NickelMaghrebV1, PascalFrancis, Curation, bibRecord, 000230

Protective effect of cactus (Opuntia flcus indica) cladode extract upon nickel-induced toxicity in rats

Identifieur interne : 000230 ( PascalFrancis/Curation ); précédent : 000229; suivant : 000231

Protective effect of cactus (Opuntia flcus indica) cladode extract upon nickel-induced toxicity in rats

Auteurs : Najla Hfaiedh [Tunisie] ; MOHAMED SALAH ALLAGUI [Tunisie] ; Mbarka Hfaiedh [Tunisie] ; ABDELFATTAH EL FEKI [Tunisie] ; Lazhar Zourgui [Tunisie] ; Francoise Croute [France]

Source :

Food and chemical toxicology [ 0278-6915 ] ; 2008.

RBID : Pascal:09-0077701

Descripteurs français

Pascal (Inist)
- Facteur de protection, Extrait, Nickel, Toxicité, Animal, Rat, Ficus, Antioxydant, Enzyme, Cholestérol, Triglycéride.
Wicri :
- topic : Nickel, Enzyme.

English descriptors

KwdEn :
- Animal, Antioxidant, Cholesterol, Enzyme, Extract, Ficus, Nickel, Protective factor, Rat, Toxicity, Triglyceride.

Abstract

The purpose of this study carried out on male Wistar rats, was to evaluate the protective effects of regular ingestion of juice from the prickly pear cactus (Opuntia ficus indica) cladodes against nickel chloride toxicity. Rats were given either normal tap water or water containing 25% of cactus juice for one month. Then, rats of each group were injected daily, for 10 days, with either NiCl₂ solution (4 mg (30 μmol)/kg body weight) or with the same volume of saline solution (300 mM NaCl). Significant increases of lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase activities and of cholesterol, triglycerides and glucose levels were observed in blood of nickel-treated rats. In the liver, nickel chloride was found to induce an oxidative stress evidenced by an increase in lipid peroxidation and changes in antioxidant enzymes activities. Superoxide-dismutase (SOD) activity was found to be increased whereas glutathione peroxidase and catalase activities were decreased. These changes did not occur in animals previously given cactus juice, demonstrating a protective effect of this vegetal extract.

A01	`01`	`1`		`@0 0278-6915`
A02	`01`			`@0 FCTOD7`
A03		`1`		`@0 Food chem. toxicol.`
A05				`@2 46`
A06				`@2 12`
A08	`01`	`1`	`ENG`	`@1 Protective effect of cactus (Opuntia flcus indica) cladode extract upon nickel-induced toxicity in rats`
A11	`01`	`1`		`@1 HFAIEDH (Najla)`
A11	`02`	`1`		`@1 MOHAMED SALAH ALLAGUI`
A11	`03`	`1`		`@1 HFAIEDH (Mbarka)`
A11	`04`	`1`		`@1 ABDELFATTAH EL FEKI`
A11	`05`	`1`		`@1 ZOURGUI (Lazhar)`
A11	`06`	`1`		`@1 CROUTE (Francoise)`
A14	`01`			`@1 Unité de recherche Biochimie macromoléculaire et Génétique, Faculté des Sciences @2 2133 Gafsa @3 TUN @Z 1 aut. @Z 3 aut. @Z 5 aut.`
A14	`02`			`@1 Laboratoire d'Ecophysiologie Animale, Faculté des Sciences @2 3018 Sfax @3 TUN @Z 2 aut. @Z 4 aut.`
A14	`03`			`@1 Laboratoire de Biologie Cellulaire et Pollution, Faculté de Médecine Toulouse-Purpan, Université Paul Sabatier @2 Toulouse @3 FRA @Z 6 aut.`
A20				`@1 3759-3763`
A21				`@1 2008`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 10616 @5 354000184562110330`
A44				`@0 0000 @1 © 2009 INIST-CNRS. All rights reserved.`
A45				`@0 3/4 p.`
A47	`01`	`1`		`@0 09-0077701`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Food and chemical toxicology`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 The purpose of this study carried out on male Wistar rats, was to evaluate the protective effects of regular ingestion of juice from the prickly pear cactus (Opuntia ficus indica) cladodes against nickel chloride toxicity. Rats were given either normal tap water or water containing 25% of cactus juice for one month. Then, rats of each group were injected daily, for 10 days, with either NiCl₂ solution (4 mg (30 μmol)/kg body weight) or with the same volume of saline solution (300 mM NaCl). Significant increases of lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase activities and of cholesterol, triglycerides and glucose levels were observed in blood of nickel-treated rats. In the liver, nickel chloride was found to induce an oxidative stress evidenced by an increase in lipid peroxidation and changes in antioxidant enzymes activities. Superoxide-dismutase (SOD) activity was found to be increased whereas glutathione peroxidase and catalase activities were decreased. These changes did not occur in animals previously given cactus juice, demonstrating a protective effect of this vegetal extract.
C02	`01`	`X`		`@0 002B03L05`
C03	`01`	`X`	`FRE`	`@0 Facteur de protection @5 02`
C03	`01`	`X`	`ENG`	`@0 Protective factor @5 02`
C03	`01`	`X`	`SPA`	`@0 Factor protector @5 02`
C03	`02`	`X`	`FRE`	`@0 Extrait @5 03`
C03	`02`	`X`	`ENG`	`@0 Extract @5 03`
C03	`02`	`X`	`SPA`	`@0 Extracto @5 03`
C03	`03`	`X`	`FRE`	`@0 Nickel @2 NC @2 FX @5 05`
C03	`03`	`X`	`ENG`	`@0 Nickel @2 NC @2 FX @5 05`
C03	`03`	`X`	`SPA`	`@0 Niquel @2 NC @2 FX @5 05`
C03	`04`	`X`	`FRE`	`@0 Toxicité @5 06`
C03	`04`	`X`	`ENG`	`@0 Toxicity @5 06`
C03	`04`	`X`	`SPA`	`@0 Toxicidad @5 06`
C03	`05`	`X`	`FRE`	`@0 Animal @5 08`
C03	`05`	`X`	`ENG`	`@0 Animal @5 08`
C03	`05`	`X`	`SPA`	`@0 Animal @5 08`
C03	`06`	`X`	`FRE`	`@0 Rat @5 09`
C03	`06`	`X`	`ENG`	`@0 Rat @5 09`
C03	`06`	`X`	`SPA`	`@0 Rata @5 09`
C03	`07`	`X`	`FRE`	`@0 Ficus @2 NS @5 11`
C03	`07`	`X`	`ENG`	`@0 Ficus @2 NS @5 11`
C03	`07`	`X`	`SPA`	`@0 Ficus @2 NS @5 11`
C03	`08`	`X`	`FRE`	`@0 Antioxydant @5 12`
C03	`08`	`X`	`ENG`	`@0 Antioxidant @5 12`
C03	`08`	`X`	`SPA`	`@0 Antioxidante @5 12`
C03	`09`	`X`	`FRE`	`@0 Enzyme @2 FE @5 16`
C03	`09`	`X`	`ENG`	`@0 Enzyme @2 FE @5 16`
C03	`09`	`X`	`SPA`	`@0 Enzima @2 FE @5 16`
C03	`10`	`X`	`FRE`	`@0 Cholestérol @2 NK @5 17`
C03	`10`	`X`	`ENG`	`@0 Cholesterol @2 NK @5 17`
C03	`10`	`X`	`SPA`	`@0 Colesterol @2 NK @5 17`
C03	`11`	`X`	`FRE`	`@0 Triglycéride @5 18`
C03	`11`	`X`	`ENG`	`@0 Triglyceride @5 18`
C03	`11`	`X`	`SPA`	`@0 Triglicérido @5 18`
C07	`01`	`X`	`FRE`	`@0 Rodentia @2 NS`
C07	`01`	`X`	`ENG`	`@0 Rodentia @2 NS`
C07	`01`	`X`	`SPA`	`@0 Rodentia @2 NS`
C07	`02`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`SPA`	`@0 Vertebrata @2 NS`
C07	`04`	`X`	`FRE`	`@0 Moraceae @2 NS`
C07	`04`	`X`	`ENG`	`@0 Moraceae @2 NS`
C07	`04`	`X`	`SPA`	`@0 Moraceae @2 NS`
C07	`05`	`X`	`FRE`	`@0 Dicotyledones @2 NS`
C07	`05`	`X`	`ENG`	`@0 Dicotyledones @2 NS`
C07	`05`	`X`	`SPA`	`@0 Dicotyledones @2 NS`
C07	`06`	`X`	`FRE`	`@0 Angiospermae @2 NS`
C07	`06`	`X`	`ENG`	`@0 Angiospermae @2 NS`
C07	`06`	`X`	`SPA`	`@0 Angiospermae @2 NS`
C07	`07`	`X`	`FRE`	`@0 Spermatophyta @2 NS`
C07	`07`	`X`	`ENG`	`@0 Spermatophyta @2 NS`
C07	`07`	`X`	`SPA`	`@0 Spermatophyta @2 NS`
C07	`08`	`X`	`FRE`	`@0 Métal transition @2 NC @5 61`
C07	`08`	`X`	`ENG`	`@0 Transition metal @2 NC @5 61`
C07	`08`	`X`	`SPA`	`@0 Metal transición @2 NC @5 61`
C07	`09`	`X`	`FRE`	`@0 Plante ligneuse @5 62`
C07	`09`	`X`	`ENG`	`@0 Woody plant @5 62`
C07	`09`	`X`	`SPA`	`@0 Planta leñosa @5 62`
C07	`10`	`X`	`FRE`	`@0 Lipide @5 63`
C07	`10`	`X`	`ENG`	`@0 Lipids @5 63`
C07	`10`	`X`	`SPA`	`@0 Lípido @5 63`
N21				`@1 061`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Links toward previous steps (curation, corpus...)

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Pascal:09-0077701

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Protective effect of cactus (Opuntia flcus indica) cladode extract upon nickel-induced toxicity in rats</title>
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<sZ>1 aut.</sZ>
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<author><name sortKey="Mohamed Salah Allagui" sort="Mohamed Salah Allagui" uniqKey="Mohamed Salah Allagui" last="Mohamed Salah Allagui">MOHAMED SALAH ALLAGUI</name>
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<term>Nickel</term>
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<front><div type="abstract" xml:lang="en">The purpose of this study carried out on male Wistar rats, was to evaluate the protective effects of regular ingestion of juice from the prickly pear cactus (Opuntia ficus indica) cladodes against nickel chloride toxicity. Rats were given either normal tap water or water containing 25% of cactus juice for one month. Then, rats of each group were injected daily, for 10 days, with either NiCl<sub>2</sub>
 solution (4 mg (30 μmol)/kg body weight) or with the same volume of saline solution (300 mM NaCl). Significant increases of lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase activities and of cholesterol, triglycerides and glucose levels were observed in blood of nickel-treated rats. In the liver, nickel chloride was found to induce an oxidative stress evidenced by an increase in lipid peroxidation and changes in antioxidant enzymes activities. Superoxide-dismutase (SOD) activity was found to be increased whereas glutathione peroxidase and catalase activities were decreased. These changes did not occur in animals previously given cactus juice, demonstrating a protective effect of this vegetal extract.</div>
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<fA14 i1="01"><s1>Unité de recherche Biochimie macromoléculaire et Génétique, Faculté des Sciences</s1>
<s2>2133 Gafsa</s2>
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<sZ>4 aut.</sZ>
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<fA14 i1="03"><s1>Laboratoire de Biologie Cellulaire et Pollution, Faculté de Médecine Toulouse-Purpan, Université Paul Sabatier</s1>
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</fA66>
<fC01 i1="01" l="ENG"><s0>The purpose of this study carried out on male Wistar rats, was to evaluate the protective effects of regular ingestion of juice from the prickly pear cactus (Opuntia ficus indica) cladodes against nickel chloride toxicity. Rats were given either normal tap water or water containing 25% of cactus juice for one month. Then, rats of each group were injected daily, for 10 days, with either NiCl<sub>2</sub>
 solution (4 mg (30 μmol)/kg body weight) or with the same volume of saline solution (300 mM NaCl). Significant increases of lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase activities and of cholesterol, triglycerides and glucose levels were observed in blood of nickel-treated rats. In the liver, nickel chloride was found to induce an oxidative stress evidenced by an increase in lipid peroxidation and changes in antioxidant enzymes activities. Superoxide-dismutase (SOD) activity was found to be increased whereas glutathione peroxidase and catalase activities were decreased. These changes did not occur in animals previously given cactus juice, demonstrating a protective effect of this vegetal extract.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B03L05</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Facteur de protection</s0>
<s5>02</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Protective factor</s0>
<s5>02</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Factor protector</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Extrait</s0>
<s5>03</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Extract</s0>
<s5>03</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Extracto</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Nickel</s0>
<s2>NC</s2>
<s2>FX</s2>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Nickel</s0>
<s2>NC</s2>
<s2>FX</s2>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Niquel</s0>
<s2>NC</s2>
<s2>FX</s2>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Toxicité</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Toxicity</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Toxicidad</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Animal</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Animal</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Animal</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Rat</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Rat</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Rata</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Ficus</s0>
<s2>NS</s2>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Ficus</s0>
<s2>NS</s2>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Ficus</s0>
<s2>NS</s2>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Antioxydant</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Antioxidant</s0>
<s5>12</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Antioxidante</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Enzyme</s0>
<s2>FE</s2>
<s5>16</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
<s5>16</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
<s5>16</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Cholestérol</s0>
<s2>NK</s2>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Cholesterol</s0>
<s2>NK</s2>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Colesterol</s0>
<s2>NK</s2>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Triglycéride</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Triglyceride</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Triglicérido</s0>
<s5>18</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Moraceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Moraceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Moraceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Métal transition</s0>
<s2>NC</s2>
<s5>61</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Transition metal</s0>
<s2>NC</s2>
<s5>61</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Metal transición</s0>
<s2>NC</s2>
<s5>61</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Plante ligneuse</s0>
<s5>62</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Woody plant</s0>
<s5>62</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Planta leñosa</s0>
<s5>62</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Lipide</s0>
<s5>63</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Lipids</s0>
<s5>63</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Lípido</s0>
<s5>63</s5>
</fC07>
<fN21><s1>061</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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	Serveur d'exploration sur le nickel au Maghreb
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Serveur d'exploration sur le nickel au Maghreb

Protective effect of cactus (Opuntia flcus indica) cladode extract upon nickel-induced toxicity in rats

Protective effect of cactus (Opuntia flcus indica) cladode extract upon nickel-induced toxicity in rats

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