Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Weight change at 1 mo of antiretroviral therapy and its association with subsequent mortality, morbidity, and CD4 T cell reconstitution in a Tanzanian HIV-infected adult cohort<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"><sup>3</sup></xref></title><author><name sortKey="Sudfeld, Christopher R" sort="Sudfeld, Christopher R" uniqKey="Sudfeld C" first="Christopher R" last="Sudfeld">Christopher R. Sudfeld</name></author><author><name sortKey="Isanaka, Sheila" sort="Isanaka, Sheila" uniqKey="Isanaka S" first="Sheila" last="Isanaka">Sheila Isanaka</name></author><author><name sortKey="Mugusi, Ferdinand M" sort="Mugusi, Ferdinand M" uniqKey="Mugusi F" first="Ferdinand M" last="Mugusi">Ferdinand M. Mugusi</name></author><author><name sortKey="Aboud, Said" sort="Aboud, Said" uniqKey="Aboud S" first="Said" last="Aboud">Said Aboud</name></author><author><name sortKey="Wang, Molin" sort="Wang, Molin" uniqKey="Wang M" first="Molin" last="Wang">Molin Wang</name></author><author><name sortKey="Chalamilla, Guerino E" sort="Chalamilla, Guerino E" uniqKey="Chalamilla G" first="Guerino E" last="Chalamilla">Guerino E. Chalamilla</name></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name></author><author><name sortKey="Fawzi, Wafaie W" sort="Fawzi, Wafaie W" uniqKey="Fawzi W" first="Wafaie W" last="Fawzi">Wafaie W. Fawzi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23636235</idno><idno type="pmc">3652924</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652924</idno><idno type="RBID">PMC:3652924</idno><idno type="doi">10.3945/ajcn.112.053728</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001575</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001575</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Weight change at 1 mo of antiretroviral therapy and its association with subsequent mortality, morbidity, and CD4 T cell reconstitution in a Tanzanian HIV-infected adult cohort<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"><sup>3</sup></xref></title><author><name sortKey="Sudfeld, Christopher R" sort="Sudfeld, Christopher R" uniqKey="Sudfeld C" first="Christopher R" last="Sudfeld">Christopher R. Sudfeld</name></author><author><name sortKey="Isanaka, Sheila" sort="Isanaka, Sheila" uniqKey="Isanaka S" first="Sheila" last="Isanaka">Sheila Isanaka</name></author><author><name sortKey="Mugusi, Ferdinand M" sort="Mugusi, Ferdinand M" uniqKey="Mugusi F" first="Ferdinand M" last="Mugusi">Ferdinand M. Mugusi</name></author><author><name sortKey="Aboud, Said" sort="Aboud, Said" uniqKey="Aboud S" first="Said" last="Aboud">Said Aboud</name></author><author><name sortKey="Wang, Molin" sort="Wang, Molin" uniqKey="Wang M" first="Molin" last="Wang">Molin Wang</name></author><author><name sortKey="Chalamilla, Guerino E" sort="Chalamilla, Guerino E" uniqKey="Chalamilla G" first="Guerino E" last="Chalamilla">Guerino E. Chalamilla</name></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name></author><author><name sortKey="Fawzi, Wafaie W" sort="Fawzi, Wafaie W" uniqKey="Fawzi W" first="Wafaie W" last="Fawzi">Wafaie W. Fawzi</name></author></analytic><series><title level="j">The American Journal of Clinical Nutrition</title><idno type="ISSN">0002-9165</idno><idno type="eISSN">1938-3207</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> The development of low-cost point-of-care technologies to improve HIV treatment is a major focus of current research in resource-limited settings.</p><p><bold>Objective:</bold> We assessed associations of body mass index (BMI; in kg/m<sup>2</sup>) at antiretroviral therapy (ART) initiation and weight change after 1 mo of treatment with mortality, morbidity, and CD4 T cell reconstitution.</p><p><bold>Design:</bold> A prospective cohort of 3389 Tanzanian adults initiating ART enrolled in a multivitamin trial was followed at monthly clinic visits (median: 19.7 mo). Proportional hazard models were used to analyze mortality and morbidity associations, whereas generalized estimating equations were used for CD4 T cell counts.</p><p><bold>Results:</bold> The median weight change at 1 mo of ART was +2.0% (IQR: −0.4% to +4.6%). The association of weight loss at 1 mo with subsequent mortality varied significantly by baseline BMI (<italic>P</italic> = 0.011). Participants with ≥2.5% weight loss had 6.43 times (95% CI: 3.78, 10.93 times) the hazard of mortality compared with that of participants with weight gains ≥2.5%, if their baseline BMI was <18.5 but only 2.73 times (95% CI: 1.49, 5.00 times) the hazard of mortality if their baseline BMI was ≥18.5 and <25.0. Weight loss at 1 mo was also associated with incident pneumonia (<italic>P</italic> = 0.002), oral thrush (<italic>P</italic> = 0.007), and pulmonary tuberculosis (<italic>P</italic> < 0.001) but not change in CD4 T cell counts (<italic>P</italic> > 0.05).</p><p><bold>Conclusions:</bold> Weight loss as early as 1 mo after ART initiation can identify adults at high risk of adverse outcomes. Studies identifying reasons for and managing early weight loss are needed to improve HIV treatment, with particular urgency for malnourished adults initiating ART. The parent trial was registered at <ext-link ext-link-type="uri" xlink:href="clinicaltrials.gov">clinicaltrials.gov</ext-link> as NCT00383669.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Clin Nutr</journal-id><journal-id journal-id-type="iso-abbrev">Am. J. Clin. Nutr</journal-id><journal-id journal-id-type="publisher-id">ajcn</journal-id><journal-title-group><journal-title>The American Journal of Clinical Nutrition</journal-title></journal-title-group><issn pub-type="ppub">0002-9165</issn><issn pub-type="epub">1938-3207</issn><publisher><publisher-name>American Society for Nutrition</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23636235</article-id><article-id pub-id-type="pmc">3652924</article-id><article-id pub-id-type="publisher-id">053728</article-id><article-id pub-id-type="doi">10.3945/ajcn.112.053728</article-id><article-categories><subj-group subj-group-type="heading"><subject>AIDS and other wasting syndromes</subject></subj-group></article-categories><title-group><article-title>Weight change at 1 mo of antiretroviral therapy and its association with subsequent mortality, morbidity, and CD4 T cell reconstitution in a Tanzanian HIV-infected adult cohort<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"><sup>3</sup></xref></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sudfeld</surname><given-names>Christopher R</given-names></name></contrib><contrib contrib-type="author"><name><surname>Isanaka</surname><given-names>Sheila</given-names></name></contrib><contrib contrib-type="author"><name><surname>Mugusi</surname><given-names>Ferdinand M</given-names></name></contrib><contrib contrib-type="author"><name><surname>Aboud</surname><given-names>Said</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Molin</given-names></name></contrib><contrib contrib-type="author"><name><surname>Chalamilla</surname><given-names>Guerino E</given-names></name></contrib><contrib contrib-type="author"><name><surname>Giovannucci</surname><given-names>Edward L</given-names></name></contrib><contrib contrib-type="author"><name><surname>Fawzi</surname><given-names>Wafaie W</given-names></name></contrib><aff id="aff1"><label>1</label>From the Departments of Epidemiology (CRS, MW, ELG, and WWF), Nutrition (SI, ELG, GEC, and WWF), Biostatistics (MW), and Global Health and Population (WWF), Harvard School of Public Health, Boston, MA; the Departments of Internal Medicine (FMM) and Microbiology and Immunology (SA), Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Management and Development for Health, Dar es Salaam, Tanzania (GEC); and the Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA (MW and ELG).</aff></contrib-group><author-notes><fn id="fn1"><label>2</label><p>Supported by the <funding-source>National Institute of Child Health and Human Development</funding-source> (grant <award-id>R01 HD32257</award-id>) and the National Institute of Allergy and Infectious Diseases (grant <award-id>T32AI007358</award-id>; to CRS).</p></fn><corresp id="cor1"><label>3</label>Address correspondence to C Sudfeld, 665 Huntington Avenue, Building 1, Room 1102, Boston, MA 02115. E-mail: <email xlink:type="simple">csudfeld@mail.harvard.edu</email>.</corresp></author-notes><pmc-comment>Fake ppub date generated by PMC from publisher pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>6</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>1</day><month>5</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>6</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
<volume>97</volume><issue>6</issue><fpage>1278</fpage><lpage>1287</lpage><history><date date-type="received"><day>20</day><month>11</month><year>2012</year></date><date date-type="accepted"><day>25</day><month>3</month><year>2013</year></date></history><permissions><copyright-statement>© 2013 American Society for Nutrition</copyright-statement><copyright-year>2013</copyright-year></permissions><abstract><p><bold>Background:</bold> The development of low-cost point-of-care technologies to improve HIV treatment is a major focus of current research in resource-limited settings.</p><p><bold>Objective:</bold> We assessed associations of body mass index (BMI; in kg/m<sup>2</sup>) at antiretroviral therapy (ART) initiation and weight change after 1 mo of treatment with mortality, morbidity, and CD4 T cell reconstitution.</p><p><bold>Design:</bold> A prospective cohort of 3389 Tanzanian adults initiating ART enrolled in a multivitamin trial was followed at monthly clinic visits (median: 19.7 mo). Proportional hazard models were used to analyze mortality and morbidity associations, whereas generalized estimating equations were used for CD4 T cell counts.</p><p><bold>Results:</bold> The median weight change at 1 mo of ART was +2.0% (IQR: −0.4% to +4.6%). The association of weight loss at 1 mo with subsequent mortality varied significantly by baseline BMI (<italic>P</italic> = 0.011). Participants with ≥2.5% weight loss had 6.43 times (95% CI: 3.78, 10.93 times) the hazard of mortality compared with that of participants with weight gains ≥2.5%, if their baseline BMI was <18.5 but only 2.73 times (95% CI: 1.49, 5.00 times) the hazard of mortality if their baseline BMI was ≥18.5 and <25.0. Weight loss at 1 mo was also associated with incident pneumonia (<italic>P</italic> = 0.002), oral thrush (<italic>P</italic> = 0.007), and pulmonary tuberculosis (<italic>P</italic> < 0.001) but not change in CD4 T cell counts (<italic>P</italic> > 0.05).</p><p><bold>Conclusions:</bold> Weight loss as early as 1 mo after ART initiation can identify adults at high risk of adverse outcomes. Studies identifying reasons for and managing early weight loss are needed to improve HIV treatment, with particular urgency for malnourished adults initiating ART. The parent trial was registered at <ext-link ext-link-type="uri" xlink:href="clinicaltrials.gov">clinicaltrials.gov</ext-link> as NCT00383669.</p></abstract><counts><page-count count="10"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001575 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001575 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= SidaSubSaharaV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.32. |  |