Serveur d'exploration sur le nickel au Maghreb

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Substitution effects of a carbonated hydroxyapatite biomaterial against intoxication chloride nickel-exposed rats.

Identifieur interne : 000028 ( PubMed/Checkpoint ); précédent : 000027; suivant : 000029

Substitution effects of a carbonated hydroxyapatite biomaterial against intoxication chloride nickel-exposed rats.

Auteurs : Salha Boulila [Tunisie] ; Abdelfattah Elfeki ; Hassane Oudadesse ; Hafed Elfeki

Source :

RBID : pubmed:25560666

English descriptors

Abstract

This study aimed to investigate the potential effects of a synthetic apatite (carbonated hydroxyapatite) on the detoxification of a group of male "Wistar" rats exposed to nickel chloride.

DOI: 10.3109/15376516.2014.1003358
PubMed: 25560666


Affiliations:


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pubmed:25560666

Le document en format XML

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<term>Biocompatible Materials (administration & dosage)</term>
<term>Biocompatible Materials (chemistry)</term>
<term>Biocompatible Materials (therapeutic use)</term>
<term>Bone and Bones (drug effects)</term>
<term>Bone and Bones (metabolism)</term>
<term>Carbonates (administration & dosage)</term>
<term>Carbonates (chemistry)</term>
<term>Carbonates (therapeutic use)</term>
<term>Chemical Phenomena</term>
<term>Chemical and Drug Induced Liver Injury (etiology)</term>
<term>Chemical and Drug Induced Liver Injury (prevention & control)</term>
<term>Drug Implants</term>
<term>Hydroxyapatites (administration & dosage)</term>
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<term>Biocompatible Materials</term>
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<term>Nickel</term>
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<term>Biocompatible Materials</term>
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<term>Hydroxyapatites</term>
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<term>Bone and Bones</term>
<term>Lipid Peroxidation</term>
<term>Tissue Distribution</term>
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<term>Chemical and Drug Induced Liver Injury</term>
<term>Renal Insufficiency</term>
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<div type="abstract" xml:lang="en">This study aimed to investigate the potential effects of a synthetic apatite (carbonated hydroxyapatite) on the detoxification of a group of male "Wistar" rats exposed to nickel chloride.</div>
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<DateCreated>
<Year>2015</Year>
<Month>05</Month>
<Day>27</Day>
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<DateCompleted>
<Year>2016</Year>
<Month>02</Month>
<Day>17</Day>
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<Day>25</Day>
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<ISSN IssnType="Electronic">1537-6524</ISSN>
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<Volume>25</Volume>
<Issue>3</Issue>
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<Year>2015</Year>
<Month>Mar</Month>
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<Title>Toxicology mechanisms and methods</Title>
<ISOAbbreviation>Toxicol. Mech. Methods</ISOAbbreviation>
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<ArticleTitle>Substitution effects of a carbonated hydroxyapatite biomaterial against intoxication chloride nickel-exposed rats.</ArticleTitle>
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<AbstractText Label="AIMS" NlmCategory="OBJECTIVE">This study aimed to investigate the potential effects of a synthetic apatite (carbonated hydroxyapatite) on the detoxification of a group of male "Wistar" rats exposed to nickel chloride.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Toxicity was evaluated by rats' bioassay of nickel chloride. Wistar rats received this metal daily by gavage for seven days (4 mg/ml nickel chloride/200 g body weight, BW). To detoxify this organism, a subcutaneous implantation of the apatite is made.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The results revealed that exposure to nickel induced oxidative stress, disorders in the balances of ferric phosphocalcic, renal failures, liver toxicity and significant increase in nickel rates in the bones of intoxicated rats. The application of the carbonated hydroxyapatite presented in this study restored those disorders back to normal. The synthetic apatite protected the rats against the toxic effects of nickel by lowering the levels of lipid peroxidation markers and improving the activities of defense enzymes. It also amended ferric and phosphocalcic equilibriums, protected liver and kidney functions and reduced the nickel rate in the bones of the rats. Overall, the results provided strong support for the protective role of carbonated hydroxyapatite in the detoxification of rats exposed to nickel. Those beneficial effects were further confirmed by physico-chemical characterization (X-ray diffraction and infrared spectroscopy), which revealed its property of anionic and cationic substitution, thus supporting its promising candidacy for future biomedical application.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The hydroxyapatite is an effective biomaterial to solve health problems, particularly detoxification against metals (nickel).</AbstractText>
</Abstract>
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<LastName>Boulila</LastName>
<ForeName>Salha</ForeName>
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<Affiliation>Faculty of Sciences of Sfax, Laboratory of Animal Ecophysiology, University of Sfax , Sfax , Tunisia .</Affiliation>
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<LastName>Oudadesse</LastName>
<ForeName>Hassane</ForeName>
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<Day>30</Day>
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<DescriptorName UI="D051437" MajorTopicYN="N">Renal Insufficiency</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D066007" MajorTopicYN="N">Toxicokinetics</DescriptorName>
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</MeshHeadingList>
<KeywordList Owner="NOTNLM">
<Keyword MajorTopicYN="N">Biomaterial</Keyword>
<Keyword MajorTopicYN="N">implantation</Keyword>
<Keyword MajorTopicYN="N">intoxication</Keyword>
<Keyword MajorTopicYN="N">metal</Keyword>
<Keyword MajorTopicYN="N">rats</Keyword>
</KeywordList>
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<PublicationStatus>ppublish</PublicationStatus>
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