Cytomegalovirus and paediatric HIV infection
Identifieur interne : 00A110 ( Main/Exploration ); précédent : 00A109; suivant : 00A111Cytomegalovirus and paediatric HIV infection
Auteurs : Jennifer A. SlykerSource :
- Journal of Virus Eradication [ 2055-6640 ] ; ????.
Abstract
Cytomegalovirus (CMV) was among the most common AIDS-defining illnesses prior to the advent of combination antiretroviral therapy (ART). In the ART era, CMV disease remains a significant public health threat among HIV-infected adults and children with delayed HIV diagnosis. CMV co-infection may additionally contribute to accelerated HIV progression, development of inflammation-related comorbidities, immune senescence and developmental deficits. Elimination of CMV would have tremendous public health significance and is an important priority; however, current vaccine strategies are not targeted at HIV-infected individuals. Antivirals active against CMV may be a novel strategy to prevent acquisition and improve outcomes, but haematological side effects are common and necessitate cautious use in pregnant women and infants. Studies in HIV-infected children on ART lag behind adults, and the clinical significance of CMV in this population is not well understood. Furthermore, the effects of CMV in HIV-exposed uninfected (HEU) children need to be clarified to understand whether CMV interventions should also be a priority for this growing population. This review discusses our current understanding of CMV transmission and pathogenesis in HIV-exposed children and highlights unanswered questions for future research.
Url:
PubMed: 27781102
PubMed Central: 5075347
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cytomegalovirus and paediatric HIV infection</title><author><name sortKey="Slyker, Jennifer A" sort="Slyker, Jennifer A" uniqKey="Slyker J" first="Jennifer A" last="Slyker">Jennifer A. Slyker</name><affiliation><nlm:aff id="jve8-aff-0001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27781102</idno><idno type="pmc">5075347</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075347</idno><idno type="RBID">PMC:5075347</idno><date when="????">????</date><idno type="wicri:Area/Pmc/Corpus">000E50</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E50</idno><idno type="wicri:Area/Pmc/Curation">000E49</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E49</idno><idno type="wicri:Area/Pmc/Checkpoint">002F42</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002F42</idno><idno type="wicri:Area/Ncbi/Merge">003A98</idno><idno type="wicri:Area/Ncbi/Curation">003A98</idno><idno type="wicri:Area/Ncbi/Checkpoint">003A98</idno><idno type="wicri:doubleKey">2055-6640:????:Slyker J:cytomegalovirus:and:paediatric</idno><idno type="wicri:Area/Main/Merge">00A364</idno><idno type="wicri:Area/Main/Curation">00A110</idno><idno type="wicri:Area/Main/Exploration">00A110</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cytomegalovirus and paediatric HIV infection</title><author><name sortKey="Slyker, Jennifer A" sort="Slyker, Jennifer A" uniqKey="Slyker J" first="Jennifer A" last="Slyker">Jennifer A. Slyker</name><affiliation><nlm:aff id="jve8-aff-0001"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virus Eradication</title><idno type="ISSN">2055-6640</idno><idno type="eISSN">2055-6659</idno><imprint><date when="????">????</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p id="jve8-para-0005">Cytomegalovirus (CMV) was among the most common AIDS-defining illnesses prior to the advent of combination antiretroviral therapy (ART). In the ART era, CMV disease remains a significant public health threat among HIV-infected adults and children with delayed HIV diagnosis. CMV co-infection may additionally contribute to accelerated HIV progression, development of inflammation-related comorbidities, immune senescence and developmental deficits. Elimination of CMV would have tremendous public health significance and is an important priority; however, current vaccine strategies are not targeted at HIV-infected individuals. Antivirals active against CMV may be a novel strategy to prevent acquisition and improve outcomes, but haematological side effects are common and necessitate cautious use in pregnant women and infants. Studies in HIV-infected children on ART lag behind adults, and the clinical significance of CMV in this population is not well understood. Furthermore, the effects of CMV in HIV-exposed uninfected (HEU) children need to be clarified to understand whether CMV interventions should also be a priority for this growing population. This review discusses our current understanding of CMV transmission and pathogenesis in HIV-exposed children and highlights unanswered questions for future research.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Drew, Wl" uniqKey="Drew W">WL. 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Cohen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chemaly, Rf" uniqKey="Chemaly R">RF Chemaly</name></author><author><name sortKey="Ullmann, Aj" uniqKey="Ullmann A">AJ Ullmann</name></author><author><name sortKey="Stoelben, S" uniqKey="Stoelben S">S Stoelben</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marty, Fm" uniqKey="Marty F">FM Marty</name></author><author><name sortKey="Boeckh, M" uniqKey="Boeckh M">M. Boeckh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mwaanza, N" uniqKey="Mwaanza N">N Mwaanza</name></author><author><name sortKey="Chilukutu, L" uniqKey="Chilukutu L">L Chilukutu</name></author><author><name sortKey="Tembo, J" uniqKey="Tembo J">J Tembo</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Slyker, Jennifer A" sort="Slyker, Jennifer A" uniqKey="Slyker J" first="Jennifer A" last="Slyker">Jennifer A. Slyker</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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