Recruitment to a trial of tuberculosis preventive therapy from a voluntary HIV testing centre in Lusaka: relevance to implementation
Identifieur interne : 004859 ( Istex/Corpus ); précédent : 004858; suivant : 004860Recruitment to a trial of tuberculosis preventive therapy from a voluntary HIV testing centre in Lusaka: relevance to implementation
Auteurs : Peter Godfrey-Faussett ; Rachel Baggaley ; Alwyn Mwinga ; Maria Hosp ; John Porter ; Nkandu Luo ; Michael Kelly ; Roland Msiska ; Keith McadamSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 1995.
English descriptors
- KwdEn :
- Active tuberculosis, Application forms, Centre, Clinic, Counselling, Counselling centre, Counsellor, Experimental nature, Human immunodeficiency virus, International conference aids, Liver function tests, London school, Lusaka, Manson house, Maximum value, Other hand, Portland place, Positive result, Practical training, Preventive theranv, Preventive therapy, Preventive therapy trial, Risky behaviour, Royal society, Seropositive, Seropositive people, Testing centre, Testing centres, Testing service, Therapy, Therapy trial, Treatment services, Trial clinic, Tropical medicine, Tuberculosis, Tuberculosis control programmes, Uganda, University teaching hospital, World health organization, Zambia.
- Teeft :
- Active tuberculosis, Application forms, Centre, Clinic, Counselling, Counselling centre, Counsellor, Experimental nature, Human immunodeficiency virus, International conference aids, Liver function tests, London school, Lusaka, Manson house, Maximum value, Other hand, Portland place, Positive result, Practical training, Preventive theranv, Preventive therapy, Preventive therapy trial, Risky behaviour, Royal society, Seropositive, Seropositive people, Testing centre, Testing centres, Testing service, Therapy, Therapy trial, Treatment services, Trial clinic, Tropical medicine, Tuberculosis, Tuberculosis control programmes, Uganda, University teaching hospital, World health organization, Zambia.
Abstract
Abstract: To determine the number of clients attending for voluntary human immunodeficiency virus (HIV) testing who are able to enter a trial of preventive therapy for tuberculosis, and the factors that determine who receives therapy, we studied 475 consecutive people attending for an HIV test at Lusaka's first voluntary HIV testing centre and the preventive therapy study clinic at the University Teaching Hospital, Lusaka, Zambia. Semi-structured interviews were conducted by counsellors and collated with recruitment data from the trial. Two hundred and twenty-five people were seropositive, of whom 201 returned to collect their results; 77 (38%) of these (16% of the total number screened) entered the trial. Reasons for not entering the trial included exclusion by trial protocol (30), including 18 who had active tuberculosis; psychological adjustment to a positive result (27); death (6); worries about confidentiality (3); the experimental nature of the trial (12); attitudes of staff in the hospital (5); and cost of transport (7). Targeting preventive therapy at those who are already choosing to be tested for HIV seems appropriate and may be cost-effective. Although visiting a hospital may deter some people, the prevalence of active tuberculosis among this group emphasized the importance of arranging adequate screening facilities.
Url:
DOI: 10.1016/0035-9203(95)90005-5
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Abstract: To determine the number of clients attending for voluntary human immunodeficiency virus (HIV) testing who are able to enter a trial of preventive therapy for tuberculosis, and the factors that determine who receives therapy, we studied 475 consecutive people attending for an HIV test at Lusaka's first voluntary HIV testing centre and the preventive therapy study clinic at the University Teaching Hospital, Lusaka, Zambia. Semi-structured interviews were conducted by counsellors and collated with recruitment data from the trial. Two hundred and twenty-five people were seropositive, of whom 201 returned to collect their results; 77 (38%) of these (16% of the total number screened) entered the trial. Reasons for not entering the trial included exclusion by trial protocol (30), including 18 who had active tuberculosis; psychological adjustment to a positive result (27); death (6); worries about confidentiality (3); the experimental nature of the trial (12); attitudes of staff in the hospital (5); and cost of transport (7). Targeting preventive therapy at those who are already choosing to be tested for HIV seems appropriate and may be cost-effective. Although visiting a hospital may deter some people, the prevalence of active tuberculosis among this group emphasized the importance of arranging adequate screening facilities.</div>
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<abstract xml:lang="en"><p>To determine the number of clients attending for voluntary human immunodeficiency virus (HIV) testing who are able to enter a trial of preventive therapy for tuberculosis, and the factors that determine who receives therapy, we studied 475 consecutive people attending for an HIV test at Lusaka's first voluntary HIV testing centre and the preventive therapy study clinic at the University Teaching Hospital, Lusaka, Zambia. Semi-structured interviews were conducted by counsellors and collated with recruitment data from the trial. Two hundred and twenty-five people were seropositive, of whom 201 returned to collect their results; 77 (38%) of these (16% of the total number screened) entered the trial. Reasons for not entering the trial included exclusion by trial protocol (30), including 18 who had active tuberculosis; psychological adjustment to a positive result (27); death (6); worries about confidentiality (3); the experimental nature of the trial (12); attitudes of staff in the hospital (5); and cost of transport (7). Targeting preventive therapy at those who are already choosing to be tested for HIV seems appropriate and may be cost-effective. Although visiting a hospital may deter some people, the prevalence of active tuberculosis among this group emphasized the importance of arranging adequate screening facilities.</p>
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<head><ce:title>Recruitment to a trial of tuberculosis preventive therapy from a voluntary HIV testing centre in Lusaka: relevance to implementation</ce:title>
<ce:author-group><ce:author><ce:given-name>Peter</ce:given-name>
<ce:surname>Godfrey-Faussett</ce:surname>
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<ce:textfn>Department of Medicine, University Teaching Hospital, Lusaka, Zambia</ce:textfn>
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<ce:textfn>Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, London, UK</ce:textfn>
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<ce:textfn>Department of Pathology and Microbiology, University Teaching Hospital, Lusaka, Zambia</ce:textfn>
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<ce:textfn>National AIDS and Tuberculosis Programme, Ministry of Health, Lusaka, Zambia</ce:textfn>
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<ce:correspondence id="COR1"><ce:label>∗</ce:label>
<ce:text>Address for correspondence: Dr Peter Godfrey-Faussett, <ce:small-caps>zambart</ce:small-caps>
Project, Department of Medicine, University Teaching Hospital, P.O. Box 50110, Lusaka, Zambia.</ce:text>
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<ce:abstract><ce:section-title>Abstract</ce:section-title>
<ce:abstract-sec><ce:simple-para>To determine the number of clients attending for voluntary human immunodeficiency virus (HIV) testing who are able to enter a trial of preventive therapy for tuberculosis, and the factors that determine who receives therapy, we studied 475 consecutive people attending for an HIV test at Lusaka's first voluntary HIV testing centre and the preventive therapy study clinic at the University Teaching Hospital, Lusaka, Zambia. Semi-structured interviews were conducted by counsellors and collated with recruitment data from the trial. Two hundred and twenty-five people were seropositive, of whom 201 returned to collect their results; 77 (38%) of these (16% of the total number screened) entered the trial. Reasons for not entering the trial included exclusion by trial protocol (30), including 18 who had active tuberculosis; psychological adjustment to a positive result (27); death (6); worries about confidentiality (3); the experimental nature of the trial (12); attitudes of staff in the hospital (5); and cost of transport (7). Targeting preventive therapy at those who are already choosing to be tested for HIV seems appropriate and may be cost-effective. Although visiting a hospital may deter some people, the prevalence of active tuberculosis among this group emphasized the importance of arranging adequate screening facilities.</ce:simple-para>
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<ce:keyword><ce:text>human immunodeficiency virus</ce:text>
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<ce:keyword><ce:text>drug trial recruitment</ce:text>
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<abstract lang="en">Abstract: To determine the number of clients attending for voluntary human immunodeficiency virus (HIV) testing who are able to enter a trial of preventive therapy for tuberculosis, and the factors that determine who receives therapy, we studied 475 consecutive people attending for an HIV test at Lusaka's first voluntary HIV testing centre and the preventive therapy study clinic at the University Teaching Hospital, Lusaka, Zambia. Semi-structured interviews were conducted by counsellors and collated with recruitment data from the trial. Two hundred and twenty-five people were seropositive, of whom 201 returned to collect their results; 77 (38%) of these (16% of the total number screened) entered the trial. Reasons for not entering the trial included exclusion by trial protocol (30), including 18 who had active tuberculosis; psychological adjustment to a positive result (27); death (6); worries about confidentiality (3); the experimental nature of the trial (12); attitudes of staff in the hospital (5); and cost of transport (7). Targeting preventive therapy at those who are already choosing to be tested for HIV seems appropriate and may be cost-effective. Although visiting a hospital may deter some people, the prevalence of active tuberculosis among this group emphasized the importance of arranging adequate screening facilities.</abstract>
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