Updates on clinical studies of selenium supplementation in radiotherapy
Identifieur interne : 000326 ( Ncbi/Merge ); précédent : 000325; suivant : 000327Updates on clinical studies of selenium supplementation in radiotherapy
Auteurs : Irma M. Puspitasari [Japon, Indonésie] ; Rizky Abdulah [Japon, Indonésie] ; Chiho Yamazaki [Japon] ; Satomi Kameo [Japon] ; Takashi Nakano [Japon] ; Hiroshi Koyama [Japon]Source :
- Radiation Oncology (London, England) [ 1748-717X ] ; 2014.
Abstract
To establish guidelines for the selenium supplementation in radiotherapy we assessed the benefits and risks of selenium supplementation in radiotherapy. Clinical studies on the use of selenium in radiotherapy were searched in the PubMed electronic database in January 2013. Sixteen clinical studies were identified among the 167 articles selected in the initial search. Ten articles were observational studies, and the other 6 articles reported studies on the effects of selenium supplementation in patients with cancer who underwent radiotherapy. The studies were conducted worldwide including European, American and Asian countries between 1987 and 2012. Plasma, serum or whole blood selenium levels were common parameters used to assess the effects of radiotherapy and the selenium supplementation status. Selenium supplementation improved the general conditions of the patients, improved their quality of life and reduced the side effects of radiotherapy. At the dose of selenium used in these studies (200–500 μg/day), selenium supplementation did not reduce the effectiveness of radiotherapy, and no toxicities were reported. Selenium supplementation may offer specific benefits for several types of cancer patients who undergo radiotherapy. Because high-dose selenium and long-term supplementation may be unsafe due to selenium toxicity, more evidence-based information and additional research are needed to ensure the therapeutic benefits of selenium supplementation.
Url:
DOI: 10.1186/1748-717X-9-125
PubMed: 24885670
PubMed Central: 4073179
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<front><div type="abstract" xml:lang="en"><p>To establish guidelines for the selenium supplementation in radiotherapy we assessed the benefits and risks of selenium supplementation in radiotherapy. Clinical studies on the use of selenium in radiotherapy were searched in the PubMed electronic database in January 2013. Sixteen clinical studies were identified among the 167 articles selected in the initial search. Ten articles were observational studies, and the other 6 articles reported studies on the effects of selenium supplementation in patients with cancer who underwent radiotherapy. The studies were conducted worldwide including European, American and Asian countries between 1987 and 2012. Plasma, serum or whole blood selenium levels were common parameters used to assess the effects of radiotherapy and the selenium supplementation status. Selenium supplementation improved the general conditions of the patients, improved their quality of life and reduced the side effects of radiotherapy. At the dose of selenium used in these studies (200–500 μg/day), selenium supplementation did not reduce the effectiveness of radiotherapy, and no toxicities were reported. Selenium supplementation may offer specific benefits for several types of cancer patients who undergo radiotherapy. Because high-dose selenium and long-term supplementation may be unsafe due to selenium toxicity, more evidence-based information and additional research are needed to ensure the therapeutic benefits of selenium supplementation.</p>
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<pmc article-type="review-article" xml:lang="en"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Radiat Oncol</journal-id>
<journal-id journal-id-type="iso-abbrev">Radiat Oncol</journal-id>
<journal-title-group><journal-title>Radiation Oncology (London, England)</journal-title>
</journal-title-group>
<issn pub-type="epub">1748-717X</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24885670</article-id>
<article-id pub-id-type="pmc">4073179</article-id>
<article-id pub-id-type="publisher-id">1748-717X-9-125</article-id>
<article-id pub-id-type="doi">10.1186/1748-717X-9-125</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Updates on clinical studies of selenium supplementation in radiotherapy</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" id="A1"><name><surname>Puspitasari</surname>
<given-names>Irma M</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I2">2</xref>
<email>m12702053@gunma-u.ac.jp</email>
</contrib>
<contrib contrib-type="author" id="A2"><name><surname>Abdulah</surname>
<given-names>Rizky</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<xref ref-type="aff" rid="I2">2</xref>
<email>abdulahrizky@gmail.com</email>
</contrib>
<contrib contrib-type="author" id="A3"><name><surname>Yamazaki</surname>
<given-names>Chiho</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>kchiho@health.gunma-u.ac.jp</email>
</contrib>
<contrib contrib-type="author" id="A4"><name><surname>Kameo</surname>
<given-names>Satomi</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>skameo-t@gunma-u.ac.jp</email>
</contrib>
<contrib contrib-type="author" id="A5"><name><surname>Nakano</surname>
<given-names>Takashi</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
<email>tnakano@med.gunma-u.ac.jp</email>
</contrib>
<contrib contrib-type="author" corresp="yes" id="A6"><name><surname>Koyama</surname>
<given-names>Hiroshi</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>hkoyama@health.gunma-u.ac.jp</email>
</contrib>
</contrib-group>
<aff id="I1"><label>1</label>
Department of Public Health, Gunma University Graduate School of Medicine, 3-39-22 Showa Machi, Maebashi 371-8511, Japan</aff>
<aff id="I2"><label>2</label>
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia</aff>
<aff id="I3"><label>3</label>
Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan</aff>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>29</day>
<month>5</month>
<year>2014</year>
</pub-date>
<volume>9</volume>
<fpage>125</fpage>
<lpage>125</lpage>
<history><date date-type="received"><day>11</day>
<month>9</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>11</day>
<month>5</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2014 Puspitasari et al.; licensee BioMed Central Ltd.</copyright-statement>
<copyright-year>2014</copyright-year>
<copyright-holder>Puspitasari et al.; licensee BioMed Central Ltd.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<self-uri xlink:href="http://www.ro-journal.com/content/9/1/125"></self-uri>
<abstract><p>To establish guidelines for the selenium supplementation in radiotherapy we assessed the benefits and risks of selenium supplementation in radiotherapy. Clinical studies on the use of selenium in radiotherapy were searched in the PubMed electronic database in January 2013. Sixteen clinical studies were identified among the 167 articles selected in the initial search. Ten articles were observational studies, and the other 6 articles reported studies on the effects of selenium supplementation in patients with cancer who underwent radiotherapy. The studies were conducted worldwide including European, American and Asian countries between 1987 and 2012. Plasma, serum or whole blood selenium levels were common parameters used to assess the effects of radiotherapy and the selenium supplementation status. Selenium supplementation improved the general conditions of the patients, improved their quality of life and reduced the side effects of radiotherapy. At the dose of selenium used in these studies (200–500 μg/day), selenium supplementation did not reduce the effectiveness of radiotherapy, and no toxicities were reported. Selenium supplementation may offer specific benefits for several types of cancer patients who undergo radiotherapy. Because high-dose selenium and long-term supplementation may be unsafe due to selenium toxicity, more evidence-based information and additional research are needed to ensure the therapeutic benefits of selenium supplementation.</p>
</abstract>
<kwd-group><kwd>Selenium</kwd>
<kwd>Supplementation</kwd>
<kwd>Clinical studies</kwd>
<kwd>Radiotherapy</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Indonésie</li>
<li>Japon</li>
</country>
</list>
<tree><country name="Japon"><noRegion><name sortKey="Puspitasari, Irma M" sort="Puspitasari, Irma M" uniqKey="Puspitasari I" first="Irma M" last="Puspitasari">Irma M. Puspitasari</name>
</noRegion>
<name sortKey="Abdulah, Rizky" sort="Abdulah, Rizky" uniqKey="Abdulah R" first="Rizky" last="Abdulah">Rizky Abdulah</name>
<name sortKey="Kameo, Satomi" sort="Kameo, Satomi" uniqKey="Kameo S" first="Satomi" last="Kameo">Satomi Kameo</name>
<name sortKey="Koyama, Hiroshi" sort="Koyama, Hiroshi" uniqKey="Koyama H" first="Hiroshi" last="Koyama">Hiroshi Koyama</name>
<name sortKey="Nakano, Takashi" sort="Nakano, Takashi" uniqKey="Nakano T" first="Takashi" last="Nakano">Takashi Nakano</name>
<name sortKey="Yamazaki, Chiho" sort="Yamazaki, Chiho" uniqKey="Yamazaki C" first="Chiho" last="Yamazaki">Chiho Yamazaki</name>
</country>
<country name="Indonésie"><noRegion><name sortKey="Puspitasari, Irma M" sort="Puspitasari, Irma M" uniqKey="Puspitasari I" first="Irma M" last="Puspitasari">Irma M. Puspitasari</name>
</noRegion>
<name sortKey="Abdulah, Rizky" sort="Abdulah, Rizky" uniqKey="Abdulah R" first="Rizky" last="Abdulah">Rizky Abdulah</name>
</country>
</tree>
</affiliations>
</record>
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