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Prevalence of Hypertension and Its Associated Risk Factors among 34,111 HAART Naïve HIV-Infected Adults in Dar es Salaam, Tanzania

Identifieur interne : 000E58 ( Main/Exploration ); précédent : 000E57; suivant : 000E59

Prevalence of Hypertension and Its Associated Risk Factors among 34,111 HAART Naïve HIV-Infected Adults in Dar es Salaam, Tanzania

Auteurs : Marina Njelekela [Tanzanie] ; Alfa Muhihi [Tanzanie] ; Akum Aveika [Tanzanie] ; Donna Spiegelman [États-Unis] ; Claudia Hawkins [États-Unis] ; Catharina Armstrong [États-Unis] ; Enju Liu [États-Unis] ; James Okuma [États-Unis] ; Guerino Chalamila [Tanzanie] ; Sylvia Kaaya [Tanzanie] ; Ferdinand Mugusi [Tanzanie] ; Wafaie Fawzi [États-Unis]

Source :

RBID : PMC:5107235

Abstract

Background. Elevated blood pressure has been reported among treatment naïve HIV-infected patients. We investigated prevalence of hypertension and its associated risk factors in a HAART naïve HIV-infected population in Dar es Salaam, Tanzania. Methods. A cross-sectional analysis was conducted among HAART naïve HIV-infected patients. Hypertension was defined as systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg. Overweight and obesity were defined as body mass index (BMI) between 25.0–29.9 kg/m2 and ≥30 kg/m2, respectively. We used relative risks to examine factors associated with hypertension. Results. Prevalence of hypertension was found to be 12.5%. After adjusting for possible confounders, risk of hypertension was 10% more in male than female patients. Patients aged ≥50 years had more than 2-fold increased risk for hypertension compared to 30–39-years-old patients. Overweight and obesity were associated with 51% and 94% increased risk for hypertension compared to normal weight patients. Low CD4+ T-cell count, advanced WHO clinical disease stage, and history of TB were associated with 10%, 42%, and 14% decreased risk for hypertension. Conclusions. Older age, male gender, and overweight/obesity were associated with hypertension. Immune suppression and history of TB were associated with lower risk for hypertension. HIV treatment programs should screen and manage hypertension even in HAART naïve individuals.


Url:
DOI: 10.1155/2016/5958382
PubMed: 27872756
PubMed Central: 5107235


Affiliations:


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<name sortKey="Armstrong, Catharina" sort="Armstrong, Catharina" uniqKey="Armstrong C" first="Catharina" last="Armstrong">Catharina Armstrong</name>
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<nlm:aff id="I9">Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA, USA</nlm:aff>
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<name sortKey="Kaaya, Sylvia" sort="Kaaya, Sylvia" uniqKey="Kaaya S" first="Sylvia" last="Kaaya">Sylvia Kaaya</name>
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<name sortKey="Njelekela, Marina" sort="Njelekela, Marina" uniqKey="Njelekela M" first="Marina" last="Njelekela">Marina Njelekela</name>
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<region type="state">Massachusetts</region>
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<nlm:aff id="I5">Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
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<name sortKey="Hawkins, Claudia" sort="Hawkins, Claudia" uniqKey="Hawkins C" first="Claudia" last="Hawkins">Claudia Hawkins</name>
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<nlm:aff id="I6">Feinberg School of Medicine, Northwestern University, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Feinberg School of Medicine, Northwestern University, Chicago, IL</wicri:regionArea>
<placeName>
<region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Armstrong, Catharina" sort="Armstrong, Catharina" uniqKey="Armstrong C" first="Catharina" last="Armstrong">Catharina Armstrong</name>
<affiliation wicri:level="2">
<nlm:aff id="I7">Tufts University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Tufts University School of Medicine, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
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<author>
<name sortKey="Liu, Enju" sort="Liu, Enju" uniqKey="Liu E" first="Enju" last="Liu">Enju Liu</name>
<affiliation wicri:level="2">
<nlm:aff id="I8">Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="I9">Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
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<name sortKey="Okuma, James" sort="Okuma, James" uniqKey="Okuma J" first="James" last="Okuma">James Okuma</name>
<affiliation wicri:level="2">
<nlm:aff id="I8">Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Chalamila, Guerino" sort="Chalamila, Guerino" uniqKey="Chalamila G" first="Guerino" last="Chalamila">Guerino Chalamila</name>
<affiliation wicri:level="1">
<nlm:aff id="I2">Management and Development for Health, HIV/AIDS Care and Treatment Program, Dar es Salaam, Tanzania</nlm:aff>
<country xml:lang="fr">Tanzanie</country>
<wicri:regionArea>Management and Development for Health, HIV/AIDS Care and Treatment Program, Dar es Salaam</wicri:regionArea>
<wicri:noRegion>Dar es Salaam</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kaaya, Sylvia" sort="Kaaya, Sylvia" uniqKey="Kaaya S" first="Sylvia" last="Kaaya">Sylvia Kaaya</name>
<affiliation wicri:level="1">
<nlm:aff id="I10">Department of Psychiatry and Mental Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania</nlm:aff>
<country xml:lang="fr">Tanzanie</country>
<wicri:regionArea>Department of Psychiatry and Mental Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam</wicri:regionArea>
<wicri:noRegion>Dar es Salaam</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mugusi, Ferdinand" sort="Mugusi, Ferdinand" uniqKey="Mugusi F" first="Ferdinand" last="Mugusi">Ferdinand Mugusi</name>
<affiliation wicri:level="1">
<nlm:aff id="I11">Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania</nlm:aff>
<country xml:lang="fr">Tanzanie</country>
<wicri:regionArea>Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam</wicri:regionArea>
<wicri:noRegion>Dar es Salaam</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Fawzi, Wafaie" sort="Fawzi, Wafaie" uniqKey="Fawzi W" first="Wafaie" last="Fawzi">Wafaie Fawzi</name>
<affiliation wicri:level="2">
<nlm:aff id="I4">Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="I8">Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="I9">Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</analytic>
<series>
<title level="j">International Journal of Hypertension</title>
<idno type="ISSN">2090-0384</idno>
<idno type="eISSN">2090-0392</idno>
<imprint>
<date when="2016">2016</date>
</imprint>
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<front>
<div type="abstract" xml:lang="en">
<p>
<italic>Background</italic>
. Elevated blood pressure has been reported among treatment naïve HIV-infected patients. We investigated prevalence of hypertension and its associated risk factors in a HAART naïve HIV-infected population in Dar es Salaam, Tanzania.
<italic> Methods</italic>
. A cross-sectional analysis was conducted among HAART naïve HIV-infected patients. Hypertension was defined as systolic blood pressure (SBP) ≥ 140 mmHg and/or diastolic blood pressure (DBP) ≥ 90 mmHg. Overweight and obesity were defined as body mass index (BMI) between 25.0–29.9 kg/m
<sup>2</sup>
and ≥30 kg/m
<sup>2</sup>
, respectively. We used relative risks to examine factors associated with hypertension.
<italic> Results</italic>
. Prevalence of hypertension was found to be 12.5%. After adjusting for possible confounders, risk of hypertension was 10% more in male than female patients. Patients aged ≥50 years had more than 2-fold increased risk for hypertension compared to 30–39-years-old patients. Overweight and obesity were associated with 51% and 94% increased risk for hypertension compared to normal weight patients. Low CD4+ T-cell count, advanced WHO clinical disease stage, and history of TB were associated with 10%, 42%, and 14% decreased risk for hypertension.
<italic> Conclusions</italic>
. Older age, male gender, and overweight/obesity were associated with hypertension. Immune suppression and history of TB were associated with lower risk for hypertension. HIV treatment programs should screen and manage hypertension even in HAART naïve individuals. </p>
</div>
</front>
<back>
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