Serum nickel, copper and zinc in Norplant users.
Identifieur interne : 000139 ( PubMed/Corpus ); précédent : 000138; suivant : 000140Serum nickel, copper and zinc in Norplant users.
Auteurs : A A Ismail ; M. Toppozada ; M. Zahran ; I. Ghanem ; A. KholeifSource :
- Contraception [ 0010-7824 ] ; 1992.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Copper, Nickel, Progesterone, Zinc.
- Adult, Anovulation, Drug Implants, Female, Humans, Levonorgestrel, Menstruation, Ovulation, Reference Values, Spectrophotometry, Atomic, Time Factors.
Abstract
Changes in serum nickel, copper and zinc were evaluated in 45 Norplant users. Two groups were selected for this study. Group I included 15 regularly menstruating females as controls and as short-term users (90 days after Norplant insertion). Group II included 30 Norplant users for one year or more as long-term users. These elements were determined by atomic absorption spectrophotometry. Serum nickel showed no significant change in short-term nor in long-term users when compared to the control group or to each other. Serum copper and zinc revealed a significant increase in short-term users for a short period of time, which returned to normal levels in long-term users. There was disappearance of the cyclic changes in serum copper and zinc concentrations on comparing their levels in ovulatory to non-ovulatory Norplant users. The use of Norplant has no deleterious effects on serum levels of nickel, copper and zinc.
PubMed: 1617965
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pubmed:1617965Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serum nickel, copper and zinc in Norplant users.</title>
<author><name sortKey="Ismail, A A" sort="Ismail, A A" uniqKey="Ismail A" first="A A" last="Ismail">A A Ismail</name>
<affiliation><nlm:affiliation>Department of Obstetrics and Gynecology, Faculty of Medicine, University of Alexandria, Egypt.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Toppozada, M" sort="Toppozada, M" uniqKey="Toppozada M" first="M" last="Toppozada">M. Toppozada</name>
</author>
<author><name sortKey="Zahran, M" sort="Zahran, M" uniqKey="Zahran M" first="M" last="Zahran">M. Zahran</name>
</author>
<author><name sortKey="Ghanem, I" sort="Ghanem, I" uniqKey="Ghanem I" first="I" last="Ghanem">I. Ghanem</name>
</author>
<author><name sortKey="Kholeif, A" sort="Kholeif, A" uniqKey="Kholeif A" first="A" last="Kholeif">A. Kholeif</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1992">1992</date>
<idno type="RBID">pubmed:1617965</idno>
<idno type="pmid">1617965</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Serum nickel, copper and zinc in Norplant users.</title>
<author><name sortKey="Ismail, A A" sort="Ismail, A A" uniqKey="Ismail A" first="A A" last="Ismail">A A Ismail</name>
<affiliation><nlm:affiliation>Department of Obstetrics and Gynecology, Faculty of Medicine, University of Alexandria, Egypt.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Toppozada, M" sort="Toppozada, M" uniqKey="Toppozada M" first="M" last="Toppozada">M. Toppozada</name>
</author>
<author><name sortKey="Zahran, M" sort="Zahran, M" uniqKey="Zahran M" first="M" last="Zahran">M. Zahran</name>
</author>
<author><name sortKey="Ghanem, I" sort="Ghanem, I" uniqKey="Ghanem I" first="I" last="Ghanem">I. Ghanem</name>
</author>
<author><name sortKey="Kholeif, A" sort="Kholeif, A" uniqKey="Kholeif A" first="A" last="Kholeif">A. Kholeif</name>
</author>
</analytic>
<series><title level="j">Contraception</title>
<idno type="ISSN">0010-7824</idno>
<imprint><date when="1992" type="published">1992</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Anovulation</term>
<term>Copper (blood)</term>
<term>Drug Implants</term>
<term>Female</term>
<term>Humans</term>
<term>Levonorgestrel</term>
<term>Menstruation</term>
<term>Nickel (blood)</term>
<term>Ovulation</term>
<term>Progesterone (blood)</term>
<term>Reference Values</term>
<term>Spectrophotometry, Atomic</term>
<term>Time Factors</term>
<term>Zinc (blood)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Copper</term>
<term>Nickel</term>
<term>Progesterone</term>
<term>Zinc</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Anovulation</term>
<term>Drug Implants</term>
<term>Female</term>
<term>Humans</term>
<term>Levonorgestrel</term>
<term>Menstruation</term>
<term>Ovulation</term>
<term>Reference Values</term>
<term>Spectrophotometry, Atomic</term>
<term>Time Factors</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Changes in serum nickel, copper and zinc were evaluated in 45 Norplant users. Two groups were selected for this study. Group I included 15 regularly menstruating females as controls and as short-term users (90 days after Norplant insertion). Group II included 30 Norplant users for one year or more as long-term users. These elements were determined by atomic absorption spectrophotometry. Serum nickel showed no significant change in short-term nor in long-term users when compared to the control group or to each other. Serum copper and zinc revealed a significant increase in short-term users for a short period of time, which returned to normal levels in long-term users. There was disappearance of the cyclic changes in serum copper and zinc concentrations on comparing their levels in ovulatory to non-ovulatory Norplant users. The use of Norplant has no deleterious effects on serum levels of nickel, copper and zinc.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1617965</PMID>
<DateCreated><Year>1992</Year>
<Month>08</Month>
<Day>03</Day>
</DateCreated>
<DateCompleted><Year>1992</Year>
<Month>08</Month>
<Day>03</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0010-7824</ISSN>
<JournalIssue CitedMedium="Print"><Volume>45</Volume>
<Issue>6</Issue>
<PubDate><Year>1992</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>Contraception</Title>
<ISOAbbreviation>Contraception</ISOAbbreviation>
</Journal>
<ArticleTitle>Serum nickel, copper and zinc in Norplant users.</ArticleTitle>
<Pagination><MedlinePgn>561-72</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Changes in serum nickel, copper and zinc were evaluated in 45 Norplant users. Two groups were selected for this study. Group I included 15 regularly menstruating females as controls and as short-term users (90 days after Norplant insertion). Group II included 30 Norplant users for one year or more as long-term users. These elements were determined by atomic absorption spectrophotometry. Serum nickel showed no significant change in short-term nor in long-term users when compared to the control group or to each other. Serum copper and zinc revealed a significant increase in short-term users for a short period of time, which returned to normal levels in long-term users. There was disappearance of the cyclic changes in serum copper and zinc concentrations on comparing their levels in ovulatory to non-ovulatory Norplant users. The use of Norplant has no deleterious effects on serum levels of nickel, copper and zinc.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ismail</LastName>
<ForeName>A A</ForeName>
<Initials>AA</Initials>
<AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, Faculty of Medicine, University of Alexandria, Egypt.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Toppozada</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zahran</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ghanem</LastName>
<ForeName>I</ForeName>
<Initials>I</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kholeif</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Author>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Contraception</MedlineTA>
<NlmUniqueID>0234361</NlmUniqueID>
<ISSNLinking>0010-7824</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004343">Drug Implants</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>4G7DS2Q64Y</RegistryNumber>
<NameOfSubstance UI="D011374">Progesterone</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>5W7SIA7YZW</RegistryNumber>
<NameOfSubstance UI="D016912">Levonorgestrel</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>789U1901C5</RegistryNumber>
<NameOfSubstance UI="D003300">Copper</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>7OV03QG267</RegistryNumber>
<NameOfSubstance UI="D009532">Nickel</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>J41CSQ7QDS</RegistryNumber>
<NameOfSubstance UI="D015032">Zinc</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CitationSubset>J</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000858" MajorTopicYN="N">Anovulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003300" MajorTopicYN="N">Copper</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004343" MajorTopicYN="N">Drug Implants</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016912" MajorTopicYN="Y">Levonorgestrel</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008598" MajorTopicYN="N">Menstruation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009532" MajorTopicYN="N">Nickel</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010060" MajorTopicYN="N">Ovulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011374" MajorTopicYN="N">Progesterone</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012016" MajorTopicYN="N">Reference Values</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013054" MajorTopicYN="N">Spectrophotometry, Atomic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015032" MajorTopicYN="N">Zinc</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="PIP">073661</OtherID>
<OtherID Source="POP">00213070</OtherID>
<OtherAbstract Type="PIP" Language="eng"><AbstractText>Serum nickel, copper, and zinc levels were monitored by atomic absorption spectrophotometry in 15 women in the proliferative and luteal phases of their cycles before beginning Norplant contraception and 3 months later, and in 30 users of Norplant for 1 year or more. Serum nickel did not change significantly in short or longterm Norplant users in comparison with before Norplant self-controls or between groups, ranging from 0.221 to 0.28 mcg.dl. Serum copper rose from 100.07 mcg.dl in new users on Cycle Day 5 to 110.86 in ovulating women and 123.5 in nonovulating women in the control cycle. Copper was 118.7 before Norplant and not significantly different at 120.87 after 3 months. Copper levels were 104.26 in the 1st sample in longterm users, rising to 129.14 and 126.5 in ovulating and non-ovulating longterm users 3 months later. Zinc averaged 121.1 mcg/dl before Norplant on Day 5, falling to 94.86 and 97.38 in ovulating and nonovulating women in the luteal phase. Zinc rose slightly from 118.9 to 125.27 before and after 3 months on Norplant. Zinc fell from 107.9 to 91.86 and 94.61 in ovulating and nonovulating longterm users. The similarities and differences of these results with prior reports of trace element in oral and injectable contraceptive users are discussed.</AbstractText>
</OtherAbstract>
<KeywordList Owner="PIP"><Keyword MajorTopicYN="N">Africa</Keyword>
<Keyword MajorTopicYN="N">Arab Countries</Keyword>
<Keyword MajorTopicYN="N">Biology</Keyword>
<Keyword MajorTopicYN="N">Contraception</Keyword>
<Keyword MajorTopicYN="Y">Contraceptive Implants</Keyword>
<Keyword MajorTopicYN="N">Contraceptive Methods</Keyword>
<Keyword MajorTopicYN="Y">Copper</Keyword>
<Keyword MajorTopicYN="N">Developing Countries</Keyword>
<Keyword MajorTopicYN="N">Egypt</Keyword>
<Keyword MajorTopicYN="N">Family Planning</Keyword>
<Keyword MajorTopicYN="Y">Hematological Effects</Keyword>
<Keyword MajorTopicYN="N">Hemic System</Keyword>
<Keyword MajorTopicYN="N">Ingredients And Chemicals</Keyword>
<Keyword MajorTopicYN="N">Inorganic Chemicals</Keyword>
<Keyword MajorTopicYN="N">Mediterranean Countries</Keyword>
<Keyword MajorTopicYN="Y">Menstrual Cycle</Keyword>
<Keyword MajorTopicYN="N">Menstruation</Keyword>
<Keyword MajorTopicYN="N">Metals</Keyword>
<Keyword MajorTopicYN="Y">Nickel</Keyword>
<Keyword MajorTopicYN="N">Northern Africa</Keyword>
<Keyword MajorTopicYN="N">Physiology</Keyword>
<Keyword MajorTopicYN="N">Reproduction</Keyword>
<Keyword MajorTopicYN="Y">Research Report</Keyword>
<Keyword MajorTopicYN="Y">Zinc</Keyword>
</KeywordList>
<GeneralNote Owner="PIP">TJ: CONTRACEPTION.</GeneralNote>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1992</Year>
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