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<title xml:lang="en">Sociodemographic characteristics and chronic medical conditions as risk factors for herpes zoster</title>
<author>
<name sortKey="Esteban Vasallo, Maria D" sort="Esteban Vasallo, Maria D" uniqKey="Esteban Vasallo M" first="María D" last="Esteban-Vasallo">María D. Esteban-Vasallo</name>
<affiliation>
<nlm:aff id="A1">Subdirectorate for Health Promotion and Prevention; Madrid Regional Health Authority; Madrid, Spain</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Dominguez Berj N, M Felicitas" sort="Dominguez Berj N, M Felicitas" uniqKey="Dominguez Berj N M" first="M Felicitas" last="Domínguez-Berj N">M Felicitas Domínguez-Berj N</name>
<affiliation>
<nlm:aff id="A1">Subdirectorate for Health Promotion and Prevention; Madrid Regional Health Authority; Madrid, Spain</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gil Prieto, Ruth" sort="Gil Prieto, Ruth" uniqKey="Gil Prieto R" first="Ruth" last="Gil-Prieto">Ruth Gil-Prieto</name>
<affiliation>
<nlm:aff id="A2">Department of Preventive Medicine and Public Health and Medical Inmunology and Microbiology; Rey Juan Carlos University; Madrid, Spain</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Astray Mochales, Jenaro" sort="Astray Mochales, Jenaro" uniqKey="Astray Mochales J" first="Jenaro" last="Astray-Mochales">Jenaro Astray-Mochales</name>
<affiliation>
<nlm:aff id="A1">Subdirectorate for Health Promotion and Prevention; Madrid Regional Health Authority; Madrid, Spain</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gil De Miguel, Angel" sort="Gil De Miguel, Angel" uniqKey="Gil De Miguel A" first="Ángel" last="Gil De Miguel">Ángel Gil De Miguel</name>
<affiliation>
<nlm:aff id="A2">Department of Preventive Medicine and Public Health and Medical Inmunology and Microbiology; Rey Juan Carlos University; Madrid, Spain</nlm:aff>
</affiliation>
</author>
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<idno type="pmid">24805130</idno>
<idno type="pmc">5396250</idno>
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<idno type="RBID">PMC:5396250</idno>
<idno type="doi">10.4161/hv.28620</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">001683</idno>
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<title xml:lang="en" level="a" type="main">Sociodemographic characteristics and chronic medical conditions as risk factors for herpes zoster</title>
<author>
<name sortKey="Esteban Vasallo, Maria D" sort="Esteban Vasallo, Maria D" uniqKey="Esteban Vasallo M" first="María D" last="Esteban-Vasallo">María D. Esteban-Vasallo</name>
<affiliation>
<nlm:aff id="A1">Subdirectorate for Health Promotion and Prevention; Madrid Regional Health Authority; Madrid, Spain</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Dominguez Berj N, M Felicitas" sort="Dominguez Berj N, M Felicitas" uniqKey="Dominguez Berj N M" first="M Felicitas" last="Domínguez-Berj N">M Felicitas Domínguez-Berj N</name>
<affiliation>
<nlm:aff id="A1">Subdirectorate for Health Promotion and Prevention; Madrid Regional Health Authority; Madrid, Spain</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gil Prieto, Ruth" sort="Gil Prieto, Ruth" uniqKey="Gil Prieto R" first="Ruth" last="Gil-Prieto">Ruth Gil-Prieto</name>
<affiliation>
<nlm:aff id="A2">Department of Preventive Medicine and Public Health and Medical Inmunology and Microbiology; Rey Juan Carlos University; Madrid, Spain</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Astray Mochales, Jenaro" sort="Astray Mochales, Jenaro" uniqKey="Astray Mochales J" first="Jenaro" last="Astray-Mochales">Jenaro Astray-Mochales</name>
<affiliation>
<nlm:aff id="A1">Subdirectorate for Health Promotion and Prevention; Madrid Regional Health Authority; Madrid, Spain</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gil De Miguel, Angel" sort="Gil De Miguel, Angel" uniqKey="Gil De Miguel A" first="Ángel" last="Gil De Miguel">Ángel Gil De Miguel</name>
<affiliation>
<nlm:aff id="A2">Department of Preventive Medicine and Public Health and Medical Inmunology and Microbiology; Rey Juan Carlos University; Madrid, Spain</nlm:aff>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Human Vaccines & Immunotherapeutics</title>
<idno type="ISSN">2164-5515</idno>
<idno type="eISSN">2164-554X</idno>
<imprint>
<date when="2014">2014</date>
</imprint>
</series>
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<div type="abstract" xml:lang="en">
<p>The objectives of this study were to estimate incidence density rates (IDR) of herpes zoster (HZ) and to analyze the association with sociodemographic characteristics and selected chronic medical conditions. The study cohort consisted of the adult population included in the Public Health System of the Autonomous Community of Madrid, Spain on 1/10/2009 (5 244 402 persons). Data source were electronic medical records from primary care between 1/10/2009–31/12/2012. Individual socioeconomic status (SES) was inferred by geocoding. Poisson regression analyses were stratified by sex, to identify factors associated with HZ. We identified 81 541 incident cases of HZ (61.7% in women and 46.5% in the group aged 60 and over). IDR was 4.11 per 1000 person-years in men and 5.95 in women. IDR were higher with age, in autochthonous population, those with lower SES and in patients with immunodeficiencies. After adjustment, higher incidence rate ratios were found with age, autochthonous origin, lower SES, and in patients with HIV-infection/AIDS (3.20, CI95% 2.90–3.53 in men and 2.98, CI95% 2.58–3.45 in women), and other immunodeficiencies (1.57, CI95% 1.41–1.75 and 1.65, CI95% 1.50–1.80). COPD, asthma, DM, ischemic heart disease, other cardiovascular diseases, and cancer were also associated with an increased incidence of HZ. We conclude that older, autochthonous patients with lower SES and with certain underlying medical conditions had a higher probability of suffering HZ. Electronic databases are useful for estimating the incidence of HZ, and for finding associations with sociodemographic and clinical characteristics. Identifying unrecognized risk factors for HZ, such as asthma or cardiovascular diseases, is crucial to interpret the epidemiology of HZ, to target vaccination programs and to monitor their effect.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Hum Vaccin Immunother</journal-id>
<journal-id journal-id-type="iso-abbrev">Hum Vaccin Immunother</journal-id>
<journal-id journal-id-type="publisher-id">HV</journal-id>
<journal-title-group>
<journal-title>Human Vaccines & Immunotherapeutics</journal-title>
</journal-title-group>
<issn pub-type="ppub">2164-5515</issn>
<issn pub-type="epub">2164-554X</issn>
<publisher>
<publisher-name>Landes Bioscience</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">24805130</article-id>
<article-id pub-id-type="pmc">5396250</article-id>
<article-id pub-id-type="publisher-id">2014HV0026R2</article-id>
<article-id pub-id-type="doi">10.4161/hv.28620</article-id>
<article-id pub-id-type="publisher-id">28620</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Research Paper</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Sociodemographic characteristics and chronic medical conditions as risk factors for herpes zoster</article-title>
<subtitle>A population-based study from primary care in Madrid (Spain)</subtitle>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Esteban-Vasallo</surname>
<given-names>María D</given-names>
</name>
<xref ref-type="aff" rid="A1">
<sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Domínguez-Berjón</surname>
<given-names>M Felicitas</given-names>
</name>
<xref ref-type="aff" rid="A1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gil-Prieto</surname>
<given-names>Ruth</given-names>
</name>
<xref ref-type="aff" rid="A2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Astray-Mochales</surname>
<given-names>Jenaro</given-names>
</name>
<xref ref-type="aff" rid="A1">
<sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gil de Miguel</surname>
<given-names>Ángel</given-names>
</name>
<xref ref-type="aff" rid="A2">
<sup>2</sup>
</xref>
</contrib>
<aff id="A1">
<label>1</label>
Subdirectorate for Health Promotion and Prevention; Madrid Regional Health Authority; Madrid, Spain</aff>
<aff id="A2">
<label>2</label>
Department of Preventive Medicine and Public Health and Medical Inmunology and Microbiology; Rey Juan Carlos University; Madrid, Spain</aff>
</contrib-group>
<author-notes>
<corresp id="cor1">
<label>*</label>
Correspondence to: María D Esteban-Vasallo, Email:
<email xlink:href="maria.estebanv@salud.madrid.org">maria.estebanv@salud.madrid.org</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub">
<day>01</day>
<month>6</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub">
<day>07</day>
<month>5</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>07</day>
<month>5</month>
<year>2015</year>
</pub-date>
<pmc-comment> PMC Release delay is 12 months and 0 days and was based on the . </pmc-comment>
<volume>10</volume>
<issue>6</issue>
<fpage>1650</fpage>
<lpage>1660</lpage>
<history>
<date date-type="received">
<day>15</day>
<month>1</month>
<year>2014</year>
</date>
<date date-type="rev-recd">
<day>07</day>
<month>3</month>
<year>2014</year>
</date>
<date date-type="accepted">
<day>21</day>
<month>3</month>
<year>2014</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright © 2014 Landes Bioscience</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract>
<p>The objectives of this study were to estimate incidence density rates (IDR) of herpes zoster (HZ) and to analyze the association with sociodemographic characteristics and selected chronic medical conditions. The study cohort consisted of the adult population included in the Public Health System of the Autonomous Community of Madrid, Spain on 1/10/2009 (5 244 402 persons). Data source were electronic medical records from primary care between 1/10/2009–31/12/2012. Individual socioeconomic status (SES) was inferred by geocoding. Poisson regression analyses were stratified by sex, to identify factors associated with HZ. We identified 81 541 incident cases of HZ (61.7% in women and 46.5% in the group aged 60 and over). IDR was 4.11 per 1000 person-years in men and 5.95 in women. IDR were higher with age, in autochthonous population, those with lower SES and in patients with immunodeficiencies. After adjustment, higher incidence rate ratios were found with age, autochthonous origin, lower SES, and in patients with HIV-infection/AIDS (3.20, CI95% 2.90–3.53 in men and 2.98, CI95% 2.58–3.45 in women), and other immunodeficiencies (1.57, CI95% 1.41–1.75 and 1.65, CI95% 1.50–1.80). COPD, asthma, DM, ischemic heart disease, other cardiovascular diseases, and cancer were also associated with an increased incidence of HZ. We conclude that older, autochthonous patients with lower SES and with certain underlying medical conditions had a higher probability of suffering HZ. Electronic databases are useful for estimating the incidence of HZ, and for finding associations with sociodemographic and clinical characteristics. Identifying unrecognized risk factors for HZ, such as asthma or cardiovascular diseases, is crucial to interpret the epidemiology of HZ, to target vaccination programs and to monitor their effect.</p>
</abstract>
<kwd-group kwd-group-type="author">
<title>Keywords: </title>
<kwd>chronic conditions</kwd>
<kwd>herpes zoster</kwd>
<kwd>incidence</kwd>
<kwd>primary health care</kwd>
<kwd>risk factor</kwd>
<kwd>vaccine</kwd>
<kwd>varicella</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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