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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prevalence and risk factors of latent Tuberculosis among adolescents in rural Eastern Uganda</title><author><name sortKey="Mumpe Mwanja, Daniel" sort="Mumpe Mwanja, Daniel" uniqKey="Mumpe Mwanja D" first="Daniel" last="Mumpe-Mwanja">Daniel Mumpe-Mwanja</name><affiliation><nlm:aff id="A1"> Makerere University School of Public Health, CDC fellowship program</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Makerere University, Iganga Mayuge Health Demographic Surveillance Site</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Makerere University College of Health Sciences, Infectious Diseases Institute</nlm:aff></affiliation><affiliation><nlm:aff id="A4"> Ministry of Health, National Tuberculosis and Leprosy Program</nlm:aff></affiliation></author><author><name sortKey="Verver, Suzanne" sort="Verver, Suzanne" uniqKey="Verver S" first="Suzanne" last="Verver">Suzanne Verver</name><affiliation><nlm:aff id="A5"> KNCV Tuberculosis Foundation; CINIMA, Academic Medical Centre</nlm:aff></affiliation></author><author><name sortKey="Yeka, Adoke" sort="Yeka, Adoke" uniqKey="Yeka A" first="Adoke" last="Yeka">Adoke Yeka</name><affiliation><nlm:aff id="A6"> Makerere University School of Public Health, Department of Disease control and Environmental Health</nlm:aff></affiliation></author><author><name sortKey="Etwom, Alfred" sort="Etwom, Alfred" uniqKey="Etwom A" first="Alfred" last="Etwom">Alfred Etwom</name><affiliation><nlm:aff id="A4"> Ministry of Health, National Tuberculosis and Leprosy Program</nlm:aff></affiliation></author><author><name sortKey="Waako, James" sort="Waako, James" uniqKey="Waako J" first="James" last="Waako">James Waako</name><affiliation><nlm:aff id="A2"> Makerere University, Iganga Mayuge Health Demographic Surveillance Site</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Makerere University College of Health Sciences, Infectious Diseases Institute</nlm:aff></affiliation></author><author><name sortKey="Ssengooba, Willy" sort="Ssengooba, Willy" uniqKey="Ssengooba W" first="Willy" last="Ssengooba">Willy Ssengooba</name><affiliation><nlm:aff id="A7"> Makerere University School of Medicine, Department of Microbiology</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Makerere University College of Health Sciences, Infectious Diseases Institute</nlm:aff></affiliation></author><author><name sortKey="Matovu, Joseph Kb" sort="Matovu, Joseph Kb" uniqKey="Matovu J" first="Joseph Kb" last="Matovu">Joseph Kb Matovu</name><affiliation><nlm:aff id="A1"> Makerere University School of Public Health, CDC fellowship program</nlm:aff></affiliation></author><author><name sortKey="Wanyenze, Rhoda K" sort="Wanyenze, Rhoda K" uniqKey="Wanyenze R" first="Rhoda K" last="Wanyenze">Rhoda K. Wanyenze</name><affiliation><nlm:aff id="A1"> Makerere University School of Public Health, CDC fellowship program</nlm:aff></affiliation><affiliation><nlm:aff id="A6"> Makerere University School of Public Health, Department of Disease control and Environmental Health</nlm:aff></affiliation></author><author><name sortKey="Musoke, Phillipa" sort="Musoke, Phillipa" uniqKey="Musoke P" first="Phillipa" last="Musoke">Phillipa Musoke</name><affiliation><nlm:aff id="A3"> Makerere University College of Health Sciences, Infectious Diseases Institute</nlm:aff></affiliation><affiliation><nlm:aff id="A8"> Makerere University School of Medicine, Department of Pediatrics and Child Health</nlm:aff></affiliation></author><author><name sortKey="Mayanja Kizza, Harriet" sort="Mayanja Kizza, Harriet" uniqKey="Mayanja Kizza H" first="Harriet" last="Mayanja-Kizza">Harriet Mayanja-Kizza</name><affiliation><nlm:aff id="A9"> Makerere University School of Medicine, Department of Medicine</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Makerere University College of Health Sciences, Infectious Diseases Institute</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26957974</idno><idno type="pmc">4765437</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765437</idno><idno type="RBID">PMC:4765437</idno><idno type="doi">10.4314/ahs.v15i3.20</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000299</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000299</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prevalence and risk factors of latent Tuberculosis among adolescents in rural Eastern Uganda</title><author><name sortKey="Mumpe Mwanja, Daniel" sort="Mumpe Mwanja, Daniel" uniqKey="Mumpe Mwanja D" first="Daniel" last="Mumpe-Mwanja">Daniel Mumpe-Mwanja</name><affiliation><nlm:aff id="A1"> Makerere University School of Public Health, CDC fellowship program</nlm:aff></affiliation><affiliation><nlm:aff id="A2"> Makerere University, Iganga Mayuge Health Demographic Surveillance Site</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Makerere University College of Health Sciences, Infectious Diseases Institute</nlm:aff></affiliation><affiliation><nlm:aff id="A4"> Ministry of Health, National Tuberculosis and Leprosy Program</nlm:aff></affiliation></author><author><name sortKey="Verver, Suzanne" sort="Verver, Suzanne" uniqKey="Verver S" first="Suzanne" last="Verver">Suzanne Verver</name><affiliation><nlm:aff id="A5"> KNCV Tuberculosis Foundation; CINIMA, Academic Medical Centre</nlm:aff></affiliation></author><author><name sortKey="Yeka, Adoke" sort="Yeka, Adoke" uniqKey="Yeka A" first="Adoke" last="Yeka">Adoke Yeka</name><affiliation><nlm:aff id="A6"> Makerere University School of Public Health, Department of Disease control and Environmental Health</nlm:aff></affiliation></author><author><name sortKey="Etwom, Alfred" sort="Etwom, Alfred" uniqKey="Etwom A" first="Alfred" last="Etwom">Alfred Etwom</name><affiliation><nlm:aff id="A4"> Ministry of Health, National Tuberculosis and Leprosy Program</nlm:aff></affiliation></author><author><name sortKey="Waako, James" sort="Waako, James" uniqKey="Waako J" first="James" last="Waako">James Waako</name><affiliation><nlm:aff id="A2"> Makerere University, Iganga Mayuge Health Demographic Surveillance Site</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Makerere University College of Health Sciences, Infectious Diseases Institute</nlm:aff></affiliation></author><author><name sortKey="Ssengooba, Willy" sort="Ssengooba, Willy" uniqKey="Ssengooba W" first="Willy" last="Ssengooba">Willy Ssengooba</name><affiliation><nlm:aff id="A7"> Makerere University School of Medicine, Department of Microbiology</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Makerere University College of Health Sciences, Infectious Diseases Institute</nlm:aff></affiliation></author><author><name sortKey="Matovu, Joseph Kb" sort="Matovu, Joseph Kb" uniqKey="Matovu J" first="Joseph Kb" last="Matovu">Joseph Kb Matovu</name><affiliation><nlm:aff id="A1"> Makerere University School of Public Health, CDC fellowship program</nlm:aff></affiliation></author><author><name sortKey="Wanyenze, Rhoda K" sort="Wanyenze, Rhoda K" uniqKey="Wanyenze R" first="Rhoda K" last="Wanyenze">Rhoda K. Wanyenze</name><affiliation><nlm:aff id="A1"> Makerere University School of Public Health, CDC fellowship program</nlm:aff></affiliation><affiliation><nlm:aff id="A6"> Makerere University School of Public Health, Department of Disease control and Environmental Health</nlm:aff></affiliation></author><author><name sortKey="Musoke, Phillipa" sort="Musoke, Phillipa" uniqKey="Musoke P" first="Phillipa" last="Musoke">Phillipa Musoke</name><affiliation><nlm:aff id="A3"> Makerere University College of Health Sciences, Infectious Diseases Institute</nlm:aff></affiliation><affiliation><nlm:aff id="A8"> Makerere University School of Medicine, Department of Pediatrics and Child Health</nlm:aff></affiliation></author><author><name sortKey="Mayanja Kizza, Harriet" sort="Mayanja Kizza, Harriet" uniqKey="Mayanja Kizza H" first="Harriet" last="Mayanja-Kizza">Harriet Mayanja-Kizza</name><affiliation><nlm:aff id="A9"> Makerere University School of Medicine, Department of Medicine</nlm:aff></affiliation><affiliation><nlm:aff id="A3"> Makerere University College of Health Sciences, Infectious Diseases Institute</nlm:aff></affiliation></author></analytic><series><title level="j">African Health Sciences</title><idno type="ISSN">1680-6905</idno><idno type="eISSN">1729-0503</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Latent Tuberculosis treatment is a key tuberculosis control intervention. Adolescents are a high risk group that is not routinely treated in low income countries. Knowledge of latent Tuberculosis (TB) burden among adolescents may influence policy.</p></sec><sec><title>Objectives</title><p>We determined the prevalence and risk factors of latent TB infection among adolescents in rural Uganda.</p></sec><sec sec-type="methods"><title>Methods</title><p>We analyzed baseline data from a study that assessed the prevalence and incidence of Tuberculosis disease among adolescents. We extracted socio-demographics, medical assessment information, and tuberculin skin test results and estimated prevalence ratios (PR) of latent TB infection risk factors by binomial regression.</p></sec><sec sec-type="results"><title>Results</title><p>The prevalence of latent TB was 16.1%, 95% CI (15.1 – 17.2). Significant risk factors were: a BCG scar, APR 1.29 (95% CI 1.12 – 1.48); male gender, APR 1.37 (95% CI 1.21 – 1.56); age 17 –18 years, APR 1.46 (95% CI 1.24 – 1.71) and 15–16 years, APR 1.25 (95% CI 1.07 – 1.46) compared to 12–14 years; being out of school, APR 1.31 (95% CI 1.05 – 1.62); and a known history of household TB contact in last 2 years, APR 1.91 (95% CI 1.55 – 2.35)</p></sec><sec sec-type="conclusions"><title>Conclusion</title><p>Targeted routine latent TB treatment among adolescents out of school may be crucial for TB disease control in low income countries.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Afr Health Sci</journal-id><journal-id journal-id-type="iso-abbrev">Afr Health Sci</journal-id><journal-title-group><journal-title>African Health Sciences</journal-title></journal-title-group><issn pub-type="ppub">1680-6905</issn><issn pub-type="epub">1729-0503</issn><publisher><publisher-name>Makerere Medical School</publisher-name><publisher-loc>Kampala, Uganda</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26957974</article-id><article-id pub-id-type="pmc">4765437</article-id><article-id pub-id-type="publisher-id">jAFHS.v15.i3.pg851</article-id><article-id pub-id-type="doi">10.4314/ahs.v15i3.20</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Prevalence and risk factors of latent Tuberculosis among adolescents in rural Eastern Uganda</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mumpe-Mwanja</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Verver</surname><given-names>Suzanne</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Yeka</surname><given-names>Adoke</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Etwom</surname><given-names>Alfred</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Waako</surname><given-names>James</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Ssengooba</surname><given-names>Willy</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Matovu</surname><given-names>Joseph KB</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wanyenze</surname><given-names>Rhoda K</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Musoke</surname><given-names>Phillipa</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Mayanja-Kizza</surname><given-names>Harriet</given-names></name><xref ref-type="aff" rid="A9">9</xref><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label> Makerere University School of Public Health, CDC fellowship program</aff><aff id="A2"><label>2</label> Makerere University, Iganga Mayuge Health Demographic Surveillance Site</aff><aff id="A3"><label>3</label> Makerere University College of Health Sciences, Infectious Diseases Institute</aff><aff id="A4"><label>4</label> Ministry of Health, National Tuberculosis and Leprosy Program</aff><aff id="A5"><label>5</label> KNCV Tuberculosis Foundation; CINIMA, Academic Medical Centre</aff><aff id="A6"><label>6</label> Makerere University School of Public Health, Department of Disease control and Environmental Health</aff><aff id="A7"><label>7</label> Makerere University School of Medicine, Department of Microbiology</aff><aff id="A8"><label>8</label> Makerere University School of Medicine, Department of Pediatrics and Child Health</aff><aff id="A9"><label>9</label> Makerere University School of Medicine, Department of Medicine</aff><author-notes><corresp>Corresponding author: Daniel Mumpe-Mwanja, Makerere University School of Public Health, CDC fellowship program; Makerere University, Iganga Mayuge Health Demographic Surveillance Site; Makerere University College of Health Sciences, Infectious Diseases Institute; Ministry of Health, National Tuberculosis and Leprosy Program <email>mwanjamumpe@yahoo.com</email></corresp></author-notes><pub-date pub-type="ppub"><month>9</month><year>2015</year></pub-date><volume>15</volume><issue>3</issue><fpage>851</fpage><lpage>860</lpage><permissions><copyright-statement>Copyright © Makerere Medical School, Uganda 2015</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract abstract-type="executive-summary"><sec><title>Background</title><p>Latent Tuberculosis treatment is a key tuberculosis control intervention. Adolescents are a high risk group that is not routinely treated in low income countries. Knowledge of latent Tuberculosis (TB) burden among adolescents may influence policy.</p></sec><sec><title>Objectives</title><p>We determined the prevalence and risk factors of latent TB infection among adolescents in rural Uganda.</p></sec><sec sec-type="methods"><title>Methods</title><p>We analyzed baseline data from a study that assessed the prevalence and incidence of Tuberculosis disease among adolescents. We extracted socio-demographics, medical assessment information, and tuberculin skin test results and estimated prevalence ratios (PR) of latent TB infection risk factors by binomial regression.</p></sec><sec sec-type="results"><title>Results</title><p>The prevalence of latent TB was 16.1%, 95% CI (15.1 – 17.2). Significant risk factors were: a BCG scar, APR 1.29 (95% CI 1.12 – 1.48); male gender, APR 1.37 (95% CI 1.21 – 1.56); age 17 –18 years, APR 1.46 (95% CI 1.24 – 1.71) and 15–16 years, APR 1.25 (95% CI 1.07 – 1.46) compared to 12–14 years; being out of school, APR 1.31 (95% CI 1.05 – 1.62); and a known history of household TB contact in last 2 years, APR 1.91 (95% CI 1.55 – 2.35)</p></sec><sec sec-type="conclusions"><title>Conclusion</title><p>Targeted routine latent TB treatment among adolescents out of school may be crucial for TB disease control in low income countries.</p></sec></abstract><kwd-group><kwd>Latent tuberculosis infection</kwd><kwd>Adolescents</kwd><kwd>Risk factors</kwd><kwd>Tuberculin skin testing</kwd><kwd>Tuberculosis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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