Clinical Characteristics of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome in North Indian Population of HIV/AIDS Patients Receiving HAART
Identifieur interne : 004A27 ( Main/Exploration ); précédent : 004A26; suivant : 004A28Clinical Characteristics of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome in North Indian Population of HIV/AIDS Patients Receiving HAART
Auteurs : Suman Karmakar [Inde] ; Surendra K. Sharma ; Richa Vashishtha [Inde] ; Abhishek Sharma [Bulgarie] ; Sanjay Ranjan [Inde] ; Deepak Gupta [Inde] ; Vishnubhatla Sreenivas [Inde] ; Sanjeev Sinha [Inde] ; Ashutosh Biswas [Inde] ; Vinay Gulati [Inde]Source :
- Clinical and Developmental Immunology [ 1740-2522 ] ; 2010.
Abstract
Url:
DOI: 10.1155/2011/239021
PubMed: 21197457
PubMed Central: 3003953
Affiliations:
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India Institute of Medical Sciences, New Delhi 110029</wicri:regionArea><wicri:noRegion>New Delhi 110029</wicri:noRegion></affiliation></author><author><name sortKey="Biswas, Ashutosh" sort="Biswas, Ashutosh" uniqKey="Biswas A" first="Ashutosh" last="Biswas">Ashutosh Biswas</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029</wicri:regionArea><wicri:noRegion>New Delhi 110029</wicri:noRegion></affiliation></author><author><name sortKey="Gulati, Vinay" sort="Gulati, Vinay" uniqKey="Gulati V" first="Vinay" last="Gulati">Vinay Gulati</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medicine, 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110029</wicri:regionArea><wicri:noRegion>New Delhi 110029</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Surendra K" sort="Sharma, Surendra K" uniqKey="Sharma S" first="Surendra K." last="Sharma">Surendra K. Sharma</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Vashishtha, Richa" sort="Vashishtha, Richa" uniqKey="Vashishtha R" first="Richa" last="Vashishtha">Richa Vashishtha</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029</wicri:regionArea><wicri:noRegion>New Delhi 110029</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Abhishek" sort="Sharma, Abhishek" uniqKey="Sharma A" first="Abhishek" last="Sharma">Abhishek Sharma</name><affiliation wicri:level="1"><nlm:aff id="I3">University of Medicine, Pleven, Bulgaria</nlm:aff><country xml:lang="fr">Bulgarie</country><wicri:regionArea>University of Medicine, Pleven</wicri:regionArea><wicri:noRegion>Pleven</wicri:noRegion></affiliation></author><author><name sortKey="Ranjan, Sanjay" sort="Ranjan, Sanjay" uniqKey="Ranjan S" first="Sanjay" last="Ranjan">Sanjay Ranjan</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029</wicri:regionArea><wicri:noRegion>New Delhi 110029</wicri:noRegion></affiliation></author><author><name sortKey="Gupta, Deepak" sort="Gupta, Deepak" uniqKey="Gupta D" first="Deepak" last="Gupta">Deepak Gupta</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029</wicri:regionArea><wicri:noRegion>New Delhi 110029</wicri:noRegion></affiliation></author><author><name sortKey="Sreenivas, Vishnubhatla" sort="Sreenivas, Vishnubhatla" uniqKey="Sreenivas V" first="Vishnubhatla" last="Sreenivas">Vishnubhatla Sreenivas</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 110029, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 110029</wicri:regionArea><wicri:noRegion>New Delhi 110029</wicri:noRegion></affiliation></author><author><name sortKey="Sinha, Sanjeev" sort="Sinha, Sanjeev" uniqKey="Sinha S" first="Sanjeev" last="Sinha">Sanjeev Sinha</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029</wicri:regionArea><wicri:noRegion>New Delhi 110029</wicri:noRegion></affiliation></author><author><name sortKey="Biswas, Ashutosh" sort="Biswas, Ashutosh" uniqKey="Biswas A" first="Ashutosh" last="Biswas">Ashutosh Biswas</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029</wicri:regionArea><wicri:noRegion>New Delhi 110029</wicri:noRegion></affiliation></author><author><name sortKey="Gulati, Vinay" sort="Gulati, Vinay" uniqKey="Gulati V" first="Vinay" last="Gulati">Vinay Gulati</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029</wicri:regionArea><wicri:noRegion>New Delhi 110029</wicri:noRegion></affiliation></author></analytic><series><title level="j">Clinical and Developmental Immunology</title><idno type="ISSN">1740-2522</idno><idno type="eISSN">1740-2530</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Background & Objective</italic>. IRIS is an important complication that occurs during management of HIV-TB coinfection and it poses difficulty in diagnosis. Previous studies have reported variable incidence of IRIS. The present study was undertaken to describe the pattern of TB-associated IRIS using recently proposed consensus case-definitions for TB-IRIS for its use in resource-limited settings. <italic>Methods</italic>. A prospective analysis of ART-naïve adults started on HAART from November, 2008 to May, 2010 was done in a tertiary care hospital in north India. A total 224 patients divided into two groups, one with HIV-TB and the other with HIV alone, were followedup for a minimum period of 3 months. The diagnosis of TB was categorised as ‘‘definitive” and ‘‘probable”. <italic>Results</italic>. Out of a total of 224 patients, 203 completed followup. Paradoxical TB-IRIS occurred in 5 of 123 (4%) HIV-TB patients while 6 of 80 (7.5%) HIV patients developed ART-associated TB. A reduction in plasma viral load was significantly (<italic>P</italic> = .016) associated with paradoxical TB-IRIS. No identifiable risk factors were associated with the development of ART-associated TB. <italic>Conclusion</italic>. The consensus case-definitions are useful tools in the diagnosis of TB-associated IRIS. 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sortKey="Tahir, M" uniqKey="Tahir M">M Tahir</name></author><author><name sortKey="Sharma, Sk" uniqKey="Sharma S">SK Sharma</name></author><author><name sortKey="Rohrberg, D S" uniqKey="Rohrberg D">D-S Rohrberg</name></author><author><name sortKey="Gupta, D" uniqKey="Gupta D">D Gupta</name></author><author><name sortKey="Singh, Ub" uniqKey="Singh U">UB Singh</name></author><author><name sortKey="Sinha, Pk" uniqKey="Sinha P">PK Sinha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meintjes, G" uniqKey="Meintjes G">G Meintjes</name></author><author><name sortKey="Lawn, Sd" uniqKey="Lawn S">SD Lawn</name></author><author><name sortKey="Scano, F" uniqKey="Scano F">F Scano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="French, Ma" uniqKey="French M">MA French</name></author><author><name sortKey="Price, P" uniqKey="Price P">P Price</name></author><author><name sortKey="Stone, Sf" uniqKey="Stone S">SF Stone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eshun Wilson, I" uniqKey="Eshun Wilson I">I Eshun-Wilson</name></author><author><name sortKey="Havers, F" uniqKey="Havers F">F Havers</name></author><author><name sortKey="Nachega, Jb" uniqKey="Nachega J">JB Nachega</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haddow, Lj" uniqKey="Haddow L">LJ Haddow</name></author><author><name sortKey="Moosa, M Ys" uniqKey="Moosa M">M-YS Moosa</name></author><author><name sortKey="Easterbrook, Pj" uniqKey="Easterbrook P">PJ Easterbrook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brodie, D" uniqKey="Brodie D">D Brodie</name></author><author><name sortKey="Schluger, Nw" uniqKey="Schluger N">NW Schluger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharma, Sk" uniqKey="Sharma S">SK Sharma</name></author><author><name sortKey="Mohan, A" uniqKey="Mohan A">A Mohan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Bulgarie</li><li>Inde</li></country></list><tree><noCountry><name sortKey="Sharma, Surendra K" sort="Sharma, Surendra K" uniqKey="Sharma S" first="Surendra K." last="Sharma">Surendra K. Sharma</name></noCountry><country name="Inde"><noRegion><name sortKey="Karmakar, Suman" sort="Karmakar, Suman" uniqKey="Karmakar S" first="Suman" last="Karmakar">Suman Karmakar</name></noRegion><name sortKey="Biswas, Ashutosh" sort="Biswas, Ashutosh" uniqKey="Biswas A" first="Ashutosh" last="Biswas">Ashutosh Biswas</name><name sortKey="Gulati, Vinay" sort="Gulati, Vinay" uniqKey="Gulati V" first="Vinay" last="Gulati">Vinay Gulati</name><name sortKey="Gupta, Deepak" sort="Gupta, Deepak" uniqKey="Gupta D" first="Deepak" last="Gupta">Deepak Gupta</name><name sortKey="Ranjan, Sanjay" sort="Ranjan, Sanjay" uniqKey="Ranjan S" first="Sanjay" last="Ranjan">Sanjay Ranjan</name><name sortKey="Sinha, Sanjeev" sort="Sinha, Sanjeev" uniqKey="Sinha S" first="Sanjeev" last="Sinha">Sanjeev Sinha</name><name sortKey="Sreenivas, Vishnubhatla" sort="Sreenivas, Vishnubhatla" uniqKey="Sreenivas V" first="Vishnubhatla" last="Sreenivas">Vishnubhatla Sreenivas</name><name sortKey="Vashishtha, Richa" sort="Vashishtha, Richa" uniqKey="Vashishtha R" first="Richa" last="Vashishtha">Richa Vashishtha</name></country><country name="Bulgarie"><noRegion><name sortKey="Sharma, Abhishek" sort="Sharma, Abhishek" uniqKey="Sharma A" first="Abhishek" last="Sharma">Abhishek Sharma</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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