Experimental Contagious Caprine Pleuropneumonia: A Long Term Study on the Course of Infection and Pathology in a Flock of Goats Infected with Mycoplasma capricolum subsp. capripneumoniae
Identifieur interne : 000243 ( Pmc/Curation ); précédent : 000242; suivant : 000244Experimental Contagious Caprine Pleuropneumonia: A Long Term Study on the Course of Infection and Pathology in a Flock of Goats Infected with Mycoplasma capricolum subsp. capripneumoniae
Auteurs : Ho Wesonga [Kenya, Suède] ; G. Bölske [Suède] ; F. Thiaucourt [France] ; C. Wanjohi [Kenya] ; R. Lindberg [Suède]Source :
- Acta Veterinaria Scandinavica [ 0044-605X ] ; 2004.
Abstract
Contagious caprine pleuropneumonia (CCPP) is a major threat to goat farming in parts of Africa and Asia. It classically causes acute high morbidity and mortality early in infection, but little is known of its long term epizootiology and course. In this study, 10 goats were inoculated with
Url:
DOI: 10.1186/1751-0147-45-167
PubMed: 15663077
PubMed Central: 1820987
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subsp. <italic>capripneumoniae</italic>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Experimental Contagious Caprine Pleuropneumonia: A Long Term Study on the Course of Infection and Pathology in a Flock of Goats Infected with <italic>Mycoplasma capricolum </italic>
subsp. <italic>capripneumoniae</italic>
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<front><div type="abstract" xml:lang="en"><p>Contagious caprine pleuropneumonia (CCPP) is a major threat to goat farming in parts of Africa and Asia. It classically causes acute high morbidity and mortality early in infection, but little is known of its long term epizootiology and course. In this study, 10 goats were inoculated with <italic>Mycoplasma capricolum </italic>
subsp. <italic>capripneumoniae (M. capripneumoniae) </italic>
and then mixed with 15 goats for contact transmission. The disease course was monitored in each goat for 56–105 days, whereafter the goats were killed and necropsied. Varying features signifying infection occurred in altogether 17 goats (7 inoculated, 10 in-contact). Clinical signs were severe in 8 goats but no fatalities occurred. Only 6 goats had serum antibody titres against <italic>M. capripneumoniae </italic>
in ELISA. Fourteen goats (5 inoculated, 9 in-contact) had chronic pleuropulmonary lesions compatible with CCPP at necropsy and 7 of those showed <italic>M. capripneumoniae </italic>
antigen in the lung by immunohistochemistry. Neither cultivation nor PCR tests were positive for the agent in any goat. The results indicate that the clinical course of CCPP in a flock may be comparatively mild, <italic>M. capripneumoniae-</italic>
associated lung lesions may be present at a late stage of infection, and chronic infection may occur without a significant serological response.</p>
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<journal-title>Acta Veterinaria Scandinavica</journal-title>
<issn pub-type="ppub">0044-605X</issn>
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<article-id pub-id-type="doi">10.1186/1751-0147-45-167</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Experimental Contagious Caprine Pleuropneumonia: A Long Term Study on the Course of Infection and Pathology in a Flock of Goats Infected with <italic>Mycoplasma capricolum </italic>
subsp. <italic>capripneumoniae</italic>
</article-title>
</title-group>
<contrib-group><contrib id="A1" corresp="yes" contrib-type="author"><name><surname>Wesonga</surname>
<given-names>HO</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I5">5</xref>
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<contrib id="A2" contrib-type="author"><name><surname>Bölske</surname>
<given-names>G</given-names>
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<xref ref-type="aff" rid="I2">2</xref>
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<contrib id="A3" contrib-type="author"><name><surname>Thiaucourt</surname>
<given-names>F</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
</contrib>
<contrib id="A4" contrib-type="author"><name><surname>Wanjohi</surname>
<given-names>C</given-names>
</name>
<xref ref-type="aff" rid="I4">4</xref>
</contrib>
<contrib id="A5" contrib-type="author"><name><surname>Lindberg</surname>
<given-names>R</given-names>
</name>
<xref ref-type="aff" rid="I5">5</xref>
</contrib>
</contrib-group>
<aff id="I1"><label>1</label>
National Veterinary Research Centre, Kenya Agricultural Research Institute, Kikuyu, Kenya</aff>
<aff id="I2"><label>2</label>
National Veterinary Institute, Uppsala, Sweden</aff>
<aff id="I3"><label>3</label>
CIRAD-EMVT, Santé Animale, Montpellier, France</aff>
<aff id="I4"><label>4</label>
Veterinary Laboratories, Private bag, Kabete, Kenya</aff>
<aff id="I5"><label>5</label>
Department of Biomedical Sciences and Veterinary Public Health, Division of Pathology, Pharmacology and Toxicology, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, Uppsala, Sweden</aff>
<pub-date pub-type="ppub"><year>2004</year>
</pub-date>
<pub-date pub-type="collection"><year>2004</year>
<pmc-comment>Collection date added for this content to allow loading of archive materials</pmc-comment>
</pub-date>
<pub-date pub-type="epub"><day>30</day>
<month>9</month>
<year>2004</year>
</pub-date>
<volume>45</volume>
<issue>3</issue>
<fpage>167</fpage>
<lpage>179</lpage>
<ext-link ext-link-type="uri" xlink:href="http://www.actavetscand.com/content/45/3/167"></ext-link>
<history><date date-type="received"><day>6</day>
<month>2</month>
<year>2004</year>
</date>
<date date-type="accepted"><day>5</day>
<month>8</month>
<year>2004</year>
</date>
</history>
<abstract><p>Contagious caprine pleuropneumonia (CCPP) is a major threat to goat farming in parts of Africa and Asia. It classically causes acute high morbidity and mortality early in infection, but little is known of its long term epizootiology and course. In this study, 10 goats were inoculated with <italic>Mycoplasma capricolum </italic>
subsp. <italic>capripneumoniae (M. capripneumoniae) </italic>
and then mixed with 15 goats for contact transmission. The disease course was monitored in each goat for 56–105 days, whereafter the goats were killed and necropsied. Varying features signifying infection occurred in altogether 17 goats (7 inoculated, 10 in-contact). Clinical signs were severe in 8 goats but no fatalities occurred. Only 6 goats had serum antibody titres against <italic>M. capripneumoniae </italic>
in ELISA. Fourteen goats (5 inoculated, 9 in-contact) had chronic pleuropulmonary lesions compatible with CCPP at necropsy and 7 of those showed <italic>M. capripneumoniae </italic>
antigen in the lung by immunohistochemistry. Neither cultivation nor PCR tests were positive for the agent in any goat. The results indicate that the clinical course of CCPP in a flock may be comparatively mild, <italic>M. capripneumoniae-</italic>
associated lung lesions may be present at a late stage of infection, and chronic infection may occur without a significant serological response.</p>
</abstract>
<kwd-group><kwd>goat</kwd>
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<kwd>contagious pleuropneumonia</kwd>
<kwd>ELISA</kwd>
<kwd>immunohistochemistry</kwd>
<kwd>serology</kwd>
<kwd>pathology.</kwd>
</kwd-group>
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</front>
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