Le SIDA en Afrique subsaharienne (serveur d'exploration)

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Challenges in PMTCT antiretroviral adherence in northern KwaZulu-Natal, South Africa.

Identifieur interne : 001144 ( Ncbi/Curation ); précédent : 001143; suivant : 001145

Challenges in PMTCT antiretroviral adherence in northern KwaZulu-Natal, South Africa.

Auteurs : S. Mepham [Afrique du Sud] ; Z. Zondi ; A. Mbuyazi ; N. Mkhwanazi ; M L Newell

Source :

RBID : pubmed:21293987

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English descriptors

Abstract

Women living with HIV in sub-Saharan Africa face significant challenges in accessing HIV care and adhering to antiretroviral therapy. Most reports have focused on issues relating to long-term adherence such as those surrounding stigma and disclosure, hunger, cultural factors, lack of accurate health information, lack of social support, medication side effects and overcrowded health systems. Information related to the challenges facing pregnant women when taking antiretrovirals for prophylactic purposes is limited. The "Kesho Bora Study" is a multicentre prevention of mother-to-child transmission (PMTCT) trial in sub-Saharan Africa evaluating the PMTCT efficacy of triple therapy until cessation of breast feeding compared to short course zidovudine monotherapy in a predominantly breast feeding population. Following unexplained discrepancies during objective adherence assessments, a sub-study was conducted at one site to examine the underlying adherence issues.

DOI: 10.1080/09540121.2010.516341
PubMed: 21293987

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pubmed:21293987

Le document en format XML

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<div type="abstract" xml:lang="en">Women living with HIV in sub-Saharan Africa face significant challenges in accessing HIV care and adhering to antiretroviral therapy. Most reports have focused on issues relating to long-term adherence such as those surrounding stigma and disclosure, hunger, cultural factors, lack of accurate health information, lack of social support, medication side effects and overcrowded health systems. Information related to the challenges facing pregnant women when taking antiretrovirals for prophylactic purposes is limited. The "Kesho Bora Study" is a multicentre prevention of mother-to-child transmission (PMTCT) trial in sub-Saharan Africa evaluating the PMTCT efficacy of triple therapy until cessation of breast feeding compared to short course zidovudine monotherapy in a predominantly breast feeding population. Following unexplained discrepancies during objective adherence assessments, a sub-study was conducted at one site to examine the underlying adherence issues.</div>
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