Interaction of Mycobacterium tuberculosis with the host: consequences for vaccine development
Identifieur interne : 005780 ( Main/Exploration ); précédent : 005779; suivant : 005781Interaction of Mycobacterium tuberculosis with the host: consequences for vaccine development
Auteurs : Jes Dietrich [Danemark] ; T. Mark Doherty [Danemark]Source :
- APMIS [ 0903-4641 ] ; 2009-05.
Descripteurs français
- Wicri :
- topic : Vaccination, Vaccin.
English descriptors
- KwdEn :
- Active tuberculosis, Acute infection, Adaptive, Adaptive immunity, Andersen, Animal models, Antigen presentation, Antigen processing, Antigenic repertoire, Apmis, Apmis interaction, Apoptosis, Authors journal compilation, Avirulent mycobacteria, Bacteria, Bacterial antigens, Bacterial growth, Bacterial replication, Bacterium, Booster vaccine, Bovis, Causative agent, Cd4t cells, Cd8t cells, Cell death, Cell microbiol, Cell wall, Cellular level, Chan, Chronic tuberculosis, Clin, Clin immunol, Clin microbiol, Clinical strains, Clinical trials, Complex strategies, Cord factor, Correct response, Curr, Cytokine, Cytokine production, Decoy proteins, Dendritic, Dendritic cells, Dietrich doherty, Different stages, Doherty, Dormancy, Dormant bacteria, Dosr genes, Dosr regulon, Early phase, Early phases, Edinburgh, Effective vaccine, Environmental mycobacteria, Gene expression, Granuloma, Host cell, Host resistance, Host response, Host responses, Human monocytes, Human tuberculosis, Hypoxic conditions, Immun, Immune, Immune cells, Immune reconstitution syndrome, Immune response, Immune responses, Immune system, Immunol, Immunol lett, Infection, Infectious disease immunology, Interferon, Interferon gamma, Intracellular, Intracellular pathogens, Latent infection, Latent stage, Latent tuberculosis, Lipid, Lipoprotein, Long periods, Macrophage, Many years, Maturation, Microarray analysis, Microbiol, Microbiol immunol, Murine, Murine macrophages, Mycobacteria, Mycobacterial, Mycobacterial infection, Mycobacterial lipoprotein, Mycobacterium, Mycobacterium bovis, Mycobacterium tuberculosis, Mycobacterium tuberculosis infection, Necrosis, Nitric, Nitric oxide, Pathogen, Phagosome, Phagosome maturation, Protective immunity, Protein expression, Pulmonary tuberculosis, Ratio increases, Reactivation, Recent work, Receptor, Replication, Same time, Statens serum institute, Subunit, Subunit vaccine, Subunit vaccines, Tissue destruction, Transcriptional responses, Trehalose dimycolate, Trends microbiol, Tuberc lung, Tuberculosis, Tuberculosis infection, Tuberculosis interference, Tuberculosis patients, Tumor necrosis, Tumor necrosis factor, Unpublished data, Vaccination, Vaccine, Vaccine design, Vaccine development, Vaccine strategies, Vaccine strategy, Virulence, World health organization.
- Teeft :
- Active tuberculosis, Acute infection, Adaptive, Adaptive immunity, Andersen, Animal models, Antigen presentation, Antigen processing, Antigenic repertoire, Apmis, Apmis interaction, Apoptosis, Authors journal compilation, Avirulent mycobacteria, Bacteria, Bacterial antigens, Bacterial growth, Bacterial replication, Bacterium, Booster vaccine, Bovis, Causative agent, Cd4t cells, Cd8t cells, Cell death, Cell microbiol, Cell wall, Cellular level, Chan, Chronic tuberculosis, Clin, Clin immunol, Clin microbiol, Clinical strains, Clinical trials, Complex strategies, Cord factor, Correct response, Curr, Cytokine, Cytokine production, Decoy proteins, Dendritic, Dendritic cells, Dietrich doherty, Different stages, Doherty, Dormancy, Dormant bacteria, Dosr genes, Dosr regulon, Early phase, Early phases, Edinburgh, Effective vaccine, Environmental mycobacteria, Gene expression, Granuloma, Host cell, Host resistance, Host response, Host responses, Human monocytes, Human tuberculosis, Hypoxic conditions, Immun, Immune, Immune cells, Immune reconstitution syndrome, Immune response, Immune responses, Immune system, Immunol, Immunol lett, Infection, Infectious disease immunology, Interferon, Interferon gamma, Intracellular, Intracellular pathogens, Latent infection, Latent stage, Latent tuberculosis, Lipid, Lipoprotein, Long periods, Macrophage, Many years, Maturation, Microarray analysis, Microbiol, Microbiol immunol, Murine, Murine macrophages, Mycobacteria, Mycobacterial, Mycobacterial infection, Mycobacterial lipoprotein, Mycobacterium, Mycobacterium bovis, Mycobacterium tuberculosis, Mycobacterium tuberculosis infection, Necrosis, Nitric, Nitric oxide, Pathogen, Phagosome, Phagosome maturation, Protective immunity, Protein expression, Pulmonary tuberculosis, Ratio increases, Reactivation, Recent work, Receptor, Replication, Same time, Statens serum institute, Subunit, Subunit vaccine, Subunit vaccines, Tissue destruction, Transcriptional responses, Trehalose dimycolate, Trends microbiol, Tuberc lung, Tuberculosis, Tuberculosis infection, Tuberculosis interference, Tuberculosis patients, Tumor necrosis, Tumor necrosis factor, Unpublished data, Vaccination, Vaccine, Vaccine design, Vaccine development, Vaccine strategies, Vaccine strategy, Virulence, World health organization.
Abstract
Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), remains a major worldwide health problem that causes more than 2 million deaths annually. In addition, an estimated 2 billion people are latently infected with M. tuberculosis. The bacterium is one of the oldest human pathogens and has evolved complex strategies for survival. Therefore, to be successful in the high endemic regions, any future TB vaccine strategy will have to be tailored in accordance with the resulting complexity of the TB infection and anti‐mycobacterial immune response. In this review, we will discuss what is presently known about the interaction of M. tuberculosis with the immune system, and how this knowledge is used in new and more advanced vaccine strategies.
Url:
DOI: 10.1111/j.1600-0463.2009.02458.x
Affiliations:
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Active tuberculosis</term>
<term>Acute infection</term>
<term>Adaptive</term>
<term>Adaptive immunity</term>
<term>Andersen</term>
<term>Animal models</term>
<term>Antigen presentation</term>
<term>Antigen processing</term>
<term>Antigenic repertoire</term>
<term>Apmis</term>
<term>Apmis interaction</term>
<term>Apoptosis</term>
<term>Authors journal compilation</term>
<term>Avirulent mycobacteria</term>
<term>Bacteria</term>
<term>Bacterial antigens</term>
<term>Bacterial growth</term>
<term>Bacterial replication</term>
<term>Bacterium</term>
<term>Booster vaccine</term>
<term>Bovis</term>
<term>Causative agent</term>
<term>Cd4t cells</term>
<term>Cd8t cells</term>
<term>Cell death</term>
<term>Cell microbiol</term>
<term>Cell wall</term>
<term>Cellular level</term>
<term>Chan</term>
<term>Chronic tuberculosis</term>
<term>Clin</term>
<term>Clin immunol</term>
<term>Clin microbiol</term>
<term>Clinical strains</term>
<term>Clinical trials</term>
<term>Complex strategies</term>
<term>Cord factor</term>
<term>Correct response</term>
<term>Curr</term>
<term>Cytokine</term>
<term>Cytokine production</term>
<term>Decoy proteins</term>
<term>Dendritic</term>
<term>Dendritic cells</term>
<term>Dietrich doherty</term>
<term>Different stages</term>
<term>Doherty</term>
<term>Dormancy</term>
<term>Dormant bacteria</term>
<term>Dosr genes</term>
<term>Dosr regulon</term>
<term>Early phase</term>
<term>Early phases</term>
<term>Edinburgh</term>
<term>Effective vaccine</term>
<term>Environmental mycobacteria</term>
<term>Gene expression</term>
<term>Granuloma</term>
<term>Host cell</term>
<term>Host resistance</term>
<term>Host response</term>
<term>Host responses</term>
<term>Human monocytes</term>
<term>Human tuberculosis</term>
<term>Hypoxic conditions</term>
<term>Immun</term>
<term>Immune</term>
<term>Immune cells</term>
<term>Immune reconstitution syndrome</term>
<term>Immune response</term>
<term>Immune responses</term>
<term>Immune system</term>
<term>Immunol</term>
<term>Immunol lett</term>
<term>Infection</term>
<term>Infectious disease immunology</term>
<term>Interferon</term>
<term>Interferon gamma</term>
<term>Intracellular</term>
<term>Intracellular pathogens</term>
<term>Latent infection</term>
<term>Latent stage</term>
<term>Latent tuberculosis</term>
<term>Lipid</term>
<term>Lipoprotein</term>
<term>Long periods</term>
<term>Macrophage</term>
<term>Many years</term>
<term>Maturation</term>
<term>Microarray analysis</term>
<term>Microbiol</term>
<term>Microbiol immunol</term>
<term>Murine</term>
<term>Murine macrophages</term>
<term>Mycobacteria</term>
<term>Mycobacterial</term>
<term>Mycobacterial infection</term>
<term>Mycobacterial lipoprotein</term>
<term>Mycobacterium</term>
<term>Mycobacterium bovis</term>
<term>Mycobacterium tuberculosis</term>
<term>Mycobacterium tuberculosis infection</term>
<term>Necrosis</term>
<term>Nitric</term>
<term>Nitric oxide</term>
<term>Pathogen</term>
<term>Phagosome</term>
<term>Phagosome maturation</term>
<term>Protective immunity</term>
<term>Protein expression</term>
<term>Pulmonary tuberculosis</term>
<term>Ratio increases</term>
<term>Reactivation</term>
<term>Recent work</term>
<term>Receptor</term>
<term>Replication</term>
<term>Same time</term>
<term>Statens serum institute</term>
<term>Subunit</term>
<term>Subunit vaccine</term>
<term>Subunit vaccines</term>
<term>Tissue destruction</term>
<term>Transcriptional responses</term>
<term>Trehalose dimycolate</term>
<term>Trends microbiol</term>
<term>Tuberc lung</term>
<term>Tuberculosis</term>
<term>Tuberculosis infection</term>
<term>Tuberculosis interference</term>
<term>Tuberculosis patients</term>
<term>Tumor necrosis</term>
<term>Tumor necrosis factor</term>
<term>Unpublished data</term>
<term>Vaccination</term>
<term>Vaccine</term>
<term>Vaccine design</term>
<term>Vaccine development</term>
<term>Vaccine strategies</term>
<term>Vaccine strategy</term>
<term>Virulence</term>
<term>World health organization</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Active tuberculosis</term>
<term>Acute infection</term>
<term>Adaptive</term>
<term>Adaptive immunity</term>
<term>Andersen</term>
<term>Animal models</term>
<term>Antigen presentation</term>
<term>Antigen processing</term>
<term>Antigenic repertoire</term>
<term>Apmis</term>
<term>Apmis interaction</term>
<term>Apoptosis</term>
<term>Authors journal compilation</term>
<term>Avirulent mycobacteria</term>
<term>Bacteria</term>
<term>Bacterial antigens</term>
<term>Bacterial growth</term>
<term>Bacterial replication</term>
<term>Bacterium</term>
<term>Booster vaccine</term>
<term>Bovis</term>
<term>Causative agent</term>
<term>Cd4t cells</term>
<term>Cd8t cells</term>
<term>Cell death</term>
<term>Cell microbiol</term>
<term>Cell wall</term>
<term>Cellular level</term>
<term>Chan</term>
<term>Chronic tuberculosis</term>
<term>Clin</term>
<term>Clin immunol</term>
<term>Clin microbiol</term>
<term>Clinical strains</term>
<term>Clinical trials</term>
<term>Complex strategies</term>
<term>Cord factor</term>
<term>Correct response</term>
<term>Curr</term>
<term>Cytokine</term>
<term>Cytokine production</term>
<term>Decoy proteins</term>
<term>Dendritic</term>
<term>Dendritic cells</term>
<term>Dietrich doherty</term>
<term>Different stages</term>
<term>Doherty</term>
<term>Dormancy</term>
<term>Dormant bacteria</term>
<term>Dosr genes</term>
<term>Dosr regulon</term>
<term>Early phase</term>
<term>Early phases</term>
<term>Edinburgh</term>
<term>Effective vaccine</term>
<term>Environmental mycobacteria</term>
<term>Gene expression</term>
<term>Granuloma</term>
<term>Host cell</term>
<term>Host resistance</term>
<term>Host response</term>
<term>Host responses</term>
<term>Human monocytes</term>
<term>Human tuberculosis</term>
<term>Hypoxic conditions</term>
<term>Immun</term>
<term>Immune</term>
<term>Immune cells</term>
<term>Immune reconstitution syndrome</term>
<term>Immune response</term>
<term>Immune responses</term>
<term>Immune system</term>
<term>Immunol</term>
<term>Immunol lett</term>
<term>Infection</term>
<term>Infectious disease immunology</term>
<term>Interferon</term>
<term>Interferon gamma</term>
<term>Intracellular</term>
<term>Intracellular pathogens</term>
<term>Latent infection</term>
<term>Latent stage</term>
<term>Latent tuberculosis</term>
<term>Lipid</term>
<term>Lipoprotein</term>
<term>Long periods</term>
<term>Macrophage</term>
<term>Many years</term>
<term>Maturation</term>
<term>Microarray analysis</term>
<term>Microbiol</term>
<term>Microbiol immunol</term>
<term>Murine</term>
<term>Murine macrophages</term>
<term>Mycobacteria</term>
<term>Mycobacterial</term>
<term>Mycobacterial infection</term>
<term>Mycobacterial lipoprotein</term>
<term>Mycobacterium</term>
<term>Mycobacterium bovis</term>
<term>Mycobacterium tuberculosis</term>
<term>Mycobacterium tuberculosis infection</term>
<term>Necrosis</term>
<term>Nitric</term>
<term>Nitric oxide</term>
<term>Pathogen</term>
<term>Phagosome</term>
<term>Phagosome maturation</term>
<term>Protective immunity</term>
<term>Protein expression</term>
<term>Pulmonary tuberculosis</term>
<term>Ratio increases</term>
<term>Reactivation</term>
<term>Recent work</term>
<term>Receptor</term>
<term>Replication</term>
<term>Same time</term>
<term>Statens serum institute</term>
<term>Subunit</term>
<term>Subunit vaccine</term>
<term>Subunit vaccines</term>
<term>Tissue destruction</term>
<term>Transcriptional responses</term>
<term>Trehalose dimycolate</term>
<term>Trends microbiol</term>
<term>Tuberc lung</term>
<term>Tuberculosis</term>
<term>Tuberculosis infection</term>
<term>Tuberculosis interference</term>
<term>Tuberculosis patients</term>
<term>Tumor necrosis</term>
<term>Tumor necrosis factor</term>
<term>Unpublished data</term>
<term>Vaccination</term>
<term>Vaccine</term>
<term>Vaccine design</term>
<term>Vaccine development</term>
<term>Vaccine strategies</term>
<term>Vaccine strategy</term>
<term>Virulence</term>
<term>World health organization</term>
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<front><div type="abstract" xml:lang="en">Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), remains a major worldwide health problem that causes more than 2 million deaths annually. In addition, an estimated 2 billion people are latently infected with M. tuberculosis. The bacterium is one of the oldest human pathogens and has evolved complex strategies for survival. Therefore, to be successful in the high endemic regions, any future TB vaccine strategy will have to be tailored in accordance with the resulting complexity of the TB infection and anti‐mycobacterial immune response. In this review, we will discuss what is presently known about the interaction of M. tuberculosis with the immune system, and how this knowledge is used in new and more advanced vaccine strategies.</div>
</front>
</TEI>
<affiliations><list><country><li>Danemark</li>
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<region><li>Hovedstaden</li>
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<settlement><li>Copenhague</li>
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<tree><country name="Danemark"><region name="Hovedstaden"><name sortKey="Dietrich, Jes" sort="Dietrich, Jes" uniqKey="Dietrich J" first="Jes" last="Dietrich">Jes Dietrich</name>
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<name sortKey="Doherty, T Mark" sort="Doherty, T Mark" uniqKey="Doherty T" first="T. Mark" last="Doherty">T. Mark Doherty</name>
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