risk factors for treatment failure, TB recurrence, and mortality. The prevalence of anemia (hemoglobin < 110 g/L) at baseline was 64%, more than one-half of which was related to iron deficiency (mean corpuscular volume , 80 fL). We found no evidence of an association between anemia (with or without iron deficiency) or iron deficiency without anemia at baseline and the risk of treatment failure at 1 mo after initiation. Anemia without iron deficiency was associated with an independent, 4-fold increased risk of TB recurrence [adjusted RR = 4.10 (95% CI = 1.88, 8.91); <italic>P</italic> < 0.001]. Iron deficiency and anemia (with and without iron deficiency) were associated with a 2- to nearly 3-fold independent increase in the risk of death [adjusted RR for iron deficiency without anemia = 2.89 (95% CI = 1.53, 5.47); <italic>P</italic> = 0.001; anemia without iron deficiency = 2.72 (95% CI = 1.50, 4.93); <italic>P</italic> = 0.001; iron deficiency anemia = 2.13 (95% CI = 1.10, 4.11); <italic>P</italic> = 0.02]. Efforts to identify and address the conditions contributing to TB-associated anemia, including iron deficiency, could play an important role in reducing morbidity and mortality in areas heavily affected by TB.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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