Comparison of Self-Reported Alcohol Consumption to Phosphatidylethanol Measurement among HIV-Infected Patients Initiating Antiretroviral Treatment in Southwestern Uganda
Identifieur interne : 002D28 ( Ncbi/Merge ); précédent : 002D27; suivant : 002D29Comparison of Self-Reported Alcohol Consumption to Phosphatidylethanol Measurement among HIV-Infected Patients Initiating Antiretroviral Treatment in Southwestern Uganda
Auteurs : Francis Bajunirwe [Ouganda] ; Jessica E. Haberer [États-Unis] ; Yap Boum [Ouganda] ; Peter Hunt [États-Unis] ; Rain Mocello [États-Unis] ; Jeffrey N. Martin [États-Unis] ; David R. Bangsberg [États-Unis] ; Judith A. Hahn [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
Alcohol consumption among HIV-infected patients may accelerate HIV disease progression or reduce antiretroviral therapy adherence. Self-reported alcohol use is frequently under-reported due to social desirability and recall bias. The aim of this study was to compare self-reported alcohol consumption to phosphatidylethanol (PEth), a biomarker of alcohol consumption, and to estimate the correlation between multiple measures of self-reported alcohol consumption with PEth.
The Uganda AIDS Rural Treatment Outcomes (UARTO) cohort is located in southwestern Uganda and follows patients on ART to measure treatment outcomes. Patients complete standardized questionnaires quarterly including questions on demographics, health status and alcohol consumption. Baseline dried blood spots (DBS) were collected and retrieved to measure PEth.
One hundred fifty samples were tested, and 56 (37.3%) were PEth positive (≥8 ng/mL). Of those, 51.7% did not report alcohol use in the past month. Men were more likely to under-report compared to women, OR 2.9, 95% CI = 1.26, 6.65) and those in the higher economic asset categories were less likely to under-report compared to those in the lowest category (OR = 0.41 95% CI: 0.17, 0.94). Among self-reported drinkers (n = 31), PEth was highly correlated with the total number of drinking days in the last 30 (Spearman R = 0.73, p<0.001).
Approximately half of HIV infected patients initiating ART and consuming alcohol under-report their use of alcohol. Given the high prevalence, clinicians should assess all patients for alcohol use with more attention to males and those in lower economic asset categories who deny alcohol use. Among those reporting current drinking, self-reported drinking days is a useful quantitative measure.
Url:
DOI: 10.1371/journal.pone.0113152
PubMed: 25436894
PubMed Central: 4249861
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Box 1410, Mbarara, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>Mbarara University of Science and Technology, Faculty of Medicine, Department of Community Health, P.O. Box 1410, Mbarara</wicri:regionArea><wicri:noRegion>Mbarara</wicri:noRegion></affiliation></author><author><name sortKey="Haberer, Jessica E" sort="Haberer, Jessica E" uniqKey="Haberer J" first="Jessica E." last="Haberer">Jessica E. 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Martin</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Medicine, University of California San Francisco, San Francisco, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of California San Francisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bangsberg, David R" sort="Bangsberg, David R" uniqKey="Bangsberg D" first="David R." last="Bangsberg">David R. Bangsberg</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hahn, Judith A" sort="Hahn, Judith A" uniqKey="Hahn J" first="Judith A." last="Hahn">Judith A. Hahn</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Department of Medicine, University of California San Francisco, San Francisco, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of California San Francisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Alcohol consumption among HIV-infected patients may accelerate HIV disease progression or reduce antiretroviral therapy adherence. Self-reported alcohol use is frequently under-reported due to social desirability and recall bias. The aim of this study was to compare self-reported alcohol consumption to phosphatidylethanol (PEth), a biomarker of alcohol consumption, and to estimate the correlation between multiple measures of self-reported alcohol consumption with PEth.</p></sec><sec><title>Methods</title><p>The Uganda AIDS Rural Treatment Outcomes (UARTO) cohort is located in southwestern Uganda and follows patients on ART to measure treatment outcomes. Patients complete standardized questionnaires quarterly including questions on demographics, health status and alcohol consumption. Baseline dried blood spots (DBS) were collected and retrieved to measure PEth.</p></sec><sec><title>Results</title><p>One hundred fifty samples were tested, and 56 (37.3%) were PEth positive (≥8 ng/mL). Of those, 51.7% did not report alcohol use in the past month. Men were more likely to under-report compared to women, OR 2.9, 95% CI = 1.26, 6.65) and those in the higher economic asset categories were less likely to under-report compared to those in the lowest category (OR = 0.41 95% CI: 0.17, 0.94). Among self-reported drinkers (n = 31), PEth was highly correlated with the total number of drinking days in the last 30 (Spearman R = 0.73, p<0.001).</p></sec><sec><title>Conclusions</title><p>Approximately half of HIV infected patients initiating ART and consuming alcohol under-report their use of alcohol. Given the high prevalence, clinicians should assess all patients for alcohol use with more attention to males and those in lower economic asset categories who deny alcohol use. Among those reporting current drinking, self-reported drinking days is a useful quantitative measure.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Samet, Jh" uniqKey="Samet J">JH Samet</name></author><author><name sortKey="Cheng, Dm" uniqKey="Cheng D">DM Cheng</name></author><author><name sortKey="Libman, H" uniqKey="Libman H">H Libman</name></author><author><name sortKey="Nunes, Dp" uniqKey="Nunes D">DP Nunes</name></author><author><name sortKey="Alperen, Jk" uniqKey="Alperen J">JK Alperen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hahn, Ja" uniqKey="Hahn J">JA Hahn</name></author><author><name sortKey="Samet, Jh" uniqKey="Samet J">JH Samet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, S" uniqKey="Kumar S">S Kumar</name></author><author><name sortKey="Jin, M" uniqKey="Jin M">M 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25436894</article-id><article-id pub-id-type="pmc">4249861</article-id><article-id pub-id-type="publisher-id">PONE-D-14-33170</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0113152</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine and health sciences</subject><subj-group><subject>Epidemiology</subject><subj-group><subject>Biomarker epidemiology</subject><subject>HIV epidemiology</subject><subject>Social epidemiology</subject></subj-group></subj-group><subj-group><subject>Infectious Diseases</subject><subj-group><subject>Viral Diseases</subject><subj-group><subject>AIDS</subject></subj-group></subj-group></subj-group><subj-group><subject>Mental Health and Psychiatry</subject><subj-group><subject>Substance-Related Disorders</subject></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Comparison of Self-Reported Alcohol Consumption to Phosphatidylethanol Measurement among HIV-Infected Patients Initiating Antiretroviral Treatment in Southwestern Uganda</article-title><alt-title alt-title-type="running-head">Self-Reported Alcohol Measures and HIV-1 Patients</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bajunirwe</surname><given-names>Francis</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Haberer</surname><given-names>Jessica E.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Boum</surname><given-names>Yap</given-names><suffix>II</suffix></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hunt</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mocello</surname><given-names>Rain</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Jeffrey N.</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bangsberg</surname><given-names>David R.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hahn</surname><given-names>Judith A.</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Mbarara University of Science and Technology, Faculty of Medicine, Department of Community Health, P.O. Box 1410, Mbarara, Uganda</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Epicentre Uganda Research Center, Mbarara, Uganda</addr-line></aff><aff id="aff4"><label>4</label><addr-line>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America</addr-line></aff><aff id="aff5"><label>5</label><addr-line>Department of Medicine, University of California San Francisco, San Francisco, California, United States of America</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Kumar</surname><given-names>Anil</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University of Missouri-Kansas City, United States of America</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>fbaj@yahoo.com</email></corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: FB DRB JNM JAH. Performed the experiments: FB JEH YB PH. Analyzed the data: FB JEH YB PH RM JNM DRB JAH. Contributed reagents/materials/analysis tools: FB JEH YB PH RM JNM DRB JAH. Wrote the paper: FB JEH YB PH RM JNM DRB JAH. Final approval of the manuscript: FB JEH YB PH RM JNM DRB JAH.</p></fn></author-notes><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>1</day><month>12</month><year>2014</year></pub-date><volume>9</volume><issue>12</issue><elocation-id>e113152</elocation-id><history><date date-type="received"><day>24</day><month>7</month><year>2014</year></date><date date-type="accepted"><day>20</day><month>10</month><year>2014</year></date></history><permissions><copyright-year>2014</copyright-year><license><license-p>This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.</license-p></license></permissions><abstract><sec><title>Background</title><p>Alcohol consumption among HIV-infected patients may accelerate HIV disease progression or reduce antiretroviral therapy adherence. Self-reported alcohol use is frequently under-reported due to social desirability and recall bias. The aim of this study was to compare self-reported alcohol consumption to phosphatidylethanol (PEth), a biomarker of alcohol consumption, and to estimate the correlation between multiple measures of self-reported alcohol consumption with PEth.</p></sec><sec><title>Methods</title><p>The Uganda AIDS Rural Treatment Outcomes (UARTO) cohort is located in southwestern Uganda and follows patients on ART to measure treatment outcomes. Patients complete standardized questionnaires quarterly including questions on demographics, health status and alcohol consumption. Baseline dried blood spots (DBS) were collected and retrieved to measure PEth.</p></sec><sec><title>Results</title><p>One hundred fifty samples were tested, and 56 (37.3%) were PEth positive (≥8 ng/mL). Of those, 51.7% did not report alcohol use in the past month. Men were more likely to under-report compared to women, OR 2.9, 95% CI = 1.26, 6.65) and those in the higher economic asset categories were less likely to under-report compared to those in the lowest category (OR = 0.41 95% CI: 0.17, 0.94). Among self-reported drinkers (n = 31), PEth was highly correlated with the total number of drinking days in the last 30 (Spearman R = 0.73, p<0.001).</p></sec><sec><title>Conclusions</title><p>Approximately half of HIV infected patients initiating ART and consuming alcohol under-report their use of alcohol. Given the high prevalence, clinicians should assess all patients for alcohol use with more attention to males and those in lower economic asset categories who deny alcohol use. Among those reporting current drinking, self-reported drinking days is a useful quantitative measure.</p></sec></abstract><funding-group><funding-statement>This work was funded by National Institutes of Health R01 MH054907 (DRB), K24AA022586 (JAH), R01AA018631 (JAH), P30 AI027763, R01 MH054907, and U01 CA066529 (JM). FB is supported by the IAS-NIDA fellowship program and JEH is supported by the NIH (K23MH 087228). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="12"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are included in the Supporting Information files.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>The authors confirm that all data underlying the findings are fully available without restriction. All relevant data are included in the Supporting Information files.</p></notes></front></pmc><affiliations><list><country><li>Ouganda</li><li>États-Unis</li></country><region><li>Californie</li><li>Massachusetts</li></region></list><tree><country name="Ouganda"><noRegion><name sortKey="Bajunirwe, Francis" sort="Bajunirwe, Francis" uniqKey="Bajunirwe F" first="Francis" last="Bajunirwe">Francis Bajunirwe</name></noRegion><name sortKey="Boum, Yap" sort="Boum, Yap" uniqKey="Boum Y" first="Yap" last="Boum">Yap Boum</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Haberer, Jessica E" sort="Haberer, Jessica E" uniqKey="Haberer J" first="Jessica E." last="Haberer">Jessica E. Haberer</name></region><name sortKey="Bangsberg, David R" sort="Bangsberg, David R" uniqKey="Bangsberg D" first="David R." last="Bangsberg">David R. Bangsberg</name><name sortKey="Hahn, Judith A" sort="Hahn, Judith A" uniqKey="Hahn J" first="Judith A." last="Hahn">Judith A. Hahn</name><name sortKey="Hahn, Judith A" sort="Hahn, Judith A" uniqKey="Hahn J" first="Judith A." last="Hahn">Judith A. Hahn</name><name sortKey="Hunt, Peter" sort="Hunt, Peter" uniqKey="Hunt P" first="Peter" last="Hunt">Peter Hunt</name><name sortKey="Martin, Jeffrey N" sort="Martin, Jeffrey N" uniqKey="Martin J" first="Jeffrey N." last="Martin">Jeffrey N. Martin</name><name sortKey="Martin, Jeffrey N" sort="Martin, Jeffrey N" uniqKey="Martin J" first="Jeffrey N." last="Martin">Jeffrey N. Martin</name><name sortKey="Mocello, Rain" sort="Mocello, Rain" uniqKey="Mocello R" first="Rain" last="Mocello">Rain Mocello</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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