SidaSubSaharaV1, Pmc, Corpus, bibRecord, 001082

Body mass index and risk of tuberculosis and death

Identifieur interne : 001082 ( Pmc/Corpus ); précédent : 001081; suivant : 001083

Body mass index and risk of tuberculosis and death

Auteurs : Colleen F. Hanrahan ; Jonathan E. Golub ; Lerato Mohapi ; Nkeko Tshabangu ; Tebogo Modisenyane ; Richard E. Chaisson ; Glenda E. Gray ; James A. Mcintyre ; Neil A. Martinson

Source :

AIDS (London, England) [ 0269-9370 ] ; 2010.

RBID : PMC:3063388

Abstract

Background

High BMI has been shown to be protective against tuberculosis (TB) among HIV-uninfected individuals, as well as against disease progression and mortality among those with HIV. We examined the effect of BMI on all-cause mortality and TB incidence among a cohort of HIV-infected adults in Soweto, South Africa.

Methods

A clinical cohort of 3456 HIV-infected adults from South Africa was prospectively followed from 2003 to 2008 with regular monitoring. The primary exposure was BMI and the outcomes of interest were all-cause mortality and a newly diagnosed episode of TB. Cox proportional hazard models assessed associations with risk of mortality or incident TB.

Results

Incidence rates of mortality were 10.4/100 person-years for baseline BMI of 18.5 or less, 3.6/100 person-years for baseline BMI 18.6–25, 1.7/100 person-years for baseline BMI 25.1–30, and 1.6/100 person-years for baseline BMI more than 30. Compared to those with normal BMI, overweight and obese participants had a significantly reduced risk of mortality [adjusted hazard ratio 0.59 (95% confidence interval, CI 0.40–0.87) and 0.48 (95% CI 0.29–0.80), respectively]. Incidence rates of TB by baseline BMI were 7.3/100 person-years for underweight, 6.0/100 person-years for normal, 3.2/100 person-years for overweight, and 1.9/100 person-years for obese. Compared to those with normal BMI, those with overweight and obese BMI were at a significantly reduced risk of developing TB [adjusted hazard ratio 0.56 (95% CI 0.38–0.83) and 0.33 (95% CI 0.19–0.55), respectively].

Conclusion

HIV-infected individuals with obese and overweight BMI have a significantly reduced risk of both mortality and TB, after adjusting for HAART use and CD4 cell count.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063388

DOI: 10.1097/QAD.0b013e32833a2a4a
PubMed: 20505496
PubMed Central: 3063388

Links to Exploration step

PMC:3063388

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Body mass index and risk of tuberculosis and death</title>
<author><name sortKey="Hanrahan, Colleen F" sort="Hanrahan, Colleen F" uniqKey="Hanrahan C" first="Colleen F." last="Hanrahan">Colleen F. Hanrahan</name>
<affiliation><nlm:aff id="A1"> Johns Hopkins Bloomberg School of Public Heath, Baltimore, Maryland, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Golub, Jonathan E" sort="Golub, Jonathan E" uniqKey="Golub J" first="Jonathan E." last="Golub">Jonathan E. Golub</name>
<affiliation><nlm:aff id="A2"> Johns Hopkins University Center for TB Research, Baltimore, Maryland, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mohapi, Lerato" sort="Mohapi, Lerato" uniqKey="Mohapi L" first="Lerato" last="Mohapi">Lerato Mohapi</name>
<affiliation><nlm:aff id="A3"> Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tshabangu, Nkeko" sort="Tshabangu, Nkeko" uniqKey="Tshabangu N" first="Nkeko" last="Tshabangu">Nkeko Tshabangu</name>
<affiliation><nlm:aff id="A3"> Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Modisenyane, Tebogo" sort="Modisenyane, Tebogo" uniqKey="Modisenyane T" first="Tebogo" last="Modisenyane">Tebogo Modisenyane</name>
<affiliation><nlm:aff id="A3"> Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chaisson, Richard E" sort="Chaisson, Richard E" uniqKey="Chaisson R" first="Richard E." last="Chaisson">Richard E. Chaisson</name>
<affiliation><nlm:aff id="A2"> Johns Hopkins University Center for TB Research, Baltimore, Maryland, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gray, Glenda E" sort="Gray, Glenda E" uniqKey="Gray G" first="Glenda E." last="Gray">Glenda E. Gray</name>
<affiliation><nlm:aff id="A3"> Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mcintyre, James A" sort="Mcintyre, James A" uniqKey="Mcintyre J" first="James A." last="Mcintyre">James A. Mcintyre</name>
<affiliation><nlm:aff id="A3"> Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Martinson, Neil A" sort="Martinson, Neil A" uniqKey="Martinson N" first="Neil A." last="Martinson">Neil A. Martinson</name>
<affiliation><nlm:aff id="A2"> Johns Hopkins University Center for TB Research, Baltimore, Maryland, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3"> Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20505496</idno>
<idno type="pmc">3063388</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063388</idno>
<idno type="RBID">PMC:3063388</idno>
<idno type="doi">10.1097/QAD.0b013e32833a2a4a</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">001082</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001082</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Body mass index and risk of tuberculosis and death</title>
<author><name sortKey="Hanrahan, Colleen F" sort="Hanrahan, Colleen F" uniqKey="Hanrahan C" first="Colleen F." last="Hanrahan">Colleen F. Hanrahan</name>
<affiliation><nlm:aff id="A1"> Johns Hopkins Bloomberg School of Public Heath, Baltimore, Maryland, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Golub, Jonathan E" sort="Golub, Jonathan E" uniqKey="Golub J" first="Jonathan E." last="Golub">Jonathan E. Golub</name>
<affiliation><nlm:aff id="A2"> Johns Hopkins University Center for TB Research, Baltimore, Maryland, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mohapi, Lerato" sort="Mohapi, Lerato" uniqKey="Mohapi L" first="Lerato" last="Mohapi">Lerato Mohapi</name>
<affiliation><nlm:aff id="A3"> Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tshabangu, Nkeko" sort="Tshabangu, Nkeko" uniqKey="Tshabangu N" first="Nkeko" last="Tshabangu">Nkeko Tshabangu</name>
<affiliation><nlm:aff id="A3"> Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Modisenyane, Tebogo" sort="Modisenyane, Tebogo" uniqKey="Modisenyane T" first="Tebogo" last="Modisenyane">Tebogo Modisenyane</name>
<affiliation><nlm:aff id="A3"> Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chaisson, Richard E" sort="Chaisson, Richard E" uniqKey="Chaisson R" first="Richard E." last="Chaisson">Richard E. Chaisson</name>
<affiliation><nlm:aff id="A2"> Johns Hopkins University Center for TB Research, Baltimore, Maryland, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gray, Glenda E" sort="Gray, Glenda E" uniqKey="Gray G" first="Glenda E." last="Gray">Glenda E. Gray</name>
<affiliation><nlm:aff id="A3"> Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mcintyre, James A" sort="Mcintyre, James A" uniqKey="Mcintyre J" first="James A." last="Mcintyre">James A. Mcintyre</name>
<affiliation><nlm:aff id="A3"> Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Martinson, Neil A" sort="Martinson, Neil A" uniqKey="Martinson N" first="Neil A." last="Martinson">Neil A. Martinson</name>
<affiliation><nlm:aff id="A2"> Johns Hopkins University Center for TB Research, Baltimore, Maryland, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3"> Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">AIDS (London, England)</title>
<idno type="ISSN">0269-9370</idno>
<idno type="eISSN">1473-5571</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">High BMI has been shown to be protective against tuberculosis (TB) among HIV-uninfected individuals, as well as against disease progression and mortality among those with HIV. We examined the effect of BMI on all-cause mortality and TB incidence among a cohort of HIV-infected adults in Soweto, South Africa.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P2">A clinical cohort of 3456 HIV-infected adults from South Africa was prospectively followed from 2003 to 2008 with regular monitoring. The primary exposure was BMI and the outcomes of interest were all-cause mortality and a newly diagnosed episode of TB. Cox proportional hazard models assessed associations with risk of mortality or incident TB.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Incidence rates of mortality were 10.4/100 person-years for baseline BMI of 18.5 or less, 3.6/100 person-years for baseline BMI 18.6–25, 1.7/100 person-years for baseline BMI 25.1–30, and 1.6/100 person-years for baseline BMI more than 30. Compared to those with normal BMI, overweight and obese participants had a significantly reduced risk of mortality [adjusted hazard ratio 0.59 (95% confidence interval, CI 0.40–0.87) and 0.48 (95% CI 0.29–0.80), respectively]. Incidence rates of TB by baseline BMI were 7.3/100 person-years for underweight, 6.0/100 person-years for normal, 3.2/100 person-years for overweight, and 1.9/100 person-years for obese. Compared to those with normal BMI, those with overweight and obese BMI were at a significantly reduced risk of developing TB [adjusted hazard ratio 0.56 (95% CI 0.38–0.83) and 0.33 (95% CI 0.19–0.55), respectively].</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">HIV-infected individuals with obese and overweight BMI have a significantly reduced risk of both mortality and TB, after adjusting for HAART use and CD4 cell count.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">8710219</journal-id>
<journal-id journal-id-type="pubmed-jr-id">1493</journal-id>
<journal-id journal-id-type="nlm-ta">AIDS</journal-id>
<journal-title>AIDS (London, England)</journal-title>
<issn pub-type="ppub">0269-9370</issn>
<issn pub-type="epub">1473-5571</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20505496</article-id>
<article-id pub-id-type="pmc">3063388</article-id>
<article-id pub-id-type="doi">10.1097/QAD.0b013e32833a2a4a</article-id>
<article-id pub-id-type="manuscript">NIHMS279591</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Body mass index and risk of tuberculosis and death</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Hanrahan</surname>
<given-names>Colleen F.</given-names>
</name>
<xref rid="A1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Golub</surname>
<given-names>Jonathan E.</given-names>
</name>
<xref rid="A2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mohapi</surname>
<given-names>Lerato</given-names>
</name>
<xref rid="A3" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tshabangu</surname>
<given-names>Nkeko</given-names>
</name>
<xref rid="A3" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Modisenyane</surname>
<given-names>Tebogo</given-names>
</name>
<xref rid="A3" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chaisson</surname>
<given-names>Richard E.</given-names>
</name>
<xref rid="A2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gray</surname>
<given-names>Glenda E.</given-names>
</name>
<xref rid="A3" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McIntyre</surname>
<given-names>James A.</given-names>
</name>
<xref rid="A3" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Martinson</surname>
<given-names>Neil A.</given-names>
</name>
<xref rid="A2" ref-type="aff">b</xref>
<xref rid="A3" ref-type="aff">c</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>a</label>
 Johns Hopkins Bloomberg School of Public Heath, Baltimore, Maryland, USA</aff>
<aff id="A2"><label>b</label>
 Johns Hopkins University Center for TB Research, Baltimore, Maryland, USA</aff>
<aff id="A3"><label>c</label>
 Perinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa</aff>
<author-notes><corresp id="FN1">Correspondence to Dr Neil A. Martinson, Perinatal HIV Research Unit, PO Box 144, Diepkloof 1864, Johannesburg, South Africa. Tel: +27 119899703; fax: +27 119899762; <email>Neil1.martinson@gmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>11</day>
<month>3</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="ppub"><day>19</day>
<month>6</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>24</day>
<month>3</month>
<year>2011</year>
</pub-date>
<volume>24</volume>
<issue>10</issue>
<fpage>1501</fpage>
<lpage>1508</lpage>
<abstract><sec id="S1"><title>Background</title>
<p id="P1">High BMI has been shown to be protective against tuberculosis (TB) among HIV-uninfected individuals, as well as against disease progression and mortality among those with HIV. We examined the effect of BMI on all-cause mortality and TB incidence among a cohort of HIV-infected adults in Soweto, South Africa.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P2">A clinical cohort of 3456 HIV-infected adults from South Africa was prospectively followed from 2003 to 2008 with regular monitoring. The primary exposure was BMI and the outcomes of interest were all-cause mortality and a newly diagnosed episode of TB. Cox proportional hazard models assessed associations with risk of mortality or incident TB.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Incidence rates of mortality were 10.4/100 person-years for baseline BMI of 18.5 or less, 3.6/100 person-years for baseline BMI 18.6–25, 1.7/100 person-years for baseline BMI 25.1–30, and 1.6/100 person-years for baseline BMI more than 30. Compared to those with normal BMI, overweight and obese participants had a significantly reduced risk of mortality [adjusted hazard ratio 0.59 (95% confidence interval, CI 0.40–0.87) and 0.48 (95% CI 0.29–0.80), respectively]. Incidence rates of TB by baseline BMI were 7.3/100 person-years for underweight, 6.0/100 person-years for normal, 3.2/100 person-years for overweight, and 1.9/100 person-years for obese. Compared to those with normal BMI, those with overweight and obese BMI were at a significantly reduced risk of developing TB [adjusted hazard ratio 0.56 (95% CI 0.38–0.83) and 0.33 (95% CI 0.19–0.55), respectively].</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">HIV-infected individuals with obese and overweight BMI have a significantly reduced risk of both mortality and TB, after adjusting for HAART use and CD4 cell count.</p>
</sec>
</abstract>
<kwd-group><kwd>body mass index</kwd>
<kwd>HAART</kwd>
<kwd>HIV</kwd>
<kwd>mortality</kwd>
<kwd>nutrition</kwd>
<kwd>tuberculosis</kwd>
</kwd-group>
<contract-num rid="TW1">U2R TW007373-05
				||TW</contract-num>
<contract-num rid="HL1">R01 HL090312-05
				||HL</contract-num>
<contract-num rid="AI1">R01 AI048526-05
				||AI</contract-num>
<contract-num rid="AI1">K24 AI001637-10
				||AI</contract-num>
<contract-num rid="AI1">K01 AI066994-05
				||AI</contract-num>
<contract-sponsor id="TW1">Fogarty International Center  : FIC</contract-sponsor>
<contract-sponsor id="HL1">National Heart, Lung, and Blood Institute  : NHLBI</contract-sponsor>
<contract-sponsor id="AI1">National Institute of Allergy and Infectious Diseases Extramural Activities  : NIAID</contract-sponsor>
</article-meta>
</front>
</pmc>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Pmc/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001082 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001082 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    SidaSubSaharaV1
   |flux=    Pmc
   |étape=   Corpus
   |type=    RBID
   |clé=     PMC:3063388
   |texte=   Body mass index and risk of tuberculosis and death
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i   -Sk "pubmed:20505496" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a SidaSubSaharaV1

This area was generated with Dilib version V0.6.32.
Data generation: Mon Nov 13 19:31:10 2017. Site generation: Wed Mar 6 19:14:32 2024

	Le SIDA en Afrique subsaharienne (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Le SIDA en Afrique subsaharienne (serveur d'exploration)

Body mass index and risk of tuberculosis and death

Body mass index and risk of tuberculosis and death

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki