Cervical dysplasia and HIV type 1 infection in African pregnant women: a cross sectional study, Kigali, Rwanda. The Pregnancy and HIV Study Group (EGE).
Identifieur interne : 002486 ( Istex/Corpus ); précédent : 002485; suivant : 002487Cervical dysplasia and HIV type 1 infection in African pregnant women: a cross sectional study, Kigali, Rwanda. The Pregnancy and HIV Study Group (EGE).
Auteurs : V. Leroy ; J. Ladner ; A. De Clercq ; A. Meheus ; M. Nyiraziraje ; E. Karita ; F. DabisSource :
- Sexually Transmitted Infections [ 1368-4973 ] ; 1999-04.
English descriptors
- KwdEn :
- African women, Antenatal care, Antenatal clinic, Bethesda system, Cell count, Centre hospitalier, Cervical, Cervical abnormalities, Cervical cancer, Cervical carcinoma, Cervical dysplasia, Chlamydia trachomatis, Clercq, Cohort, Educational level, Family planning clinics, Grade lesions, High prevalence, Hospitalier, Human papillomavirus, Human papillomavirus infection, Human virus infections, Kigali, Ladner, Last trimester, Leroy, Marital status, National aids control program, Papanicolaou, Papanicolaou smear, Papanicolaou smears, Papillomavirus, Pregnancy outcome, Pregnant women, Prospective cohort study, Reference group, Risk factors, Rwanda, Sexual partners, Sils, Smear, Std, Study group, Study sample, Trichomonas vaginalis, Victor segalen bordeaux.
- Teeft :
- African women, Antenatal care, Antenatal clinic, Bethesda system, Cell count, Centre hospitalier, Cervical, Cervical abnormalities, Cervical cancer, Cervical carcinoma, Cervical dysplasia, Chlamydia trachomatis, Clercq, Cohort, Educational level, Family planning clinics, Grade lesions, High prevalence, Hospitalier, Human papillomavirus, Human papillomavirus infection, Human virus infections, Kigali, Ladner, Last trimester, Leroy, Marital status, National aids control program, Papanicolaou, Papanicolaou smear, Papanicolaou smears, Papillomavirus, Pregnancy outcome, Pregnant women, Prospective cohort study, Reference group, Risk factors, Rwanda, Sexual partners, Sils, Smear, Std, Study group, Study sample, Trichomonas vaginalis, Victor segalen bordeaux.
Abstract
OBJECTIVE: To study the prevalence of cervical squamous intraepithelial lesions (SILs) and their association with HIV-1 infection and immunodeficiency among pregnant women in Kigali, Rwanda. METHODS: As part of a cohort study on the impact of HIV-1 infection on pregnancy outcome, HIV-1 seropositive (HIV+) and seronegative (HIV-) pregnant women were enrolled during the last trimester of pregnancy at the maternity ward of the Centre Hospitalier de Kigali from July 1992 to August 1993. At inclusion, women were screened for sexually transmitted diseases (STDs)--syphilis, Neisseria gonorrhoeae, chlamydia trachomatis, Trichomonas vaginalis. CD4+ lymphocyte counts were measured and a Papanicolaou smear performed. RESULTS: Papanicolaou smear was interpretable in 103 HIV+ women and 107 HIV- women. Prevalence of SILs was significantly higher in HIV+ women than in HIV- women: 24.3% v 6.5% (odds ratio = 4.6; 95% CI: 1.8-12.3). SIL+ women (n = 32) tended to have more STDs than SIL- women (n = 178), but this did not reach a statistical difference: 37.5% and 24.7% respectively (p = 0.13). They also had a mean CD4 count significantly lower than SIL- women (623 and 784 CD4+ cells x 10(6)/l, respectively; p = 0.02). CONCLUSION: SILs were HIV related and the association with immunosuppression was statistically significant. Prevalence of SILs was high in this population of pregnant women with high HIV/STDs prevalence. Screening policy for STDs and SILs in African women should be assessed in prenatal care.
Url:
DOI: 10.1136/sti.75.2.103
Links to Exploration step
ISTEX:715520D67FC0EA42E43F4D22DFE45CB98413D7C5Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cervical dysplasia and HIV type 1 infection in African pregnant women: a cross sectional study, Kigali, Rwanda. The Pregnancy and HIV Study Group (EGE).</title><author><name sortKey="Leroy, V" sort="Leroy, V" uniqKey="Leroy V" first="V" last="Leroy">V. Leroy</name><affiliation><mods:affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</mods:affiliation></affiliation></author><author><name sortKey="Ladner, J" sort="Ladner, J" uniqKey="Ladner J" first="J" last="Ladner">J. Ladner</name><affiliation><mods:affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</mods:affiliation></affiliation></author><author><name sortKey="De Clercq, A" sort="De Clercq, A" uniqKey="De Clercq A" first="A" last="De Clercq">A. De Clercq</name><affiliation><mods:affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</mods:affiliation></affiliation></author><author><name sortKey="Meheus, A" sort="Meheus, A" uniqKey="Meheus A" first="A" last="Meheus">A. Meheus</name><affiliation><mods:affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</mods:affiliation></affiliation></author><author><name sortKey="Nyiraziraje, M" sort="Nyiraziraje, M" uniqKey="Nyiraziraje M" first="M" last="Nyiraziraje">M. Nyiraziraje</name><affiliation><mods:affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</mods:affiliation></affiliation></author><author><name sortKey="Karita, E" sort="Karita, E" uniqKey="Karita E" first="E" last="Karita">E. Karita</name><affiliation><mods:affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</mods:affiliation></affiliation></author><author><name sortKey="Dabis, F" sort="Dabis, F" uniqKey="Dabis F" first="F" last="Dabis">F. Dabis</name><affiliation><mods:affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:715520D67FC0EA42E43F4D22DFE45CB98413D7C5</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1136/sti.75.2.103</idno><idno type="url">https://api.istex.fr/document/715520D67FC0EA42E43F4D22DFE45CB98413D7C5/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002486</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002486</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cervical dysplasia and HIV type 1 infection in African pregnant women: a cross sectional study, Kigali, Rwanda. The Pregnancy and HIV Study Group (EGE).</title><author><name sortKey="Leroy, V" sort="Leroy, V" uniqKey="Leroy V" first="V" last="Leroy">V. Leroy</name><affiliation><mods:affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</mods:affiliation></affiliation></author><author><name sortKey="Ladner, J" sort="Ladner, J" uniqKey="Ladner J" first="J" last="Ladner">J. Ladner</name><affiliation><mods:affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</mods:affiliation></affiliation></author><author><name sortKey="De Clercq, A" sort="De Clercq, A" uniqKey="De Clercq A" first="A" last="De Clercq">A. De Clercq</name><affiliation><mods:affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</mods:affiliation></affiliation></author><author><name sortKey="Meheus, A" sort="Meheus, A" uniqKey="Meheus A" first="A" last="Meheus">A. Meheus</name><affiliation><mods:affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</mods:affiliation></affiliation></author><author><name sortKey="Nyiraziraje, M" sort="Nyiraziraje, M" uniqKey="Nyiraziraje M" first="M" last="Nyiraziraje">M. Nyiraziraje</name><affiliation><mods:affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</mods:affiliation></affiliation></author><author><name sortKey="Karita, E" sort="Karita, E" uniqKey="Karita E" first="E" last="Karita">E. Karita</name><affiliation><mods:affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</mods:affiliation></affiliation></author><author><name sortKey="Dabis, F" sort="Dabis, F" uniqKey="Dabis F" first="F" last="Dabis">F. Dabis</name><affiliation><mods:affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Sexually Transmitted Infections</title><title level="j" type="abbrev">Sex Transm Infect</title><idno type="ISSN">1368-4973</idno><idno type="eISSN">1472-3263</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="1999-04">1999-04</date><biblScope unit="volume">75</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="103">103</biblScope><biblScope unit="page">103-6</biblScope></imprint><idno type="ISSN">1368-4973</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1368-4973</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>African women</term><term>Antenatal care</term><term>Antenatal clinic</term><term>Bethesda system</term><term>Cell count</term><term>Centre hospitalier</term><term>Cervical</term><term>Cervical abnormalities</term><term>Cervical cancer</term><term>Cervical carcinoma</term><term>Cervical dysplasia</term><term>Chlamydia trachomatis</term><term>Clercq</term><term>Cohort</term><term>Educational level</term><term>Family planning clinics</term><term>Grade lesions</term><term>High prevalence</term><term>Hospitalier</term><term>Human papillomavirus</term><term>Human papillomavirus infection</term><term>Human virus infections</term><term>Kigali</term><term>Ladner</term><term>Last trimester</term><term>Leroy</term><term>Marital status</term><term>National aids control program</term><term>Papanicolaou</term><term>Papanicolaou smear</term><term>Papanicolaou smears</term><term>Papillomavirus</term><term>Pregnancy outcome</term><term>Pregnant women</term><term>Prospective cohort study</term><term>Reference group</term><term>Risk factors</term><term>Rwanda</term><term>Sexual partners</term><term>Sils</term><term>Smear</term><term>Std</term><term>Study group</term><term>Study sample</term><term>Trichomonas vaginalis</term><term>Victor segalen bordeaux</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>African women</term><term>Antenatal care</term><term>Antenatal clinic</term><term>Bethesda system</term><term>Cell count</term><term>Centre hospitalier</term><term>Cervical</term><term>Cervical abnormalities</term><term>Cervical cancer</term><term>Cervical carcinoma</term><term>Cervical dysplasia</term><term>Chlamydia trachomatis</term><term>Clercq</term><term>Cohort</term><term>Educational level</term><term>Family planning clinics</term><term>Grade lesions</term><term>High prevalence</term><term>Hospitalier</term><term>Human papillomavirus</term><term>Human papillomavirus infection</term><term>Human virus infections</term><term>Kigali</term><term>Ladner</term><term>Last trimester</term><term>Leroy</term><term>Marital status</term><term>National aids control program</term><term>Papanicolaou</term><term>Papanicolaou smear</term><term>Papanicolaou smears</term><term>Papillomavirus</term><term>Pregnancy outcome</term><term>Pregnant women</term><term>Prospective cohort study</term><term>Reference group</term><term>Risk factors</term><term>Rwanda</term><term>Sexual partners</term><term>Sils</term><term>Smear</term><term>Std</term><term>Study group</term><term>Study sample</term><term>Trichomonas vaginalis</term><term>Victor segalen bordeaux</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECTIVE: To study the prevalence of cervical squamous intraepithelial lesions (SILs) and their association with HIV-1 infection and immunodeficiency among pregnant women in Kigali, Rwanda. METHODS: As part of a cohort study on the impact of HIV-1 infection on pregnancy outcome, HIV-1 seropositive (HIV+) and seronegative (HIV-) pregnant women were enrolled during the last trimester of pregnancy at the maternity ward of the Centre Hospitalier de Kigali from July 1992 to August 1993. At inclusion, women were screened for sexually transmitted diseases (STDs)--syphilis, Neisseria gonorrhoeae, chlamydia trachomatis, Trichomonas vaginalis. CD4+ lymphocyte counts were measured and a Papanicolaou smear performed. RESULTS: Papanicolaou smear was interpretable in 103 HIV+ women and 107 HIV- women. Prevalence of SILs was significantly higher in HIV+ women than in HIV- women: 24.3% v 6.5% (odds ratio = 4.6; 95% CI: 1.8-12.3). SIL+ women (n = 32) tended to have more STDs than SIL- women (n = 178), but this did not reach a statistical difference: 37.5% and 24.7% respectively (p = 0.13). They also had a mean CD4 count significantly lower than SIL- women (623 and 784 CD4+ cells x 10(6)/l, respectively; p = 0.02). CONCLUSION: SILs were HIV related and the association with immunosuppression was statistically significant. Prevalence of SILs was high in this population of pregnant women with high HIV/STDs prevalence. Screening policy for STDs and SILs in African women should be assessed in prenatal care.</div></front></TEI><istex><corpusName>bmj</corpusName><keywords><teeft><json:string>cervical</json:string><json:string>kigali</json:string><json:string>sils</json:string><json:string>rwanda</json:string><json:string>pregnant women</json:string><json:string>papillomavirus</json:string><json:string>ladner</json:string><json:string>cohort</json:string><json:string>std</json:string><json:string>centre hospitalier</json:string><json:string>clercq</json:string><json:string>hospitalier</json:string><json:string>cervical dysplasia</json:string><json:string>papanicolaou smear</json:string><json:string>papanicolaou</json:string><json:string>cell count</json:string><json:string>african women</json:string><json:string>human papillomavirus</json:string><json:string>study group</json:string><json:string>smear</json:string><json:string>educational level</json:string><json:string>trichomonas vaginalis</json:string><json:string>chlamydia trachomatis</json:string><json:string>pregnancy outcome</json:string><json:string>prospective cohort study</json:string><json:string>marital status</json:string><json:string>risk factors</json:string><json:string>cervical cancer</json:string><json:string>sexual partners</json:string><json:string>antenatal care</json:string><json:string>human papillomavirus infection</json:string><json:string>leroy</json:string><json:string>bethesda system</json:string><json:string>grade lesions</json:string><json:string>reference group</json:string><json:string>cervical carcinoma</json:string><json:string>victor segalen bordeaux</json:string><json:string>national aids control program</json:string><json:string>study sample</json:string><json:string>human virus infections</json:string><json:string>last trimester</json:string><json:string>family planning clinics</json:string><json:string>cervical abnormalities</json:string><json:string>antenatal clinic</json:string><json:string>papanicolaou smears</json:string><json:string>high prevalence</json:string></teeft></keywords><author><json:item><name>V Leroy</name><affiliations><json:string>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</json:string></affiliations></json:item><json:item><name>J Ladner</name><affiliations><json:string>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</json:string></affiliations></json:item><json:item><name>A De Clercq</name><affiliations><json:string>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</json:string></affiliations></json:item><json:item><name>A Meheus</name><affiliations><json:string>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</json:string></affiliations></json:item><json:item><name>M Nyiraziraje</name><affiliations><json:string>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</json:string></affiliations></json:item><json:item><name>E Karita</name><affiliations><json:string>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</json:string></affiliations></json:item><json:item><name>F Dabis</name><affiliations><json:string>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Journal Article</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Research Support, Non-U.S. Gov't</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>abstract</json:string></originalGenre><abstract>OBJECTIVE: To study the prevalence of cervical squamous intraepithelial lesions (SILs) and their association with HIV-1 infection and immunodeficiency among pregnant women in Kigali, Rwanda. METHODS: As part of a cohort study on the impact of HIV-1 infection on pregnancy outcome, HIV-1 seropositive (HIV+) and seronegative (HIV-) pregnant women were enrolled during the last trimester of pregnancy at the maternity ward of the Centre Hospitalier de Kigali from July 1992 to August 1993. At inclusion, women were screened for sexually transmitted diseases (STDs)--syphilis, Neisseria gonorrhoeae, chlamydia trachomatis, Trichomonas vaginalis. CD4+ lymphocyte counts were measured and a Papanicolaou smear performed. RESULTS: Papanicolaou smear was interpretable in 103 HIV+ women and 107 HIV- women. Prevalence of SILs was significantly higher in HIV+ women than in HIV- women: 24.3% v 6.5% (odds ratio = 4.6; 95% CI: 1.8-12.3). SIL+ women (n = 32) tended to have more STDs than SIL- women (n = 178), but this did not reach a statistical difference: 37.5% and 24.7% respectively (p = 0.13). They also had a mean CD4 count significantly lower than SIL- women (623 and 784 CD4+ cells x 10(6)/l, respectively; p = 0.02). CONCLUSION: SILs were HIV related and the association with immunosuppression was statistically significant. Prevalence of SILs was high in this population of pregnant women with high HIV/STDs prevalence. Screening policy for STDs and SILs in African women should be assessed in prenatal care.</abstract><qualityIndicators><score>5.319</score><pdfVersion>1.1</pdfVersion><pdfPageSize>595 x 842 pts (A4)</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>2</keywordCount><abstractCharCount>1510</abstractCharCount><pdfWordCount>2535</pdfWordCount><pdfCharCount>16742</pdfCharCount><pdfPageCount>4</pdfPageCount><abstractWordCount>232</abstractWordCount></qualityIndicators><title>Cervical dysplasia and HIV type 1 infection in African pregnant women: a cross sectional study, Kigali, Rwanda. The Pregnancy and HIV Study Group (EGE).</title><pmid><json:string>10448362</json:string></pmid><genre><json:string>abstract</json:string></genre><host><title>Sexually Transmitted Infections</title><language><json:string>unknown</json:string></language><issn><json:string>1368-4973</json:string></issn><eissn><json:string>1472-3263</json:string></eissn><volume>75</volume><issue>2</issue><pages><first>103</first></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>infectious diseases</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>public health & health services</json:string><json:string>public health</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string><json:string>gynecologie. andrologie. obstetrique</json:string></inist></categories><publicationDate>1999</publicationDate><copyrightDate>1999</copyrightDate><doi><json:string>10.1136/sti.75.2.103</json:string></doi><id>715520D67FC0EA42E43F4D22DFE45CB98413D7C5</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/715520D67FC0EA42E43F4D22DFE45CB98413D7C5/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/715520D67FC0EA42E43F4D22DFE45CB98413D7C5/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/715520D67FC0EA42E43F4D22DFE45CB98413D7C5/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Cervical dysplasia and HIV type 1 infection in African pregnant women: a cross sectional study, Kigali, Rwanda. The Pregnancy and HIV Study Group (EGE).</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://publisher-list.data.istex.fr">BMJ Publishing Group Ltd</publisher><availability><licence><p>© British Medical Journal Publishing Group</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-7M42M2QJ-2">bmj</p></availability><date>1999-04-01</date></publicationStmt><notesStmt><note type="abstract" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-HPN7T1Q2-R">abstract</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Cervical dysplasia and HIV type 1 infection in African pregnant women: a cross sectional study, Kigali, Rwanda. The Pregnancy and HIV Study Group (EGE).</title><author xml:id="author-0000"><persName><forename type="first">V</forename><surname>Leroy</surname></persName><affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">J</forename><surname>Ladner</surname></persName><affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</affiliation></author><author xml:id="author-0002"><persName><forename type="first">A</forename><surname>De Clercq</surname></persName><affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</affiliation></author><author xml:id="author-0003"><persName><forename type="first">A</forename><surname>Meheus</surname></persName><affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</affiliation></author><author xml:id="author-0004"><persName><forename type="first">M</forename><surname>Nyiraziraje</surname></persName><affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</affiliation></author><author xml:id="author-0005"><persName><forename type="first">E</forename><surname>Karita</surname></persName><affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</affiliation></author><author xml:id="author-0006"><persName><forename type="first">F</forename><surname>Dabis</surname></persName><affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</affiliation></author><idno type="istex">715520D67FC0EA42E43F4D22DFE45CB98413D7C5</idno><idno type="ark">ark:/67375/NVC-T28RDRKW-V</idno><idno type="DOI">10.1136/sti.75.2.103</idno><idno type="href">sextrans-75-103.pdf</idno><idno type="PMID">10448362</idno><idno type="local">sextrans;75/2/103</idno></analytic><monogr><title level="j">Sexually Transmitted Infections</title><title level="j" type="abbrev">Sex Transm Infect</title><idno type="pISSN">1368-4973</idno><idno type="eISSN">1472-3263</idno><idno type="PublisherID-hwp">sextrans</idno><idno type="PublisherID-nlm-ta">Sex Transm Infect</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="1999-04"></date><biblScope unit="volume">75</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="103">103</biblScope><biblScope unit="page">103-6</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1999-04-01</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>OBJECTIVE: To study the prevalence of cervical squamous intraepithelial lesions (SILs) and their association with HIV-1 infection and immunodeficiency among pregnant women in Kigali, Rwanda. METHODS: As part of a cohort study on the impact of HIV-1 infection on pregnancy outcome, HIV-1 seropositive (HIV+) and seronegative (HIV-) pregnant women were enrolled during the last trimester of pregnancy at the maternity ward of the Centre Hospitalier de Kigali from July 1992 to August 1993. At inclusion, women were screened for sexually transmitted diseases (STDs)--syphilis, Neisseria gonorrhoeae, chlamydia trachomatis, Trichomonas vaginalis. CD4+ lymphocyte counts were measured and a Papanicolaou smear performed. RESULTS: Papanicolaou smear was interpretable in 103 HIV+ women and 107 HIV- women. Prevalence of SILs was significantly higher in HIV+ women than in HIV- women: 24.3% v 6.5% (odds ratio = 4.6; 95% CI: 1.8-12.3). SIL+ women (n = 32) tended to have more STDs than SIL- women (n = 178), but this did not reach a statistical difference: 37.5% and 24.7% respectively (p = 0.13). They also had a mean CD4 count significantly lower than SIL- women (623 and 784 CD4+ cells x 10(6)/l, respectively; p = 0.02). CONCLUSION: SILs were HIV related and the association with immunosuppression was statistically significant. Prevalence of SILs was high in this population of pregnant women with high HIV/STDs prevalence. Screening policy for STDs and SILs in African women should be assessed in prenatal care.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>pubmed-pt</head><item><term>Journal Article</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>pubmed-pt</head><item><term>Research Support, Non-U.S. Gov't</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999-04-01">Created</change><change when="1999-04">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-10-17">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/715520D67FC0EA42E43F4D22DFE45CB98413D7C5/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="abstract" xml:lang="EN"><front><journal-meta><journal-id journal-id-type="hwp">sextrans</journal-id><journal-id journal-id-type="nlm-ta">Sex Transm Infect</journal-id><journal-title>Sexually Transmitted Infections</journal-title><abbrev-journal-title abbrev-type="publisher">Sex Transm Infect</abbrev-journal-title><abbrev-journal-title abbrev-type="medline">Sex Transm Infect</abbrev-journal-title><issn pub-type="ppub">1368-4973</issn><issn pub-type="epub">1472-3263</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">10448362</article-id><article-id pub-id-type="other">sextrans;75/2/103</article-id><article-id pub-id-type="doi">10.1136/sti.75.2.103</article-id><article-id pub-id-type="other">103</article-id><article-id pub-id-type="other">sti.75.2.103</article-id><article-categories><subj-group subj-group-type="pubmed-pt"><subject>Journal Article</subject></subj-group><subj-group subj-group-type="pubmed-pt"><subject>Research Support, Non-U.S. Gov't</subject></subj-group></article-categories><title-group><article-title>Cervical dysplasia and HIV type 1 infection in African pregnant women: a cross sectional study, Kigali, Rwanda. The Pregnancy and HIV Study Group (EGE).</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Leroy</surname><given-names>V</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Ladner</surname><given-names>J</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>De Clercq</surname><given-names>A</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Meheus</surname><given-names>A</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Nyiraziraje</surname><given-names>M</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Karita</surname><given-names>E</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Dabis</surname><given-names>F</given-names></name></contrib></contrib-group><aff>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</aff><pub-date pub-type="ppub"><month>Apr</month><year>1999</year></pub-date><pub-date pub-type="epub"><day>1</day><month>4</month><year>1999</year></pub-date><volume>75</volume><volume-id pub-id-type="other">75</volume-id><volume-id pub-id-type="other">75</volume-id><issue>2</issue><issue-id pub-id-type="other">sextrans;75/2</issue-id><issue-id pub-id-type="other">2</issue-id><issue-id pub-id-type="other">75/2</issue-id><fpage>103</fpage><page-range>103-6</page-range><self-uri content-type="pdf" xlink:role="full-text" xlink:href="sextrans-75-103.pdf"></self-uri><abstract><p>OBJECTIVE: To study the prevalence of cervical squamous intraepithelial lesions (SILs) and their association with HIV-1 infection and immunodeficiency among pregnant women in Kigali, Rwanda. METHODS: As part of a cohort study on the impact of HIV-1 infection on pregnancy outcome, HIV-1 seropositive (HIV+) and seronegative (HIV-) pregnant women were enrolled during the last trimester of pregnancy at the maternity ward of the Centre Hospitalier de Kigali from July 1992 to August 1993. At inclusion, women were screened for sexually transmitted diseases (STDs)--syphilis, Neisseria gonorrhoeae, chlamydia trachomatis, Trichomonas vaginalis. CD4+ lymphocyte counts were measured and a Papanicolaou smear performed. RESULTS: Papanicolaou smear was interpretable in 103 HIV+ women and 107 HIV- women. Prevalence of SILs was significantly higher in HIV+ women than in HIV- women: 24.3% v 6.5% (odds ratio = 4.6; 95% CI: 1.8-12.3). SIL+ women (n = 32) tended to have more STDs than SIL- women (n = 178), but this did not reach a statistical difference: 37.5% and 24.7% respectively (p = 0.13). They also had a mean CD4 count significantly lower than SIL- women (623 and 784 CD4+ cells x 10(6)/l, respectively; p = 0.02). CONCLUSION: SILs were HIV related and the association with immunosuppression was statistically significant. Prevalence of SILs was high in this population of pregnant women with high HIV/STDs prevalence. Screening policy for STDs and SILs in African women should be assessed in prenatal care.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Cervical dysplasia and HIV type 1 infection in African pregnant women: a cross sectional study, Kigali, Rwanda. The Pregnancy and HIV Study Group (EGE).</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Cervical dysplasia and HIV type 1 infection in African pregnant women: a cross sectional study, Kigali, Rwanda. The Pregnancy and HIV Study Group (EGE).</title></titleInfo><name type="personal"><namePart type="given">V</namePart><namePart type="family">Leroy</namePart><affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Ladner</namePart><affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">De Clercq</namePart><affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Meheus</namePart><affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Nyiraziraje</namePart><affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Karita</namePart><affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Dabis</namePart><affiliation>INSERM U 330, Université Victor Segalen Bordeaux 2, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="abstract" displayLabel="abstract" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-HPN7T1Q2-R">abstract</genre><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">1999-04</dateIssued><dateCreated encoding="w3cdtf">1999-04-01</dateCreated><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">OBJECTIVE: To study the prevalence of cervical squamous intraepithelial lesions (SILs) and their association with HIV-1 infection and immunodeficiency among pregnant women in Kigali, Rwanda. METHODS: As part of a cohort study on the impact of HIV-1 infection on pregnancy outcome, HIV-1 seropositive (HIV+) and seronegative (HIV-) pregnant women were enrolled during the last trimester of pregnancy at the maternity ward of the Centre Hospitalier de Kigali from July 1992 to August 1993. At inclusion, women were screened for sexually transmitted diseases (STDs)--syphilis, Neisseria gonorrhoeae, chlamydia trachomatis, Trichomonas vaginalis. CD4+ lymphocyte counts were measured and a Papanicolaou smear performed. RESULTS: Papanicolaou smear was interpretable in 103 HIV+ women and 107 HIV- women. Prevalence of SILs was significantly higher in HIV+ women than in HIV- women: 24.3% v 6.5% (odds ratio = 4.6; 95% CI: 1.8-12.3). SIL+ women (n = 32) tended to have more STDs than SIL- women (n = 178), but this did not reach a statistical difference: 37.5% and 24.7% respectively (p = 0.13). They also had a mean CD4 count significantly lower than SIL- women (623 and 784 CD4+ cells x 10(6)/l, respectively; p = 0.02). CONCLUSION: SILs were HIV related and the association with immunosuppression was statistically significant. Prevalence of SILs was high in this population of pregnant women with high HIV/STDs prevalence. Screening policy for STDs and SILs in African women should be assessed in prenatal care.</abstract><relatedItem type="host"><titleInfo><title>Sexually Transmitted Infections</title></titleInfo><titleInfo type="abbreviated"><title>Sex Transm Infect</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>pubmed-pt</genre><topic>Journal Article</topic></subject><subject><genre>pubmed-pt</genre><topic>Research Support, Non-U.S. Gov't</topic></subject><identifier type="ISSN">1368-4973</identifier><identifier type="eISSN">1472-3263</identifier><identifier type="PublisherID-hwp">sextrans</identifier><identifier type="PublisherID-nlm-ta">Sex Transm Infect</identifier><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>75</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>103</start><list>103-6</list></extent></part></relatedItem><identifier type="istex">715520D67FC0EA42E43F4D22DFE45CB98413D7C5</identifier><identifier type="ark">ark:/67375/NVC-T28RDRKW-V</identifier><identifier type="DOI">10.1136/sti.75.2.103</identifier><identifier type="href">sextrans-75-103.pdf</identifier><identifier type="PMID">10448362</identifier><identifier type="local">sextrans;75/2/103</identifier><accessCondition type="use and reproduction" contentType="copyright">© British Medical Journal Publishing Group</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-7M42M2QJ-2">bmj</recordContentSource><recordOrigin>© British Medical Journal Publishing Group</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/715520D67FC0EA42E43F4D22DFE45CB98413D7C5/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002486 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 002486 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= SidaSubSaharaV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:715520D67FC0EA42E43F4D22DFE45CB98413D7C5
|texte= Cervical dysplasia and HIV type 1 infection in African pregnant women: a cross sectional study, Kigali, Rwanda. The Pregnancy and HIV Study Group (EGE).
}}
| This area was generated with Dilib version V0.6.32. |  |