Fresh from the field: some controversies in tropical medicine and hygiene
Identifieur interne : 001163 ( Istex/Corpus ); précédent : 001162; suivant : 001164Fresh from the field: some controversies in tropical medicine and hygiene
Auteurs : Neil French ; Charles F. GilksSource :
- Transactions of The Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2000-05.
English descriptors
- KwdEn :
Abstract
Malaria and human immunodeficiency virus (HIV) infections are common, widespread and overlapping problems in the tropics. Despite this there has been minimal evidence to support an important interaction, other than during pregnancy in multigravid HIV-infected women. The lack of an interaction in other groups is surprising, and would be unexpected based on present knowledge of anti-malarial immunity. However, most of the reported studies have been cross-sectional and performed in selected groups, making their findings difficult to interpret. Two cohort studies in children were similarly inconclusive, although both hinted at a decreased ability to control parasitaemia with more advanced HIV-disease. Recent work from Entebbe carried out in a well-characterized cohort of HIV-infected adults revealed an increase in malarial fever with deteriorating immune status. Rates by CD4+ T-cell count groups >500, 200–499 and <200 cells/μL were 45, 73 and 115 cases per 1000 person-years respectively, P < 0·01 for trend. These findings support an important interaction between HIV and malaria. The public health consequences and the relevance of these findings outwith Entebbe are uncertain. The importance of understanding this interaction further must be a priority for sub-Saharan Africa: consequently further studies designed primarily to answer these questions will be necessary. Meanwhile, the optimism that the global malaria situation was largely unaffected by the HIV pandemic may need to be reconsidered.
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DOI: 10.1016/S0035-9203(00)90301-8
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ISTEX:36C1621B24226DAF16E943C7FBB48E575D4ADA8FLe document en format XML
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Despite this there has been minimal evidence to support an important interaction, other than during pregnancy in multigravid HIV-infected women. The lack of an interaction in other groups is surprising, and would be unexpected based on present knowledge of anti-malarial immunity. However, most of the reported studies have been cross-sectional and performed in selected groups, making their findings difficult to interpret. Two cohort studies in children were similarly inconclusive, although both hinted at a decreased ability to control parasitaemia with more advanced HIV-disease. Recent work from Entebbe carried out in a well-characterized cohort of HIV-infected adults revealed an increase in malarial fever with deteriorating immune status. Rates by CD4+ T-cell count groups >500, 200–499 and <200 cells/μL were 45, 73 and 115 cases per 1000 person-years respectively, P < 0·01 for trend. These findings support an important interaction between HIV and malaria. The public health consequences and the relevance of these findings outwith Entebbe are uncertain. The importance of understanding this interaction further must be a priority for sub-Saharan Africa: consequently further studies designed primarily to answer these questions will be necessary. Meanwhile, the optimism that the global malaria situation was largely unaffected by the HIV pandemic may need to be reconsidered.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Neil French</name><affiliations><json:string>Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK</json:string><json:string>E-mail: nfrenc@aol.com</json:string></affiliations></json:item><json:item><name>Charles F. 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However, most of the reported studies have been cross-sectional and performed in selected groups, making their findings difficult to interpret. Two cohort studies in children were similarly inconclusive, although both hinted at a decreased ability to control parasitaemia with more advanced HIV-disease. Recent work from Entebbe carried out in a well-characterized cohort of HIV-infected adults revealed an increase in malarial fever with deteriorating immune status. Rates by CD4+ T-cell count groups >500, 200–499 and >200 cells/μL were 45, 73 and 115 cases per 1000 person-years respectively, P > 0·01 for trend. These findings support an important interaction between HIV and malaria. The public health consequences and the relevance of these findings outwith Entebbe are uncertain. The importance of understanding this interaction further must be a priority for sub-Saharan Africa: consequently further studies designed primarily to answer these questions will be necessary. 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The public health consequences and the relevance of these findings outwith Entebbe are uncertain. The importance of understanding this interaction further must be a priority for sub-Saharan Africa: consequently further studies designed primarily to answer these questions will be necessary. 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<article-title>Fresh from the field: some controversies in tropical medicine and hygiene</article-title>
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<author-notes>
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<label>∗</label>Author for correspondence: phone +44 (0)151 708 9393, fax +44 (0) 151 707 9193. <email>nfrenc@aol.com</email></corresp></author-notes>
<pub-date pub-type="ppub">
<month>5</month>
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<year>2000</year></date></history>
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<abstract>
<p>Malaria and human immunodeficiency virus (HIV) infections are common, widespread and overlapping problems in the tropics. Despite this there has been minimal evidence to support an important interaction, other than during pregnancy in multigravid HIV-infected women. The lack of an interaction in other groups is surprising, and would be unexpected based on present knowledge of anti-malarial immunity. However, most of the reported studies have been cross-sectional and performed in selected groups, making their findings difficult to interpret. Two cohort studies in children were similarly inconclusive, although both hinted at a decreased ability to control parasitaemia with more advanced HIV-disease. Recent work from Entebbe carried out in a well-characterized cohort of HIV-infected adults revealed an increase in malarial fever with deteriorating immune status. Rates by CD4+ T-cell count groups >500, 200–499 and <200 cells/μL were 45, 73 and 115 cases per 1000 person-years respectively, <italic>P</italic> < 0·01 for trend. These findings support an important interaction between HIV and malaria. The public health consequences and the relevance of these findings outwith Entebbe are uncertain. The importance of understanding this interaction further must be a priority for sub-Saharan Africa: consequently further studies designed primarily to answer these questions will be necessary. Meanwhile, the optimism that the global malaria situation was largely unaffected by the HIV pandemic may need to be reconsidered.</p></abstract>
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<title>Keywords</title>
<kwd>HIV</kwd>
<kwd>malaria</kwd>
<kwd>clinical disease</kwd>
<kwd>Africa</kwd></kwd-group>
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<ref-list>
<title>References</title>
<ref id="BIB1">
<label>Allen et al., 1991</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Allen</surname>
<given-names>S.</given-names></name>
<name>
<surname>van de Perre</surname>
<given-names>P.</given-names></name>
<name>
<surname>Serufilira</surname>
<given-names>A.</given-names></name>
<name>
<surname>Lepage</surname>
<given-names>P.</given-names></name>
<name>
<surname>Carael</surname>
<given-names>M.</given-names></name>
<name>
<surname>DeClercq</surname>
<given-names>A.</given-names></name>
<name>
<surname>Tice</surname>
<given-names>J.</given-names></name>
<name>
<surname>Black</surname>
<given-names>D.</given-names></name>
<name>
<surname>Nsengumuremyi</surname>
<given-names>F.</given-names></name>
<name>
<surname>Ziegler</surname>
<given-names>J.</given-names></name>
</person-group>
<article-title>Human immunodeficiency virus and malaria in a representative sample of childbearing women in Kigali, Rwanda</article-title>
<source>Journal of Infectious Diseases</source>
<year>1991</year>
<volume>164</volume>
<fpage>67</fpage>
<lpage>71</lpage>
</nlm-citation>
</ref>
<ref id="BIB2">
<label>Atzori et al., 1993</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Atzori</surname>
<given-names>C.</given-names></name>
<name>
<surname>Bruno</surname>
<given-names>A.</given-names></name>
<name>
<surname>Chichino</surname>
<given-names>G.</given-names></name>
<name>
<surname>Cevini</surname>
<given-names>C.</given-names></name>
<name>
<surname>Bernuzzi</surname>
<given-names>A.M.</given-names></name>
<name>
<surname>Gatti</surname>
<given-names>S.</given-names></name>
<name>
<surname>Comolli</surname>
<given-names>G.</given-names></name>
<name>
<surname>Scaglia</surname>
<given-names>M.</given-names></name>
</person-group>
<article-title>HIV-1 and parasitic infections in rural Tanzania</article-title>
<source>Annals of Tropical Medicine and Parasitology</source>
<year>1993</year>
<volume>87</volume>
<fpage>585</fpage>
<lpage>593</lpage>
</nlm-citation>
</ref>
<ref id="BIB3">
<label>Bloland et al., 1995</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Bloland</surname>
<given-names>P.B.</given-names></name>
<name>
<surname>Wirima</surname>
<given-names>J.J.</given-names></name>
<name>
<surname>Steketee</surname>
<given-names>R.W.</given-names></name>
<name>
<surname>Chilima</surname>
<given-names>B.</given-names></name>
<name>
<surname>Hightower</surname>
<given-names>A.</given-names></name>
<name>
<surname>Breman</surname>
<given-names>J.G.</given-names></name>
</person-group>
<article-title>Maternal HIV infection and infant mortality in Malawi: evidence for increased mortality due to placental malaria infection</article-title>
<source>AIDS</source>
<year>1995</year>
<volume>9</volume>
<fpage>721</fpage>
<lpage>726</lpage>
</nlm-citation>
</ref>
<ref id="BIB4">
<label>Chintu et al., 1995</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Chintu</surname>
<given-names>C.</given-names></name>
<name>
<surname>Luo</surname>
<given-names>C.</given-names></name>
<name>
<surname>Bhat</surname>
<given-names>G.</given-names></name>
<name>
<surname>DuPont</surname>
<given-names>H.L.</given-names></name>
<name>
<surname>Mwansa-Salamu</surname>
<given-names>P.</given-names></name>
<name>
<surname>Kabika</surname>
<given-names>M.</given-names></name>
<name>
<surname>Zumla</surname>
<given-names>A.</given-names></name>
</person-group>
<article-title>Impact of the human immunodeficiency virus type-1 on common pediatric illnesses in Zambia</article-title>
<source>Journal of Tropical Pediatrics</source>
<year>1995</year>
<volume>41</volume>
<fpage>348</fpage>
<lpage>353</lpage>
</nlm-citation>
</ref>
<ref id="BIB5">
<label>Colebunders et al., 1990</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Colebunders</surname>
<given-names>R.</given-names></name>
<name>
<surname>Bahwe</surname>
<given-names>Y.</given-names></name>
<name>
<surname>Nekwei</surname>
<given-names>W.</given-names></name>
<name>
<surname>Ryder</surname>
<given-names>R.</given-names></name>
<name>
<surname>Perriens</surname>
<given-names>J.</given-names></name>
<name>
<surname>Nsimba</surname>
<given-names>K.</given-names></name>
<name>
<surname>Turner</surname>
<given-names>A.</given-names></name>
<name>
<surname>Francis</surname>
<given-names>H.</given-names></name>
<name>
<surname>Lebughe</surname>
<given-names>I.</given-names></name>
<name>
<surname>van der Stuyft</surname>
<given-names>P.</given-names></name>
</person-group>
<article-title>Incidence of malaria and efficacy of oral quinine in patients recently infected with human immunodeficiency virus in Kinshasa, Zaire</article-title>
<source>Journal of Infection</source>
<year>1990</year>
<volume>21</volume>
<fpage>167</fpage>
<lpage>173</lpage>
</nlm-citation>
</ref>
<ref id="BIB6">
<label>Elliott et al., 1990</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Elliott</surname>
<given-names>A.M.</given-names></name>
<name>
<surname>Luo</surname>
<given-names>N.</given-names></name>
<name>
<surname>Tembo</surname>
<given-names>G.</given-names></name>
<name>
<surname>Halwiindi</surname>
<given-names>B.</given-names></name>
<name>
<surname>Steenbergen</surname>
<given-names>G.</given-names></name>
<name>
<surname>Machiels</surname>
<given-names>L.</given-names></name>
<name>
<surname>Pobee</surname>
<given-names>J.</given-names></name>
<name>
<surname>Nunn</surname>
<given-names>P.</given-names></name>
<name>
<surname>Hayes</surname>
<given-names>R.J.</given-names></name>
<name>
<surname>McAdam</surname>
<given-names>K.P.</given-names></name>
</person-group>
<article-title>Impact of HIV on tuberculosis in Zambia: a cross sectional study</article-title>
<source>British Medical Journal</source>
<year>1990</year>
<volume>301</volume>
<fpage>412</fpage>
<lpage>415</lpage>
</nlm-citation>
</ref>
<ref id="BIB7">
<label>French et al., 1998</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>French</surname>
<given-names>N.</given-names></name>
<name>
<surname>Gilks</surname>
<given-names>C.F.</given-names></name>
<name>
<surname>Mujugira</surname>
<given-names>A.</given-names></name>
<name>
<surname>Fasching</surname>
<given-names>C.</given-names></name>
<name>
<surname>O'Brien</surname>
<given-names>J.</given-names></name>
<name>
<surname>Janoff</surname>
<given-names>E.N.</given-names></name>
</person-group>
<article-title>Pneumococcal vaccination in HIV-1-infected adults in Uganda: humoral response and two vaccine failures</article-title>
<source>AIDS</source>
<year>1998</year>
<volume>12</volume>
<fpage>1683</fpage>
<lpage>1689</lpage>
</nlm-citation>
</ref>
<ref id="BIB8">
<label>French et al., 2000</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>French</surname>
<given-names>N.</given-names></name>
<name>
<surname>Nakiyingi</surname>
<given-names>J.</given-names></name>
<name>
<surname>Carpenter</surname>
<given-names>L.</given-names></name>
<name>
<surname>Lugadda</surname>
<given-names>E.</given-names></name>
<name>
<surname>Watera</surname>
<given-names>C.</given-names></name>
<name>
<surname>Moore</surname>
<given-names>M.</given-names></name>
<name>
<surname>Moi</surname>
<given-names>K.</given-names></name>
<name>
<surname>Mulder</surname>
<given-names>D.</given-names></name>
<name>
<surname>Antvelink</surname>
<given-names>D.</given-names></name>
<name>
<surname>Janoff</surname>
<given-names>E.</given-names></name>
<name>
<surname>Whitworth</surname>
<given-names>J.</given-names></name>
<name>
<surname>Gilks</surname>
<given-names>C.F.</given-names></name>
</person-group>
<article-title>A double-blind randomised and placebo controlled trial of 23-valent pneumococcal polysaccharide vaccine in HIV-1-infected Ugandan adults</article-title>
<source>Lancet</source>
<year>2000</year>
<comment>in press</comment>
</nlm-citation>
</ref>
<ref id="BIB9">
<label>Gilks et al., 1990</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Gilks</surname>
<given-names>C.F.</given-names></name>
<name>
<surname>Brindle</surname>
<given-names>R.J.</given-names></name>
<name>
<surname>Otieno</surname>
<given-names>L.S.</given-names></name>
<name>
<surname>Simani</surname>
<given-names>P.M.</given-names></name>
<name>
<surname>Newnham</surname>
<given-names>R.S.</given-names></name>
<name>
<surname>Bhatt</surname>
<given-names>S.M.</given-names></name>
<name>
<surname>Lule</surname>
<given-names>G.N.</given-names></name>
<name>
<surname>Okelo</surname>
<given-names>G.B.</given-names></name>
<name>
<surname>Watkins</surname>
<given-names>W.M.</given-names></name>
<name>
<surname>Waiyaki</surname>
<given-names>P.G.</given-names></name>
</person-group>
<article-title>Life-threatening bacteraemia in HIV-1 seropositive adults admitted to hospital in Nairobi, Kenya</article-title>
<source>Lancet</source>
<year>1990</year>
<volume>336</volume>
<fpage>545</fpage>
<lpage>549</lpage>
</nlm-citation>
</ref>
<ref id="BIB10">
<label>Gilks et al., 1992</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Gilks</surname>
<given-names>C.F.</given-names></name>
<name>
<surname>Otieno</surname>
<given-names>L.S.</given-names></name>
<name>
<surname>Brindle</surname>
<given-names>R.J.</given-names></name>
<name>
<surname>Newnham</surname>
<given-names>R.S.</given-names></name>
<name>
<surname>Lule</surname>
<given-names>G.N.</given-names></name>
<name>
<surname>Were</surname>
<given-names>J.B.O.</given-names></name>
<name>
<surname>Simani</surname>
<given-names>P.M.</given-names></name>
<name>
<surname>Bhatt</surname>
<given-names>S.M.</given-names></name>
<name>
<surname>Okelo</surname>
<given-names>G.B.</given-names></name>
<name>
<surname>Waiyaki</surname>
<given-names>P.G.</given-names></name>
<name>
<surname>Warrell</surname>
<given-names>D.A.</given-names></name>
</person-group>
<article-title>The presentation and outcome of HIV-related disease in Nairobi</article-title>
<source>Quarterly Journal of Medicine</source>
<year>1992</year>
<volume>297</volume>
<fpage>25</fpage>
<lpage>32</lpage>
</nlm-citation>
</ref>
<ref id="BIB11">
<label>Gilks et al., 1996</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Gilks</surname>
<given-names>C.F.</given-names></name>
<name>
<surname>Ojoo</surname>
<given-names>S.A.</given-names></name>
<name>
<surname>Ojoo</surname>
<given-names>J.C.</given-names></name>
<name>
<surname>Brindle</surname>
<given-names>R.J.</given-names></name>
<name>
<surname>Paul</surname>
<given-names>J.</given-names></name>
<name>
<surname>Batchelor</surname>
<given-names>B.I.</given-names></name>
<name>
<surname>Kimari</surname>
<given-names>J.N.</given-names></name>
<name>
<surname>Newnham</surname>
<given-names>R.</given-names></name>
<name>
<surname>Bwayo</surname>
<given-names>J.</given-names></name>
<name>
<surname>Plummer</surname>
<given-names>F.A.</given-names></name>
<name>
<surname>Warrell</surname>
<given-names>D.A.</given-names></name>
</person-group>
<article-title>Invasive pneumococcal disease in a cohort of predominantly HIV-1 infected female sex-workers in Nairobi, Kenya</article-title>
<source>Lancet</source>
<year>1996</year>
<volume>347</volume>
<fpage>718</fpage>
<lpage>723</lpage>
</nlm-citation>
</ref>
<ref id="BIB12">
<label>Greenberg et al., 1991</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Greenberg</surname>
<given-names>A.E.</given-names></name>
<name>
<surname>Nsa</surname>
<given-names>W.</given-names></name>
<name>
<surname>Ryder</surname>
<given-names>R.W.</given-names></name>
<name>
<surname>Medi</surname>
<given-names>M.</given-names></name>
<name>
<surname>Nzeza</surname>
<given-names>M.</given-names></name>
<name>
<surname>Kitadi</surname>
<given-names>N.</given-names></name>
<name>
<surname>Baangi</surname>
<given-names>M.</given-names></name>
<name>
<surname>Malanda</surname>
<given-names>N.</given-names></name>
<name>
<surname>Davachi</surname>
<given-names>F.</given-names></name>
<name>
<surname>Hassig</surname>
<given-names>S.E.</given-names></name>
</person-group>
<article-title><italic>Plasmodium falciparum</italic> malaria and perinatally acquired human immunodeficiency virus type 1 infection in Kinshasa, Zaire. A prospective, longitudinal cohort study of 587 children</article-title>
<source>New England Journal of Medicine</source>
<year>1991</year>
<volume>325</volume>
<fpage>105</fpage>
<lpage>109</lpage>
</nlm-citation>
</ref>
<ref id="BIB13">
<label>Hoffman et al., 1999</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Hoffman</surname>
<given-names>I.F.</given-names></name>
<name>
<surname>Jere</surname>
<given-names>C.S.</given-names></name>
<name>
<surname>Taylor</surname>
<given-names>T.E.</given-names></name>
<name>
<surname>Munthali</surname>
<given-names>P.</given-names></name>
<name>
<surname>Dyer</surname>
<given-names>J.R.</given-names></name>
<name>
<surname>Wirima</surname>
<given-names>J.J.</given-names></name>
<name>
<surname>Rogerson</surname>
<given-names>S.J.</given-names></name>
<name>
<surname>Kumwenda</surname>
<given-names>N.</given-names></name>
<name>
<surname>Eron</surname>
<given-names>J.J.</given-names></name>
<name>
<surname>Fiscus</surname>
<given-names>S.A.</given-names></name>
<name>
<surname>Chakraborty</surname>
<given-names>H.</given-names></name>
<name>
<surname>Taha</surname>
<given-names>T.E.</given-names></name>
<name>
<surname>Cohen</surname>
<given-names>M.S.</given-names></name>
<name>
<surname>Molyneux</surname>
<given-names>M.E.</given-names></name>
</person-group>
<article-title>The effect of <italic>Plasmodium falciparum</italic> malaria on HIV-1 RNA blood plasma concentration</article-title>
<source>AIDS</source>
<year>1999</year>
<volume>13</volume>
<fpage>487</fpage>
<lpage>494</lpage>
</nlm-citation>
</ref>
<ref id="BIB14">
<label>Kalyesubula et al., 1997</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Kalyesubula</surname>
<given-names>I.</given-names></name>
<name>
<surname>Musoke-Mudido</surname>
<given-names>P.</given-names></name>
<name>
<surname>Marum</surname>
<given-names>L.</given-names></name>
<name>
<surname>Bagenda</surname>
<given-names>D.</given-names></name>
<name>
<surname>Aceng</surname>
<given-names>E.</given-names></name>
<name>
<surname>Ndugwa</surname>
<given-names>C.</given-names></name>
<name>
<surname>Olness</surname>
<given-names>K.</given-names></name>
</person-group>
<article-title>Effects of malaria infection in human immunodeficiency virus type 1-infected Ugandan children</article-title>
<source>Pediatric Infectious Diseases Journal</source>
<year>1997</year>
<volume>16</volume>
<fpage>876</fpage>
<lpage>881</lpage>
</nlm-citation>
</ref>
<ref id="BIB15">
<label>Müller and Moser, 1990</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Müller</surname>
<given-names>O.</given-names></name>
<name>
<surname>Moser</surname>
<given-names>R.</given-names></name>
</person-group>
<article-title>The clinical and parasitological presentation of <italic>Plasmodium falciparum</italic> malaria in Uganda is unaffected by HIV-1 infection</article-title>
<source>Transactions of the Royal Society of Tropical Medicine and Hygiene</source>
<year>1990</year>
<volume>84</volume>
<fpage>336</fpage>
<lpage>338</lpage>
</nlm-citation>
</ref>
<ref id="BIB16">
<label>Nguyen-Dinh et al., 1987</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Nguyen-Dinh</surname>
<given-names>P.</given-names></name>
<name>
<surname>Greenberg</surname>
<given-names>A.E.</given-names></name>
<name>
<surname>Mann</surname>
<given-names>J.M.</given-names></name>
<name>
<surname>Kabote</surname>
<given-names>N.</given-names></name>
<name>
<surname>Francis</surname>
<given-names>H.</given-names></name>
<name>
<surname>Colebunders</surname>
<given-names>R.L.</given-names></name>
<name>
<surname>Huong</surname>
<given-names>A.Y.</given-names></name>
<name>
<surname>Quinn</surname>
<given-names>T.C.</given-names></name>
<name>
<surname>Davachi</surname>
<given-names>F.</given-names></name>
<name>
<surname>Lyamba</surname>
<given-names>B.</given-names></name>
</person-group>
<article-title>Absence of association between <italic>Plasmodium falciparum</italic> malaria and human immunodeficiency virus infection in children in Kinshasa, Zaire</article-title>
<source>Bulletin of the World Health Organization</source>
<year>1987</year>
<volume>65</volume>
<fpage>607</fpage>
<lpage>613</lpage>
</nlm-citation>
</ref>
<ref id="BIB17">
<label>Serwadda et al., 1985</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Serwadda</surname>
<given-names>D.</given-names></name>
<name>
<surname>Mugerwa</surname>
<given-names>R.D.</given-names></name>
<name>
<surname>Sewankambo</surname>
<given-names>N.K.</given-names></name>
<name>
<surname>Lwegaba</surname>
<given-names>A.</given-names></name>
<name>
<surname>Carswell</surname>
<given-names>J.W.</given-names></name>
<name>
<surname>Kirya</surname>
<given-names>G.B.</given-names></name>
<name>
<surname>Bayley</surname>
<given-names>A.C.</given-names></name>
<name>
<surname>Downing</surname>
<given-names>R.G.</given-names></name>
<name>
<surname>Tedder</surname>
<given-names>R.S.</given-names></name>
<name>
<surname>Clayden</surname>
<given-names>S.A.</given-names></name>
</person-group>
<article-title>Slim disease: a new disease in Uganda and its association with HTLV-III infection</article-title>
<source>Lancet</source>
<year>1985</year>
<volume>2</volume>
<fpage>849</fpage>
<lpage>852</lpage>
</nlm-citation>
</ref>
<ref id="BIB18">
<label>Simooya et al., 1988</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Simooya</surname>
<given-names>O.</given-names></name>
<name>
<surname>Mwendapole</surname>
<given-names>R.</given-names></name>
<name>
<surname>Siziya</surname>
<given-names>S.</given-names></name>
<name>
<surname>Fleming</surname>
<given-names>A.</given-names></name>
</person-group>
<article-title>Relationship between falciparum malaria and HIV positivity in Ndola, Zambia</article-title>
<source>British Medical Journal</source>
<year>1988</year>
<volume>297</volume>
<fpage>30</fpage>
<lpage>31</lpage>
</nlm-citation>
</ref>
<ref id="BIB19">
<label>Steketee et al., 1996a</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Steketee</surname>
<given-names>R.W.</given-names></name>
<name>
<surname>Wirima</surname>
<given-names>J.J.</given-names></name>
<name>
<surname>Bloland</surname>
<given-names>P.B.</given-names></name>
<name>
<surname>Chilima</surname>
<given-names>B.</given-names></name>
<name>
<surname>Mermin</surname>
<given-names>J.H.</given-names></name>
<name>
<surname>Chitsulo</surname>
<given-names>L.</given-names></name>
<name>
<surname>Breman</surname>
<given-names>J.G.</given-names></name>
</person-group>
<article-title>Impairment of a pregnant woman's acquired ability to limit <italic>Plasmodium falciparum</italic> by infection with human immunodeficiency virus type-1</article-title>
<source>American Journal of Tropical Medicine and Hygiene</source>
<year>1996</year>
<volume>55</volume>
<fpage>42</fpage>
<lpage>49</lpage>
</nlm-citation>
</ref>
<ref id="BIB20">
<label>Steketee et al., 1996b</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Steketee</surname>
<given-names>R.W.</given-names></name>
<name>
<surname>Wirima</surname>
<given-names>J.J.</given-names></name>
<name>
<surname>Slutsker</surname>
<given-names>L.</given-names></name>
<name>
<surname>Roberts</surname>
<given-names>J.M.</given-names></name>
<name>
<surname>Khoromana</surname>
<given-names>C.O.</given-names></name>
<name>
<surname>Heymann</surname>
<given-names>D.L.</given-names></name>
<name>
<surname>Breman</surname>
<given-names>J.G.</given-names></name>
</person-group>
<article-title>Malaria parasite infection during pregnancy and at delivery in mother, placenta, and newborn: efficacy of chloroquine and mefloquine in rural Malawi</article-title>
<source>American Journal of Tropical Medicine and Hygiene</source>
<year>1996</year>
<volume>55</volume>
<fpage>24</fpage>
<lpage>32</lpage>
</nlm-citation>
</ref>
<ref id="BIB21">
<label>Steketee et al., 1998</label>
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname>Steketee</surname>
<given-names>R.W.</given-names></name>
<name>
<surname>Nahlen</surname>
<given-names>B.D.</given-names></name>
<name>
<surname>Ayisi</surname>
<given-names>J.</given-names></name>
<name>
<surname>Van Eijk</surname>
<given-names>A.</given-names></name>
<name>
<surname>Misore</surname>
<given-names>A.</given-names></name>
</person-group>
<article-title>HIV and malaria overlap and do interact in sub-Saharan African pregnant women</article-title>
<source>Proceedings of the XIIth International Conference on AIDS abstract no. 13298</source>
<year>1998</year>
<fpage>145</fpage>
<comment>Geneva, 28 June–3 July 1998</comment>
</nlm-citation>
</ref>
<ref id="BIB22">
<label>Taha et al., 1994</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Taha</surname>
<given-names>T.E.T.</given-names></name>
<name>
<surname>Canner</surname>
<given-names>J.K.</given-names></name>
<name>
<surname>Dallabetta</surname>
<given-names>G.A.</given-names></name>
<name>
<surname>Chiphangwi</surname>
<given-names>J.D.</given-names></name>
<name>
<surname>Liomba</surname>
<given-names>G.</given-names></name>
<name>
<surname>Wangel</surname>
<given-names>A.M.</given-names></name>
<name>
<surname>Saah</surname>
<given-names>A.J.</given-names></name>
<name>
<surname>Miotti</surname>
<given-names>P.G.</given-names></name>
</person-group>
<article-title>Childhood malaria parasitaemia and human immunodeficiency virus infection in Malawi</article-title>
<source>Transactions of the Royal Society of Tropical Medicine and Hygiene</source>
<year>1994</year>
<volume>88</volume>
<fpage>164</fpage>
<lpage>165</lpage>
</nlm-citation>
</ref>
<ref id="BIB23">
<label>Verhoeff et al., 1999</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname>Verhoeff</surname>
<given-names>F.H.</given-names></name>
<name>
<surname>Brabin</surname>
<given-names>B.J.</given-names></name>
<name>
<surname>Hart</surname>
<given-names>C.A.</given-names></name>
<name>
<surname>Chimsuku</surname>
<given-names>L.</given-names></name>
<name>
<surname>Kazembe</surname>
<given-names>P.</given-names></name>
<name>
<surname>Broadhead</surname>
<given-names>R.L.</given-names></name>
</person-group>
<article-title>Increased prevalence of malaria in HIV-infected pregnant women and its implications for malaria control</article-title>
<source>Tropical Medicine and International Health</source>
<year>1999</year>
<volume>4</volume>
<fpage>5</fpage>
<lpage>12</lpage>
</nlm-citation>
</ref>
</ref-list>
</back>
</article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Fresh from the field: some controversies in tropical medicine and hygiene</title><subTitle>HIV and malaria, do they interact?</subTitle></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Fresh from the field: some controversies in tropical medicine and hygiene</title><subTitle>HIV and malaria, do they interact?</subTitle></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Neil</namePart><namePart type="family">French</namePart><affiliation>Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK</affiliation><affiliation>E-mail: nfrenc@aol.com</affiliation><affiliation>Author for correspondence: phone +44</affiliation><affiliation>E-mail: nfrenc@aol.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Charles F.</namePart><namePart type="family">Gilks</namePart><affiliation>Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Royal Society of Tropical Medicine and Hygiene</publisher><dateIssued encoding="w3cdtf">2000-05</dateIssued><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><abstract>Malaria and human immunodeficiency virus (HIV) infections are common, widespread and overlapping problems in the tropics. Despite this there has been minimal evidence to support an important interaction, other than during pregnancy in multigravid HIV-infected women. The lack of an interaction in other groups is surprising, and would be unexpected based on present knowledge of anti-malarial immunity. However, most of the reported studies have been cross-sectional and performed in selected groups, making their findings difficult to interpret. Two cohort studies in children were similarly inconclusive, although both hinted at a decreased ability to control parasitaemia with more advanced HIV-disease. Recent work from Entebbe carried out in a well-characterized cohort of HIV-infected adults revealed an increase in malarial fever with deteriorating immune status. Rates by CD4+ T-cell count groups >500, 200–499 and <200 cells/μL were 45, 73 and 115 cases per 1000 person-years respectively, P < 0·01 for trend. These findings support an important interaction between HIV and malaria. The public health consequences and the relevance of these findings outwith Entebbe are uncertain. The importance of understanding this interaction further must be a priority for sub-Saharan Africa: consequently further studies designed primarily to answer these questions will be necessary. Meanwhile, the optimism that the global malaria situation was largely unaffected by the HIV pandemic may need to be reconsidered.</abstract><subject lang="en"><genre>Keywords</genre><topic>HIV</topic><topic>malaria</topic><topic>clinical disease</topic><topic>Africa</topic></subject><relatedItem type="host"><titleInfo><title>Transactions of The Royal Society of Tropical Medicine and Hygiene</title></titleInfo><titleInfo type="abbreviated"><title>Trans R Soc Trop Med Hyg</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0035-9203</identifier><identifier type="eISSN">1878-3503</identifier><identifier type="PublisherID">trstmh</identifier><identifier type="PublisherID-hwp">trstmh</identifier><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>94</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>233</start><end>237</end></extent></part></relatedItem><identifier type="istex">36C1621B24226DAF16E943C7FBB48E575D4ADA8F</identifier><identifier type="DOI">10.1016/S0035-9203(00)90301-8</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-GTWS0RDP-M">oup</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/36C1621B24226DAF16E943C7FBB48E575D4ADA8F/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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