Nickel Nanoparticles Exposure and Reproductive Toxicity in Healthy Adult Rats
Identifieur interne : 000069 ( Main/Exploration ); précédent : 000068; suivant : 000070Nickel Nanoparticles Exposure and Reproductive Toxicity in Healthy Adult Rats
Auteurs : Lu Kong ; Meng Tang ; Ting Zhang ; Dayong Wang ; Ke Hu ; Weiqi Lu ; Chao Wei ; Geyu Liang ; Yuepu PuSource :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2014.
Abstract
Nickel is associated with reproductive toxicity. However, the reproductive toxicity of nickel nanoparticles (Ni NPs) is unclear. Our goal was to determine the association between nickel nanoparticle exposure and reproductive toxicity. According to the one-generation reproductive toxicity standard, rats were exposed to nickel nanoparticles by gavage and we selected indicators including sex hormone levels, sperm motility, histopathology, and reproductive outcome
Url:
DOI: 10.3390/ijms151121253
PubMed: 25407529
PubMed Central: 4264223
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nickel Nanoparticles Exposure and Reproductive Toxicity in Healthy Adult Rats</title><author><name sortKey="Kong, Lu" sort="Kong, Lu" uniqKey="Kong L" first="Lu" last="Kong">Lu Kong</name><affiliation><nlm:aff id="af1-ijms-15-21253">Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; E-Mails:<email>konglu@seu.edu.cn</email> (L.K.);<email>zhangting1207@gmail.com</email> (T.Z.);<email>18051969217@163.com</email> (K.H.);<email>starvich@126.com</email> (W.L.);<email>seuweichao@163.com</email> (C.W.);<email>gyliang@seu.edu.cn</email> (G.L.)</nlm:aff></affiliation></author><author><name sortKey="Tang, Meng" sort="Tang, Meng" uniqKey="Tang M" first="Meng" last="Tang">Meng Tang</name><affiliation><nlm:aff id="af1-ijms-15-21253">Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; E-Mails:<email>konglu@seu.edu.cn</email> (L.K.);<email>zhangting1207@gmail.com</email> (T.Z.);<email>18051969217@163.com</email> (K.H.);<email>starvich@126.com</email> (W.L.);<email>seuweichao@163.com</email> (C.W.);<email>gyliang@seu.edu.cn</email> (G.L.)</nlm:aff></affiliation></author><author><name sortKey="Zhang, Ting" sort="Zhang, Ting" uniqKey="Zhang T" first="Ting" last="Zhang">Ting Zhang</name><affiliation><nlm:aff id="af1-ijms-15-21253">Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; E-Mails:<email>konglu@seu.edu.cn</email> (L.K.);<email>zhangting1207@gmail.com</email> (T.Z.);<email>18051969217@163.com</email> (K.H.);<email>starvich@126.com</email> (W.L.);<email>seuweichao@163.com</email> (C.W.);<email>gyliang@seu.edu.cn</email> (G.L.)</nlm:aff></affiliation></author><author><name sortKey="Wang, Dayong" sort="Wang, Dayong" uniqKey="Wang D" first="Dayong" last="Wang">Dayong Wang</name><affiliation><nlm:aff id="af2-ijms-15-21253">Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Medical School of Southeast University, Nanjing 210009, China; E-Mail:<email>dayongw@seu.edu.cn</email></nlm:aff></affiliation></author><author><name sortKey="Hu, Ke" sort="Hu, Ke" uniqKey="Hu K" first="Ke" last="Hu">Ke Hu</name><affiliation><nlm:aff id="af1-ijms-15-21253">Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; E-Mails:<email>konglu@seu.edu.cn</email> (L.K.);<email>zhangting1207@gmail.com</email> (T.Z.);<email>18051969217@163.com</email> (K.H.);<email>starvich@126.com</email> (W.L.);<email>seuweichao@163.com</email> (C.W.);<email>gyliang@seu.edu.cn</email> (G.L.)</nlm:aff></affiliation></author><author><name sortKey="Lu, Weiqi" sort="Lu, Weiqi" uniqKey="Lu W" first="Weiqi" last="Lu">Weiqi Lu</name><affiliation><nlm:aff id="af1-ijms-15-21253">Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; E-Mails:<email>konglu@seu.edu.cn</email> (L.K.);<email>zhangting1207@gmail.com</email> (T.Z.);<email>18051969217@163.com</email> (K.H.);<email>starvich@126.com</email> (W.L.);<email>seuweichao@163.com</email> (C.W.);<email>gyliang@seu.edu.cn</email> (G.L.)</nlm:aff></affiliation></author><author><name sortKey="Wei, Chao" sort="Wei, Chao" uniqKey="Wei C" first="Chao" last="Wei">Chao Wei</name><affiliation><nlm:aff id="af1-ijms-15-21253">Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; E-Mails:<email>konglu@seu.edu.cn</email> (L.K.);<email>zhangting1207@gmail.com</email> (T.Z.);<email>18051969217@163.com</email> (K.H.);<email>starvich@126.com</email> (W.L.);<email>seuweichao@163.com</email> (C.W.);<email>gyliang@seu.edu.cn</email> (G.L.)</nlm:aff></affiliation></author><author><name sortKey="Liang, Geyu" sort="Liang, Geyu" uniqKey="Liang G" first="Geyu" last="Liang">Geyu Liang</name><affiliation><nlm:aff id="af1-ijms-15-21253">Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; E-Mails:<email>konglu@seu.edu.cn</email> (L.K.);<email>zhangting1207@gmail.com</email> (T.Z.);<email>18051969217@163.com</email> (K.H.);<email>starvich@126.com</email> (W.L.);<email>seuweichao@163.com</email> (C.W.);<email>gyliang@seu.edu.cn</email> (G.L.)</nlm:aff></affiliation></author><author><name sortKey="Pu, Yuepu" sort="Pu, Yuepu" uniqKey="Pu Y" first="Yuepu" last="Pu">Yuepu Pu</name><affiliation><nlm:aff id="af1-ijms-15-21253">Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; E-Mails:<email>konglu@seu.edu.cn</email> (L.K.);<email>zhangting1207@gmail.com</email> (T.Z.);<email>18051969217@163.com</email> (K.H.);<email>starvich@126.com</email> (W.L.);<email>seuweichao@163.com</email> (C.W.);<email>gyliang@seu.edu.cn</email> (G.L.)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25407529</idno><idno type="pmc">4264223</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264223</idno><idno type="RBID">PMC:4264223</idno><idno type="doi">10.3390/ijms151121253</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000036</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000036</idno><idno type="wicri:Area/Pmc/Curation">000036</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000036</idno><idno type="wicri:Area/Pmc/Checkpoint">000017</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000017</idno><idno type="wicri:Area/Ncbi/Merge">000123</idno><idno type="wicri:Area/Ncbi/Curation">000123</idno><idno type="wicri:Area/Ncbi/Checkpoint">000123</idno><idno type="wicri:Area/Main/Merge">000069</idno><idno type="wicri:Area/Main/Curation">000069</idno><idno type="wicri:Area/Main/Exploration">000069</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Nickel Nanoparticles Exposure and Reproductive Toxicity in Healthy Adult Rats</title><author><name sortKey="Kong, Lu" sort="Kong, Lu" uniqKey="Kong L" first="Lu" last="Kong">Lu Kong</name><affiliation><nlm:aff id="af1-ijms-15-21253">Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; E-Mails:<email>konglu@seu.edu.cn</email> (L.K.);<email>zhangting1207@gmail.com</email> (T.Z.);<email>18051969217@163.com</email> (K.H.);<email>starvich@126.com</email> (W.L.);<email>seuweichao@163.com</email> (C.W.);<email>gyliang@seu.edu.cn</email> (G.L.)</nlm:aff></affiliation></author><author><name sortKey="Tang, Meng" sort="Tang, Meng" uniqKey="Tang M" first="Meng" last="Tang">Meng Tang</name><affiliation><nlm:aff id="af1-ijms-15-21253">Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; E-Mails:<email>konglu@seu.edu.cn</email> (L.K.);<email>zhangting1207@gmail.com</email> (T.Z.);<email>18051969217@163.com</email> (K.H.);<email>starvich@126.com</email> (W.L.);<email>seuweichao@163.com</email> (C.W.);<email>gyliang@seu.edu.cn</email> (G.L.)</nlm:aff></affiliation></author><author><name sortKey="Zhang, Ting" sort="Zhang, Ting" uniqKey="Zhang T" first="Ting" last="Zhang">Ting Zhang</name><affiliation><nlm:aff id="af1-ijms-15-21253">Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; E-Mails:<email>konglu@seu.edu.cn</email> (L.K.);<email>zhangting1207@gmail.com</email> (T.Z.);<email>18051969217@163.com</email> (K.H.);<email>starvich@126.com</email> (W.L.);<email>seuweichao@163.com</email> (C.W.);<email>gyliang@seu.edu.cn</email> (G.L.)</nlm:aff></affiliation></author><author><name sortKey="Wang, Dayong" sort="Wang, Dayong" uniqKey="Wang D" first="Dayong" last="Wang">Dayong Wang</name><affiliation><nlm:aff id="af2-ijms-15-21253">Key Laboratory of Developmental Genes and Human Disease in Ministry of Education, Medical School of Southeast University, Nanjing 210009, China; E-Mail:<email>dayongw@seu.edu.cn</email></nlm:aff></affiliation></author><author><name sortKey="Hu, Ke" sort="Hu, Ke" uniqKey="Hu K" first="Ke" last="Hu">Ke Hu</name><affiliation><nlm:aff id="af1-ijms-15-21253">Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; E-Mails:<email>konglu@seu.edu.cn</email> (L.K.);<email>zhangting1207@gmail.com</email> (T.Z.);<email>18051969217@163.com</email> (K.H.);<email>starvich@126.com</email> (W.L.);<email>seuweichao@163.com</email> (C.W.);<email>gyliang@seu.edu.cn</email> (G.L.)</nlm:aff></affiliation></author><author><name sortKey="Lu, Weiqi" sort="Lu, Weiqi" uniqKey="Lu W" first="Weiqi" last="Lu">Weiqi Lu</name><affiliation><nlm:aff id="af1-ijms-15-21253">Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; E-Mails:<email>konglu@seu.edu.cn</email> (L.K.);<email>zhangting1207@gmail.com</email> (T.Z.);<email>18051969217@163.com</email> (K.H.);<email>starvich@126.com</email> (W.L.);<email>seuweichao@163.com</email> (C.W.);<email>gyliang@seu.edu.cn</email> (G.L.)</nlm:aff></affiliation></author><author><name sortKey="Wei, Chao" sort="Wei, Chao" uniqKey="Wei C" first="Chao" last="Wei">Chao Wei</name><affiliation><nlm:aff id="af1-ijms-15-21253">Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; E-Mails:<email>konglu@seu.edu.cn</email> (L.K.);<email>zhangting1207@gmail.com</email> (T.Z.);<email>18051969217@163.com</email> (K.H.);<email>starvich@126.com</email> (W.L.);<email>seuweichao@163.com</email> (C.W.);<email>gyliang@seu.edu.cn</email> (G.L.)</nlm:aff></affiliation></author><author><name sortKey="Liang, Geyu" sort="Liang, Geyu" uniqKey="Liang G" first="Geyu" last="Liang">Geyu Liang</name><affiliation><nlm:aff id="af1-ijms-15-21253">Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; E-Mails:<email>konglu@seu.edu.cn</email> (L.K.);<email>zhangting1207@gmail.com</email> (T.Z.);<email>18051969217@163.com</email> (K.H.);<email>starvich@126.com</email> (W.L.);<email>seuweichao@163.com</email> (C.W.);<email>gyliang@seu.edu.cn</email> (G.L.)</nlm:aff></affiliation></author><author><name sortKey="Pu, Yuepu" sort="Pu, Yuepu" uniqKey="Pu Y" first="Yuepu" last="Pu">Yuepu Pu</name><affiliation><nlm:aff id="af1-ijms-15-21253">Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China; E-Mails:<email>konglu@seu.edu.cn</email> (L.K.);<email>zhangting1207@gmail.com</email> (T.Z.);<email>18051969217@163.com</email> (K.H.);<email>starvich@126.com</email> (W.L.);<email>seuweichao@163.com</email> (C.W.);<email>gyliang@seu.edu.cn</email> (G.L.)</nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Molecular Sciences</title><idno type="eISSN">1422-0067</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Nickel is associated with reproductive toxicity. However, the reproductive toxicity of nickel nanoparticles (Ni NPs) is unclear. Our goal was to determine the association between nickel nanoparticle exposure and reproductive toxicity. According to the one-generation reproductive toxicity standard, rats were exposed to nickel nanoparticles by gavage and we selected indicators including sex hormone levels, sperm motility, histopathology, and reproductive outcome <italic>etc</italic>. Experimental results showed nickel nanoparticles increased follicle stimulating hormone (FSH) and luteinizing hormone (LH), and lowered etradiol (E<sub>2</sub>) serum levels at a dose of 15 and 45 mg/kg in female rats. Ovarian lymphocytosis, vascular dilatation and congestion, inflammatory cell infiltration, and increase in apoptotic cells were found in ovary tissues in exposure groups. For male rats, the weights decreased gradually, the ratio of epididymis weight over body weight increased, the motility of rat sperm changed, and the levels of FSH and testosterone (T) diminished. Pathological results showed the shedding of epithelial cells of raw seminiferous tubule, disordered arrangement of cells in the tube, and the appearance of cell apoptosis and death in the exposure group. At the same time, Ni NPs resulted in a change of the reproductive index and the offspring development of rats. Further research is needed to elucidate exposure to human populations and mechanism of actions.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Arita, A" uniqKey="Arita A">A. Arita</name></author><author><name sortKey="Niu, J" uniqKey="Niu J">J. Niu</name></author><author><name sortKey="Qu, Q" uniqKey="Qu Q">Q. Qu</name></author><author><name sortKey="Zhao, N" uniqKey="Zhao N">N. 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