Risk of iatrogenic human immunodeficiency virus infection through transfusion of blood tested by inappropriately stored or expired rapid antibody assays in a Zambian hospital
Identifieur interne : 003C93 ( Istex/Corpus ); précédent : 003C92; suivant : 003C94Risk of iatrogenic human immunodeficiency virus infection through transfusion of blood tested by inappropriately stored or expired rapid antibody assays in a Zambian hospital
Auteurs : E. C. J. Consten ; J. T. M. Van Der Meer ; F. De Wolf ; H. A. Heij ; P. C. Henny ; J. J. B. Van LanschotSource :
- Transfusion [ 0041-1132 ] ; 1997-09.
English descriptors
- KwdEn :
- Allogeneic, Allogeneic blood, Allogeneic blood transfusion, Allogeneic blood transfusions, Antibody assays, Assay, Associate professor, Blood donors, Blood transfusion practices, Blood transfusions, Comparative evaluation, Data analysis, Donor, Donor blood, Donor population, Francis hospital, Iatrogenic, Infectious diseases, Internal medicine, Laboratory staff, Management board, Medical centre, Nonexpired, Nonexpired tests, Present study, Rapid antibody assays, Reagent, Room temperature, Seropositive samples, Seroprevalence, Serum samples, Single unit, Statistical analysis, Surgical, Surgical patients, Test results, Transfusion, Transfusion volume, Tropical medicine, University hospital, Zambia.
- Teeft :
- Allogeneic, Allogeneic blood, Allogeneic blood transfusion, Allogeneic blood transfusions, Antibody assays, Assay, Associate professor, Blood donors, Blood transfusion practices, Blood transfusions, Comparative evaluation, Data analysis, Donor, Donor blood, Donor population, Francis hospital, Iatrogenic, Infectious diseases, Internal medicine, Laboratory staff, Management board, Medical centre, Nonexpired, Nonexpired tests, Present study, Rapid antibody assays, Reagent, Room temperature, Seropositive samples, Seroprevalence, Serum samples, Single unit, Statistical analysis, Surgical, Surgical patients, Test results, Transfusion, Transfusion volume, Tropical medicine, University hospital, Zambia.
Abstract
BACKGROUND: The purpose of this study was to estimate the risk of human immunodeficiency virus (HIV) infection via the transfusion of blood tested by inappropriately stored or expired rapid antibody assays in Zambia. STUDY DESIGN AND METHODS: Surgical patients (n = 370) were tested with antibody assays (HIV‐spot and HIV 1+2) that had expired 3 to 6 months previously. Blood donors (n = 211) were tested by inappropriately stored but non‐expired HIV‐spot assay. Serum samples from both groups were retested with enzyme immunoassays, and the seropositivity of samples was confirmed by immunoblotting. RESULTS: Seroprevalence in surgical patients and blood donors was 19.8 and 11.6 percent, respectively. Sensitivity and specificity of HIV‐spot (expired) were 88.2 and 98.1 percent; those of HIV 1+2 (expired) were 82.1 and 94.7 percent; and those of HIV‐spot (non‐expired) were 91.7 and 98.8 percent, respectively. The risk of HIV infection via the transfusion of blood tested by HIV‐spot (expired), HIV‐spot (nonexpired), or HIV 1+2 (expired) was calculated to be 1.4, 1.0, and 3.2 percent, respectively. CONCLUSION: Manufacturers of the HIV‐spot and HIV 1+2 assays claim sensitivity and specificity of 98.8 and 100 percent and 100 and 99.5 percent, respectively. In this study, sensitivity and specificity were 11 to 18 percent lower. Moreover, in‐ date reagents also performed less well than the manufacturers claimed, but the worst results were with expired or improperly stored reagents. According to the manufacturers of HIV‐spot and HIV 1+2, the risk of HIV infection would be 0.2 and 0 percent, respectively. However, the risk of contracting HIV through transfusion is at least six times higher than expected.
Url:
DOI: 10.1046/j.1537-2995.1997.37997454020.x
Links to Exploration step
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<front><div type="abstract" xml:lang="en">BACKGROUND: The purpose of this study was to estimate the risk of human immunodeficiency virus (HIV) infection via the transfusion of blood tested by inappropriately stored or expired rapid antibody assays in Zambia. STUDY DESIGN AND METHODS: Surgical patients (n = 370) were tested with antibody assays (HIV‐spot and HIV 1+2) that had expired 3 to 6 months previously. Blood donors (n = 211) were tested by inappropriately stored but non‐expired HIV‐spot assay. Serum samples from both groups were retested with enzyme immunoassays, and the seropositivity of samples was confirmed by immunoblotting. RESULTS: Seroprevalence in surgical patients and blood donors was 19.8 and 11.6 percent, respectively. Sensitivity and specificity of HIV‐spot (expired) were 88.2 and 98.1 percent; those of HIV 1+2 (expired) were 82.1 and 94.7 percent; and those of HIV‐spot (non‐expired) were 91.7 and 98.8 percent, respectively. The risk of HIV infection via the transfusion of blood tested by HIV‐spot (expired), HIV‐spot (nonexpired), or HIV 1+2 (expired) was calculated to be 1.4, 1.0, and 3.2 percent, respectively. CONCLUSION: Manufacturers of the HIV‐spot and HIV 1+2 assays claim sensitivity and specificity of 98.8 and 100 percent and 100 and 99.5 percent, respectively. In this study, sensitivity and specificity were 11 to 18 percent lower. Moreover, in‐ date reagents also performed less well than the manufacturers claimed, but the worst results were with expired or improperly stored reagents. According to the manufacturers of HIV‐spot and HIV 1+2, the risk of HIV infection would be 0.2 and 0 percent, respectively. However, the risk of contracting HIV through transfusion is at least six times higher than expected.</div>
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<abstract>BACKGROUND: The purpose of this study was to estimate the risk of human immunodeficiency virus (HIV) infection via the transfusion of blood tested by inappropriately stored or expired rapid antibody assays in Zambia. STUDY DESIGN AND METHODS: Surgical patients (n = 370) were tested with antibody assays (HIV‐spot and HIV 1+2) that had expired 3 to 6 months previously. Blood donors (n = 211) were tested by inappropriately stored but non‐expired HIV‐spot assay. Serum samples from both groups were retested with enzyme immunoassays, and the seropositivity of samples was confirmed by immunoblotting. RESULTS: Seroprevalence in surgical patients and blood donors was 19.8 and 11.6 percent, respectively. Sensitivity and specificity of HIV‐spot (expired) were 88.2 and 98.1 percent; those of HIV 1+2 (expired) were 82.1 and 94.7 percent; and those of HIV‐spot (non‐expired) were 91.7 and 98.8 percent, respectively. The risk of HIV infection via the transfusion of blood tested by HIV‐spot (expired), HIV‐spot (nonexpired), or HIV 1+2 (expired) was calculated to be 1.4, 1.0, and 3.2 percent, respectively. CONCLUSION: Manufacturers of the HIV‐spot and HIV 1+2 assays claim sensitivity and specificity of 98.8 and 100 percent and 100 and 99.5 percent, respectively. In this study, sensitivity and specificity were 11 to 18 percent lower. Moreover, in‐ date reagents also performed less well than the manufacturers claimed, but the worst results were with expired or improperly stored reagents. According to the manufacturers of HIV‐spot and HIV 1+2, the risk of HIV infection would be 0.2 and 0 percent, respectively. However, the risk of contracting HIV through transfusion is at least six times higher than expected.</abstract>
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<titleGroup><title type="main">Risk of iatrogenic human immunodeficiency virus infection through transfusion of blood tested by inappropriately stored or expired rapid antibody assays in a Zambian hospital</title>
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<creators><creator creatorRole="author" xml:id="cr1" noteRef="#fn1"><personName><givenNames>E.C.J.</givenNames>
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<creator creatorRole="author" xml:id="cr2" noteRef="#fn2"><personName><givenNames>J.T.M.</givenNames>
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<creator creatorRole="author" xml:id="cr4" noteRef="#fn4"><personName><givenNames>H.A.</givenNames>
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<familyName>Henny</familyName>
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<abstractGroup><abstract type="main" xml:lang="en"><p>BACKGROUND: The purpose of this study was to estimate the risk of human immunodeficiency virus (HIV) infection via the transfusion of blood tested by inappropriately stored or expired rapid antibody assays in Zambia. STUDY DESIGN AND METHODS: Surgical patients (n = 370) were tested with antibody assays (HIV‐spot and HIV 1+2) that had expired 3 to 6 months previously. Blood donors (n = 211) were tested by inappropriately stored but non‐expired HIV‐spot assay. Serum samples from both groups were retested with enzyme immunoassays, and the seropositivity of samples was confirmed by immunoblotting. RESULTS: Seroprevalence in surgical patients and blood donors was 19.8 and 11.6 percent, respectively. Sensitivity and specificity of HIV‐spot (expired) were 88.2 and 98.1 percent; those of HIV 1+2 (expired) were 82.1 and 94.7 percent; and those of HIV‐spot (non‐expired) were 91.7 and 98.8 percent, respectively. The risk of HIV infection via the transfusion of blood tested by HIV‐spot (expired), HIV‐spot (nonexpired), or HIV 1+2 (expired) was calculated to be 1.4, 1.0, and 3.2 percent, respectively. CONCLUSION: Manufacturers of the HIV‐spot and HIV 1+2 assays claim sensitivity and specificity of 98.8 and 100 percent and 100 and 99.5 percent, respectively. In this study, sensitivity and specificity were 11 to 18 percent lower. Moreover, in‐ date reagents also performed less well than the manufacturers claimed, but the worst results were with expired or improperly stored reagents. According to the manufacturers of HIV‐spot and HIV 1+2, the risk of HIV infection would be 0.2 and 0 percent, respectively. However, the risk of contracting HIV through transfusion is at least six times higher than expected.</p>
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<p>E.C.J. Consten, MD, Surgery Resident, Department of Surgery (G4–105), Academic Medical Centre, Meibergdreef 9,1105 AZ Amsterdam, the Netherlands. [No reprints available]</p>
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<note xml:id="fn2"><label>2</label>
<p>J.T.M. van der Meer, MD, Associate Professor, Subdivision of Infectious Diseases, Tropical Medicine and AIDS, Department of Internal Medicine, Academic Medical Centre.</p>
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<p>F. de Wolf, MD, Associate Professor, Laboratory of Human Retrovirology, Academic Medical Centre.</p>
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<note xml:id="fn4"><label>4</label>
<p>H.A. Heij, MD, Associate Professor, Department of Paediatric Surgery, Academic Medical Centre; current address: Superintendant, St. Francis Hospital, Katete, Zambia.</p>
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<p>P.C. Henny, MD, Associate Professor, Department of Anaesthesiology, Academic Medical Centre.</p>
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<p>J.J. B. van Lanschot, MD, Associate Professor, Department of Surgery, Academic Medical Centre.</p>
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<abstract lang="en">BACKGROUND: The purpose of this study was to estimate the risk of human immunodeficiency virus (HIV) infection via the transfusion of blood tested by inappropriately stored or expired rapid antibody assays in Zambia. STUDY DESIGN AND METHODS: Surgical patients (n = 370) were tested with antibody assays (HIV‐spot and HIV 1+2) that had expired 3 to 6 months previously. Blood donors (n = 211) were tested by inappropriately stored but non‐expired HIV‐spot assay. Serum samples from both groups were retested with enzyme immunoassays, and the seropositivity of samples was confirmed by immunoblotting. RESULTS: Seroprevalence in surgical patients and blood donors was 19.8 and 11.6 percent, respectively. Sensitivity and specificity of HIV‐spot (expired) were 88.2 and 98.1 percent; those of HIV 1+2 (expired) were 82.1 and 94.7 percent; and those of HIV‐spot (non‐expired) were 91.7 and 98.8 percent, respectively. The risk of HIV infection via the transfusion of blood tested by HIV‐spot (expired), HIV‐spot (nonexpired), or HIV 1+2 (expired) was calculated to be 1.4, 1.0, and 3.2 percent, respectively. CONCLUSION: Manufacturers of the HIV‐spot and HIV 1+2 assays claim sensitivity and specificity of 98.8 and 100 percent and 100 and 99.5 percent, respectively. In this study, sensitivity and specificity were 11 to 18 percent lower. Moreover, in‐ date reagents also performed less well than the manufacturers claimed, but the worst results were with expired or improperly stored reagents. According to the manufacturers of HIV‐spot and HIV 1+2, the risk of HIV infection would be 0.2 and 0 percent, respectively. However, the risk of contracting HIV through transfusion is at least six times higher than expected.</abstract>
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