SidaSubSaharaV1, Istex, Corpus, bibRecord, 004E74

Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans

Identifieur interne : 004E74 ( Istex/Corpus ); précédent : 004E73; suivant : 004E75

Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans

Auteurs : Alison M. Elliott ; Jacqueline Kyosiimire ; Maria A. Quigley ; Jessica Nakiyingi ; Christine Watera ; Michael Brown ; Sarah Joseph ; Neil French ; Charles F. Gilks ; James A. G. Whitworth

Source :

Transactions of The Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2003-08.

RBID : ISTEX:F1C6284293048E892E0A7AF5995F18D7672E35F8

English descriptors

KwdEn :
- HIV, Uganda, eosinophilia, tuberculosis.

Abstract

It has been suggested that type 1 immune responses protect against tuberculosis (TB), while type 2 responses, such as those induced by helminths, may suppress protective responses and increase susceptibility to TB. Factors associated with progression to active TB were investigated in a cohort of HIV-1-infected Ugandan adults, a group at high risk of TB. High rates of subsequent progression to active TB were associated with eosinophil counts ⩾ 0.4 × 109/L at enrolment. Eosinophilia at enrolment was associated with male gender, low socio-economic status, high CD4+ T cell counts, and schistosomiasis, but adjusting for these factors did not explain the association of eosinophilia with progression to active TB (adjusted rate ratio = 2.76, P = 0.004). Eosinophilia is most likely to be indicative of a type 2 immune response induced by helminth infection in this Ugandan cohort, but the mechanism of the observed association between eosinophilia and risk of TB remains to be determined.

Url:

https://api.istex.fr/document/F1C6284293048E892E0A7AF5995F18D7672E35F8/fulltext/pdf

DOI: 10.1016/S0035-9203(03)90096-4

Links to Exploration step

ISTEX:F1C6284293048E892E0A7AF5995F18D7672E35F8

Le document en format XML

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<front>

<journal-meta>

<journal-id journal-id-type="hwp">trstmh</journal-id>

<journal-id journal-id-type="publisher-id">trstmh</journal-id>

<journal-title>Transactions of The Royal Society of Tropical Medicine and Hygiene</journal-title>

<abbrev-journal-title>Trans R Soc Trop Med Hyg</abbrev-journal-title>

<issn pub-type="ppub">0035-9203</issn>

<issn pub-type="epub">1878-3503</issn>

<publisher>

<publisher-name>Royal Society of Tropical Medicine and Hygiene</publisher-name>

</publisher>

</journal-meta>

<article-meta>

<article-id pub-id-type="doi">10.1016/S0035-9203(03)90096-4</article-id>

<article-categories>

<subj-group subj-group-type="heading">

<subject>Article</subject>
</subj-group>
</article-categories>

<title-group>

<article-title>Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans</article-title>

</title-group>

<contrib-group>

<contrib contrib-type="author" corresp="yes">

<name>

<surname>Elliott</surname>

<given-names>Alison M.</given-names>
</name>
<xref ref-type="corresp" rid="COR1"><sup>∗</sup>
</xref>
<xref ref-type="aff" rid="AFF1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="AFF2"><sup>2</sup>
</xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Kyosiimire</surname>

<given-names>Jacqueline</given-names>
</name>
<xref ref-type="aff" rid="AFF1"><sup>1</sup>
</xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Quigley</surname>

<given-names>Maria A.</given-names>
</name>
<xref ref-type="aff" rid="AFF2"><sup>2</sup>
</xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Nakiyingi</surname>

<given-names>Jessica</given-names>
</name>
<xref ref-type="aff" rid="AFF1"><sup>1</sup>
</xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Watera</surname>

<given-names>Christine</given-names>
</name>
<xref ref-type="aff" rid="AFF1"><sup>1</sup>
</xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Brown</surname>

<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="AFF1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="AFF2"><sup>2</sup>
</xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Joseph</surname>

<given-names>Sarah</given-names>
</name>
<xref ref-type="aff" rid="AFF3"><sup>3</sup>
</xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>French</surname>

<given-names>Neil</given-names>
</name>
<xref ref-type="aff" rid="AFF4"><sup>4</sup>
</xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Gilks</surname>

<given-names>Charles F.</given-names>
</name>
<xref ref-type="aff" rid="AFF5"><sup>5</sup>
</xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Whitworth</surname>

<given-names>James A.G.</given-names>
</name>
<xref ref-type="aff" rid="AFF1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="AFF2"><sup>2</sup>
</xref>

</contrib>

<aff id="AFF1">

<label>1</label>
Uganda Virus Research Institute, P. O. Box 49, Entebbe, Uganda</aff>

<aff id="AFF2">

<label>2</label>
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK</aff>

<aff id="AFF3">

<label>3</label>
Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK</aff>

<aff id="AFF4">

<label>4</label>
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK</aff>

<aff id="AFF5">

<label>5</label>
Department of Medicine, Imperial College, St Mary's Campus, Norfolk Place, London W2 1PG, UK</aff>
</contrib-group>

<author-notes>

<corresp id="COR1">

<label>∗</label>
Address for correspondence: Dr A. M. Elliott, Uganda Virus Research Institute, P.O. Box 49, Entebbe, Uganda; phone +256 41 320272, fax +256 41 321173 <email>mrc@starcom.co.ug</email>
</corresp>
</author-notes>

<pub-date pub-type="ppub">

<month>8</month>

<year>2003</year>
</pub-date>

<volume>97</volume>

<issue>4</issue>

<fpage>477</fpage>

<lpage>480</lpage>

<history><date date-type="received"><day>14</day>

<month>10</month>

<year>2002</year>
</date>
<date date-type="rev-recd"><day>9</day>

<month>1</month>

<year>2003</year>
</date>
<date date-type="accepted"><day>14</day>

<month>1</month>

<year>2003</year>
</date>
</history>

<permissions><copyright-year>2003</copyright-year>
</permissions>

<abstract>

<p>It has been suggested that type 1 immune responses protect against tuberculosis (TB), while type 2 responses, such as those induced by helminths, may suppress protective responses and increase susceptibility to TB. Factors associated with progression to active TB were investigated in a cohort of HIV-1-infected Ugandan adults, a group at high risk of TB. High rates of subsequent progression to active TB were associated with eosinophil counts ⩾ 0.4 × 10<sup>9</sup>
/L at enrolment. Eosinophilia at enrolment was associated with male gender, low socio-economic status, high CD4+ T cell counts, and schistosomiasis, but adjusting for these factors did not explain the association of eosinophilia with progression to active TB (adjusted rate ratio = 2.76, <italic>P</italic>
 = 0.004). Eosinophilia is most likely to be indicative of a type 2 immune response induced by helminth infection in this Ugandan cohort, but the mechanism of the observed association between eosinophilia and risk of TB remains to be determined.</p>
</abstract>

<kwd-group xml:lang="en">

<title>Keywords</title>

<kwd>tuberculosis</kwd>

<kwd>HIV</kwd>

<kwd>eosinophilia</kwd>

<kwd>Uganda</kwd>
</kwd-group>

<custom-meta-wrap>

<custom-meta>

<meta-name>cover-date</meta-name>

<meta-value>July-August 2003</meta-value>

</custom-meta>

</custom-meta-wrap>

</article-meta>

</front>

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<mods version="3.6"><titleInfo><title>Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA"><title>Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans</title>
</titleInfo>
<name type="personal" displayLabel="corresp"><namePart type="given">Alison M.</namePart>
<namePart type="family">Elliott</namePart>
<affiliation>Uganda Virus Research Institute, P. O. Box 49, Entebbe, Uganda</affiliation>
<affiliation>Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK</affiliation>
<affiliation>E-mail: mrc@starcom.co.ug</affiliation>
<affiliation></affiliation>
<affiliation>E-mail: mrc@starcom.co.ug</affiliation>
<role><roleTerm type="text">author</roleTerm>
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</name>
<name type="personal"><namePart type="given">Jacqueline</namePart>
<namePart type="family">Kyosiimire</namePart>
<affiliation>Uganda Virus Research Institute, P. O. Box 49, Entebbe, Uganda</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Maria A.</namePart>
<namePart type="family">Quigley</namePart>
<affiliation>Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Jessica</namePart>
<namePart type="family">Nakiyingi</namePart>
<affiliation>Uganda Virus Research Institute, P. O. Box 49, Entebbe, Uganda</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Christine</namePart>
<namePart type="family">Watera</namePart>
<affiliation>Uganda Virus Research Institute, P. O. Box 49, Entebbe, Uganda</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Michael</namePart>
<namePart type="family">Brown</namePart>
<affiliation>Uganda Virus Research Institute, P. O. Box 49, Entebbe, Uganda</affiliation>
<affiliation>Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Sarah</namePart>
<namePart type="family">Joseph</namePart>
<affiliation>Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Neil</namePart>
<namePart type="family">French</namePart>
<affiliation>Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Charles F.</namePart>
<namePart type="family">Gilks</namePart>
<affiliation>Department of Medicine, Imperial College, St Mary's Campus, Norfolk Place, London W2 1PG, UK</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">James A.G.</namePart>
<namePart type="family">Whitworth</namePart>
<affiliation>Uganda Virus Research Institute, P. O. Box 49, Entebbe, Uganda</affiliation>
<affiliation>Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK</affiliation>
<role><roleTerm type="text">author</roleTerm>
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<originInfo><publisher>Royal Society of Tropical Medicine and Hygiene</publisher>
<dateIssued encoding="w3cdtf">2003-08</dateIssued>
<copyrightDate encoding="w3cdtf">2003</copyrightDate>
</originInfo>
<abstract>It has been suggested that type 1 immune responses protect against tuberculosis (TB), while type 2 responses, such as those induced by helminths, may suppress protective responses and increase susceptibility to TB. Factors associated with progression to active TB were investigated in a cohort of HIV-1-infected Ugandan adults, a group at high risk of TB. High rates of subsequent progression to active TB were associated with eosinophil counts ⩾ 0.4 × 109/L at enrolment. Eosinophilia at enrolment was associated with male gender, low socio-economic status, high CD4+ T cell counts, and schistosomiasis, but adjusting for these factors did not explain the association of eosinophilia with progression to active TB (adjusted rate ratio = 2.76, P = 0.004). Eosinophilia is most likely to be indicative of a type 2 immune response induced by helminth infection in this Ugandan cohort, but the mechanism of the observed association between eosinophilia and risk of TB remains to be determined.</abstract>
<subject lang="en"><genre>Keywords</genre>
<topic>tuberculosis</topic>
<topic>HIV</topic>
<topic>eosinophilia</topic>
<topic>Uganda</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Transactions of The Royal Society of Tropical Medicine and Hygiene</title>
</titleInfo>
<titleInfo type="abbreviated"><title>Trans R Soc Trop Med Hyg</title>
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<identifier type="ISSN">0035-9203</identifier>
<identifier type="eISSN">1878-3503</identifier>
<identifier type="PublisherID">trstmh</identifier>
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<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>97</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>4</number>
</detail>
<extent unit="pages"><start>477</start>
<end>480</end>
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</part>
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<identifier type="istex">F1C6284293048E892E0A7AF5995F18D7672E35F8</identifier>
<identifier type="DOI">10.1016/S0035-9203(03)90096-4</identifier>
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Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans

Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans

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