A new tool for the paediatric HIV research: general data from the Cohort of the Spanish Paediatric HIV Network (CoRISpe)
Identifieur interne : 000E76 ( Pmc/Corpus ); précédent : 000E75; suivant : 000E77A new tool for the paediatric HIV research: general data from the Cohort of the Spanish Paediatric HIV Network (CoRISpe)
Auteurs : Ma Isabel De Jose ; Santiago Jiménez De Ory ; Maria Espiau ; Claudia Fortuny ; Ma Luisa Navarro ; Pere Soler-Palacín ; Ma Angeles Mu Oz-FernandezSource :
- BMC Infectious Diseases [ 1471-2334 ] ; 2013.
Abstract
There are approximately from 1,100 to 1,200 HIV-infected children in a follow-up in Spain. In 2008 an open, multicentral, retrospective and prospective Cohort of the Spanish Paediatric HIV Network (CoRISpe) was founded. The CoRISpe is divided into the node 1 and node 2 representing geographically almost the whole territory of Spain. Since 2008 seventy-five hospitals have been participating in the CoRISpe. All the retrospective data of the HIV-infected children have been kept in the CoRISpe since 1995 and prospective data since 2008. In this article we are going to present the notion of CoRISpe, its role, the structure, how the CoRISpe works and the process how a child is transferred from Paediatric to Adults Units.
The main objective of the CoRISpe is to contribute to furthering scientific knowledge on paediatric HIV infection by providing demographic, sociopsychological, clinical and laboratory data from HIV-infected paediatric patients. Its aim is to enable high-quality research studies on HIV-infected children.
Url:
DOI: 10.1186/1471-2334-13-2
PubMed: 23282073
PubMed Central: 3544738
Links to Exploration step
PMC:3544738Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A new tool for the paediatric HIV research: general data from the Cohort of the Spanish Paediatric HIV Network (CoRISpe)</title><author><name sortKey="De Jose, Ma Isabel" sort="De Jose, Ma Isabel" uniqKey="De Jose M" first="Ma Isabel" last="De Jose">Ma Isabel De Jose</name><affiliation><nlm:aff id="I1">Servicio Infecciosas Infantil, Hospital Universitario “La Paz”, Paseo de la Castellana 26, Madrid, 128046, Spain</nlm:aff></affiliation></author><author><name sortKey="Jimenez De Ory, Santiago" sort="Jimenez De Ory, Santiago" uniqKey="Jimenez De Ory S" first="Santiago" last="Jiménez De Ory">Santiago Jiménez De Ory</name><affiliation><nlm:aff id="I2">Laboratorio de Inmuno-Biología Molecular. Spanish HIV HGM BioBank. Hospital General Universitario “Gregorio Marañón” and Instituto de Investigación Sanitaria Gregorio Marañón, C/Dr. Esquerdo 46, Madrid, 28007, Spain</nlm:aff></affiliation></author><author><name sortKey="Espiau, Maria" sort="Espiau, Maria" uniqKey="Espiau M" first="Maria" last="Espiau">Maria Espiau</name><affiliation><nlm:aff id="I3">Unitat de Patologia Infecciosa i Immunodeficiències de Pediatria, Hospital Universitari Vall d` Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Fortuny, Claudia" sort="Fortuny, Claudia" uniqKey="Fortuny C" first="Claudia" last="Fortuny">Claudia Fortuny</name><affiliation><nlm:aff id="I4">Servicio Infecciosas Infantil, Hospital Sant Joan de Dèu, Esplugues de Llobregat, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Navarro, Ma Luisa" sort="Navarro, Ma Luisa" uniqKey="Navarro M" first="Ma Luisa" last="Navarro">Ma Luisa Navarro</name><affiliation><nlm:aff id="I5">Sección de Enfermedades Infecciosas. Servicio de Pediatría. Hospital General Universitario “Gregorio Marañón”, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Soler Palacin, Pere" sort="Soler Palacin, Pere" uniqKey="Soler Palacin P" first="Pere" last="Soler-Palacín">Pere Soler-Palacín</name><affiliation><nlm:aff id="I3">Unitat de Patologia Infecciosa i Immunodeficiències de Pediatria, Hospital Universitari Vall d` Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Mu Oz Fernandez, Ma Angeles" sort="Mu Oz Fernandez, Ma Angeles" uniqKey="Mu Oz Fernandez M" first="Ma Angeles" last="Mu Oz-Fernandez">Ma Angeles Mu Oz-Fernandez</name><affiliation><nlm:aff id="I2">Laboratorio de Inmuno-Biología Molecular. Spanish HIV HGM BioBank. Hospital General Universitario “Gregorio Marañón” and Instituto de Investigación Sanitaria Gregorio Marañón, C/Dr. Esquerdo 46, Madrid, 28007, Spain</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23282073</idno><idno type="pmc">3544738</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544738</idno><idno type="RBID">PMC:3544738</idno><idno type="doi">10.1186/1471-2334-13-2</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000E76</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E76</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A new tool for the paediatric HIV research: general data from the Cohort of the Spanish Paediatric HIV Network (CoRISpe)</title><author><name sortKey="De Jose, Ma Isabel" sort="De Jose, Ma Isabel" uniqKey="De Jose M" first="Ma Isabel" last="De Jose">Ma Isabel De Jose</name><affiliation><nlm:aff id="I1">Servicio Infecciosas Infantil, Hospital Universitario “La Paz”, Paseo de la Castellana 26, Madrid, 128046, Spain</nlm:aff></affiliation></author><author><name sortKey="Jimenez De Ory, Santiago" sort="Jimenez De Ory, Santiago" uniqKey="Jimenez De Ory S" first="Santiago" last="Jiménez De Ory">Santiago Jiménez De Ory</name><affiliation><nlm:aff id="I2">Laboratorio de Inmuno-Biología Molecular. Spanish HIV HGM BioBank. Hospital General Universitario “Gregorio Marañón” and Instituto de Investigación Sanitaria Gregorio Marañón, C/Dr. Esquerdo 46, Madrid, 28007, Spain</nlm:aff></affiliation></author><author><name sortKey="Espiau, Maria" sort="Espiau, Maria" uniqKey="Espiau M" first="Maria" last="Espiau">Maria Espiau</name><affiliation><nlm:aff id="I3">Unitat de Patologia Infecciosa i Immunodeficiències de Pediatria, Hospital Universitari Vall d` Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Fortuny, Claudia" sort="Fortuny, Claudia" uniqKey="Fortuny C" first="Claudia" last="Fortuny">Claudia Fortuny</name><affiliation><nlm:aff id="I4">Servicio Infecciosas Infantil, Hospital Sant Joan de Dèu, Esplugues de Llobregat, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Navarro, Ma Luisa" sort="Navarro, Ma Luisa" uniqKey="Navarro M" first="Ma Luisa" last="Navarro">Ma Luisa Navarro</name><affiliation><nlm:aff id="I5">Sección de Enfermedades Infecciosas. Servicio de Pediatría. Hospital General Universitario “Gregorio Marañón”, Madrid, Spain</nlm:aff></affiliation></author><author><name sortKey="Soler Palacin, Pere" sort="Soler Palacin, Pere" uniqKey="Soler Palacin P" first="Pere" last="Soler-Palacín">Pere Soler-Palacín</name><affiliation><nlm:aff id="I3">Unitat de Patologia Infecciosa i Immunodeficiències de Pediatria, Hospital Universitari Vall d` Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff></affiliation></author><author><name sortKey="Mu Oz Fernandez, Ma Angeles" sort="Mu Oz Fernandez, Ma Angeles" uniqKey="Mu Oz Fernandez M" first="Ma Angeles" last="Mu Oz-Fernandez">Ma Angeles Mu Oz-Fernandez</name><affiliation><nlm:aff id="I2">Laboratorio de Inmuno-Biología Molecular. Spanish HIV HGM BioBank. Hospital General Universitario “Gregorio Marañón” and Instituto de Investigación Sanitaria Gregorio Marañón, C/Dr. Esquerdo 46, Madrid, 28007, Spain</nlm:aff></affiliation></author></analytic><series><title level="j">BMC Infectious Diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>There are approximately from 1,100 to 1,200 HIV-infected children in a follow-up in Spain. In 2008 an open, multicentral, retrospective and prospective Cohort of the Spanish Paediatric HIV Network (CoRISpe) was founded. The CoRISpe is divided into the node 1 and node 2 representing geographically almost the whole territory of Spain. Since 2008 seventy-five hospitals have been participating in the CoRISpe. All the retrospective data of the HIV-infected children have been kept in the CoRISpe since 1995 and prospective data since 2008. In this article we are going to present the notion of CoRISpe, its role, the structure, how the CoRISpe works and the process how a child is transferred from Paediatric to Adults Units.</p><p>The main objective of the CoRISpe is to contribute to furthering scientific knowledge on paediatric HIV infection by providing demographic, sociopsychological, clinical and laboratory data from HIV-infected paediatric patients. Its aim is to enable high-quality research studies on HIV-infected children.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Palladino, C" uniqKey="Palladino C">C Palladino</name></author><author><name sortKey="Bellon, Jm" uniqKey="Bellon J">JM Bellon</name></author><author><name sortKey="Perez Hoyos, S" uniqKey="Perez Hoyos S">S Perez-Hoyos</name></author><author><name sortKey="Resino, R" uniqKey="Resino R">R Resino</name></author><author><name sortKey="Guillen, S" uniqKey="Guillen S">S Guillen</name></author><author><name sortKey="Garcia, D" uniqKey="Garcia D">D Garcia</name></author><author><name sortKey="Gurbindo, Md" uniqKey="Gurbindo M">MD Gurbindo</name></author><author><name sortKey="Ramos, Jt" uniqKey="Ramos J">JT Ramos</name></author><author><name sortKey="De Jose, Mi" uniqKey="De Jose M">MI de Jose</name></author><author><name sortKey="Mellado, Mj" uniqKey="Mellado M">MJ Mellado</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Dunn, D" uniqKey="Dunn D">D Dunn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Judd, A" uniqKey="Judd A">A Judd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcgrath, Cj" uniqKey="Mcgrath C">CJ McGrath</name></author><author><name sortKey="Chung, Mh" uniqKey="Chung M">MH Chung</name></author><author><name sortKey="Richardson, Ba" uniqKey="Richardson B">BA Richardson</name></author><author><name sortKey="Benki Nugent, S" uniqKey="Benki Nugent S">S Benki-Nugent</name></author><author><name sortKey="Warui, D" uniqKey="Warui D">D Warui</name></author><author><name sortKey="John Stewart, Gc" uniqKey="John Stewart G">GC John-Stewart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Resino, S" uniqKey="Resino S">S Resino</name></author><author><name sortKey="Resino, R" uniqKey="Resino R">R Resino</name></author><author><name sortKey="Maria Bellon, J" uniqKey="Maria Bellon J">J Maria Bellon</name></author><author><name sortKey="Micheloud, D" uniqKey="Micheloud D">D Micheloud</name></author><author><name sortKey="Gutierrez, Md" uniqKey="Gutierrez M">MD Gutierrez</name></author><author><name sortKey="De Jose, Mi" uniqKey="De Jose M">MI de Jose</name></author><author><name sortKey="Ramos, Jt" uniqKey="Ramos J">JT Ramos</name></author><author><name sortKey="Fontelos, Pm" uniqKey="Fontelos P">PM Fontelos</name></author><author><name sortKey="Ciria, L" uniqKey="Ciria L">L Ciria</name></author><author><name sortKey="Munoz Fernandez, Ma" uniqKey="Munoz Fernandez M">MA Munoz-Fernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palladino, C" uniqKey="Palladino C">C Palladino</name></author><author><name sortKey="Briz, V" uniqKey="Briz V">V Briz</name></author><author><name sortKey="Policarpo, Sn" uniqKey="Policarpo S">SN Policarpo</name></author><author><name sortKey="Silveira, Lf" uniqKey="Silveira L">LF Silveira</name></author><author><name sortKey="De Jose, Mi" uniqKey="De Jose M">MI de Jose</name></author><author><name sortKey="Gonzalez Tome, Mi" uniqKey="Gonzalez Tome M">MI Gonzalez-Tome</name></author><author><name sortKey="Moreno, D" uniqKey="Moreno D">D Moreno</name></author><author><name sortKey="Leon Leal, Ja" uniqKey="Leon Leal J">JA Leon Leal</name></author><author><name sortKey="Mellado, Mj" uniqKey="Mellado M">MJ Mellado</name></author><author><name sortKey="De Ory, Sj" uniqKey="De Ory S">SJ de Ory</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saez Llorens, X" uniqKey="Saez Llorens X">X Saez-Llorens</name></author><author><name sortKey="Violari, A" uniqKey="Violari A">A Violari</name></author><author><name sortKey="Ndiweni, D" uniqKey="Ndiweni D">D Ndiweni</name></author><author><name sortKey="Yogev, R" uniqKey="Yogev R">R Yogev</name></author><author><name sortKey="Cashat, M" uniqKey="Cashat M">M Cashat</name></author><author><name sortKey="Wiznia, A" uniqKey="Wiznia A">A Wiznia</name></author><author><name sortKey="Chittick, G" uniqKey="Chittick G">G Chittick</name></author><author><name sortKey="Harris, J" uniqKey="Harris J">J Harris</name></author><author><name sortKey="Hinkle, J" uniqKey="Hinkle J">J Hinkle</name></author><author><name sortKey="Blum, Mr" uniqKey="Blum M">MR Blum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Resino, S" uniqKey="Resino S">S Resino</name></author><author><name sortKey="Gurbindo, D" uniqKey="Gurbindo D">D Gurbindo</name></author><author><name sortKey="Cano, Jm" uniqKey="Cano J">JM Cano</name></author><author><name sortKey="Sanchez Ramon, S" uniqKey="Sanchez Ramon S">S Sanchez-Ramon</name></author><author><name sortKey="Mu Oz Fernandez, Ma" uniqKey="Mu Oz Fernandez M">MA Muñoz-Fernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez Ramon, S" uniqKey="Sanchez Ramon S">S Sanchez-Ramon</name></author><author><name sortKey="Bellon, Jm" uniqKey="Bellon J">JM Bellon</name></author><author><name sortKey="Resino, S" uniqKey="Resino S">S Resino</name></author><author><name sortKey="Canto Nogues, C" uniqKey="Canto Nogues C">C Canto-Nogues</name></author><author><name sortKey="Gurbindo, D" uniqKey="Gurbindo D">D Gurbindo</name></author><author><name sortKey="Ramos, Jt" uniqKey="Ramos J">JT Ramos</name></author><author><name sortKey="Munoz Fernandez, Ma" uniqKey="Munoz Fernandez M">MA Munoz-Fernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gurbindo, D" uniqKey="Gurbindo D">D Gurbindo</name></author><author><name sortKey="Resino, S" uniqKey="Resino S">S Resino</name></author><author><name sortKey="Sanchez Ramon, S" uniqKey="Sanchez Ramon S">S Sanchez-Ramon</name></author><author><name sortKey="Leon, Ja" uniqKey="Leon J">JA Leon</name></author><author><name sortKey="Munoz Fernandez, Ma" uniqKey="Munoz Fernandez M">MA Munoz-Fernandez</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ramos, Jt" uniqKey="Ramos J">JT Ramos</name></author><author><name sortKey="De Jose, Mi" uniqKey="De Jose M">MI de Jose</name></author><author><name sortKey="Polo, R" uniqKey="Polo R">R Polo</name></author><author><name sortKey="Fortuny, C" uniqKey="Fortuny C">C Fortuny</name></author><author><name sortKey="Mellado, Mj" uniqKey="Mellado M">MJ Mellado</name></author><author><name sortKey="Munoz Fernandez, Ma" uniqKey="Munoz Fernandez M">MA Munoz-Fernandez</name></author><author><name sortKey="Beceiro, J" uniqKey="Beceiro J">J Beceiro</name></author><author><name sortKey="Bertran, Jm" uniqKey="Bertran J">JM Bertran</name></author><author><name sortKey="Calvo, C" uniqKey="Calvo C">C Calvo</name></author><author><name sortKey="Chamorro, L" uniqKey="Chamorro L">L Chamorro</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Garcia Merino, I" uniqKey="Garcia Merino I">I Garcia-Merino</name></author><author><name sortKey="De Las Cuevas, N" uniqKey="De Las Cuevas N">N de Las Cuevas</name></author><author><name sortKey="Jimenez, Jl" uniqKey="Jimenez J">JL Jimenez</name></author><author><name sortKey="Garcia, A" uniqKey="Garcia A">A Garcia</name></author><author><name sortKey="Gallego, J" uniqKey="Gallego J">J Gallego</name></author><author><name sortKey="Gomez, C" uniqKey="Gomez C">C Gomez</name></author><author><name sortKey="Garcia, D" uniqKey="Garcia D">D Garcia</name></author><author><name sortKey="Munoz Fernandez, Ma" uniqKey="Munoz Fernandez M">MA Munoz-Fernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia Merino, I" uniqKey="Garcia Merino I">I Garcia-Merino</name></author><author><name sortKey="De Las Cuevas, N" uniqKey="De Las Cuevas N">N de Las Cuevas</name></author><author><name sortKey="Jimenez, Jl" uniqKey="Jimenez J">JL Jimenez</name></author><author><name sortKey="Gallego, J" uniqKey="Gallego J">J Gallego</name></author><author><name sortKey="Gomez, C" uniqKey="Gomez C">C Gomez</name></author><author><name sortKey="Prieto, C" uniqKey="Prieto C">C Prieto</name></author><author><name sortKey="Serramia, Mj" uniqKey="Serramia M">MJ Serramia</name></author><author><name sortKey="Lorente, R" uniqKey="Lorente R">R Lorente</name></author><author><name sortKey="Munoz Fernandez, Ma" uniqKey="Munoz Fernandez M">MA Munoz-Fernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nso, Ap" uniqKey="Nso A">AP Nso</name></author><author><name sortKey="Larru, B" uniqKey="Larru B">B Larru</name></author><author><name sortKey="Bellon, Jm" uniqKey="Bellon J">JM Bellon</name></author><author><name sortKey="Mellado, Mj" uniqKey="Mellado M">MJ Mellado</name></author><author><name sortKey="Ramos, Jt" uniqKey="Ramos J">JT Ramos</name></author><author><name sortKey="Gonzalez, Mi" uniqKey="Gonzalez M">MI Gonzalez</name></author><author><name sortKey="Navarro, Ml" uniqKey="Navarro M">ML Navarro</name></author><author><name sortKey="Munoz Fernandez, Ma" uniqKey="Munoz Fernandez M">MA Munoz-Fernandez</name></author><author><name sortKey="Jose, Mi" uniqKey="Jose M">MI Jose</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Maturo, D" uniqKey="Maturo D">D Maturo</name></author><author><name sortKey="Powell, A" uniqKey="Powell A">A Powell</name></author><author><name sortKey="Major Wilson, H" uniqKey="Major Wilson H">H Major-Wilson</name></author><author><name sortKey="Sanchez, K" uniqKey="Sanchez K">K Sanchez</name></author><author><name sortKey="De Santis, Jp" uniqKey="De Santis J">JP De Santis</name></author><author><name sortKey="Friedman, Lb" uniqKey="Friedman L">LB Friedman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abadi, J" uniqKey="Abadi J">J Abadi</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Freed, Gl" uniqKey="Freed G">GL Freed</name></author><author><name sortKey="Hudson, Ej" uniqKey="Hudson E">EJ Hudson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lewis Gary, Md" uniqKey="Lewis Gary M">MD Lewis-Gary</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Por, J" uniqKey="Por J">J Por</name></author><author><name sortKey="Golberg, B" uniqKey="Golberg B">B Golberg</name></author><author><name sortKey="Lennox, V" uniqKey="Lennox V">V Lennox</name></author><author><name sortKey="Burr, P" uniqKey="Burr P">P Burr</name></author><author><name sortKey="Barrow, J" uniqKey="Barrow J">J Barrow</name></author><author><name sortKey="Dennard, L" uniqKey="Dennard L">L Dennard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lotstein, Ds" uniqKey="Lotstein D">DS Lotstein</name></author><author><name sortKey="Mcpherson, M" uniqKey="Mcpherson M">M McPherson</name></author><author><name sortKey="Strickland, B" uniqKey="Strickland B">B Strickland</name></author><author><name sortKey="Newacheck, Pw" uniqKey="Newacheck P">PW Newacheck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosen, Ds" uniqKey="Rosen D">DS Rosen</name></author><author><name sortKey="Blum, Rw" uniqKey="Blum R">RW Blum</name></author><author><name sortKey="Britto, M" uniqKey="Britto M">M Britto</name></author><author><name sortKey="Sawyer, Sm" uniqKey="Sawyer S">SM Sawyer</name></author><author><name sortKey="Siegel, Dm" uniqKey="Siegel D">DM Siegel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flume, Pa" uniqKey="Flume P">PA Flume</name></author><author><name sortKey="Taylor, La" uniqKey="Taylor L">LA Taylor</name></author><author><name sortKey="Anderson, Dl" uniqKey="Anderson D">DL Anderson</name></author><author><name sortKey="Gray, S" uniqKey="Gray S">S Gray</name></author><author><name sortKey="Turner, D" uniqKey="Turner D">D Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vigano, A" uniqKey="Vigano A">A Vigano</name></author><author><name sortKey="Bedogni, G" uniqKey="Bedogni G">G Bedogni</name></author><author><name sortKey="Manfredini, V" uniqKey="Manfredini V">V Manfredini</name></author><author><name sortKey="Giacomet, V" uniqKey="Giacomet V">V Giacomet</name></author><author><name sortKey="Cerini, C" uniqKey="Cerini C">C Cerini</name></author><author><name sortKey="Di Nello, F" uniqKey="Di Nello F">F di Nello</name></author><author><name sortKey="Penagini, F" uniqKey="Penagini F">F Penagini</name></author><author><name sortKey="Caprio, C" uniqKey="Caprio C">C Caprio</name></author><author><name sortKey="Zuccotti, Gv" uniqKey="Zuccotti G">GV Zuccotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cruz, Ml" uniqKey="Cruz M">ML Cruz</name></author><author><name sortKey="Cardoso, Ca" uniqKey="Cardoso C">CA Cardoso</name></author><author><name sortKey="Joao, Ec" uniqKey="Joao E">EC Joao</name></author><author><name sortKey="Gomes, Im" uniqKey="Gomes I">IM Gomes</name></author><author><name sortKey="Abreu, Tf" uniqKey="Abreu T">TF Abreu</name></author><author><name sortKey="Oliveira, Rh" uniqKey="Oliveira R">RH Oliveira</name></author><author><name sortKey="Machado, Es" uniqKey="Machado E">ES Machado</name></author><author><name sortKey="Dias, Ir" uniqKey="Dias I">IR Dias</name></author><author><name sortKey="Rubini, Nm" uniqKey="Rubini N">NM Rubini</name></author><author><name sortKey="Succi, Rm" uniqKey="Succi R">RM Succi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Judd, A" uniqKey="Judd A">A Judd</name></author><author><name sortKey="Ferrand, Ra" uniqKey="Ferrand R">RA Ferrand</name></author><author><name sortKey="Jungmann, E" uniqKey="Jungmann E">E Jungmann</name></author><author><name sortKey="Foster, C" uniqKey="Foster C">C Foster</name></author><author><name sortKey="Masters, J" uniqKey="Masters J">J Masters</name></author><author><name sortKey="Rice, B" uniqKey="Rice B">B Rice</name></author><author><name sortKey="Lyall, H" uniqKey="Lyall H">H Lyall</name></author><author><name sortKey="Tookey, Pa" uniqKey="Tookey P">PA Tookey</name></author><author><name sortKey="Prime, K" uniqKey="Prime K">K Prime</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dunn, D" uniqKey="Dunn D">D Dunn</name></author><author><name sortKey="Woodburn, P" uniqKey="Woodburn P">P Woodburn</name></author><author><name sortKey="Duong, T" uniqKey="Duong T">T Duong</name></author><author><name sortKey="Peto, J" uniqKey="Peto J">J Peto</name></author><author><name sortKey="Phillips, A" uniqKey="Phillips A">A Phillips</name></author><author><name sortKey="Gibb, D" uniqKey="Gibb D">D Gibb</name></author><author><name sortKey="Porter, K" uniqKey="Porter K">K Porter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clemente, Mi" uniqKey="Clemente M">MI Clemente</name></author><author><name sortKey="Alvarez, S" uniqKey="Alvarez S">S Alvarez</name></author><author><name sortKey="Serramia, Mj" uniqKey="Serramia M">MJ Serramia</name></author><author><name sortKey="Turriziani, O" uniqKey="Turriziani O">O Turriziani</name></author><author><name sortKey="Genebat, M" uniqKey="Genebat M">M Genebat</name></author><author><name sortKey="Leal, M" uniqKey="Leal M">M Leal</name></author><author><name sortKey="Fresno, M" uniqKey="Fresno M">M Fresno</name></author><author><name sortKey="Munoz Fernandez, Ma" uniqKey="Munoz Fernandez M">MA Munoz-Fernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Genebat, M" uniqKey="Genebat M">M Genebat</name></author><author><name sortKey="Ruiz Mateos, E" uniqKey="Ruiz Mateos E">E Ruiz-Mateos</name></author><author><name sortKey="Leon, Ja" uniqKey="Leon J">JA Leon</name></author><author><name sortKey="Gonzalez Serna, A" uniqKey="Gonzalez Serna A">A Gonzalez-Serna</name></author><author><name sortKey="Pulido, I" uniqKey="Pulido I">I Pulido</name></author><author><name sortKey="Rivas, I" uniqKey="Rivas I">I Rivas</name></author><author><name sortKey="Ferrando Martinez, S" uniqKey="Ferrando Martinez S">S Ferrando-Martinez</name></author><author><name sortKey="Sanchez, B" uniqKey="Sanchez B">B Sanchez</name></author><author><name sortKey="Munoz Fernandez, Ma" uniqKey="Munoz Fernandez M">MA Munoz-Fernandez</name></author><author><name sortKey="Leal, M" uniqKey="Leal M">M Leal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palladino, C" uniqKey="Palladino C">C Palladino</name></author><author><name sortKey="Briz, V" uniqKey="Briz V">V Briz</name></author><author><name sortKey="Gonzalez Tome, Mi" uniqKey="Gonzalez Tome M">MI Gonzalez-Tome</name></author><author><name sortKey="Leon Leal, Ja" uniqKey="Leon Leal J">JA Leon Leal</name></author><author><name sortKey="Navarro, Ml" uniqKey="Navarro M">ML Navarro</name></author><author><name sortKey="De Jose, Mi" uniqKey="De Jose M">MI de Jose</name></author><author><name sortKey="Ramos, Jt" uniqKey="Ramos J">JT Ramos</name></author><author><name sortKey="Munoz Fernandez, Ma" uniqKey="Munoz Fernandez M">MA Munoz-Fernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Resino, S" uniqKey="Resino S">S Resino</name></author><author><name sortKey="Micheloud, D" uniqKey="Micheloud D">D Micheloud</name></author><author><name sortKey="Lorente, R" uniqKey="Lorente R">R Lorente</name></author><author><name sortKey="Bellon, Jm" uniqKey="Bellon J">JM Bellon</name></author><author><name sortKey="Navarro, Ml" uniqKey="Navarro M">ML Navarro</name></author><author><name sortKey="Munoz Fernandez, Ma" uniqKey="Munoz Fernandez M">MA Munoz-Fernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Babiker, A" uniqKey="Babiker A">A Babiker</name></author><author><name sortKey="Castro Nee Green, H" uniqKey="Castro Nee Green H">H Castro nee Green</name></author><author><name sortKey="Compagnucci, A" uniqKey="Compagnucci A">A Compagnucci</name></author><author><name sortKey="Fiscus, S" uniqKey="Fiscus S">S Fiscus</name></author><author><name sortKey="Giaquinto, C" uniqKey="Giaquinto C">C Giaquinto</name></author><author><name sortKey="Gibb, Dm" uniqKey="Gibb D">DM Gibb</name></author><author><name sortKey="Harper, L" uniqKey="Harper L">L Harper</name></author><author><name sortKey="Harrison, L" uniqKey="Harrison L">L Harrison</name></author><author><name sortKey="Hughes, M" uniqKey="Hughes M">M Hughes</name></author><author><name sortKey="Mckinney, R" uniqKey="Mckinney R">R McKinney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palladino, C" uniqKey="Palladino C">C Palladino</name></author><author><name sortKey="Climent, Fj" uniqKey="Climent F">FJ Climent</name></author><author><name sortKey="Jose, Mi" uniqKey="Jose M">MI Jose</name></author><author><name sortKey="Jimenez De Ory, S" uniqKey="Jimenez De Ory S">S Jimenez De Ory</name></author><author><name sortKey="Bellon, Jm" uniqKey="Bellon J">JM Bellon</name></author><author><name sortKey="Guillen, S" uniqKey="Guillen S">S Guillen</name></author><author><name sortKey="Gurbindo, Md" uniqKey="Gurbindo M">MD Gurbindo</name></author><author><name sortKey="Gonzalez Tome, I" uniqKey="Gonzalez Tome I">I Gonzalez-Tome</name></author><author><name sortKey="Mellado, Mj" uniqKey="Mellado M">MJ Mellado</name></author><author><name sortKey="Martinez Perez, J" uniqKey="Martinez Perez J">J Martinez Perez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cambon Thomsen, A" uniqKey="Cambon Thomsen A">A Cambon-Thomsen</name></author><author><name sortKey="Thorisson, Ga" uniqKey="Thorisson G">GA Thorisson</name></author><author><name sortKey="Mabile, L" uniqKey="Mabile L">L Mabile</name></author><author><name sortKey="Andrieu, S" uniqKey="Andrieu S">S Andrieu</name></author><author><name sortKey="Bertier, G" uniqKey="Bertier G">G Bertier</name></author><author><name sortKey="Boeckhout, M" uniqKey="Boeckhout M">M Boeckhout</name></author><author><name sortKey="Carpenter, J" uniqKey="Carpenter J">J Carpenter</name></author><author><name sortKey="Dagher, G" uniqKey="Dagher G">G Dagher</name></author><author><name sortKey="Dalgleish, R" uniqKey="Dalgleish R">R Dalgleish</name></author><author><name sortKey="Deschenes, M" uniqKey="Deschenes M">M Deschenes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Mulder, M" uniqKey="De Mulder M">M de Mulder</name></author><author><name sortKey="Yebra, G" uniqKey="Yebra G">G Yebra</name></author><author><name sortKey="Martin, L" uniqKey="Martin L">L Martin</name></author><author><name sortKey="Prieto, L" uniqKey="Prieto L">L Prieto</name></author><author><name sortKey="Mellado, Mj" uniqKey="Mellado M">MJ Mellado</name></author><author><name sortKey="Rojo, P" uniqKey="Rojo P">P Rojo</name></author><author><name sortKey="Jimenez De Ory, S" uniqKey="Jimenez De Ory S">S Jimenez de Ory</name></author><author><name sortKey="Munoz Fernandez, Ma" uniqKey="Munoz Fernandez M">MA Munoz-Fernandez</name></author><author><name sortKey="Ramos, Jt" uniqKey="Ramos J">JT Ramos</name></author><author><name sortKey="Holguin, A" uniqKey="Holguin A">A Holguin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Briz, V" uniqKey="Briz V">V Briz</name></author><author><name sortKey="Palladino, C" uniqKey="Palladino C">C Palladino</name></author><author><name sortKey="Navarro, M" uniqKey="Navarro M">M Navarro</name></author><author><name sortKey="Jimenez De Ory, S" uniqKey="Jimenez De Ory S">S Jimenez de Ory</name></author><author><name sortKey="Gonzalez Tome, M" uniqKey="Gonzalez Tome M">M Gonzalez-Tome</name></author><author><name sortKey="Leon, J" uniqKey="Leon J">J Leon</name></author><author><name sortKey="Nunez Cuadros, E" uniqKey="Nunez Cuadros E">E Nunez-Cuadros</name></author><author><name sortKey="De Jose, M" uniqKey="De Jose M">M de Jose</name></author><author><name sortKey="Ramos, J" uniqKey="Ramos J">J Ramos</name></author><author><name sortKey="Munoz Fernandez, M" uniqKey="Munoz Fernandez M">M Munoz-Fernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferrando Martinez, S" uniqKey="Ferrando Martinez S">S Ferrando-Martinez</name></author><author><name sortKey="Casazza, Jp" uniqKey="Casazza J">JP Casazza</name></author><author><name sortKey="Leal, M" uniqKey="Leal M">M Leal</name></author><author><name sortKey="Machmach, K" uniqKey="Machmach K">K Machmach</name></author><author><name sortKey="Munoz Fernandez, Ma" uniqKey="Munoz Fernandez M">MA Munoz-Fernandez</name></author><author><name sortKey="Viciana, P" uniqKey="Viciana P">P Viciana</name></author><author><name sortKey="Koup, Ra" uniqKey="Koup R">RA Koup</name></author><author><name sortKey="Ruiz Mateos, E" uniqKey="Ruiz Mateos E">E Ruiz-Mateos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soler Palacin, P" uniqKey="Soler Palacin P">P Soler-Palacin</name></author><author><name sortKey="Melendo, S" uniqKey="Melendo S">S Melendo</name></author><author><name sortKey="Noguera Julian, A" uniqKey="Noguera Julian A">A Noguera-Julian</name></author><author><name sortKey="Fortuny, C" uniqKey="Fortuny C">C Fortuny</name></author><author><name sortKey="Navarro, Ml" uniqKey="Navarro M">ML Navarro</name></author><author><name sortKey="Mellado, Mj" uniqKey="Mellado M">MJ Mellado</name></author><author><name sortKey="Garcia, L" uniqKey="Garcia L">L Garcia</name></author><author><name sortKey="Uriona, S" uniqKey="Uriona S">S Uriona</name></author><author><name sortKey="Martin Nalda, A" uniqKey="Martin Nalda A">A Martin-Nalda</name></author><author><name sortKey="Figueras, C" uniqKey="Figueras C">C Figueras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noguera Julian, A" uniqKey="Noguera Julian A">A Noguera-Julian</name></author><author><name sortKey="Provens, Ac" uniqKey="Provens A">AC Provens</name></author><author><name sortKey="Soler Palacin, P" uniqKey="Soler Palacin P">P Soler-Palacin</name></author><author><name sortKey="Espiau, M" uniqKey="Espiau M">M Espiau</name></author><author><name sortKey="Mur, A" uniqKey="Mur A">A Mur</name></author><author><name sortKey="Mendez, M" uniqKey="Mendez M">M Mendez</name></author><author><name sortKey="Fortuny, C" uniqKey="Fortuny C">C Fortuny</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="other" xml:lang="en"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">BMC Infect. Dis</journal-id><journal-title-group><journal-title>BMC Infectious Diseases</journal-title></journal-title-group><issn pub-type="epub">1471-2334</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23282073</article-id><article-id pub-id-type="pmc">3544738</article-id><article-id pub-id-type="publisher-id">1471-2334-13-2</article-id><article-id pub-id-type="doi">10.1186/1471-2334-13-2</article-id><article-categories><subj-group subj-group-type="heading"><subject>Correspondence</subject></subj-group></article-categories><title-group><article-title>A new tool for the paediatric HIV research: general data from the Cohort of the Spanish Paediatric HIV Network (CoRISpe)</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>de Jose</surname><given-names>Ma Isabel</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>ijose.hulp@salud.madrid.org</email></contrib><contrib contrib-type="author" id="A2"><name><surname>Jiménez de Ory</surname><given-names>Santiago</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>santiago.jimenezde@salud.madrid.org</email></contrib><contrib contrib-type="author" id="A3"><name><surname>Espiau</surname><given-names>Maria</given-names></name><xref ref-type="aff" rid="I3">3</xref><email>mariaespiau@hotmail.com</email></contrib><contrib contrib-type="author" id="A4"><name><surname>Fortuny</surname><given-names>Claudia</given-names></name><xref ref-type="aff" rid="I4">4</xref><email>cfortuny@hsjdbcn.org</email></contrib><contrib contrib-type="author" id="A5"><name><surname>Navarro</surname><given-names>Ma Luisa</given-names></name><xref ref-type="aff" rid="I5">5</xref><email>mnavarrog.hgugm@salud.madrid.org</email></contrib><contrib contrib-type="author" id="A6"><name><surname>Soler-Palacín</surname><given-names>Pere</given-names></name><xref ref-type="aff" rid="I3">3</xref><email>psoler@vhebron.net</email></contrib><contrib contrib-type="author" corresp="yes" id="A7"><name><surname>Muñoz-Fernandez</surname><given-names>Ma Angeles</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>mmunoz.hgugm@salud.madrid.org</email></contrib><on-behalf-of>from the working groups of CoRISpe and HIV HGM BioBank</on-behalf-of></contrib-group><aff id="I1"><label>1</label>Servicio Infecciosas Infantil, Hospital Universitario “La Paz”, Paseo de la Castellana 26, Madrid, 128046, Spain</aff><aff id="I2"><label>2</label>Laboratorio de Inmuno-Biología Molecular. Spanish HIV HGM BioBank. Hospital General Universitario “Gregorio Marañón” and Instituto de Investigación Sanitaria Gregorio Marañón, C/Dr. Esquerdo 46, Madrid, 28007, Spain</aff><aff id="I3"><label>3</label>Unitat de Patologia Infecciosa i Immunodeficiències de Pediatria, Hospital Universitari Vall d` Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain</aff><aff id="I4"><label>4</label>Servicio Infecciosas Infantil, Hospital Sant Joan de Dèu, Esplugues de Llobregat, Barcelona, Spain</aff><aff id="I5"><label>5</label>Sección de Enfermedades Infecciosas. Servicio de Pediatría. Hospital General Universitario “Gregorio Marañón”, Madrid, Spain</aff><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>2</day><month>1</month><year>2013</year></pub-date><volume>13</volume><fpage>2</fpage><lpage>2</lpage><history><date date-type="received"><day>16</day><month>4</month><year>2012</year></date><date date-type="accepted"><day>18</day><month>12</month><year>2012</year></date></history><permissions><copyright-statement>Copyright ©2013 de José et al.; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>de José et al.; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://www.biomedcentral.com/1471-2334/13/2"></self-uri><abstract><p>There are approximately from 1,100 to 1,200 HIV-infected children in a follow-up in Spain. In 2008 an open, multicentral, retrospective and prospective Cohort of the Spanish Paediatric HIV Network (CoRISpe) was founded. The CoRISpe is divided into the node 1 and node 2 representing geographically almost the whole territory of Spain. Since 2008 seventy-five hospitals have been participating in the CoRISpe. All the retrospective data of the HIV-infected children have been kept in the CoRISpe since 1995 and prospective data since 2008. In this article we are going to present the notion of CoRISpe, its role, the structure, how the CoRISpe works and the process how a child is transferred from Paediatric to Adults Units.</p><p>The main objective of the CoRISpe is to contribute to furthering scientific knowledge on paediatric HIV infection by providing demographic, sociopsychological, clinical and laboratory data from HIV-infected paediatric patients. Its aim is to enable high-quality research studies on HIV-infected children.</p></abstract><kwd-group><kwd>HIV paediatric cohort</kwd><kwd>Paediatric HIV infection</kwd><kwd>Spanish HIV HGM biobank</kwd></kwd-group></article-meta></front><body><sec><title>Background</title><p>Current treatment to prevent mother-to-child transmission (MTCT) of HIV is very different from that a few years ago [<xref ref-type="bibr" rid="B1">1</xref>]. In the first years of HIV infection there were not treatments for HIV-infected children [<xref ref-type="bibr" rid="B2">2</xref>,<xref ref-type="bibr" rid="B3">3</xref>]. In the years from 1985 to 1996 children were treated with monotherapy or combination therapy [<xref ref-type="bibr" rid="B4">4</xref>]. Since then, highly active antiretroviral therapy (HAART) has been used [<xref ref-type="bibr" rid="B5">5</xref>-<xref ref-type="bibr" rid="B9">9</xref>]. Spain has had free general access to HAART since 1996. By the end of 2011 there have been around from 1,000 to 1,200 children diagnosed with HIV, all of them infected through MTCT. Vertically HIV-infected children have unique significance because the HIV infection takes place in immature immune and nervous systems, which is of particular interest to researchers [<xref ref-type="bibr" rid="B10">10</xref>-<xref ref-type="bibr" rid="B12">12</xref>].</p><p>A treatment immediately used after the birth has made a tremendous difference to the HIV-infected children. At the present moment it is not known how the HAART era will affect the health and the survival of these children [<xref ref-type="bibr" rid="B13">13</xref>]. Today HIV-infected infants and children survive to adolescence and adulthood. The challenge of providing HIV care involves both acute and chronic, lifelong care. Families and health providers are interested in all aspects of child’s progress and how HIV may affect her/his performance in everyday tasks. In Spain the first HIV-infected child was diagnosed in 1980. At present he is 32 years old [<xref ref-type="bibr" rid="B14">14</xref>].</p><p>There is no the National Registry of HIV-infected children and adults in Spain. The only Registry, which exists, is the National Registry of AIDS. The main objective of the Cohort of the Spanish Paediatric HIV Network (CoRISpe) is to contribute to furthering scientific knowledge on paediatric HIV infection by providing the demographic (the country of birth, nationality of the parents, the date of birth, the date of diagnosis, the day of death, sex, race, etc), sociopsychological (educational level of parents, foster parents, social status of the childs family, etc), clinical (HIV-progression, different illness related to HIV infection, the percentage and absolute number of CD4 and CD8, the level of plasma viral load, etc) and laboratory data (the level of cholesterol, triglycerides, transaminases, leucocytes, limphocytes, etc). Its aim is to enable high-quality research studies on HIV-infected children.</p><sec><title>The role of the CoRISpe</title><p>The CoRISpe was founded in 2008 and was set up in accordance with the Spanish official law on protection of personal data [<xref ref-type="bibr" rid="B15">15</xref>]. We would like to emphasize the fact that it is difficult to find an electronic database (CoRISpe) containing demographic, sociopsychological, clinical and laboratory data of HIV-infected children nationally, mainly because these children are widely spread in various cities and are taken care of by different paediatricians. At the moment there are 84 hospitals with HIV-infected children in Spain and 75 of these hospitals are included in the CoRISpe representing geographically almost the entire territory of Spain (the highest number of HIV-infected children can be seen in Catalonia, Madrid Community and Andalusia; Figure <xref ref-type="fig" rid="F1">1A</xref>). These hospitals are responsible for entering the dataset into the electronic database. Retrospective data have been collected since 1995 and prospective data since 2008. There are only 7 hospitals, which treat HIV-1 infected children not included in the CoRISpe.</p><fig id="F1" position="float"><label>Figure 1</label><caption><p><bold>A. The number of HIV-infected children for each Autonomous Community is represented in the colours indicated.</bold> The highest number of HIV-infected children can be seen in Catalonia, Madrid Community and Andalusia. <bold>B</bold>. Spanish: HIV-infected children born in Spain parents: Immigrats: immigrants or the HIV-infected children of the immigrants.</p></caption><graphic xlink:href="1471-2334-13-2-1"></graphic></fig><p>To obtain a database of high quality we contact all paediatricians in Spain, and explain the objectives of the CoRISpe project trying to encourage co-operation. The CoRISpe electronic database allows remote data entry by clinicians themselves and is password protected. The confidentiality and security of the patients’ data are strictly guarded and respected [<xref ref-type="bibr" rid="B15">15</xref>].</p></sec><sec><title>The structure</title><p>The CoRISpe consists of the Steering Committee, Ethical Committee and two coordinators in the position of directors whose responsibility is to guarantee the correct performance of the CoRISpe. The Steering Committee represented by clinical researchers and participating institutions has created the basic regulations for the Internal Organization of the CoRISpe and participates in the scientific reviews of the procedures.</p><p>The Ethical Committee revises the agreements on the patients’ consents and/or assents made with different hospitals. All research projects presented in the CoRISpe have to be approved by the Ethical Committee.</p><p>The CoRISpe also has a data manager responsible to the Coordinators who clarifies any queries and gives professional advice. To increase the quality of the dataset, regular trips on a three-month basis are made by the data manager to the hospitals participating in the CoRISpe.</p></sec><sec><title>The way the CoRISpe works</title><p>To provide data to the CoRISpe the parents or a legal representative of an HIV-infected child must sign an informed consent form in which the discomforts associated with obtaining the clinical and laboratory data as well as the research objectives are clearly explained. The CoRISpe respects the Declaration of Helsinki, which states that although parents or a legal representative of a child sign the consent, a child is required to give her/his assent for the participation in the study if s/he is able to do so. If after having read the assent, a child decides not to participate in the study, this decision must be respected. These informed consent and assent forms must be approved by the Ethical Committee. As a general rule, the consent can be cancelled at any time [<xref ref-type="bibr" rid="B16">16</xref>,<xref ref-type="bibr" rid="B17">17</xref>].</p><p>All the participating hospitals send to the CoRISpe the retrospective (since 1995) and prospective (since 2008) dataset of the HIV-infected children, who fulfill the inclusion criteria and have been in the clinical follow-up through the online application. By the inclusion criteria we understand: 1.The age -- younger than 18 years old at the moment of the diagnosis in the Paediatric Unit; 2. The Diagnosis of the HIV infection confirmed; 3. The predicted follow-up in the hospital and 4. The children who have seen a paediatrician at least once since 1st of January 1995. The follow-up visits of the children take place every three months and are fixed by paediatricians. There are records for teenagers and adults in the database [<xref ref-type="bibr" rid="B18">18</xref>]. The follow-up of each child ends when a child dies or changes to a no-CoRISpe hospital.</p><p>The electronic database applications have been designed in accordance with the norms of data protection in force and guarantee the security access pursuant to Ley Orgánica 15/1999, de 13 of December [<xref ref-type="bibr" rid="B15">15</xref>]. Each paediatrician has an exclusive user account, which enables the user to access her/his own data and to update the data.</p><p>The CoRISpe, which is located in the Hospital General Universitario Gregorio Marañon, provides a profound quality internal control on a regular basis. The potential errors of CoRISpe data are returned to each participating hospital for checking every 6 months. A specialised agency carries out a CoRISpe external audition verifying if the database information is in accordance with clinical records of the HIV-infected patients. This audition is performed annually on 10% of the clinical records in each hospital.</p><p>Any researcher who is a member of the RED RIS [<xref ref-type="bibr" rid="B19">19</xref>] or anyone who is in collaboration with a member can apply for the CoRISpe dataset as long as the project is scientifically, technically and ethically viable. A researcher must complete a data release application to receive data. This application must be submitted to the members of the Steering Committee for an evaluation. If the project is approved of, a researcher signs a release agreement with the coordinators of the CoRISpe where the commitments of both parts regarding the usage of information, criteria of follow-ups, authorship and spread of results are stated. The CoRISpe is responsible for supplying the dataset needed to carry out projects. Once the above data have been given, the principal researcher sends a scientific report containing the project results once a year so that the CoRISpe could keep updated records on all the projects. The CoRISpe does not charge any fee for providing data to research groups.</p><p>There is a special authorship policy for publications as well as for abstracts/ communication presented to the congress and approved by the Steering Committee. Regardless the amount of work each writer puts, s/he will appear on the list of authors of a given article in proportional turns among all the researchers of the participating centres.</p><p>The CoRISpe organises a general meeting with the Steering Committee and paediatricians from all the parts of Spain once a year to evaluate the stage of the objective and to plan new aims, projects, studies and numbers of research. Also, the CoRISpe prepares professional training, symposia, conferences and scientific fora.</p></sec><sec><title>Transition from paediatric to adults units</title><sec><title>The criteria to establish the age of HIV-infected children to be transferred to the Adult Units</title><p>The chronological and cognitive limits of the adolescent period are unclear as there are several theoretical and practical approaches [<xref ref-type="bibr" rid="B20">20</xref>]. WHO recognizes the adolescent age as the period between 12 and 21 years. The American Academy of Paediatrics between 13 and 21 years [<xref ref-type="bibr" rid="B21">21</xref>], whereas for the CDC adolescence lasts up to the age of 24 [<xref ref-type="bibr" rid="B22">22</xref>]. In Spain, adolescence ends at the age of 18 when an individual acquires legal autonomy.</p><p>The transfer of an adolescent suffering from a chronic disease (heart disease, cystic fibrosis, diabetes) to the Adult Unit is usually difficult [<xref ref-type="bibr" rid="B23">23</xref>-<xref ref-type="bibr" rid="B28">28</xref>]. Therefore, the records stored by the transfer units of those adolescents suffered from chronic diseases can be used as a point of reference for the transfer units of HIV-infected children taking into consideration the scarcity of data of the last ones [<xref ref-type="bibr" rid="B20">20</xref>,<xref ref-type="bibr" rid="B21">21</xref>].</p></sec><sec><title>The way to obtain the dataset from the Adult Units</title><p>It is very important to know what happens with the vertically HIV-infected children who have been transferred to the Adult Units. These vertically HIV-infected adults have different social, psychological, clinical, immunological, neurological and virological characteristics from the patients infected by different ways [<xref ref-type="bibr" rid="B29">29</xref>-<xref ref-type="bibr" rid="B32">32</xref>]. To obtain data from the Adult Units a paediatrician contacts an adult clinician to explain the objective of the CoRISpe and then their collaboration begins. A coordinator of the CoRISpe contacts an adult clinician and requests him to complete the online form.</p></sec><sec><title>Building efficient contacts between paediatricians, adult clinicians and patients</title><p>In the first year the clinical contact between a paediatrician and an adult clinician and a child who is in the process of becoming an adult patient must be well established to work efficiently. Very often the second year brings confusion because a HIV-vertically infected adult, not a child any more, is entitled to choose her/his doctor and to change a hospital. At that moment the contact between a paediatrician and a child is broken. In some cases it is difficult to find an adult patient and match her/his data with the data when s/he was a child. Therefore, at present we have a low level of follow-up of vertically infected young people once they are transferred to the Adult Units.</p></sec></sec><sec><title>General data</title><p>The entire population of HIV-1 infected children calculates for 1,100 to 1,200 in Spain. Up to now the CoRISpe has recruited 838 patients. Some of the patients of 262-362, which is a difference between 1,100-1,200 and 838 has not obtained the Ethical Committee approval and some of them has not signed the inform consent because they do not want to participate in the CoRISpe. Out of 838 patients 802 (95.7%) were vertically HIV-infected. At this moment we cannot calculate the rate of loss-to-follow-up of the coRISpe because we do not have the number of dead patients and those who interrupted the treatment. We are in the process of getting the data from paediatricians. The data of the 802 vertically HIV-infected patients included in the CoRISpe are shown in the Table <xref ref-type="table" rid="T1">1</xref>. Vertically HIV-infected patients according to the year of birth and if the patients were born in Spain or somewhere else (Figure <xref ref-type="fig" rid="F1">1B</xref>).</p><table-wrap position="float" id="T1"><label>Table 1</label><caption><p>Demographic, immunological and virological profile of the vertically-HIV infected patients in the CoRISpe</p></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="top"><tr><th align="left" valign="bottom"> <hr></hr></th><th align="center" valign="bottom"><bold>Group A <18 years</bold><hr></hr></th><th align="center" valign="bottom"><bold>Group B ≥18 years</bold><hr></hr></th><th align="center" valign="bottom"><bold>Total</bold><hr></hr></th></tr><tr><th align="left"> </th><th align="center"><bold>N=520</bold></th><th align="center"><bold>N=282</bold></th><th align="center"><bold>N=802</bold></th></tr></thead><tbody valign="top"><tr><td align="left" valign="bottom">Age (years) mean (range)<hr></hr></td><td align="center" valign="bottom">12,6 (0,04-17,98)<hr></hr></td><td align="center" valign="bottom">22 (18,1-29,7)<hr></hr></td><td align="center" valign="bottom">15,1 (0,04-29,7)<hr></hr></td></tr><tr><td colspan="4" align="left" valign="bottom">Sex: N (%)<hr></hr></td></tr><tr><td align="left" valign="bottom">Male<hr></hr></td><td align="center" valign="bottom">241 (46,3)<hr></hr></td><td align="center" valign="bottom">127 (45)<hr></hr></td><td align="center" valign="bottom">368 (45,9)<hr></hr></td></tr><tr><td align="left" valign="bottom">Female<hr></hr></td><td align="center" valign="bottom">279 (53,7)<hr></hr></td><td align="center" valign="bottom">155 (55)<hr></hr></td><td align="center" valign="bottom">434 (54,1)<hr></hr></td></tr><tr><td colspan="4" align="left" valign="bottom">Origin: N (%)<hr></hr></td></tr><tr><td align="left" valign="bottom">Spain<hr></hr></td><td align="center" valign="bottom">353 (67,9)<hr></hr></td><td align="center" valign="bottom">261 (92,5)<hr></hr></td><td align="center" valign="bottom">614 (76,6)<hr></hr></td></tr><tr><td align="left" valign="bottom">Sub-Saharan Africa<hr></hr></td><td align="center" valign="bottom">102 (19,6)<hr></hr></td><td align="center" valign="bottom">7 (2,5)<hr></hr></td><td align="center" valign="bottom">109 (13,6)<hr></hr></td></tr><tr><td align="left" valign="bottom">Latin America<hr></hr></td><td align="center" valign="bottom">39 (7,5)<hr></hr></td><td align="center" valign="bottom">7 (2,5)<hr></hr></td><td align="center" valign="bottom">46 (5,7)<hr></hr></td></tr><tr><td align="left" valign="bottom">North Africa<hr></hr></td><td align="center" valign="bottom">10 (1,9)<hr></hr></td><td align="center" valign="bottom">3 (1,1)<hr></hr></td><td align="center" valign="bottom">13 (1,6)<hr></hr></td></tr><tr><td align="left" valign="bottom">East Europe<hr></hr></td><td align="center" valign="bottom">9 (1,7)<hr></hr></td><td align="center" valign="bottom">0 (0,0)<hr></hr></td><td align="center" valign="bottom">9 (1,1)<hr></hr></td></tr><tr><td align="left" valign="bottom">Asia<hr></hr></td><td align="center" valign="bottom">4 (0,8)<hr></hr></td><td align="center" valign="bottom">1 (0,3)<hr></hr></td><td align="center" valign="bottom">5 (0,6)<hr></hr></td></tr><tr><td align="left" valign="bottom">West Europe<hr></hr></td><td align="center" valign="bottom">3 (0,6)<hr></hr></td><td align="center" valign="bottom">3 (1,1)<hr></hr></td><td align="center" valign="bottom">6 (08)<hr></hr></td></tr><tr><td colspan="4" align="left" valign="bottom">Time of identification of infection<hr></hr></td></tr><tr><td align="left" valign="bottom">At Birth<hr></hr></td><td align="center" valign="bottom">79 (15,2)<hr></hr></td><td align="center" valign="bottom">11 (3,9)<hr></hr></td><td align="center" valign="bottom">90 (11,2)<hr></hr></td></tr><tr><td align="left" valign="bottom">After Birth (asymptomatic)<hr></hr></td><td align="center" valign="bottom">264 (50,8)<hr></hr></td><td align="center" valign="bottom">160 (56,7)<hr></hr></td><td align="center" valign="bottom">424 (52,9)<hr></hr></td></tr><tr><td align="left" valign="bottom">After Birth (symptomatic)<hr></hr></td><td align="center" valign="bottom">151 (29)<hr></hr></td><td align="center" valign="bottom">87 (30,9)<hr></hr></td><td align="center" valign="bottom">238 (29,7)<hr></hr></td></tr><tr><td align="left" valign="bottom">Unknown<hr></hr></td><td align="center" valign="bottom">26 (5)<hr></hr></td><td align="center" valign="bottom">24 (8,5)<hr></hr></td><td align="center" valign="bottom">50 (6,2)<hr></hr></td></tr><tr><td colspan="4" align="left" valign="bottom">Group age at 1<sup>st</sup> presentation (years)<hr></hr></td></tr><tr><td align="left" valign="bottom"><1<hr></hr></td><td align="center" valign="bottom">316 (60,8)<hr></hr></td><td align="center" valign="bottom">104 (36,9)<hr></hr></td><td align="center" valign="bottom">420 (52,3)<hr></hr></td></tr><tr><td align="left" valign="bottom">1-5<hr></hr></td><td align="center" valign="bottom">150 (28,8)<hr></hr></td><td align="center" valign="bottom">132 (46,8)<hr></hr></td><td align="center" valign="bottom">282 (35,2)<hr></hr></td></tr><tr><td align="left" valign="bottom">≥6<hr></hr></td><td align="center" valign="bottom">54 (10,4)<hr></hr></td><td align="center" valign="bottom">46 (16,3)<hr></hr></td><td align="center" valign="bottom">100 (12,5)<hr></hr></td></tr><tr><td colspan="4" align="left" valign="bottom">Group year of 1<sup>st</sup> presentation (years)<hr></hr></td></tr><tr><td align="left" valign="bottom">1975-1990<hr></hr></td><td align="center" valign="bottom">0 (0,0)<hr></hr></td><td align="center" valign="bottom">73 (25,9)<hr></hr></td><td align="center" valign="bottom">73 (9,1)<hr></hr></td></tr><tr><td align="left" valign="bottom">1991-2000<hr></hr></td><td align="center" valign="bottom">289 (55,6)<hr></hr></td><td align="center" valign="bottom">199 (70,6)<hr></hr></td><td align="center" valign="bottom">488 (60,8)<hr></hr></td></tr><tr><td align="left" valign="bottom">2001-2011<hr></hr></td><td align="center" valign="bottom">231 (44,4)<hr></hr></td><td align="center" valign="bottom">10 (3,5)<hr></hr></td><td align="center" valign="bottom">241 (30,1)<hr></hr></td></tr><tr><td colspan="4" align="left" valign="bottom">Group age at most recent follow-up visit (years)<hr></hr></td></tr><tr><td align="left" valign="bottom">0-5<hr></hr></td><td align="center" valign="bottom">70 (13,5)<hr></hr></td><td align="center" valign="bottom">0 (0,0)<hr></hr></td><td align="center" valign="bottom">70 (8,7)<hr></hr></td></tr><tr><td align="left" valign="bottom">6-11<hr></hr></td><td align="center" valign="bottom">209 (40,2)<hr></hr></td><td align="center" valign="bottom">0 (0,0)<hr></hr></td><td align="center" valign="bottom">209 (26,1)<hr></hr></td></tr><tr><td align="left" valign="bottom">12-17<hr></hr></td><td align="center" valign="bottom">241 (46,3)<hr></hr></td><td align="center" valign="bottom">0 (0,0)<hr></hr></td><td align="center" valign="bottom">241 (30)<hr></hr></td></tr><tr><td align="left" valign="bottom">≥18<hr></hr></td><td align="center" valign="bottom">0 (0,0)<hr></hr></td><td align="center" valign="bottom">282 (100)<hr></hr></td><td align="center" valign="bottom">282 (35,2)<hr></hr></td></tr><tr><td colspan="4" align="left" valign="bottom">CDC: N (%)<hr></hr></td></tr><tr><td align="left" valign="bottom">N-A<hr></hr></td><td align="center" valign="bottom">270 (51,9)<hr></hr></td><td align="center" valign="bottom">91 (32,3)<hr></hr></td><td align="center" valign="bottom">361 (45)<hr></hr></td></tr><tr><td align="left" valign="bottom">B<hr></hr></td><td align="center" valign="bottom">127 (24,4)<hr></hr></td><td align="center" valign="bottom">106 (37,6)<hr></hr></td><td align="center" valign="bottom">233 (29,1)<hr></hr></td></tr><tr><td align="left" valign="bottom">C<hr></hr></td><td align="center" valign="bottom">123 (23,7)<hr></hr></td><td align="center" valign="bottom">85 (30,1)<hr></hr></td><td align="center" valign="bottom">208 (25,9)<hr></hr></td></tr><tr><td colspan="4" align="left" valign="bottom">Co-infections: N (%)<hr></hr></td></tr><tr><td align="left" valign="bottom">HCV<hr></hr></td><td align="center" valign="bottom">24 (4,6)<hr></hr></td><td align="center" valign="bottom">31 (11)<hr></hr></td><td align="center" valign="bottom">55 (6,9)<hr></hr></td></tr><tr><td align="left" valign="bottom">HBV<hr></hr></td><td align="center" valign="bottom">7 (1,3)<hr></hr></td><td align="center" valign="bottom">3 (1,1)<hr></hr></td><td align="center" valign="bottom">10 (1,3)<hr></hr></td></tr><tr><td align="left" valign="bottom">CMV<hr></hr></td><td align="center" valign="bottom">19 (3,7)<hr></hr></td><td align="center" valign="bottom">3 (1,1)<hr></hr></td><td align="center" valign="bottom">22 (2,7)<hr></hr></td></tr><tr><td align="left" valign="bottom">Other<hr></hr></td><td align="center" valign="bottom">4 (0,8)<hr></hr></td><td align="center" valign="bottom">2 (0,7)<hr></hr></td><td align="center" valign="bottom">6 (0,7)<hr></hr></td></tr><tr><td align="left" valign="bottom">No Co-infections<hr></hr></td><td align="center" valign="bottom">466 (89,6)<hr></hr></td><td align="center" valign="bottom">243 (86,1)<hr></hr></td><td align="center" valign="bottom">709 (88,4)<hr></hr></td></tr><tr><td colspan="4" align="left" valign="bottom">Immunological status (%CD4) N (%)<hr></hr></td></tr><tr><td align="left" valign="bottom"><15%<hr></hr></td><td align="center" valign="bottom">9 (1,8)<hr></hr></td><td align="center" valign="bottom">20 (7,1)<hr></hr></td><td align="center" valign="bottom">29 (3,6)<hr></hr></td></tr><tr><td align="left" valign="bottom">15-25%<hr></hr></td><td align="center" valign="bottom">49 (9,4)<hr></hr></td><td align="center" valign="bottom">49 (17,4)<hr></hr></td><td align="center" valign="bottom">98 (12,3)<hr></hr></td></tr><tr><td align="left" valign="bottom">>25%<hr></hr></td><td align="center" valign="bottom">462 (88,8)<hr></hr></td><td align="center" valign="bottom">183 (64,9)<hr></hr></td><td align="center" valign="bottom">645 (80,4)<hr></hr></td></tr><tr><td align="left" valign="bottom">Unknown<hr></hr></td><td align="center" valign="bottom">0 (0,0)<hr></hr></td><td align="center" valign="bottom">30 (10,6)<hr></hr></td><td align="center" valign="bottom">30 (3,7)<hr></hr></td></tr><tr><td colspan="4" align="left" valign="bottom">Viral load (copies/ml) N (%)<hr></hr></td></tr><tr><td align="left" valign="bottom"><50<hr></hr></td><td align="center" valign="bottom">341 (65,6)<hr></hr></td><td align="center" valign="bottom">134 (47,5)<hr></hr></td><td align="center" valign="bottom">475 (59,2)<hr></hr></td></tr><tr><td align="left" valign="bottom">50-10000<hr></hr></td><td align="center" valign="bottom">92 (17,7)<hr></hr></td><td align="center" valign="bottom">83 (29,4)<hr></hr></td><td align="center" valign="bottom">175 (21,8)<hr></hr></td></tr><tr><td align="left" valign="bottom">>10000<hr></hr></td><td align="center" valign="bottom">27 (5,2)<hr></hr></td><td align="center" valign="bottom">36 (12,8)<hr></hr></td><td align="center" valign="bottom">63 (7,9)<hr></hr></td></tr><tr><td align="left">Unknown</td><td align="center">60 (11,5)</td><td align="center">29 (10,3)</td><td align="center">89 (11,1)</td></tr></tbody></table></table-wrap><p>We divided the 838 HIV-infected children into two groups. The group A: 536 children <18 years old that had a follow-up in the Paediatric Units. Out of 536 patients 520 (97%) were vertically HIV-infected of average 12.6 years old (range from 0.04 to 17.98 years old). 53.7% out of 520 were girls. 353 (67.9%) out of 520 patients were born in Spain from Spanish parents, 167 (32.1%) out of 520 were immigrants or the children of the immigrants (Table <xref ref-type="table" rid="T1">1</xref>). Fifty-four out of 520 (10.4%) children were also co-infected by other viruses such us HCV, HBV or CMV.</p><p>The group B: 302 HIV-infected patients ≥18 years of age were transferred to the Adult Units. Out of 302 HIV-infected patients 282 (93.4%) were vertically HIV-infected of average 22 years old (range from 18.1 to 29.7 years old). 155 (55%) out of 282 were girls. The average age of the patients followed up in the Adult Units was 2.38 years (range from 1.5 to 4.8 years old). 261 (92.5%) were born in Spain from Spanish parents and only 7.5% were immigrants or the children of the immigrants (Table <xref ref-type="table" rid="T1">1</xref>).</p><p>At the moment we are in the process of getting data from the Adult Units as so far we have only been working with the Pediatric Units. The antiretroviral treatment of only 484 children out of 520 has been available. In 21 HIV-infected children the treatment was interrupted and 3 did not receive any antiretroviral treatment. 460 patients out of 484 received the HAART. 225 (48.9%) patients received 2 nucleoside analogs and protease inhibitors. Moreover, 141 (30.7%) patients received 2 nucleoside analogs and 1 non analog, 42 (9.1%) patients 1 nucleoside analog, 1 nucleoside non analog and 1 protease inhibitor, 14 (3%) patients took 3 nucleoside analogs, 24 (5.2%) patients received various treatments including CCR5 enter inhibitor or integrase inhibitors. Finally, 14 (3%) patients took monotherapy with IPs. The most used antiretroviral drugs in the CoRISpe were Lopinavir/r (51.1%), 3TC (40%), ABV (39.1%) and FTC (30.2%) [<xref ref-type="bibr" rid="B13">13</xref>].</p><p>It is important to point out that there is a close co-operation between the CoRISpe and the Spanish Paediatric HIV BioBank [<xref ref-type="bibr" rid="B16">16</xref>]. We have done seven research projects with the data provided by the CoRISpe and/or with the samples supplied by the BioBank. The results of all these projects are available to the paediatricians participating in the CoRISpe with a view to improving the state of health of their patients [<xref ref-type="bibr" rid="B8">8</xref>,<xref ref-type="bibr" rid="B33">33</xref>-<xref ref-type="bibr" rid="B44">44</xref>].</p></sec></sec><sec sec-type="conclusions"><title>Conclusions</title><p>To have the CoRISpe electronic database available has been a very important issue in the research of vertically HIV-infected children since the first years of the pandemic. We have a follow-up of the HIV-infected children in the CoRISpe database of the Paediatric Units and we have been working with these data obtaining interesting results as it is seen in a great number of our published articles [<xref ref-type="bibr" rid="B8">8</xref>,<xref ref-type="bibr" rid="B16">16</xref>,<xref ref-type="bibr" rid="B33">33</xref>-<xref ref-type="bibr" rid="B44">44</xref>]. Moreover, the CoRISpe has been collaborating with different European Cohorts (EPPICC, COHERE and PENTA) for many years.</p><p>The CoRISpe represents a novel approach to HIV research that might be of general interest not only for basic and clinical research teams working with HIV, but also for those groups trying to establish large networks focused on researching specific clinical problems. It also represents a model to stimulate cooperative research on specific clinical issues.</p><p>The main objective of this article has been to present the notion of the CoRISpe, its role and to describe how it works. The new exciting era of personalised medicine is accompanied by the rise in the importance of the databases and the biobanks. The quality of the data of the CoRISpe, the number and quality of the samples stored in the Spanish Paediatric HIV BioBank [<xref ref-type="bibr" rid="B16">16</xref>] are required to fulfill the needs of personalised medicine. In the coming years the databases and biobanks will represent the most important structures through which a high number of researches in the majority of scientific fields will be carried out.</p></sec><sec><title>Abbreviations</title><p>CoRISpe: Cohort of the Spanish Paediatric HIV Network; MTCT: Mother-to-child transmission; HAART: Highly active antiretroviral therapy.</p></sec><sec><title>Competing interests</title><p>We declare that we have no conflict of interest.</p></sec><sec><title>Authors’ contributions</title><p>MªIJ and MAMF conceived the study, designed and wrote the manuscript. MªIJ, MAMF and SJ designed the CoRISpe database. SJ and ME provided and analyzed the patients`s data. MªIJ, MAMF, CF, SJ, MN and PS prepared the figures and tables. MªIJ, MAMF, CF, MN and PS discussed the final manuscript. All authors read and approved the final manuscript.</p></sec><sec><title>Pre-publication history</title><p>The pre-publication history for this paper can be accessed here:</p><p><ext-link ext-link-type="uri" xlink:href="http://www.biomedcentral.com/1471-2334/13/2/prepub">http://www.biomedcentral.com/1471-2334/13/2/prepub</ext-link></p></sec></body><back><sec><title>Acknowledgments</title><p><bold>Steering Committee of the CoRISpe (alphabetical order)</bold>De José, MI (Coordinator of the CoRISpe-1 March 2008/January 2010); Fortuny, C (Coordinator of the CoRISpe-2 March 2008/January 2010); Gurbindo, D; León JA; Martín Fontelos, P; Mellado, MJ; Muñoz-Fernández, MA; Navarro, M (coordinator of the CoRISpe-1, since January 2010); Soler, P (Coordinator of the CoRISpe-2, since January 2010).</p><p><bold>Participating Centres</bold> (Autonomous Community in the alphabetical order):</p><p>Andalusia and Melilla</p><p>1. Complejo Hospitalario Ciudad de Jaén, Jaén (de la Cruz, J);</p><p>2. Complejo Hospitalario Torrecárdenas, Almería (Lendínez, F);</p><p>3. Hospital Clínico San Cecilio, Granada (Uberos, J);</p><p>4. Hospital Comarcal, Melilla (Lamas, J);</p><p>5. Hospital de La Línea de la Concepción, Cádiz (Espinosa, D; Montiel, R; Gutiérrez, MC);</p><p>6. Hospital de Motril, Granada (Olivares, L);</p><p>7. Hospital de Poniente-El Ejido, Almería (Muñoz-Vilches, MJ);</p><p>8. Hospital General Universitario Reina Sofía, Córdoba (Rumbao, J);</p><p>9. Hospital Juan Ramón Jiménez, Huelva (Rodríguez, M; Ceballos, J);</p><p>10. Hospital Regional Universitario Carlos Haya, Málaga (Moreno, D; Núñez, E;);</p><p>11. Hospital Universitario Puerta del Mar, Cádiz (Flores, C);</p><p>12. Hospital Universitario Virgen de la Macarena, Sevilla (Terol, P; Romero, J);</p><p>13. Hospital Universitario Virgen de las Nieves, Granada (Santos, JL);</p><p>14. Hospital Universitario Virgen del Rocío, Sevilla (León, JA; Neth, O; Falcón, D);</p><p>Aragon</p><p>1. Hospital Clínico Universitario Lozano Blesa, Zaragoza (Gracia, M; Herráiz, G);</p><p>2. Hospital General San Jorge, Huesca (Egido, M);</p><p>3. Hospital Universitario Miguel Servet, Zaragoza (Ciria, LM; Bouthelier, M; de Juan, F);</p><p>Asturias</p><p>1. Hospital de Cabueñes, Asturias (Pérez, C);</p><p>2.Hospital Universitario Central, Asturias (Ruiz, P);</p><p>Cantabria</p><p>3. Hospital Universitario Marqués de Valdecilla de Santander, Cantabria (Cabero, MJ; Álvarez, C);</p><p>Castilla La Mancha</p><p>1. Complejo Hospitalario Universitario, Albacete (Lillo, M);</p><p>2. Hospital Virgen de la Salud, Toledo (Losada, B);</p><p>Castilla Leon</p><p>1. Complejo Hospitalario, León (Lapeña, S; Andrés, AG);</p><p>2. Complejo Hospitalario, Zamora (Marugán, V; Ochoa, C);</p><p>3. Hospital Clínico Universitario, Valladolid (Solís, P);</p><p>4. Hospital General Yagüe, Burgos (Sastre, E);</p><p>Catalonia</p><p>1. Hospital Asil de Granollers, Barcelona (Coll, MT);</p><p>2. Hospital de Mataró, Barcelona (García, L);</p><p>3. Hospital del Mar, Barcelona (Mur, A);</p><p>4. Hospital Josep Trueta, Girona (Mayol, L);</p><p>5. Hospital Parc Taulí de Sabadell, Barcelona (Pineda, V);</p><p>6. Hospital Sant Joan de Dèu de Esplugues de Llobregat, Barcelona (Fortuny, C; Noguera, T);</p><p>7. Hospital Universitario Arnau de Vilanova, Lleida (Vallmanya, T);</p><p>8. Hospital Universitario Germans Trías i Pujol de Badalona, Barcelona (Rodrigo, C; Méndez, M);</p><p>9. Hospital Universitario Joan XXIII, Tarragona (Soriano, T; Calavia, O);</p><p>10. Hospital Universitario Materno Infantil Vall d` Hebron, Barcelona (Soler-Palacín, P; Espiau, M; Pérez-Hoyos, S);</p><p>11. Hospital Universitario Sant Joan de Reus, Tarragona (Escribano, J);</p><p>Community of Valencia</p><p>1. Hospital Clínico Universitario San Juan, Alicante (Gavilán, C);</p><p>2. Hospital Clínico Universitario, Valencia (Jareño, E; Teresa, M; López-Prats, JL);</p><p>3. Hospital de Sagunto, Valencia (Haro, J);</p><p>4. Hospital Francesc Borja de Gandía, Valencia (Oltra, M);</p><p>5. Hospital General Universitario, Alicante (Vicent, M);</p><p>6. Hospital General Universitario, Valencia (Montesinos, E);</p><p>7. Hospital General, Castellón (López, C; Amat, M; Pelechano, F);</p><p>8. Hospital Universitario Doctor Peset, Valencia (Bretón, R);</p><p>9. Hospital Universitario La Fe, Valencia (Otero, MC; Ortí, A; Pérez, A);</p><p>Estremadura</p><p>1. Complejo Hospitalario Universitario Infanta Cristina, Badajoz (Grande, A);</p><p>2. Complejo Hospitalario, Cáceres (Romero, FJ)</p><p>Galicia</p><p>1. Complejo Hospitalario Juan Canalejo, La Coruña (Vila, L);</p><p>2. Complejo Hospitalario Xeral Calde, Lugo (Calviño, C);</p><p>3. Complejo Hospitalario, Pontevedra (Couceiro, JA);</p><p>Balearic Islands</p><p>1. Hospital Universitario Son Espases, Mallorca (Dueñas, J).</p><p>Canary Islands</p><p>1. Complejo Hospitalario Universitario de Canarias, Tenerife (Montesdeoca, A; Mateo, M)</p><p>2. Hospital General, Fuerteventura (Cuadrillero, ML);</p><p>3. Hospital General, Lanzarote(Román, V; Garzón, MB);</p><p>4. Hospital Universitario Materno Infantil de Las Palmas, Gran Canaria (Colino, E);</p><p>5. Hospital Universitario Nuestra Señora de la Candelaria, Tenerife (Gómez-Sirvent, JE);</p><p>Rioja</p><p>1. Complejo Hospitalario San Millán-San Pedro, La Rioja (Garijo, MC)</p><p>Community of Madrid</p><p>1. Hospital Carlos III, Madrid (Mellado, MJ; García, M; Martín-Fontelos,P);</p><p>2. Hospital de Móstoles, Madrid (Roa, MA);</p><p>3. Hospital General Universitario Gregorio Marañón, Madrid (Gurbindo, D; Navarro, ML;</p><p>4. Saavedra, J; Jimenez de Ory, S; Muñoz-Fernández MA);</p><p>5. Hospital Infantil Universitario Niño Jesús, Madrid (Martínez, J);</p><p>6. Hospital Universitario 12 de Octubre, Madrid (González-Tomé, MI; Rojo, P; Blázquez, D; González, I; Contreras, J);</p><p>7. Hospital Universitario de Getafe, Madrid (Ramos, JT);</p><p>8. Hospital Universitario La Paz, Madrid (de José, MI; Aracil, FJ);</p><p>9. Hospital Universitario Príncipe de Asturias de Alcalá de Henares, Madrid (Beceiro, J);</p><p>10. Hospital Universitario Severo Ochoa de Leganés, Madrid (Calvo, C);</p><p>11. Hospital de Torrejón, Madrid (Badillo, K);</p><p>Murcia</p><p>1. Hospital General Universitario Santa María del Rosell de Cartagena, Murcia (Rex, C);</p><p>2. Hospital Rafael Méndez de Lorca, Murcia (Salinas, R);</p><p>3. Hospital Universitario Virgen de la Arrixaca, Murcia (Alfayate, S; Menasalvas, AI);</p><p>Navarre</p><p>1. Hospital Virgen del Camino de Pamplona, Navarra (Herranz, M; Bernaola, E);</p><p>Basque Country</p><p>1. Hospital de Cruces, Vizcaya (Pocheville, I);</p><p>2. Hospital Txagorritxu, Vitoria (Euba, A);</p><p>3. Hospital Universitario Donostia, Guipúzcoa (Echeverría, J);</p><p><bold>Spanish Research HIV BioBank Personnel (in the alphabetical order)</bold>: Consuegra, I; Díaz, L; Gallego, J; García-Alonso D; García-Merino, I; García, A; Gómez, C; Jiménez, JL; Lorente, R; Muñoz- Fernández, MA (Director) and Serramía, MJ.</p><p>Ethical principles referred to in this article are those expressed, for example, in the Declaration of Helsinki published by the World Medical Association, the United Nations’ Convention on the Rights of the Child, the Charter of Fundamental Rights of the European Union (2000), the Universal Declaration on Bioethics and Human Rights (UNESCO, 2005), the Universal Declaration on the Human Genome and Human Rights (UNESCO, 1997), the International Declaration on Human Genetic Data (UNESCO, 2003), the Universal Declaration of Human Rights of 1948, the Council of Europe’s Convention for the Protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine: Convention on Human Rights and Biomedicine, the Ley de Protección de Datos de Caracter Personal (1999) and the Ley de Investigación Biomédica (2007). These principles are also echoed and referred to in the ICH E guidelines on Good Clinical Practice.</p><p><bold>Additional information</bold>: The detailed description of patients recruited by the CoRISpe can be found on its web http://www.retic-ris.net/. The coordinator centre of the data of CoRISpe-1 is located in the Hospital General Universitario Gregorio Marañón in Madrid and the CoRISpe-2 in Vall d’Hebron, Barcelona. The information on how to get in touch with the coordinators of the cohort can be found in the page before. The information prepared and presented by the cohort is available for all the researchers of the cohort on a permanent basis to help them to carry out their projects on HIV infection.</p><sec><title>Funding</title><p>This work was supported in part by grants from <italic>Fundación para la Investigación y Prevención del SIDA en España</italic> (FIPSE 240800/09, FIPSE 361910/10), <italic>Red Temática de Investigación Cooperativa Sanitaria ISCIII</italic> (RED RIS RD06/0006/0035 and RD06/0006/0021) and Paediatric European Network for Treatment of AIDS (PENTA).</p></sec></sec><ref-list><ref id="B1"><mixed-citation publication-type="journal"><name><surname>Palladino</surname><given-names>C</given-names></name><name><surname>Bellon</surname><given-names>JM</given-names></name><name><surname>Perez-Hoyos</surname><given-names>S</given-names></name><name><surname>Resino</surname><given-names>R</given-names></name><name><surname>Guillen</surname><given-names>S</given-names></name><name><surname>Garcia</surname><given-names>D</given-names></name><name><surname>Gurbindo</surname><given-names>MD</given-names></name><name><surname>Ramos</surname><given-names>JT</given-names></name><name><surname>de Jose</surname><given-names>MI</given-names></name><name><surname>Mellado</surname><given-names>MJ</given-names></name><etal></etal><article-title>Spatial pattern of HIV-1 mother-to-child-transmission in Madrid (Spain) from 1980 till now: demographic and socioeconomic factors</article-title><source>AIDS</source><year>2008</year><volume>22</volume><issue>16</issue><fpage>2199</fpage><lpage>2205</lpage><pub-id pub-id-type="doi">10.1097/QAD.0b013e328310fa96</pub-id><pub-id pub-id-type="pmid">18832883</pub-id></mixed-citation></ref><ref id="B2"><mixed-citation publication-type="journal"><article-title>HIV-1 viral load and CD4 cell count in untreated children with vertically acquired asymptomatic or mild disease. Paediatric European Network for Treatment of AIDS (PENTA)</article-title><source>AIDS</source><year>1998</year><volume>12</volume><issue>4</issue><fpage>1</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">9456249</pub-id></mixed-citation></ref><ref id="B3"><mixed-citation publication-type="journal"><article-title>Children born to women with HIV-1 infection: natural history and risk of transmission. European Collaborative Study</article-title><source>Lancet</source><year>1991</year><volume>337</volume><issue>8736</issue><fpage>253</fpage><lpage>260</lpage><pub-id pub-id-type="pmid">1671109</pub-id></mixed-citation></ref><ref id="B4"><mixed-citation publication-type="journal"><name><surname>Dunn</surname><given-names>D</given-names></name><article-title>Short-term risk of disease progression in HIV-1-infected children receiving no antiretroviral therapy or zidovudine monotherapy: a meta-analysis</article-title><source>Lancet</source><year>2003</year><volume>362</volume><issue>9396</issue><fpage>1605</fpage><lpage>1611</lpage><pub-id pub-id-type="pmid">14630440</pub-id></mixed-citation></ref><ref id="B5"><mixed-citation publication-type="journal"><name><surname>Judd</surname><given-names>A</given-names></name><article-title>Early antiretroviral therapy in HIV-1-infected infants, 1996-2008: treatment response and duration of first-line regimens</article-title><source>AIDS</source><year>2011</year><volume>25</volume><issue>18</issue><fpage>2279</fpage><lpage>2287</lpage><pub-id pub-id-type="pmid">21971357</pub-id></mixed-citation></ref><ref id="B6"><mixed-citation publication-type="journal"><name><surname>McGrath</surname><given-names>CJ</given-names></name><name><surname>Chung</surname><given-names>MH</given-names></name><name><surname>Richardson</surname><given-names>BA</given-names></name><name><surname>Benki-Nugent</surname><given-names>S</given-names></name><name><surname>Warui</surname><given-names>D</given-names></name><name><surname>John-Stewart</surname><given-names>GC</given-names></name><article-title>Younger age at HAART initiation is associated with more rapid growth reconstitution</article-title><source>AIDS</source><year>2011</year><volume>25</volume><issue>3</issue><fpage>345</fpage><lpage>355</lpage><pub-id pub-id-type="doi">10.1097/QAD.0b013e32834171db</pub-id><pub-id pub-id-type="pmid">21102302</pub-id></mixed-citation></ref><ref id="B7"><mixed-citation publication-type="journal"><name><surname>Resino</surname><given-names>S</given-names></name><name><surname>Resino</surname><given-names>R</given-names></name><name><surname>Maria Bellon</surname><given-names>J</given-names></name><name><surname>Micheloud</surname><given-names>D</given-names></name><name><surname>Gutierrez</surname><given-names>MD</given-names></name><name><surname>de Jose</surname><given-names>MI</given-names></name><name><surname>Ramos</surname><given-names>JT</given-names></name><name><surname>Fontelos</surname><given-names>PM</given-names></name><name><surname>Ciria</surname><given-names>L</given-names></name><name><surname>Munoz-Fernandez</surname><given-names>MA</given-names></name><article-title>Clinical outcomes improve with highly active antiretroviral therapy in vertically HIV type-1-infected children</article-title><source>Clin Infect Dis</source><year>2006</year><volume>43</volume><issue>2</issue><fpage>243</fpage><lpage>252</lpage><pub-id pub-id-type="doi">10.1086/505213</pub-id><pub-id pub-id-type="pmid">16779753</pub-id></mixed-citation></ref><ref id="B8"><mixed-citation publication-type="other"><name><surname>Palladino</surname><given-names>C</given-names></name><name><surname>Briz</surname><given-names>V</given-names></name><name><surname>Policarpo</surname><given-names>SN</given-names></name><name><surname>Silveira</surname><given-names>LF</given-names></name><name><surname>de Jose</surname><given-names>MI</given-names></name><name><surname>Gonzalez-Tome</surname><given-names>MI</given-names></name><name><surname>Moreno</surname><given-names>D</given-names></name><name><surname>Leon Leal</surname><given-names>JA</given-names></name><name><surname>Mellado</surname><given-names>MJ</given-names></name><name><surname>de Ory</surname><given-names>SJ</given-names></name><etal></etal><article-title>Long-term efficacy and safety of fosamprenavir in human immunodeficiency virus-infected pediatric patients</article-title><source>Pediatr Infect Dis J</source><volume>29</volume><issue>6</issue><fpage>563</fpage><lpage>566</lpage><pub-id pub-id-type="pmid">20160659</pub-id></mixed-citation></ref><ref id="B9"><mixed-citation publication-type="journal"><name><surname>Saez-Llorens</surname><given-names>X</given-names></name><name><surname>Violari</surname><given-names>A</given-names></name><name><surname>Ndiweni</surname><given-names>D</given-names></name><name><surname>Yogev</surname><given-names>R</given-names></name><name><surname>Cashat</surname><given-names>M</given-names></name><name><surname>Wiznia</surname><given-names>A</given-names></name><name><surname>Chittick</surname><given-names>G</given-names></name><name><surname>Harris</surname><given-names>J</given-names></name><name><surname>Hinkle</surname><given-names>J</given-names></name><name><surname>Blum</surname><given-names>MR</given-names></name><etal></etal><article-title>Long-term safety and efficacy results of once-daily emtricitabine-based highly active antiretroviral therapy regimens in human immunodeficiency virus-infected pediatric subjects</article-title><source>Pediatrics</source><year>2008</year><volume>121</volume><issue>4</issue><fpage>e827</fpage><lpage>835</lpage><pub-id pub-id-type="doi">10.1542/peds.2006-3078</pub-id><pub-id pub-id-type="pmid">18332076</pub-id></mixed-citation></ref><ref id="B10"><mixed-citation publication-type="journal"><name><surname>Resino</surname><given-names>S</given-names></name><name><surname>Gurbindo</surname><given-names>D</given-names></name><name><surname>Cano</surname><given-names>JM</given-names></name><name><surname>Sanchez-Ramon</surname><given-names>S</given-names></name><name><surname>Muñoz-Fernandez</surname><given-names>MA</given-names></name><article-title>Predictive markers of clinical outcome in vertically HIV-1-infected infants. A prospective longitudinal study</article-title><source>Pediatr Res</source><year>2000</year><volume>47</volume><issue>4 Pt 1</issue><fpage>509</fpage><lpage>515</lpage><pub-id pub-id-type="pmid">10759159</pub-id></mixed-citation></ref><ref id="B11"><mixed-citation publication-type="journal"><name><surname>Sanchez-Ramon</surname><given-names>S</given-names></name><name><surname>Bellon</surname><given-names>JM</given-names></name><name><surname>Resino</surname><given-names>S</given-names></name><name><surname>Canto-Nogues</surname><given-names>C</given-names></name><name><surname>Gurbindo</surname><given-names>D</given-names></name><name><surname>Ramos</surname><given-names>JT</given-names></name><name><surname>Munoz-Fernandez</surname><given-names>MA</given-names></name><article-title>Low blood CD8+ T-lymphocytes and high circulating monocytes are predictors of HIV-1-associated progressive encephalopathy in children</article-title><source>Pediatrics</source><year>2003</year><volume>111</volume><issue>2</issue><fpage>E168</fpage><lpage>175</lpage><pub-id pub-id-type="doi">10.1542/peds.111.2.e168</pub-id><pub-id pub-id-type="pmid">12563091</pub-id></mixed-citation></ref><ref id="B12"><mixed-citation publication-type="journal"><name><surname>Gurbindo</surname><given-names>D</given-names></name><name><surname>Resino</surname><given-names>S</given-names></name><name><surname>Sanchez-Ramon</surname><given-names>S</given-names></name><name><surname>Leon</surname><given-names>JA</given-names></name><name><surname>Munoz-Fernandez</surname><given-names>MA</given-names></name><article-title>Correlation of viral load and CD8 T-lymphocytes with development of neurological manifestations in vertically HIV-1-infected infants. A prospective longitudinal study</article-title><source>Neuropediatrics</source><year>1999</year><volume>30</volume><issue>4</issue><fpage>197</fpage><lpage>204</lpage><pub-id pub-id-type="doi">10.1055/s-2007-973490</pub-id><pub-id pub-id-type="pmid">10569211</pub-id></mixed-citation></ref><ref id="B13"><mixed-citation publication-type="other"><source>Panel on Antiretroviral Therapy and Medical Management of HIV-Infected Children. Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection.August 11 p-Aa</source></mixed-citation></ref><ref id="B14"><mixed-citation publication-type="journal"><name><surname>Ramos</surname><given-names>JT</given-names></name><name><surname>de Jose</surname><given-names>MI</given-names></name><name><surname>Polo</surname><given-names>R</given-names></name><name><surname>Fortuny</surname><given-names>C</given-names></name><name><surname>Mellado</surname><given-names>MJ</given-names></name><name><surname>Munoz-Fernandez</surname><given-names>MA</given-names></name><name><surname>Beceiro</surname><given-names>J</given-names></name><name><surname>Bertran</surname><given-names>JM</given-names></name><name><surname>Calvo</surname><given-names>C</given-names></name><name><surname>Chamorro</surname><given-names>L</given-names></name><etal></etal><article-title>[Recommendations of the CEVIHP/SEIP/AEP/PNS on antiretroviral treatment in HIV-infected children and teenagers]</article-title><source>Enferm Infecc Microbiol Clin</source><year>2005</year><volume>23</volume><issue>5</issue><fpage>279</fpage><lpage>312</lpage><pub-id pub-id-type="doi">10.1157/13074970</pub-id><pub-id pub-id-type="pmid">15899180</pub-id></mixed-citation></ref><ref id="B15"><mixed-citation publication-type="other"><article-title>Ley 15/1999 ddD, de Protección de datos de caracter personal</article-title><source>BOE N8 298</source><fpage>43088</fpage><lpage>43099</lpage></mixed-citation></ref><ref id="B16"><mixed-citation publication-type="other"><name><surname>Garcia-Merino</surname><given-names>I</given-names></name><name><surname>de Las Cuevas</surname><given-names>N</given-names></name><name><surname>Jimenez</surname><given-names>JL</given-names></name><name><surname>Garcia</surname><given-names>A</given-names></name><name><surname>Gallego</surname><given-names>J</given-names></name><name><surname>Gomez</surname><given-names>C</given-names></name><name><surname>Garcia</surname><given-names>D</given-names></name><name><surname>Munoz-Fernandez</surname><given-names>MA</given-names></name><article-title>Pediatric HIV BioBank: a new role of the Spanish HIV BioBank in pediatric HIV research</article-title><source>AIDS Res Hum Retroviruses</source><volume>26</volume><issue>2</issue><fpage>241</fpage><lpage>244</lpage><pub-id pub-id-type="pmid">20156108</pub-id></mixed-citation></ref><ref id="B17"><mixed-citation publication-type="journal"><name><surname>Garcia-Merino</surname><given-names>I</given-names></name><name><surname>de Las Cuevas</surname><given-names>N</given-names></name><name><surname>Jimenez</surname><given-names>JL</given-names></name><name><surname>Gallego</surname><given-names>J</given-names></name><name><surname>Gomez</surname><given-names>C</given-names></name><name><surname>Prieto</surname><given-names>C</given-names></name><name><surname>Serramia</surname><given-names>MJ</given-names></name><name><surname>Lorente</surname><given-names>R</given-names></name><name><surname>Munoz-Fernandez</surname><given-names>MA</given-names></name><article-title>The Spanish HIV BioBank: a model of cooperative HIV research</article-title><source>Retrovirology</source><year>2009</year><volume>6</volume><fpage>27</fpage><pub-id pub-id-type="doi">10.1186/1742-4690-6-27</pub-id><pub-id pub-id-type="pmid">19272145</pub-id></mixed-citation></ref><ref id="B18"><mixed-citation publication-type="other"><name><surname>Nso</surname><given-names>AP</given-names></name><name><surname>Larru</surname><given-names>B</given-names></name><name><surname>Bellon</surname><given-names>JM</given-names></name><name><surname>Mellado</surname><given-names>MJ</given-names></name><name><surname>Ramos</surname><given-names>JT</given-names></name><name><surname>Gonzalez</surname><given-names>MI</given-names></name><name><surname>Navarro</surname><given-names>ML</given-names></name><name><surname>Munoz-Fernandez</surname><given-names>MA</given-names></name><name><surname>Jose</surname><given-names>MI</given-names></name><article-title>HIV-infected adolescents: relationship between atazanavir plasma levels and bilirubin concentrations</article-title><source>J Adolesc Health</source><volume>48</volume><issue>1</issue><fpage>100</fpage><lpage>102</lpage><pub-id pub-id-type="pmid">21185531</pub-id></mixed-citation></ref><ref id="B19"><mixed-citation publication-type="other"><source>Red RIS web site</source><comment>In <ext-link ext-link-type="uri" xlink:href="http://www.retic-ris.net;">http://www.retic-ris.net;</ext-link> Accessed February 29</comment></mixed-citation></ref><ref id="B20"><mixed-citation publication-type="journal"><name><surname>Maturo</surname><given-names>D</given-names></name><name><surname>Powell</surname><given-names>A</given-names></name><name><surname>Major-Wilson</surname><given-names>H</given-names></name><name><surname>Sanchez</surname><given-names>K</given-names></name><name><surname>De Santis</surname><given-names>JP</given-names></name><name><surname>Friedman</surname><given-names>LB</given-names></name><article-title>Development of a protocol for transitioning adolescents with HIV infection to adult care</article-title><source>J Pediatr Health Care</source><year>2011</year><volume>25</volume><issue>1</issue><fpage>16</fpage><lpage>23</lpage><pub-id pub-id-type="doi">10.1016/j.pedhc.2009.12.005</pub-id><pub-id pub-id-type="pmid">21147403</pub-id></mixed-citation></ref><ref id="B21"><mixed-citation publication-type="other"><name><surname>Abadi</surname><given-names>J</given-names></name><source>Transitioning HIV-infected adolescents into adult care</source><year>2011</year><comment><ext-link ext-link-type="uri" xlink:href="http://www.medscape.com/viewarticle/748356">http://www.medscape.com/viewarticle/748356</ext-link></comment></mixed-citation></ref><ref id="B22"><mixed-citation publication-type="other"><collab>Centers for Disease Control and Prevention</collab><source>Fact sheet: HIV/AIDS among youth</source><year>2008</year><comment><ext-link ext-link-type="uri" xlink:href="http://www.cdc.gov/hiv/resources/factsheets/PDF/youth.htm">http://www.cdc.gov/hiv/resources/factsheets/PDF/youth.htm</ext-link></comment></mixed-citation></ref><ref id="B23"><mixed-citation publication-type="journal"><name><surname>Freed</surname><given-names>GL</given-names></name><name><surname>Hudson</surname><given-names>EJ</given-names></name><article-title>Transitioning children with chronic diseases to adult care: current knowledge, practices, and directions</article-title><source>J Pediatr</source><year>2006</year><volume>148</volume><issue>6</issue><fpage>824</fpage><lpage>827</lpage><pub-id pub-id-type="doi">10.1016/j.jpeds.2006.02.010</pub-id><pub-id pub-id-type="pmid">16769396</pub-id></mixed-citation></ref><ref id="B24"><mixed-citation publication-type="journal"><name><surname>Lewis-Gary</surname><given-names>MD</given-names></name><article-title>Transitioning to adult health care facilities for young adults with a chronic condition</article-title><source>Pediatr Nurs</source><year>2001</year><volume>27</volume><issue>5</issue><fpage>521</fpage><lpage>524</lpage><pub-id pub-id-type="pmid">12025316</pub-id></mixed-citation></ref><ref id="B25"><mixed-citation publication-type="journal"><name><surname>Por</surname><given-names>J</given-names></name><name><surname>Golberg</surname><given-names>B</given-names></name><name><surname>Lennox</surname><given-names>V</given-names></name><name><surname>Burr</surname><given-names>P</given-names></name><name><surname>Barrow</surname><given-names>J</given-names></name><name><surname>Dennard</surname><given-names>L</given-names></name><article-title>Transition of care: health care professionals' view</article-title><source>J Nurs Manag</source><year>2004</year><volume>12</volume><issue>5</issue><fpage>354</fpage><lpage>361</lpage><pub-id pub-id-type="doi">10.1111/j.1365-2834.2004.00428.x</pub-id><pub-id pub-id-type="pmid">15315492</pub-id></mixed-citation></ref><ref id="B26"><mixed-citation publication-type="journal"><name><surname>Lotstein</surname><given-names>DS</given-names></name><name><surname>McPherson</surname><given-names>M</given-names></name><name><surname>Strickland</surname><given-names>B</given-names></name><name><surname>Newacheck</surname><given-names>PW</given-names></name><article-title>Transition planning for youth with special health care needs: results from the National Survey of Children with Special Health Care Needs</article-title><source>Pediatrics</source><year>2005</year><volume>115</volume><issue>6</issue><fpage>1562</fpage><lpage>1568</lpage><pub-id pub-id-type="doi">10.1542/peds.2004-1262</pub-id><pub-id pub-id-type="pmid">15930217</pub-id></mixed-citation></ref><ref id="B27"><mixed-citation publication-type="journal"><name><surname>Rosen</surname><given-names>DS</given-names></name><name><surname>Blum</surname><given-names>RW</given-names></name><name><surname>Britto</surname><given-names>M</given-names></name><name><surname>Sawyer</surname><given-names>SM</given-names></name><name><surname>Siegel</surname><given-names>DM</given-names></name><article-title>Transition to adult health care for adolescents and young adults with chronic conditions: position paper of the Society for Adolescent Medicine</article-title><source>J Adolesc Health</source><year>2003</year><volume>33</volume><issue>4</issue><fpage>309</fpage><lpage>311</lpage><pub-id pub-id-type="doi">10.1016/S1054-139X(03)00208-8</pub-id><pub-id pub-id-type="pmid">14519573</pub-id></mixed-citation></ref><ref id="B28"><mixed-citation publication-type="journal"><name><surname>Flume</surname><given-names>PA</given-names></name><name><surname>Taylor</surname><given-names>LA</given-names></name><name><surname>Anderson</surname><given-names>DL</given-names></name><name><surname>Gray</surname><given-names>S</given-names></name><name><surname>Turner</surname><given-names>D</given-names></name><article-title>Transition programs in cystic fibrosis centers: perceptions of team members</article-title><source>Pediatr Pulmonol</source><year>2004</year><volume>37</volume><issue>1</issue><fpage>4</fpage><lpage>7</lpage><pub-id pub-id-type="doi">10.1002/ppul.10391</pub-id><pub-id pub-id-type="pmid">14679482</pub-id></mixed-citation></ref><ref id="B29"><mixed-citation publication-type="journal"><name><surname>Vigano</surname><given-names>A</given-names></name><name><surname>Bedogni</surname><given-names>G</given-names></name><name><surname>Manfredini</surname><given-names>V</given-names></name><name><surname>Giacomet</surname><given-names>V</given-names></name><name><surname>Cerini</surname><given-names>C</given-names></name><name><surname>di Nello</surname><given-names>F</given-names></name><name><surname>Penagini</surname><given-names>F</given-names></name><name><surname>Caprio</surname><given-names>C</given-names></name><name><surname>Zuccotti</surname><given-names>GV</given-names></name><article-title>Long-term renal safety of tenofovir disoproxil fumarate in vertically HIV-infected children, adolescents and young adults: a 60-month follow-up study</article-title><source>Clin Drug Investig</source><year>2011</year><volume>31</volume><issue>6</issue><fpage>407</fpage><lpage>415</lpage><pub-id pub-id-type="doi">10.2165/11590400-000000000-00000</pub-id></mixed-citation></ref><ref id="B30"><mixed-citation publication-type="journal"><name><surname>Cruz</surname><given-names>ML</given-names></name><name><surname>Cardoso</surname><given-names>CA</given-names></name><name><surname>Joao</surname><given-names>EC</given-names></name><name><surname>Gomes</surname><given-names>IM</given-names></name><name><surname>Abreu</surname><given-names>TF</given-names></name><name><surname>Oliveira</surname><given-names>RH</given-names></name><name><surname>Machado</surname><given-names>ES</given-names></name><name><surname>Dias</surname><given-names>IR</given-names></name><name><surname>Rubini</surname><given-names>NM</given-names></name><name><surname>Succi</surname><given-names>RM</given-names></name><article-title>Pregnancy in HIV vertically infected adolescents and young women: a new generation of HIV-exposed infants</article-title><source>AIDS</source><year>2010</year><volume>24</volume><issue>17</issue><fpage>2727</fpage><lpage>2731</lpage><pub-id pub-id-type="doi">10.1097/QAD.0b013e32833e50d4</pub-id><pub-id pub-id-type="pmid">20827164</pub-id></mixed-citation></ref><ref id="B31"><mixed-citation publication-type="journal"><name><surname>Judd</surname><given-names>A</given-names></name><name><surname>Ferrand</surname><given-names>RA</given-names></name><name><surname>Jungmann</surname><given-names>E</given-names></name><name><surname>Foster</surname><given-names>C</given-names></name><name><surname>Masters</surname><given-names>J</given-names></name><name><surname>Rice</surname><given-names>B</given-names></name><name><surname>Lyall</surname><given-names>H</given-names></name><name><surname>Tookey</surname><given-names>PA</given-names></name><name><surname>Prime</surname><given-names>K</given-names></name><article-title>Vertically acquired HIV diagnosed in adolescence and early adulthood in the United Kingdom and Ireland: findings from national surveillance</article-title><source>HIV Med</source><year>2009</year><volume>10</volume><issue>4</issue><fpage>253</fpage><lpage>256</lpage><pub-id pub-id-type="doi">10.1111/j.1468-1293.2008.00676.x</pub-id><pub-id pub-id-type="pmid">19187173</pub-id></mixed-citation></ref><ref id="B32"><mixed-citation publication-type="journal"><name><surname>Dunn</surname><given-names>D</given-names></name><name><surname>Woodburn</surname><given-names>P</given-names></name><name><surname>Duong</surname><given-names>T</given-names></name><name><surname>Peto</surname><given-names>J</given-names></name><name><surname>Phillips</surname><given-names>A</given-names></name><name><surname>Gibb</surname><given-names>D</given-names></name><name><surname>Porter</surname><given-names>K</given-names></name><article-title>Current CD4 cell count and the short-term risk of AIDS and death before the availability of effective antiretroviral therapy in HIV-infected children and adults</article-title><source>J Infect Dis</source><year>2008</year><volume>197</volume><issue>3</issue><fpage>398</fpage><lpage>404</lpage><pub-id pub-id-type="doi">10.1086/524686</pub-id><pub-id pub-id-type="pmid">18248303</pub-id></mixed-citation></ref><ref id="B33"><mixed-citation publication-type="journal"><name><surname>Clemente</surname><given-names>MI</given-names></name><name><surname>Alvarez</surname><given-names>S</given-names></name><name><surname>Serramia</surname><given-names>MJ</given-names></name><name><surname>Turriziani</surname><given-names>O</given-names></name><name><surname>Genebat</surname><given-names>M</given-names></name><name><surname>Leal</surname><given-names>M</given-names></name><name><surname>Fresno</surname><given-names>M</given-names></name><name><surname>Munoz-Fernandez</surname><given-names>MA</given-names></name><article-title>Non-steroidal anti-inflammatory drugs increase the antiretroviral activity of nucleoside reverse transcriptase inhibitors in HIV type-1-infected T-lymphocytes: role of multidrug resistance protein 4</article-title><source>Antivir Ther</source><year>2009</year><volume>14</volume><issue>8</issue><fpage>1101</fpage><lpage>1111</lpage><pub-id pub-id-type="pmid">20032540</pub-id></mixed-citation></ref><ref id="B34"><mixed-citation publication-type="journal"><name><surname>Genebat</surname><given-names>M</given-names></name><name><surname>Ruiz-Mateos</surname><given-names>E</given-names></name><name><surname>Leon</surname><given-names>JA</given-names></name><name><surname>Gonzalez-Serna</surname><given-names>A</given-names></name><name><surname>Pulido</surname><given-names>I</given-names></name><name><surname>Rivas</surname><given-names>I</given-names></name><name><surname>Ferrando-Martinez</surname><given-names>S</given-names></name><name><surname>Sanchez</surname><given-names>B</given-names></name><name><surname>Munoz-Fernandez</surname><given-names>MA</given-names></name><name><surname>Leal</surname><given-names>M</given-names></name><article-title>Correlation between the Trofile test and virological response to a short-term maraviroc exposure in HIV-infected patients</article-title><source>J Antimicrob Chemother</source><year>2009</year><volume>64</volume><issue>4</issue><fpage>845</fpage><lpage>849</lpage><pub-id pub-id-type="doi">10.1093/jac/dkp293</pub-id><pub-id pub-id-type="pmid">19671585</pub-id></mixed-citation></ref><ref id="B35"><mixed-citation publication-type="journal"><name><surname>Palladino</surname><given-names>C</given-names></name><name><surname>Briz</surname><given-names>V</given-names></name><name><surname>Gonzalez-Tome</surname><given-names>MI</given-names></name><name><surname>Leon Leal</surname><given-names>JA</given-names></name><name><surname>Navarro</surname><given-names>ML</given-names></name><name><surname>de Jose</surname><given-names>MI</given-names></name><name><surname>Ramos</surname><given-names>JT</given-names></name><name><surname>Munoz-Fernandez</surname><given-names>MA</given-names></name><article-title>Short communication: evaluation of the effect of enfuvirtide in 11 HIV-1 vertically infected pediatric patients outside clinical trials</article-title><source>AIDS Res Hum Retroviruses</source><year>2010</year><volume>26</volume><issue>3</issue><fpage>301</fpage><lpage>305</lpage><pub-id pub-id-type="doi">10.1089/aid.2009.0151</pub-id><pub-id pub-id-type="pmid">20334565</pub-id></mixed-citation></ref><ref id="B36"><mixed-citation publication-type="journal"><name><surname>Resino</surname><given-names>S</given-names></name><name><surname>Micheloud</surname><given-names>D</given-names></name><name><surname>Lorente</surname><given-names>R</given-names></name><name><surname>Bellon</surname><given-names>JM</given-names></name><name><surname>Navarro</surname><given-names>ML</given-names></name><name><surname>Munoz-Fernandez</surname><given-names>MA</given-names></name><article-title>Adipokine profiles and lipodystrophy in HIV-infected children during the first 4 years on highly active antiretroviral therapy</article-title><source>HIV Med</source><year>2011</year><volume>12</volume><issue>1</issue><fpage>54</fpage><lpage>60</lpage><pub-id pub-id-type="doi">10.1111/j.1468-1293.2010.00837.x</pub-id><pub-id pub-id-type="pmid">20497248</pub-id></mixed-citation></ref><ref id="B37"><mixed-citation publication-type="journal"><name><surname>Babiker</surname><given-names>A</given-names></name><name><surname>Castro nee Green</surname><given-names>H</given-names></name><name><surname>Compagnucci</surname><given-names>A</given-names></name><name><surname>Fiscus</surname><given-names>S</given-names></name><name><surname>Giaquinto</surname><given-names>C</given-names></name><name><surname>Gibb</surname><given-names>DM</given-names></name><name><surname>Harper</surname><given-names>L</given-names></name><name><surname>Harrison</surname><given-names>L</given-names></name><name><surname>Hughes</surname><given-names>M</given-names></name><name><surname>McKinney</surname><given-names>R</given-names></name><etal></etal><article-title>First-line antiretroviral therapy with a protease inhibitor versus non-nucleoside reverse transcriptase inhibitor and switch at higher versus low viral load in HIV-infected children: an open-label, randomised phase 2/3 trial</article-title><source>Lancet Infect Dis</source><year>2011</year><volume>11</volume><issue>4</issue><fpage>273</fpage><lpage>283</lpage><pub-id pub-id-type="pmid">21288774</pub-id></mixed-citation></ref><ref id="B38"><mixed-citation publication-type="journal"><name><surname>Palladino</surname><given-names>C</given-names></name><name><surname>Climent</surname><given-names>FJ</given-names></name><name><surname>Jose</surname><given-names>MI</given-names></name><name><surname>Jimenez De Ory</surname><given-names>S</given-names></name><name><surname>Bellon</surname><given-names>JM</given-names></name><name><surname>Guillen</surname><given-names>S</given-names></name><name><surname>Gurbindo</surname><given-names>MD</given-names></name><name><surname>Gonzalez-Tome</surname><given-names>I</given-names></name><name><surname>Mellado</surname><given-names>MJ</given-names></name><name><surname>Martinez Perez</surname><given-names>J</given-names></name><etal></etal><article-title>Causes of death in pediatric patients vertically infected by the human immunodeficiency virus type 1 in Madrid, Spain, from 1982 to mid-2009</article-title><source>Pediatr Infect Dis J</source><year>2011</year><volume>30</volume><issue>6</issue><fpage>495</fpage><lpage>500</lpage><pub-id pub-id-type="pmid">21326134</pub-id></mixed-citation></ref><ref id="B39"><mixed-citation publication-type="journal"><name><surname>Cambon-Thomsen</surname><given-names>A</given-names></name><name><surname>Thorisson</surname><given-names>GA</given-names></name><name><surname>Mabile</surname><given-names>L</given-names></name><name><surname>Andrieu</surname><given-names>S</given-names></name><name><surname>Bertier</surname><given-names>G</given-names></name><name><surname>Boeckhout</surname><given-names>M</given-names></name><name><surname>Carpenter</surname><given-names>J</given-names></name><name><surname>Dagher</surname><given-names>G</given-names></name><name><surname>Dalgleish</surname><given-names>R</given-names></name><name><surname>Deschenes</surname><given-names>M</given-names></name><etal></etal><article-title>The role of a Bioresource Research Impact Factor as an incentive to share human bioresources</article-title><source>Nat Genet</source><year>2011</year><volume>43</volume><issue>6</issue><fpage>503</fpage><lpage>504</lpage><pub-id pub-id-type="doi">10.1038/ng.831</pub-id><pub-id pub-id-type="pmid">21614086</pub-id></mixed-citation></ref><ref id="B40"><mixed-citation publication-type="journal"><name><surname>de Mulder</surname><given-names>M</given-names></name><name><surname>Yebra</surname><given-names>G</given-names></name><name><surname>Martin</surname><given-names>L</given-names></name><name><surname>Prieto</surname><given-names>L</given-names></name><name><surname>Mellado</surname><given-names>MJ</given-names></name><name><surname>Rojo</surname><given-names>P</given-names></name><name><surname>Jimenez de Ory</surname><given-names>S</given-names></name><name><surname>Munoz-Fernandez</surname><given-names>MA</given-names></name><name><surname>Ramos</surname><given-names>JT</given-names></name><name><surname>Holguin</surname><given-names>A</given-names></name><article-title>Drug resistance prevalence and HIV-1 variant characterization in the naive and pretreated HIV-1-infected paediatric population in Madrid, Spain</article-title><source>J Antimicrob Chemother</source><year>2011</year><volume>66</volume><issue>10</issue><fpage>2362</fpage><lpage>2371</lpage><pub-id pub-id-type="doi">10.1093/jac/dkr305</pub-id><pub-id pub-id-type="pmid">21810838</pub-id></mixed-citation></ref><ref id="B41"><mixed-citation publication-type="journal"><name><surname>Briz</surname><given-names>V</given-names></name><name><surname>Palladino</surname><given-names>C</given-names></name><name><surname>Navarro</surname><given-names>M</given-names></name><name><surname>Jimenez de Ory</surname><given-names>S</given-names></name><name><surname>Gonzalez-Tome</surname><given-names>M</given-names></name><name><surname>Leon</surname><given-names>J</given-names></name><name><surname>Nunez-Cuadros</surname><given-names>E</given-names></name><name><surname>de Jose</surname><given-names>M</given-names></name><name><surname>Ramos</surname><given-names>J</given-names></name><name><surname>Munoz-Fernandez</surname><given-names>M</given-names></name><article-title>Etravirine-based highly active antiretroviral therapy in HIV-1-infected paediatric patients</article-title><source>HIV Med</source><year>2011</year><volume>12</volume><issue>7</issue><fpage>442</fpage><lpage>446</lpage><pub-id pub-id-type="doi">10.1111/j.1468-1293.2010.00907.x</pub-id><pub-id pub-id-type="pmid">21395964</pub-id></mixed-citation></ref><ref id="B42"><mixed-citation publication-type="journal"><name><surname>Ferrando-Martinez</surname><given-names>S</given-names></name><name><surname>Casazza</surname><given-names>JP</given-names></name><name><surname>Leal</surname><given-names>M</given-names></name><name><surname>Machmach</surname><given-names>K</given-names></name><name><surname>Munoz-Fernandez</surname><given-names>MA</given-names></name><name><surname>Viciana</surname><given-names>P</given-names></name><name><surname>Koup</surname><given-names>RA</given-names></name><name><surname>Ruiz-Mateos</surname><given-names>E</given-names></name><article-title>Differential Gag-Specific Polyfunctional T Cell Maturation Patterns in HIV-1 Elite Controllers</article-title><source>J Virol</source><year>2012</year><volume>86</volume><issue>7</issue><fpage>3667</fpage><lpage>3674</lpage><pub-id pub-id-type="doi">10.1128/JVI.07034-11</pub-id><pub-id pub-id-type="pmid">22278254</pub-id></mixed-citation></ref><ref id="B43"><mixed-citation publication-type="journal"><name><surname>Soler-Palacin</surname><given-names>P</given-names></name><name><surname>Melendo</surname><given-names>S</given-names></name><name><surname>Noguera-Julian</surname><given-names>A</given-names></name><name><surname>Fortuny</surname><given-names>C</given-names></name><name><surname>Navarro</surname><given-names>ML</given-names></name><name><surname>Mellado</surname><given-names>MJ</given-names></name><name><surname>Garcia</surname><given-names>L</given-names></name><name><surname>Uriona</surname><given-names>S</given-names></name><name><surname>Martin-Nalda</surname><given-names>A</given-names></name><name><surname>Figueras</surname><given-names>C</given-names></name><article-title>Prospective study of renal function in HIV-infected pediatric patients receiving tenofovir-containing HAART regimens</article-title><source>AIDS</source><year>2011</year><volume>25</volume><issue>2</issue><fpage>171</fpage><lpage>176</lpage><pub-id pub-id-type="doi">10.1097/QAD.0b013e328340fdca</pub-id><pub-id pub-id-type="pmid">21076275</pub-id></mixed-citation></ref><ref id="B44"><mixed-citation publication-type="journal"><name><surname>Noguera-Julian</surname><given-names>A</given-names></name><name><surname>Provens</surname><given-names>AC</given-names></name><name><surname>Soler-Palacin</surname><given-names>P</given-names></name><name><surname>Espiau</surname><given-names>M</given-names></name><name><surname>Mur</surname><given-names>A</given-names></name><name><surname>Mendez</surname><given-names>M</given-names></name><name><surname>Fortuny</surname><given-names>C</given-names></name><article-title>Pandemic influenza a (2009 H1N1) in human immunodeficiency virus-infected catalan children</article-title><source>Pediatr Infect Dis J</source><year>2011</year><volume>30</volume><issue>2</issue><fpage>173</fpage><lpage>175</lpage><pub-id pub-id-type="doi">10.1097/INF.0b013e3181f5358b</pub-id><pub-id pub-id-type="pmid">20802374</pub-id></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E76 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000E76 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= SidaSubSaharaV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé= PMC:3544738
|texte= A new tool for the paediatric HIV research: general data from the Cohort of the Spanish Paediatric HIV Network (CoRISpe)
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:23282073" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a SidaSubSaharaV1
| This area was generated with Dilib version V0.6.32. |  |