Recent Advances in Drug Discovery from South African Marine Invertebrates
Identifieur interne : 000411 ( Ncbi/Merge ); précédent : 000410; suivant : 000412Recent Advances in Drug Discovery from South African Marine Invertebrates
Auteurs : Michael T. Davies-Coleman [Afrique du Sud] ; Clinton G. L. VealeSource :
- Marine Drugs [ 1660-3397 ] ; 2015.
Abstract
Recent developments in marine drug discovery from three South African marine invertebrates, the tube worm
Url:
DOI: 10.3390/md13106366
PubMed: 26473891
PubMed Central: 4626695
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<author><name sortKey="Davies Coleman, Michael T" sort="Davies Coleman, Michael T" uniqKey="Davies Coleman M" first="Michael T." last="Davies-Coleman">Michael T. Davies-Coleman</name>
<affiliation wicri:level="1"><nlm:aff id="af1-marinedrugs-13-06366">Department of Chemistry, University of the Western Cape, Robert Sobukwe Road, Bellville 7535, South Africa</nlm:aff>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Department of Chemistry, University of the Western Cape, Robert Sobukwe Road, Bellville 7535</wicri:regionArea>
<wicri:noRegion>Bellville 7535</wicri:noRegion>
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<author><name sortKey="Veale, Clinton G L" sort="Veale, Clinton G L" uniqKey="Veale C" first="Clinton G. L." last="Veale">Clinton G. L. Veale</name>
<affiliation><nlm:aff id="af2-marinedrugs-13-06366">Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa; E-Mail:<email>C.Veale@ru.ac.za</email>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Recent Advances in Drug Discovery from South African Marine Invertebrates</title>
<author><name sortKey="Davies Coleman, Michael T" sort="Davies Coleman, Michael T" uniqKey="Davies Coleman M" first="Michael T." last="Davies-Coleman">Michael T. Davies-Coleman</name>
<affiliation wicri:level="1"><nlm:aff id="af1-marinedrugs-13-06366">Department of Chemistry, University of the Western Cape, Robert Sobukwe Road, Bellville 7535, South Africa</nlm:aff>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Department of Chemistry, University of the Western Cape, Robert Sobukwe Road, Bellville 7535</wicri:regionArea>
<wicri:noRegion>Bellville 7535</wicri:noRegion>
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<author><name sortKey="Veale, Clinton G L" sort="Veale, Clinton G L" uniqKey="Veale C" first="Clinton G. L." last="Veale">Clinton G. L. Veale</name>
<affiliation><nlm:aff id="af2-marinedrugs-13-06366">Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa; E-Mail:<email>C.Veale@ru.ac.za</email>
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<series><title level="j">Marine Drugs</title>
<idno type="eISSN">1660-3397</idno>
<imprint><date when="2015">2015</date>
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<front><div type="abstract" xml:lang="en"><p>Recent developments in marine drug discovery from three South African marine invertebrates, the tube worm <italic>Cephalodiscus gilchristi</italic>
, the ascidian <italic>Lissoclinum</italic>
sp. and the sponge <italic>Topsentia pachastrelloides</italic>
, are presented. Recent reports of the bioactivity and synthesis of the anti-cancer secondary metabolites cephalostatin and mandelalides (from <italic>C. gilchristi</italic>
and <italic>Lissoclinum</italic>
sp., respectively) and various analogues are presented. The threat of drug-resistant pathogens, e.g., methicillin-resistant <italic>Staphylococcus aureus</italic>
(MRSA), is assuming greater global significance, and medicinal chemistry strategies to exploit the potent MRSA PK inhibition, first revealed by two marine secondary metabolites, <italic>cis</italic>
-3,4-dihydrohamacanthin B and bromodeoxytopsentin from <italic>T. pachastrelloides</italic>
, are compared.</p>
</div>
</front>
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</back>
</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Mar Drugs</journal-id>
<journal-id journal-id-type="iso-abbrev">Mar Drugs</journal-id>
<journal-id journal-id-type="publisher-id">marinedrugs</journal-id>
<journal-title-group><journal-title>Marine Drugs</journal-title>
</journal-title-group>
<issn pub-type="epub">1660-3397</issn>
<publisher><publisher-name>MDPI</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26473891</article-id>
<article-id pub-id-type="pmc">4626695</article-id>
<article-id pub-id-type="doi">10.3390/md13106366</article-id>
<article-id pub-id-type="publisher-id">marinedrugs-13-06366</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Recent Advances in Drug Discovery from South African Marine Invertebrates</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Davies-Coleman</surname>
<given-names>Michael T.</given-names>
</name>
<xref ref-type="aff" rid="af1-marinedrugs-13-06366">1</xref>
<xref rid="c1-marinedrugs-13-06366" ref-type="corresp">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Veale</surname>
<given-names>Clinton G. L.</given-names>
</name>
<xref ref-type="aff" rid="af2-marinedrugs-13-06366">2</xref>
</contrib>
</contrib-group>
<contrib-group><contrib contrib-type="editor"><name><surname>Urban</surname>
<given-names>Sylvia</given-names>
</name>
<role>Academic Editor</role>
</contrib>
</contrib-group>
<aff id="af1-marinedrugs-13-06366"><label>1</label>
Department of Chemistry, University of the Western Cape, Robert Sobukwe Road, Bellville 7535, South Africa</aff>
<aff id="af2-marinedrugs-13-06366"><label>2</label>
Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa; E-Mail:<email>C.Veale@ru.ac.za</email>
</aff>
<author-notes><corresp id="c1-marinedrugs-13-06366"><label>*</label>
Author to whom correspondence should be addressed; E-Mail: <email>mdavies-coleman@uwc.ac.za</email>
; Tel.: +27-21-959-2255.</corresp>
</author-notes>
<pub-date pub-type="epub"><day>14</day>
<month>10</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><month>10</month>
<year>2015</year>
</pub-date>
<volume>13</volume>
<issue>10</issue>
<fpage>6366</fpage>
<lpage>6383</lpage>
<history><date date-type="received"><day>25</day>
<month>7</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>29</day>
<month>9</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© 2015 by the authors; licensee MDPI, Basel, Switzerland.</copyright-statement>
<copyright-year>2015</copyright-year>
<license><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
).</license-p>
</license>
</permissions>
<abstract><p>Recent developments in marine drug discovery from three South African marine invertebrates, the tube worm <italic>Cephalodiscus gilchristi</italic>
, the ascidian <italic>Lissoclinum</italic>
sp. and the sponge <italic>Topsentia pachastrelloides</italic>
, are presented. Recent reports of the bioactivity and synthesis of the anti-cancer secondary metabolites cephalostatin and mandelalides (from <italic>C. gilchristi</italic>
and <italic>Lissoclinum</italic>
sp., respectively) and various analogues are presented. The threat of drug-resistant pathogens, e.g., methicillin-resistant <italic>Staphylococcus aureus</italic>
(MRSA), is assuming greater global significance, and medicinal chemistry strategies to exploit the potent MRSA PK inhibition, first revealed by two marine secondary metabolites, <italic>cis</italic>
-3,4-dihydrohamacanthin B and bromodeoxytopsentin from <italic>T. pachastrelloides</italic>
, are compared.</p>
</abstract>
<kwd-group><kwd>cephalostatin</kwd>
<kwd>mandelalide</kwd>
<kwd>methicillin resistant <italic>Staphylococcus aureus</italic>
</kwd>
<kwd>MRSA PK</kwd>
<kwd>bisindole alkaloids</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Afrique du Sud</li>
</country>
</list>
<tree><noCountry><name sortKey="Veale, Clinton G L" sort="Veale, Clinton G L" uniqKey="Veale C" first="Clinton G. L." last="Veale">Clinton G. L. Veale</name>
</noCountry>
<country name="Afrique du Sud"><noRegion><name sortKey="Davies Coleman, Michael T" sort="Davies Coleman, Michael T" uniqKey="Davies Coleman M" first="Michael T." last="Davies-Coleman">Michael T. Davies-Coleman</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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