Le SIDA en Afrique subsaharienne (serveur d'exploration)

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Interaction of Mycobacterium tuberculosis with the host: consequences for vaccine development

Identifieur interne : 005780 ( Main/Exploration ); précédent : 005779; suivant : 005781

Interaction of Mycobacterium tuberculosis with the host: consequences for vaccine development

Auteurs : Jes Dietrich [Danemark] ; T. Mark Doherty [Danemark]

Source :

RBID : ISTEX:01AD0E6E3B41C6A984C35C7B7661FB557EC3AB67

Descripteurs français

English descriptors

Abstract

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), remains a major worldwide health problem that causes more than 2 million deaths annually. In addition, an estimated 2 billion people are latently infected with M. tuberculosis. The bacterium is one of the oldest human pathogens and has evolved complex strategies for survival. Therefore, to be successful in the high endemic regions, any future TB vaccine strategy will have to be tailored in accordance with the resulting complexity of the TB infection and anti‐mycobacterial immune response. In this review, we will discuss what is presently known about the interaction of M. tuberculosis with the immune system, and how this knowledge is used in new and more advanced vaccine strategies.

Url:
DOI: 10.1111/j.1600-0463.2009.02458.x


Affiliations:


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Le document en format XML

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<term>Trehalose dimycolate</term>
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<term>Animal models</term>
<term>Antigen presentation</term>
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<term>Authors journal compilation</term>
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<term>Booster vaccine</term>
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<term>Cytokine</term>
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<term>Dormant bacteria</term>
<term>Dosr genes</term>
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<term>Edinburgh</term>
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<term>Environmental mycobacteria</term>
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<term>Latent tuberculosis</term>
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<term>Mycobacterial lipoprotein</term>
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<term>Mycobacterium bovis</term>
<term>Mycobacterium tuberculosis</term>
<term>Mycobacterium tuberculosis infection</term>
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<term>Phagosome</term>
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<term>Protein expression</term>
<term>Pulmonary tuberculosis</term>
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<term>Reactivation</term>
<term>Recent work</term>
<term>Receptor</term>
<term>Replication</term>
<term>Same time</term>
<term>Statens serum institute</term>
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<term>Subunit vaccine</term>
<term>Subunit vaccines</term>
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<term>Tuberculosis infection</term>
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<term>Tumor necrosis</term>
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<term>Vaccine design</term>
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<front>
<div type="abstract" xml:lang="en">Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), remains a major worldwide health problem that causes more than 2 million deaths annually. In addition, an estimated 2 billion people are latently infected with M. tuberculosis. The bacterium is one of the oldest human pathogens and has evolved complex strategies for survival. Therefore, to be successful in the high endemic regions, any future TB vaccine strategy will have to be tailored in accordance with the resulting complexity of the TB infection and anti‐mycobacterial immune response. In this review, we will discuss what is presently known about the interaction of M. tuberculosis with the immune system, and how this knowledge is used in new and more advanced vaccine strategies.</div>
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