Normal Iron Metabolism and the Pathophysiology of Iron Overload Disorders
Identifieur interne : 000837 ( Main/Curation ); précédent : 000836; suivant : 000838Normal Iron Metabolism and the Pathophysiology of Iron Overload Disorders
Auteurs : Chiang W. Siah ; John Ombiga ; Leon A. Adams ; Debbie Trinder [Australie] ; John K. Olynyk [Australie]Source :
- Clinical Biochemist Reviews [ 0159-8090 ] ; 2006.
Abstract
Iron overload disorders represent a heterogenous group of conditions resulting from inherited and acquired causes. If undiagnosed they can be progressive and fatal. Early detection and phlebotomy prior to the onset of cirrhosis can reduce morbidity and normalise life expectancy. We now have greater insight into the complex mechanisms of normal and disordered iron homeostasis following the discovery of new proteins and genetic defects. Here we review the normal mechanisms and regulation of gastrointestinal iron absorption and liver iron transport and their dysregulation in iron overload states. Advances in the understanding of the natural history of iron overload disorders and new methods for clinical detection and management of hereditary haemochromatosis are also reviewed. The current screening strategies target high-risk groups such as first-degree relatives of affected individuals and those with clinical features suggestive of iron loading. Potential ethical, legal and psychosocial issues arising through application of genetic screening programs need to be resolved prior to implementation of general population screening programs.
Url:
PubMed: 16886043
PubMed Central: 1390789
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000482
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000481
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000356
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000061
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000061
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000061
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :000846
Links to Exploration step
PMC:1390789Curation
No country items
Chiang W. Siah<affiliation><nlm:aff id="af1-cbr27_1p005"> Department of Gastroenterology, Liverpool Hospital, Elizabeth Street, Liverpool, NSW 2170,</nlm:aff>
<wicri:noCountry code="subfield">NSW 2170</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-cbr27_1p005"> Department of Gastroenterology, Fremantle Hospital, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-cbr27_1p005"> Department of Gastroenterology, Fremantle Hospital, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af3-cbr27_1p005"> School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af3-cbr27_1p005"> School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af3-cbr27_1p005"> School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af4-cbr27_1p005"> Western Australian Institute of Medical Research, Perth, WA, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Western Australian Institute of Medical Research, Perth, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
<affiliation><nlm:aff id="af2-cbr27_1p005"> Department of Gastroenterology, Fremantle Hospital, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af3-cbr27_1p005"> School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af4-cbr27_1p005"> Western Australian Institute of Medical Research, Perth, WA, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Western Australian Institute of Medical Research, Perth, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
<affiliation><nlm:aff id="af3-cbr27_1p005"> School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af4-cbr27_1p005"> Western Australian Institute of Medical Research, Perth, WA, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Western Australian Institute of Medical Research, Perth, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Normal Iron Metabolism and the Pathophysiology of Iron Overload Disorders</title>
<author><name sortKey="Siah, Chiang W" sort="Siah, Chiang W" uniqKey="Siah C" first="Chiang W" last="Siah">Chiang W. Siah</name>
<affiliation><nlm:aff id="af1-cbr27_1p005"> Department of Gastroenterology, Liverpool Hospital, Elizabeth Street, Liverpool, NSW 2170,</nlm:aff>
<wicri:noCountry code="subfield">NSW 2170</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ombiga, John" sort="Ombiga, John" uniqKey="Ombiga J" first="John" last="Ombiga">John Ombiga</name>
<affiliation><nlm:aff id="af2-cbr27_1p005"> Department of Gastroenterology, Fremantle Hospital, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Adams, Leon A" sort="Adams, Leon A" uniqKey="Adams L" first="Leon A" last="Adams">Leon A. Adams</name>
<affiliation><nlm:aff id="af2-cbr27_1p005"> Department of Gastroenterology, Fremantle Hospital, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af3-cbr27_1p005"> School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Trinder, Debbie" sort="Trinder, Debbie" uniqKey="Trinder D" first="Debbie" last="Trinder">Debbie Trinder</name>
<affiliation><nlm:aff id="af3-cbr27_1p005"> School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af4-cbr27_1p005"> Western Australian Institute of Medical Research, Perth, WA, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Western Australian Institute of Medical Research, Perth, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Olynyk, John K" sort="Olynyk, John K" uniqKey="Olynyk J" first="John K" last="Olynyk">John K. Olynyk</name>
<affiliation><nlm:aff id="af2-cbr27_1p005"> Department of Gastroenterology, Fremantle Hospital, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af3-cbr27_1p005"> School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af4-cbr27_1p005"> Western Australian Institute of Medical Research, Perth, WA, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Western Australian Institute of Medical Research, Perth, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">16886043</idno>
<idno type="pmc">1390789</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1390789</idno>
<idno type="RBID">PMC:1390789</idno>
<date when="2006">2006</date>
<idno type="wicri:Area/Pmc/Corpus">000482</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000482</idno>
<idno type="wicri:Area/Pmc/Curation">000481</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000481</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000356</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000356</idno>
<idno type="wicri:Area/Ncbi/Merge">000061</idno>
<idno type="wicri:Area/Ncbi/Curation">000061</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000061</idno>
<idno type="wicri:doubleKey">0159-8090:2006:Siah C:normal:iron:metabolism</idno>
<idno type="wicri:Area/Main/Merge">000846</idno>
<idno type="wicri:Area/Main/Curation">000837</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Normal Iron Metabolism and the Pathophysiology of Iron Overload Disorders</title>
<author><name sortKey="Siah, Chiang W" sort="Siah, Chiang W" uniqKey="Siah C" first="Chiang W" last="Siah">Chiang W. Siah</name>
<affiliation><nlm:aff id="af1-cbr27_1p005"> Department of Gastroenterology, Liverpool Hospital, Elizabeth Street, Liverpool, NSW 2170,</nlm:aff>
<wicri:noCountry code="subfield">NSW 2170</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ombiga, John" sort="Ombiga, John" uniqKey="Ombiga J" first="John" last="Ombiga">John Ombiga</name>
<affiliation><nlm:aff id="af2-cbr27_1p005"> Department of Gastroenterology, Fremantle Hospital, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Adams, Leon A" sort="Adams, Leon A" uniqKey="Adams L" first="Leon A" last="Adams">Leon A. Adams</name>
<affiliation><nlm:aff id="af2-cbr27_1p005"> Department of Gastroenterology, Fremantle Hospital, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af3-cbr27_1p005"> School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Trinder, Debbie" sort="Trinder, Debbie" uniqKey="Trinder D" first="Debbie" last="Trinder">Debbie Trinder</name>
<affiliation><nlm:aff id="af3-cbr27_1p005"> School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af4-cbr27_1p005"> Western Australian Institute of Medical Research, Perth, WA, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Western Australian Institute of Medical Research, Perth, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Olynyk, John K" sort="Olynyk, John K" uniqKey="Olynyk J" first="John K" last="Olynyk">John K. Olynyk</name>
<affiliation><nlm:aff id="af2-cbr27_1p005"> Department of Gastroenterology, Fremantle Hospital, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af3-cbr27_1p005"> School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital Campus, Alma Street, Fremantle, WA 6160,</nlm:aff>
<wicri:noCountry code="subfield">WA 6160</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af4-cbr27_1p005"> Western Australian Institute of Medical Research, Perth, WA, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Western Australian Institute of Medical Research, Perth, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Clinical Biochemist Reviews</title>
<idno type="ISSN">0159-8090</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Iron overload disorders represent a heterogenous group of conditions resulting from inherited and acquired causes. If undiagnosed they can be progressive and fatal. Early detection and phlebotomy prior to the onset of cirrhosis can reduce morbidity and normalise life expectancy. We now have greater insight into the complex mechanisms of normal and disordered iron homeostasis following the discovery of new proteins and genetic defects. Here we review the normal mechanisms and regulation of gastrointestinal iron absorption and liver iron transport and their dysregulation in iron overload states. Advances in the understanding of the natural history of iron overload disorders and new methods for clinical detection and management of hereditary haemochromatosis are also reviewed. The current screening strategies target high-risk groups such as first-degree relatives of affected individuals and those with clinical features suggestive of iron loading. Potential ethical, legal and psychosocial issues arising through application of genetic screening programs need to be resolved prior to implementation of general population screening programs.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/CobaltMaghrebV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000837 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000837 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Terre |area= CobaltMaghrebV1 |flux= Main |étape= Curation |type= RBID |clé= PMC:1390789 |texte= Normal Iron Metabolism and the Pathophysiology of Iron Overload Disorders }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:16886043" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a CobaltMaghrebV1
![]() | This area was generated with Dilib version V0.6.32. | ![]() |