A Randomized, Double-Blind Study of the Efficacy of Fleroxacin versus Trimethoprim-Sulfamethoxazole in Men with Culture-Proven Chancroid
Identifieur interne : 009D10 ( Main/Exploration ); précédent : 009D09; suivant : 009D11A Randomized, Double-Blind Study of the Efficacy of Fleroxacin versus Trimethoprim-Sulfamethoxazole in Men with Culture-Proven Chancroid
Auteurs : Pierre J. Plourde [Canada] ; Lourdes J. D'Costa [Canada] ; Elizabeth Agoki [Canada] ; John Ombette [Canada] ; Jackoniah O. Ndinya-Achola [Canada] ; Leslie A. Slaney [Canada] ; Allan R. Ronald [Canada] ; Francis A. Plummer [Canada]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1992-05.
Abstract
Chancroid is linked to the spread of human immunodeficiency virus type 1 (HIV-1) in East Africa. Effective, easily administered therapy is a priority for the control of Haemophilus ducreyi. The efficacy of a single oral dose of fleroxacin, 400 mg, was compared to a 3-day oral course of trimethoprim-sulfamethoxazole (TMP-SMZ), 160/800 mg, twice daily for the treatment of chancroid in 98 HIV-l-seronegative men in Nairobi, Kenya. No differences were noted between the two groups with respect to demographic characteristics, sexual behavior, and clinical characteristics. Culture-proven failure occurred in 1 (3%) of 36 fleroxacin-treated patients and in 11 (30%) of 37 TMP-SMZ-treated patients (P = .005). Fleroxacin, as a single oral dose, is an effective treatment for culture-proven chancroid in patients who are HIV-1 seronegative. TMP-SMZ is no longer predictably effectivedue to the recent emergence of resistance to both sulfonamides and to trimethoprim.
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DOI: 10.1093/infdis/165.5.949
Affiliations:
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Effective, easily administered therapy is a priority for the control of Haemophilus ducreyi. The efficacy of a single oral dose of fleroxacin, 400 mg, was compared to a 3-day oral course of trimethoprim-sulfamethoxazole (TMP-SMZ), 160/800 mg, twice daily for the treatment of chancroid in 98 HIV-l-seronegative men in Nairobi, Kenya. No differences were noted between the two groups with respect to demographic characteristics, sexual behavior, and clinical characteristics. Culture-proven failure occurred in 1 (3%) of 36 fleroxacin-treated patients and in 11 (30%) of 37 TMP-SMZ-treated patients (P = .005). Fleroxacin, as a single oral dose, is an effective treatment for culture-proven chancroid in patients who are HIV-1 seronegative. TMP-SMZ is no longer predictably effectivedue to the recent emergence of resistance to both sulfonamides and to trimethoprim.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Plourde, Pierre J" sort="Plourde, Pierre J" uniqKey="Plourde P" first="Pierre J." last="Plourde">Pierre J. Plourde</name></noRegion><name sortKey="Agoki, Elizabeth" sort="Agoki, Elizabeth" uniqKey="Agoki E" first="Elizabeth" last="Agoki">Elizabeth Agoki</name><name sortKey="D Costa, Lourdes J" sort="D Costa, Lourdes J" uniqKey="D Costa L" first="Lourdes J." last="D'Costa">Lourdes J. D'Costa</name><name sortKey="Ndinya Achola, Jackoniah O" sort="Ndinya Achola, Jackoniah O" uniqKey="Ndinya Achola J" first="Jackoniah O." last="Ndinya-Achola">Jackoniah O. Ndinya-Achola</name><name sortKey="Ombette, John" sort="Ombette, John" uniqKey="Ombette J" first="John" last="Ombette">John Ombette</name><name sortKey="Plummer, Francis A" sort="Plummer, Francis A" uniqKey="Plummer F" first="Francis A." last="Plummer">Francis A. Plummer</name><name sortKey="Ronald, Allan R" sort="Ronald, Allan R" uniqKey="Ronald A" first="Allan R." last="Ronald">Allan R. Ronald</name><name sortKey="Slaney, Leslie A" sort="Slaney, Leslie A" uniqKey="Slaney L" first="Leslie A." last="Slaney">Leslie A. Slaney</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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