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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Consanguinity and reproductive health among Arabs</title><author><name sortKey="Tadmouri, Ghazi O" sort="Tadmouri, Ghazi O" uniqKey="Tadmouri G" first="Ghazi O" last="Tadmouri">Ghazi O. Tadmouri</name><affiliation><nlm:aff id="I1">Centre for Arab Genomic Studies, Dubai, United Arab Emirates</nlm:aff></affiliation></author><author><name sortKey="Nair, Pratibha" sort="Nair, Pratibha" uniqKey="Nair P" first="Pratibha" last="Nair">Pratibha Nair</name><affiliation><nlm:aff id="I1">Centre for Arab Genomic Studies, Dubai, United Arab Emirates</nlm:aff></affiliation></author><author><name sortKey="Obeid, Tasneem" sort="Obeid, Tasneem" uniqKey="Obeid T" first="Tasneem" last="Obeid">Tasneem Obeid</name><affiliation><nlm:aff id="I1">Centre for Arab Genomic Studies, Dubai, United Arab Emirates</nlm:aff></affiliation></author><author><name sortKey="Al Ali, Mahmoud T" sort="Al Ali, Mahmoud T" uniqKey="Al Ali M" first="Mahmoud T" last="Al Ali">Mahmoud T. Al Ali</name><affiliation><nlm:aff id="I1">Centre for Arab Genomic Studies, Dubai, United Arab Emirates</nlm:aff></affiliation></author><author><name sortKey="Al Khaja, Najib" sort="Al Khaja, Najib" uniqKey="Al Khaja N" first="Najib" last="Al Khaja">Najib Al Khaja</name><affiliation><nlm:aff id="I1">Centre for Arab Genomic Studies, Dubai, United Arab Emirates</nlm:aff></affiliation></author><author><name sortKey="Hamamy, Hanan A" sort="Hamamy, Hanan A" uniqKey="Hamamy H" first="Hanan A" last="Hamamy">Hanan A. Hamamy</name><affiliation><nlm:aff id="I1">Centre for Arab Genomic Studies, Dubai, United Arab Emirates</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Geneva Foundation for Medical Education and Research, Geneva, Switzerland</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19811666</idno><idno type="pmc">2765422</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765422</idno><idno type="RBID">PMC:2765422</idno><idno type="doi">10.1186/1742-4755-6-17</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000123</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000123</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Consanguinity and reproductive health among Arabs</title><author><name sortKey="Tadmouri, Ghazi O" sort="Tadmouri, Ghazi O" uniqKey="Tadmouri G" first="Ghazi O" last="Tadmouri">Ghazi O. Tadmouri</name><affiliation><nlm:aff id="I1">Centre for Arab Genomic Studies, Dubai, United Arab Emirates</nlm:aff></affiliation></author><author><name sortKey="Nair, Pratibha" sort="Nair, Pratibha" uniqKey="Nair P" first="Pratibha" last="Nair">Pratibha Nair</name><affiliation><nlm:aff id="I1">Centre for Arab Genomic Studies, Dubai, United Arab Emirates</nlm:aff></affiliation></author><author><name sortKey="Obeid, Tasneem" sort="Obeid, Tasneem" uniqKey="Obeid T" first="Tasneem" last="Obeid">Tasneem Obeid</name><affiliation><nlm:aff id="I1">Centre for Arab Genomic Studies, Dubai, United Arab Emirates</nlm:aff></affiliation></author><author><name sortKey="Al Ali, Mahmoud T" sort="Al Ali, Mahmoud T" uniqKey="Al Ali M" first="Mahmoud T" last="Al Ali">Mahmoud T. Al Ali</name><affiliation><nlm:aff id="I1">Centre for Arab Genomic Studies, Dubai, United Arab Emirates</nlm:aff></affiliation></author><author><name sortKey="Al Khaja, Najib" sort="Al Khaja, Najib" uniqKey="Al Khaja N" first="Najib" last="Al Khaja">Najib Al Khaja</name><affiliation><nlm:aff id="I1">Centre for Arab Genomic Studies, Dubai, United Arab Emirates</nlm:aff></affiliation></author><author><name sortKey="Hamamy, Hanan A" sort="Hamamy, Hanan A" uniqKey="Hamamy H" first="Hanan A" last="Hamamy">Hanan A. Hamamy</name><affiliation><nlm:aff id="I1">Centre for Arab Genomic Studies, Dubai, United Arab Emirates</nlm:aff></affiliation><affiliation><nlm:aff id="I2">Geneva Foundation for Medical Education and Research, Geneva, Switzerland</nlm:aff></affiliation></author></analytic><series><title level="j">Reproductive Health</title><idno type="eISSN">1742-4755</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Consanguineous marriages have been practiced since the early existence of modern humans. Until now consanguinity is widely practiced in several global communities with variable rates depending on religion, culture, and geography. Arab populations have a long tradition of consanguinity due to socio-cultural factors. Many Arab countries display some of the highest rates of consanguineous marriages in the world, and specifically first cousin marriages which may reach 25-30% of all marriages. In some countries like Qatar, Yemen, and UAE, consanguinity rates are increasing in the current generation. Research among Arabs and worldwide has indicated that consanguinity could have an effect on some reproductive health parameters such as postnatal mortality and rates of congenital malformations. The association of consanguinity with other reproductive health parameters, such as fertility and fetal wastage, is controversial. The main impact of consanguinity, however, is an increase in the rate of homozygotes for autosomal recessive genetic disorders. Worldwide, known dominant disorders are more numerous than known recessive disorders. However, data on genetic disorders in Arab populations as extracted from the Catalogue of Transmission Genetics in Arabs (CTGA) database indicate a relative abundance of recessive disorders in the region that is clearly associated with the practice of consanguinity.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Reprod Health</journal-id><journal-title>Reproductive Health</journal-title><issn pub-type="epub">1742-4755</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19811666</article-id><article-id pub-id-type="pmc">2765422</article-id><article-id pub-id-type="publisher-id">1742-4755-6-17</article-id><article-id pub-id-type="doi">10.1186/1742-4755-6-17</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Consanguinity and reproductive health among Arabs</article-title></title-group><contrib-group><contrib id="A1" contrib-type="author"><name><surname>Tadmouri</surname><given-names>Ghazi O</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>tadmouri@hotmail.com</email></contrib><contrib id="A2" contrib-type="author"><name><surname>Nair</surname><given-names>Pratibha</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>pratibha.nair@gmail.com</email></contrib><contrib id="A3" contrib-type="author"><name><surname>Obeid</surname><given-names>Tasneem</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>obaid_tasneem@yahoo.ca</email></contrib><contrib id="A4" contrib-type="author"><name><surname>Al Ali</surname><given-names>Mahmoud T</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>mtalali@gmail.com</email></contrib><contrib id="A5" contrib-type="author"><name><surname>Al Khaja</surname><given-names>Najib</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>drnajib@emirates.net.ae</email></contrib><contrib id="A6" corresp="yes" contrib-type="author"><name><surname>Hamamy</surname><given-names>Hanan A</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref><email>hananhamamy@yahoo.com</email></contrib></contrib-group><aff id="I1"><label>1</label>Centre for Arab Genomic Studies, Dubai, United Arab Emirates</aff><aff id="I2"><label>2</label>Geneva Foundation for Medical Education and Research, Geneva, Switzerland</aff><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>8</day><month>10</month><year>2009</year></pub-date><volume>6</volume><fpage>17</fpage><lpage>17</lpage><ext-link ext-link-type="uri" xlink:href="http://www.reproductive-health-journal.com/content/6/1/17"></ext-link><history><date date-type="received"><day>7</day><month>5</month><year>2009</year></date><date date-type="accepted"><day>8</day><month>10</month><year>2009</year></date></history><permissions><copyright-statement>Copyright © 2009 Tadmouri et al; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2009</copyright-year><copyright-holder>Tadmouri et al; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0"></ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p><pmc-comment>
Tadmouri
O
Ghazi
tadmouri@hotmail.com
Consanguinity and reproductive health among Arabs
2009 Reproductive Health 6(1): 17-. (2009) 1742-4755(2009)6:1<17> urn:ISSN:1742-4755
</license></permissions><abstract><p>Consanguineous marriages have been practiced since the early existence of modern humans. Until now consanguinity is widely practiced in several global communities with variable rates depending on religion, culture, and geography. Arab populations have a long tradition of consanguinity due to socio-cultural factors. Many Arab countries display some of the highest rates of consanguineous marriages in the world, and specifically first cousin marriages which may reach 25-30% of all marriages. In some countries like Qatar, Yemen, and UAE, consanguinity rates are increasing in the current generation. Research among Arabs and worldwide has indicated that consanguinity could have an effect on some reproductive health parameters such as postnatal mortality and rates of congenital malformations. The association of consanguinity with other reproductive health parameters, such as fertility and fetal wastage, is controversial. The main impact of consanguinity, however, is an increase in the rate of homozygotes for autosomal recessive genetic disorders. Worldwide, known dominant disorders are more numerous than known recessive disorders. However, data on genetic disorders in Arab populations as extracted from the Catalogue of Transmission Genetics in Arabs (CTGA) database indicate a relative abundance of recessive disorders in the region that is clearly associated with the practice of consanguinity.</p></abstract></article-meta></front><body><sec><title>Introduction</title><p>Linguistically, consanguinity is a term that is derived from two Latin words "<italic>con</italic>" meaning common, or of the same and "<italic>sanguineus</italic>" meaning blood, hence, referring to a relationship between two people who share a common ancestor or blood. In other words, consanguineous marriage refers to unions contracted between biologically-related individuals. In clinical genetics, a consanguineous marriage means union between couples who are related as second cousins or closer [<xref ref-type="bibr" rid="B1">1</xref>,<xref ref-type="bibr" rid="B2">2</xref>]. Among Arabs, this would include double first cousins, first cousins, first cousins once removed, and second cousins. Uncle-niece marriage is prohibited in Islam and so is absent among Arabs. In population genetics, consanguinity may also refer to unions of individuals with at least one common ancestor such as those occurring within population isolates, small towns, and tribes; intra-community or endogamous marriages. The custom of endogamy among individuals belonging to the same tribe (<italic>hamula </italic>or <italic>kabeela</italic>) is and has been strongly favored among Arabs, with the consequence of unequal distribution of founder mutations among the population. A large number of studies into the effects of consanguinity on health and disease have not taken such discrepancies into consideration.</p></sec><sec><title>Consanguinity in World Populations</title><p>Consanguineous marriages have been practiced since the early existence of modern humans. At present, about 20% of world populations live in communities with a preference for consanguineous marriage [<xref ref-type="bibr" rid="B2">2</xref>]. Consanguinity rates vary from one population to another depending on religion, culture, and geography. Noticeably, many Arab countries display some of the highest rates of consanguineous marriages in the world ranging around 20-50% of all marriages, and specifically favoring first cousin marriages with average rates of about 20-30% (Table <xref ref-type="table" rid="T1">1</xref>, Figure <xref ref-type="fig" rid="F1">1</xref>, Additional file <xref ref-type="supplementary-material" rid="S1">1</xref>).</p><fig position="float" id="F1"><label>Figure 1</label><caption><p><bold>Schematic representation of consanguineous marriage rates worldwide (adapted from Table 1, references </bold>[<xref ref-type="bibr" rid="B82">82</xref>], <bold>and </bold>[<xref ref-type="bibr" rid="B139">139</xref>]. Only second-cousin and closer marriages are represented.</p></caption><graphic xlink:href="1742-4755-6-17-1"></graphic></fig><table-wrap position="float" id="T1"><label>Table 1</label><caption><p>Consanguinity rates in Arab populations. Minimum and maximum reported rates are indicated when available</p></caption><table frame="hsides" rules="groups"><thead><tr><td align="left"><bold>Country</bold></td><td align="left"><bold>>1C, 1C</bold></td><td align="left"><bold>Overall consanguinity</bold></td><td align="left"><bold>References</bold></td></tr></thead><tbody><tr><td align="left"><bold>Algeria</bold></td><td align="left">11.3</td><td align="left">22.6-34</td><td align="left">[<xref ref-type="bibr" rid="B14">14</xref>,<xref ref-type="bibr" rid="B100">100</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Bahrain</bold></td><td align="left">24.5</td><td align="left">39.4-45.5</td><td align="left">[<xref ref-type="bibr" rid="B10">10</xref>,<xref ref-type="bibr" rid="B101">101</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Egypt</bold></td><td align="left">14.3-23.2</td><td align="left">20.9-32.8</td><td align="left">[<xref ref-type="bibr" rid="B15">15</xref>,<xref ref-type="bibr" rid="B70">70</xref>,<xref ref-type="bibr" rid="B102">102</xref>-<xref ref-type="bibr" rid="B104">104</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Egypt (Nubia)</bold></td><td align="left">39-47.2</td><td align="left">60.5-80.4</td><td align="left">[<xref ref-type="bibr" rid="B105">105</xref>,<xref ref-type="bibr" rid="B106">106</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Iraq</bold></td><td align="left">29-33</td><td align="left">47-60</td><td align="left">[<xref ref-type="bibr" rid="B86">86</xref>,<xref ref-type="bibr" rid="B107">107</xref>-<xref ref-type="bibr" rid="B109">109</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Jordan</bold></td><td align="left">19.5-39</td><td align="left">28.5-63.7</td><td align="left">[<xref ref-type="bibr" rid="B6">6</xref>,<xref ref-type="bibr" rid="B9">9</xref>,<xref ref-type="bibr" rid="B43">43</xref>,<xref ref-type="bibr" rid="B110">110</xref>-<xref ref-type="bibr" rid="B113">113</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Kuwait</bold></td><td align="left">16.9-31.7</td><td align="left">22.5-64.3</td><td align="left">[<xref ref-type="bibr" rid="B114">114</xref>-<xref ref-type="bibr" rid="B117">117</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Lebanon</bold></td><td align="left">6.7-31.6</td><td align="left">12.8-42</td><td align="left">[<xref ref-type="bibr" rid="B4">4</xref>,<xref ref-type="bibr" rid="B5">5</xref>,<xref ref-type="bibr" rid="B118">118</xref>-<xref ref-type="bibr" rid="B120">120</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Libya</bold></td><td></td><td align="left">48.4</td><td align="left">[<xref ref-type="bibr" rid="B121">121</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Mauritania</bold></td><td></td><td align="left">47.2</td><td align="left">[<xref ref-type="bibr" rid="B93">93</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Morocco</bold></td><td align="left">8.6-10</td><td align="left">19.9-28</td><td align="left">[<xref ref-type="bibr" rid="B21">21</xref>,<xref ref-type="bibr" rid="B122">122</xref>-<xref ref-type="bibr" rid="B124">124</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Oman</bold></td><td align="left">24.1</td><td align="left">56.3</td><td align="left">[<xref ref-type="bibr" rid="B125">125</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Palestine</bold></td><td align="left">13.6-34.2</td><td align="left">17.5-66.3</td><td align="left">[<xref ref-type="bibr" rid="B7">7</xref>,<xref ref-type="bibr" rid="B11">11</xref>-<xref ref-type="bibr" rid="B13">13</xref>,<xref ref-type="bibr" rid="B71">71</xref>,<xref ref-type="bibr" rid="B126">126</xref>-<xref ref-type="bibr" rid="B129">129</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Qatar</bold></td><td align="left">34.8</td><td align="left">54</td><td align="left">[<xref ref-type="bibr" rid="B19">19</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Saudi Arabia</bold></td><td align="left">24.6-42.3</td><td align="left">42.1-66.7</td><td align="left">[<xref ref-type="bibr" rid="B67">67</xref>,<xref ref-type="bibr" rid="B84">84</xref>,<xref ref-type="bibr" rid="B99">99</xref>,<xref ref-type="bibr" rid="B130">130</xref>,<xref ref-type="bibr" rid="B131">131</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Sudan</bold></td><td align="left">44.2-49.5</td><td align="left">44.2-63.3</td><td align="left">[<xref ref-type="bibr" rid="B66">66</xref>,<xref ref-type="bibr" rid="B132">132</xref>,<xref ref-type="bibr" rid="B133">133</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Syria</bold></td><td align="left">28.7</td><td align="left">30-3-39.8</td><td align="left">[<xref ref-type="bibr" rid="B16">16</xref>,<xref ref-type="bibr" rid="B134">134</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Tunisia</bold></td><td align="left">17.4-23</td><td align="left">20.1-39.3</td><td align="left">[<xref ref-type="bibr" rid="B18">18</xref>,<xref ref-type="bibr" rid="B9">9</xref>,<xref ref-type="bibr" rid="B135">135</xref>,<xref ref-type="bibr" rid="B136">136</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>United Arab Emirates</bold></td><td align="left">20.7-28.2</td><td align="left">40-54.2</td><td align="left">[<xref ref-type="bibr" rid="B20">20</xref>,<xref ref-type="bibr" rid="B36">36</xref>,<xref ref-type="bibr" rid="B137">137</xref>]</td></tr><tr><td colspan="4"><hr></hr></td></tr><tr><td align="left"><bold>Yemen</bold></td><td align="left">32-34</td><td align="left">40-44.7</td><td align="left">[<xref ref-type="bibr" rid="B17">17</xref>,<xref ref-type="bibr" rid="B138">138</xref>]</td></tr></tbody></table><table-wrap-foot><p>For comprehensive details and additional data, see Additional File <xref ref-type="supplementary-material" rid="S1">1</xref>.</p><p>Abbreviations: [>1C] = Double first-cousin marriage; [1C] = First-cousin marriage.</p></table-wrap-foot></table-wrap></sec><sec><title>Consanguinity in Arab Populations</title><p>Socio-cultural factors, such as maintenance of family structure and property, ease of marital arrangements, better relations with in-laws, and financial advantages relating to dowry seem to play a crucial role in the preference of consanguinity in Arab populations [<xref ref-type="bibr" rid="B3">3</xref>]. Consanguineous marriages are generally thought to be more stable than marriages between non-relatives, though there are no studies to compare divorce rates of consanguineous and non-consanguineous marriages among Arabs. It is generally believed that the husband's family would side with the consanguineous wife in marital disputes since she is considered part of the extended family. When there are children with disabilities, more family members share in caring for these children. Unlike what is thought, consanguinity in the Arab World is not only confined to Muslim communities. Several other communities, including the Lebanese, Jordanian, and Palestinian Christian populations, have also practiced consanguinity, but to a lesser extent than Muslims [<xref ref-type="bibr" rid="B4">4</xref>-<xref ref-type="bibr" rid="B7">7</xref>].</p><p>Consanguinity rates show wide variations among Arab countries, as well as within the same country (Table <xref ref-type="table" rid="T1">1</xref>, Additional file <xref ref-type="supplementary-material" rid="S1">1</xref>). However, reports from Arab countries on consanguinity rates may sometimes include marriages between third cousins or far relatives within the consanguineous category. Although this discrepancy affects the total consanguinity rate, it does not markedly alter the average inbreeding coefficient. Therefore, for comparison of consanguinity rates among populations, two parameters are best used; the mean inbreeding coefficient (F) and marriages between first cousins. However, Arab societies have a long tradition of consanguinity, and the cumulative estimate of (F) may exceed the estimated value which is calculated for a single generation [<xref ref-type="bibr" rid="B8">8</xref>].</p><p>Secular changes in the consanguinity rates have been noticed in some Arab populations. In Jordan [<xref ref-type="bibr" rid="B9">9</xref>], Lebanon [<xref ref-type="bibr" rid="B5">5</xref>], Bahrain [<xref ref-type="bibr" rid="B10">10</xref>], and among Palestinians [<xref ref-type="bibr" rid="B11">11</xref>-<xref ref-type="bibr" rid="B13">13</xref>], the frequency of consanguineous marriage is decreasing. Several factors may be playing a role in decreasing the consanguinity rates in Arab countries. Amongst these factors are the increasing higher female education levels, the declining fertility resulting in lower numbers of suitable relatives to marry, more mobility from rural to urban settings, and the improving economic status of families. Moreover, genetic diseases may be feared more now that infectious diseases are on the decline as causes of severe morbidity and mortality.</p><p>Generally, the highest rates of marriages to close relatives are consistently reported in the more traditional rural areas and among the poorest and least educated in society [<xref ref-type="bibr" rid="B8">8</xref>]. Reports from some Arab countries have shown that consanguinity rates are lower in urban when compared to rural settings. Urban to rural first cousin rates in Algeria were 10% and 15% [<xref ref-type="bibr" rid="B14">14</xref>], in Egypt, 8.3% and 17.2% [<xref ref-type="bibr" rid="B15">15</xref>], and in Jordan, 29.8% and 37.9% [<xref ref-type="bibr" rid="B6">6</xref>], respectively. Likewise the mean inbreeding coefficient was lower in urban as compared to rural settings in Syria (0.0203 versus 0.0265) [<xref ref-type="bibr" rid="B16">16</xref>]. In Jordan, it was evident that the higher the level of education of the female partner, the lower the consanguinity rate. Only 12% of university educated females would marry their first cousins, whereas 25% of university educated males tend to marry first cousins [<xref ref-type="bibr" rid="B6">6</xref>]. Similar trends of lower consanguinity rates among educated women, but not educated men, were noticed in Yemen [<xref ref-type="bibr" rid="B17">17</xref>] and Tunisia [<xref ref-type="bibr" rid="B18">18</xref>].</p><p>On the other hand, social, religious, cultural, political and economic factors still play roles in favoring consanguineous marriages among the new generations just as strongly as they did among the older generations, particularly in rural areas. Consanguinity rates seem to be increasing at a higher pace in Qatar [<xref ref-type="bibr" rid="B19">19</xref>], Yemen [<xref ref-type="bibr" rid="B17">17</xref>], the United Arab Emirates (UAE) [<xref ref-type="bibr" rid="B20">20</xref>], and Tlemcen in Algeria [<xref ref-type="bibr" rid="B14">14</xref>]. In Morocco, a study indicated an increasing consanguinity rate from the previous (21.5%) to the present (25.4%) generation [<xref ref-type="bibr" rid="B21">21</xref>], while another study indicated a decreasing consanguinity rate [<xref ref-type="bibr" rid="B22">22</xref>]. Consanguinity rates are not declining in some Arab countries because it is generally accepted that the social advantages of consanguinity outweigh the disadvantages [<xref ref-type="bibr" rid="B23">23</xref>], and consanguinity is regarded as a deeply rooted cultural trend. It is believed that the practice of consanguinity has significant social and economic advantages. Consanguineous marriages among Arabs are respected because it is thought that they promote family stability, simplify financial premarital negotiations, offer a greater compatibility between the spouses and other family members, offer a lesser risk of hidden financial and health issues, and maintain the family land possessions [<xref ref-type="bibr" rid="B3">3</xref>,<xref ref-type="bibr" rid="B24">24</xref>,<xref ref-type="bibr" rid="B25">25</xref>]. Among 390 women attending reproductive health clinics in Jordan, consanguinity was protective against violence during pregnancy [<xref ref-type="bibr" rid="B26">26</xref>]. In all cases, reports on secular trends in consanguinity need to be treated with some caution because in countries where consanguinity is favored, major regional and ethnic differences in prevalence are commonly observed [<xref ref-type="bibr" rid="B3">3</xref>].</p></sec><sec><title>Consanguinity and Reproductive Health</title><p>Research on the association of consanguinity with the different parameters of reproductive health in Arab countries is limited, both in quantity and in quality. Many studies fail to indicate clearly the different categories of consanguineous marriages in their methodology and thus the results are presented for consanguineous marriages as a single entity with the conclusions relying on a simple consanguineous versus non-consanguineous dichotomy. Given the wide range of F values in the 'consanguineous' group (F = 0.0156-0.125), with second cousin offspring (F = 0.0156) closer to non-consanguineous (F = 0) than to first cousins (F = 0.0625) or double first cousins (F = 0.125), such comparisons between consanguineous and non-consanguineous are thus not accurate. However, owing to the dearth of publications in the field among Arabs, this review will mention these studies with clear indication of the categories of consanguinity that are being compared.</p></sec><sec><title>Negative Effects of Consanguinity on Reproductive Health</title><sec><title>Consanguinity and Congenital Malformations</title><p>Approximately 3-5% of all live newborns have a medically significant birth defect. The recent report by March of Dimes estimated birth defects to be >69.9/1000 live births in most Arab countries, as opposed to <52.1/1000 live births in Europe, North America and Australia [<xref ref-type="bibr" rid="B27">27</xref>]. Lower observed rates of 7.92/1000 births and 12.5/1000 births were registered in the UAE and Kuwait, respectively [<xref ref-type="bibr" rid="B28">28</xref>,<xref ref-type="bibr" rid="B29">29</xref>]. In Oman, among 21,988 births, 24.6 per 1000 births had major malformations [<xref ref-type="bibr" rid="B30">30</xref>]. Differences in birth defect rates in different countries and studies could be attributed to true differences among different populations or to different definitions of birth defects, different methods, and different time periods for ascertainment. The risk of birth defects in first-cousin marriages may be estimated to be 2-2.5 times the general population rate, mainly due to the expression of autosomal recessive disorders [<xref ref-type="bibr" rid="B23">23</xref>,<xref ref-type="bibr" rid="B31">31</xref>-<xref ref-type="bibr" rid="B33">33</xref>]. Another estimate puts the offspring of first cousin unions at a 1.7-2.8% increased risk for congenital defects above the population background risk [<xref ref-type="bibr" rid="B34">34</xref>]. However, these risk figures need validation for Arab countries through further well controlled evidence based and standardized research.</p><p>Frequency of consanguineous marriages was higher among parents of offspring with congenital malformations compared with the figures for the general population in all studies reported among Arabs, including in the UAE [<xref ref-type="bibr" rid="B28">28</xref>,<xref ref-type="bibr" rid="B35">35</xref>-<xref ref-type="bibr" rid="B37">37</xref>], Kuwait [<xref ref-type="bibr" rid="B29">29</xref>], Oman [<xref ref-type="bibr" rid="B30">30</xref>,<xref ref-type="bibr" rid="B38">38</xref>,<xref ref-type="bibr" rid="B39">39</xref>], Iraq [<xref ref-type="bibr" rid="B40">40</xref>,<xref ref-type="bibr" rid="B41">41</xref>], Jordan [<xref ref-type="bibr" rid="B42">42</xref>,<xref ref-type="bibr" rid="B43">43</xref>], Egypt [<xref ref-type="bibr" rid="B44">44</xref>], Lebanon [<xref ref-type="bibr" rid="B4">4</xref>,<xref ref-type="bibr" rid="B45">45</xref>], Tunisia [<xref ref-type="bibr" rid="B46">46</xref>], Arabs in Jerusalem [<xref ref-type="bibr" rid="B33">33</xref>], and Saudi Arabia [<xref ref-type="bibr" rid="B47">47</xref>]. After controlling for confounders, first cousin consanguinity remained significantly associated with an increased risk of congenital heart defects (CHD), where infants born to consanguineous parents had a higher risk of having a CHD diagnosed at birth compared to those born to unrelated parents in Lebanon [<xref ref-type="bibr" rid="B48">48</xref>,<xref ref-type="bibr" rid="B49">49</xref>], Saudi Arabia [<xref ref-type="bibr" rid="B47">47</xref>,<xref ref-type="bibr" rid="B50">50</xref>,<xref ref-type="bibr" rid="B51">51</xref>], Egypt [<xref ref-type="bibr" rid="B52">52</xref>], and Arabs in Israel [<xref ref-type="bibr" rid="B53">53</xref>]. Conversely, the overall incidence of CHD among 140,000 newborns in Oman, a country with high consanguinity rate, was similar to that reported from developed countries in Europe and America, insinuating that consanguinity is not a risk factor for CHD [<xref ref-type="bibr" rid="B54">54</xref>]. It could be argued, however, that although the overall incidence is not increased, the rates among consanguineous and non-consanguineous marriages may be different, a point that was not investigated in the study.</p><p>Consanguinity rates were noted to be higher among parents of newborns with congenital hydrocephalus [<xref ref-type="bibr" rid="B55">55</xref>] and neural tube defects [<xref ref-type="bibr" rid="B56">56</xref>,<xref ref-type="bibr" rid="B57">57</xref>] than in the general population in some studies, but not in others [<xref ref-type="bibr" rid="B58">58</xref>]. A positive association of consanguinity with cleft lip and/or palate was reported in the Palestinians [<xref ref-type="bibr" rid="B59">59</xref>], and the Lebanese [<xref ref-type="bibr" rid="B60">60</xref>], but not from studies in Kuwait and Saudi Arabia [<xref ref-type="bibr" rid="B61">61</xref>,<xref ref-type="bibr" rid="B62">62</xref>].</p></sec><sec><title>Consanguinity and Postnatal Mortality</title><p>Countries with high rates of consanguineous marriages generally report smaller effects of consanguinity on mortality than populations with low rates of consanguineous marriages [<xref ref-type="bibr" rid="B63">63</xref>]. This finding is unsurprising, given the limited control for concomitant variables such as socioeconomic status, maternal education, birth intervals and public health facilities and practices in most consanguinity studies.</p><p>The most recent mortality estimate derived from a multinational study of over 600,000 pregnancies and live births, is that first cousin progeny experience 4.4% more pre-reproductive deaths than the offspring of non-consanguineous unions [<xref ref-type="bibr" rid="B64">64</xref>]. Most studies among Arabs have indicated that postnatal mortality is higher among offspring of consanguineous parents than among non-related parents [<xref ref-type="bibr" rid="B4">4</xref>,<xref ref-type="bibr" rid="B42">42</xref>,<xref ref-type="bibr" rid="B65">65</xref>-<xref ref-type="bibr" rid="B71">71</xref>]. Few studies have not detected this increase in postnatal mortality [<xref ref-type="bibr" rid="B35">35</xref>,<xref ref-type="bibr" rid="B68">68</xref>]. The increased postnatal mortality among the offspring of consanguineous parents may be related to the action of deleterious recessive genes and multi-gene complexes inherited from a common ancestor. The higher parity rate among consanguineous couples counterbalances the higher infant mortality; as a result, there may be equality in the number of living children among consanguineous and non-consanguineous couples.</p></sec><sec><title>Consanguinity and Autosomal Recessive Disorders</title><p>In mathematical terms, consanguinity does not alter the allele frequencies of common disorders, but increases the probability of a mating between two individual heterozygotes for the same recessive mutant allele. In this regard, the risk for birth defects in the offspring of first-cousin marriage is expected to increase sharply compared to non-consanguineous marriages particularly for rare autosomal recessive disease genes, because for common recessive conditions, there is a high chance that the abnormal gene may be carried by unrelated spouses and may be expressed in their progeny.</p><p>In Arab populations and Diasporas, the deep-rooted norm of consanguineous marriage has been widely accused of being an important factor contributing to the preponderance of autosomal recessive genetic disorders [<xref ref-type="bibr" rid="B35">35</xref>,<xref ref-type="bibr" rid="B47">47</xref>,<xref ref-type="bibr" rid="B72">72</xref>-<xref ref-type="bibr" rid="B76">76</xref>]. In many parts of the Arab world, the society is still tribal. This has made the epidemiology of genetic disorders complicated, as many families and tribal groups are descended from a limited number of ancestors and some conditions are confined to specific villages, families, and tribal groups, leading to an unusual burden of genetic diseases in these communities [<xref ref-type="bibr" rid="B77">77</xref>]. Thus the extended family structure, commonly present in Arab societies and mostly associated with consanguinity, tends to display unique distribution patterns for genetic diseases that are not present in many other societies. There are disorders that are specifically prevalent among the Arabs, either uniformly or in certain locations, such as Bardet-Biedl syndrome, Meckel-Gruber syndrome, spinal muscular atrophy, osteopetrosis and renal tubular acidosis, Sanjad-Sakati syndrome, and congenital chloride diarrhea [<xref ref-type="bibr" rid="B78">78</xref>,<xref ref-type="bibr" rid="B79">79</xref>]. In an Arab society, mutation carriers mostly remain concentrated within the extended family and consanguineous marriages increase the probability of expression of autosomal recessive disorders when both mother and father are carriers of the mutation. Sometimes, autosomal recessive genes stay hidden within the family for generations and then show on the surface in a new consanguineous marriage within the family.</p><p>An analysis of data in the Catalogue for Transmission Genetics in Arabs (CTGA), a database on genetic disorders in Arab populations maintained by the Centre for Arab Genomic Studies, indicates that in contrast to international databases, the overwhelming proportion of the disorders in the CTGA Database follow a recessive mode of inheritance (63%) compared to the smaller proportion of dominantly inherited traits (27%). A detailed study of countries for which surveys on the occurrence of genetic disorders have been completed (United Arab Emirates, Bahrain, and Oman) indicates that recessive disorders are more in number than the dominant ones [<xref ref-type="bibr" rid="B80">80</xref>-<xref ref-type="bibr" rid="B82">82</xref>]. As explained above, given the high rates of consanguinity in these countries, this pattern is not entirely surprising. In a study from Jordan, the consanguinity rate among parents of affected with autosomal recessive conditions was around 85%, while it was 25-30% among parents of affected with other genetic conditions such as X-linked recessive, chromosomal and autosomal dominant [<xref ref-type="bibr" rid="B76">76</xref>].</p></sec></sec><sec><title>Neutral or Positive Effects of Consanguinity on Reproductive Health</title><p>Parallel to the huge body of literature detailing the negative effects of consanguinity on human health, there also exists a considerable amount of data that suggests that the practice of consanguinity is not the great evil that it is generally thought to be.</p><sec><title>Fetal Wastage</title><p>Multiple studies in highly consanguineous world populations have noted that fetal loss has no significant association with consanguinity. In Sudan, among 4,471 pregnancies, no significant difference in the reproductive loss was observed between the inbred and outbred groups [<xref ref-type="bibr" rid="B66">66</xref>]. In a study in Saudi Arabia, total prenatal losses were essentially the same among consanguineous and non-consanguineous couples [<xref ref-type="bibr" rid="B67">67</xref>]. Among 1867 married couples in Jordan, abortion rate was not affected by consanguinity [<xref ref-type="bibr" rid="B42">42</xref>]. Other studies have reported similar results [<xref ref-type="bibr" rid="B4">4</xref>,<xref ref-type="bibr" rid="B35">35</xref>,<xref ref-type="bibr" rid="B68">68</xref>,<xref ref-type="bibr" rid="B69">69</xref>,<xref ref-type="bibr" rid="B83">83</xref>-<xref ref-type="bibr" rid="B86">86</xref>]. Fewer studies noticed a higher rate of prenatal losses among consanguineous couples [<xref ref-type="bibr" rid="B13">13</xref>,<xref ref-type="bibr" rid="B70">70</xref>,<xref ref-type="bibr" rid="B87">87</xref>].</p></sec><sec><title>Fertility</title><p>Consanguinity was generally not found to be associated with a significant positive or negative effect on fertility [<xref ref-type="bibr" rid="B83">83</xref>,<xref ref-type="bibr" rid="B88">88</xref>,<xref ref-type="bibr" rid="B89">89</xref>], although some international studies report a higher fertility among consanguineous couples [<xref ref-type="bibr" rid="B90">90</xref>,<xref ref-type="bibr" rid="B91">91</xref>]. Among Arabs, higher fertility rates and higher rates of live births were reported among first cousin couples than non-consanguineous couples in Qatar [<xref ref-type="bibr" rid="B87">87</xref>], Kuwait [<xref ref-type="bibr" rid="B92">92</xref>], Saudi Arabia [<xref ref-type="bibr" rid="B84">84</xref>], and Tunisia [<xref ref-type="bibr" rid="B69">69</xref>]. Similarly, in various ethnic groups from Mauritania (including: Soninkes, Poulard, Maures, Wolofs, and black Maures) consanguineous couples had averages of fertility significantly higher than those of non consanguineous couples [<xref ref-type="bibr" rid="B93">93</xref>]. Researchers tend to think that this increase in fertility could be a biological means of compensating for the increased risk of postnatal loss expected in related marriages or possibly to the earlier age at marriage, earlier first maternity and longer reproductive span among consanguineous as compared to non-consanguineous couples [<xref ref-type="bibr" rid="B88">88</xref>].</p><p>Effects of consanguineous marriages on couples' fertility and on offspring mortality were investigated in Beirut through a population-based health survey of 2,752 households. Total pregnancies, live births, and living children were significantly higher among consanguineous couples than among non-consanguineous ones, as was the proportion of dead among children ever born. However, no difference remained in either fertility or mortality, when allowance was made for socioeconomic status, religious affiliation, and marriage duration. The lack of significant pattern in the final analysis is interpreted as resulting from a long-term practice of consanguineous marriages [<xref ref-type="bibr" rid="B4">4</xref>].</p><p>Reports on the association of consanguinity with infertility are scarce among Arabs; a recent study from Lebanon pointed to a positive association between consanguinity and male factor infertility among 120 infertile males indicating the important contribution of recessive genetic factors to the etiology of male infertility [<xref ref-type="bibr" rid="B94">94</xref>].</p></sec><sec><title>Consanguinity and Birth Anthropometric Measurements</title><p>Studies among Arabs related to the effect of consanguinity on anthropometric measurements such as birth weight gave conflicting results [<xref ref-type="bibr" rid="B84">84</xref>,<xref ref-type="bibr" rid="B95">95</xref>-<xref ref-type="bibr" rid="B99">99</xref>]. Studies from Jordan [<xref ref-type="bibr" rid="B43">43</xref>] and Arabs in Israel [<xref ref-type="bibr" rid="B85">85</xref>] detected a significant reduction in birth weight with consanguinity.</p><p>It seems that there is no definite correlation between consanguinity and anthropometric measurements in populations with high consanguinity rates. More studies using standardized methodology are recommended to verify any such correlation taking into consideration the changing socioeconomic and nutritional parameters among Arabs.</p></sec></sec><sec><title>Conclusive Remarks</title><p>Consanguineous marriages are widely practiced in several global populations, with some of the highest rates observed in the Arab World. Reports abound on both the negative and positive biological effects of consanguinity. In net terms, the reproductive criteria related to consanguineous versus non-consanguineous couples include earlier parental age at marriage, younger maternal age at first live birth, higher number of infants born to consanguineous parents, similar rates of abortions, and higher rates of postnatal mortality and birth defects in offspring of consanguineous parents. Furthermore, consanguineous unions lead to increased expression of autosomal recessive disorders. The CTGA Database on genetic disorders in Arab populations offers a clear evidence for a direct correlation between these two factors.</p><p>Studies on the association of consanguinity with chromosomal abnormalities such as Down syndrome and association with non-communicable disorders such as diabetes, hypertension, and psychiatric disorders among Arabs are presently non conclusive with the recommendation of performing standardized research in the future. Likewise, studies on the association of consanguinity with traits such as intelligence quotient and stature are scanty among Arabs and results of studies performed in Western countries cannot be applied directly to societies with high consanguinity rates such as the Arab society.</p><p>Scientifically, a considerable number of genes causing autosomal recessive conditions have been structurally and functionally determined at the molecular level through the joint collaboration of international and Arab scientists; these efforts should continue and expand given the high number of rare recessive disorders in the region.</p><p>Young Arabs contemplating marriage are nowadays seeking a scientifically sound answer to their questions: "Will our children be physically or mentally abnormal if I marry my cousin?" "How can we prevent having abnormal children?" Research on inbreeding is considered a priority in societies with high consanguinity rates to help understand and prevent the deleterious impact of consanguinity on health, and to provide standardized and evidence-based guidelines for health care providers to assist them in counseling for consanguinity.</p></sec><sec><title>Conflicting interests</title><p>The authors declare that they have no competing interests.</p></sec><sec><title>Authors' contributions</title><p>GOT: Initiated the concept of the paper, collected partial data on consanguinity (Table <xref ref-type="table" rid="T1">1</xref> and additional file <xref ref-type="supplementary-material" rid="S1">1</xref>), made the illustration used in the paper, supervised all the primary text authoring written by co-authors in Dubai.</p><p>PN: Authored the review on the positive aspects of consanguinity and collected partial data on consanguinity (Table <xref ref-type="table" rid="T1">1</xref> and additional file <xref ref-type="supplementary-material" rid="S1">1</xref>).</p><p>TO: Authored the review on the negative aspects of consanguinity and collected partial data on consanguinity (Table <xref ref-type="table" rid="T1">1</xref> and additional file <xref ref-type="supplementary-material" rid="S1">1</xref>).</p><p>MTA: Facilitated the collection of published data on consanguinity by offering services available at government medical bibliographic facilities and reviewed the final version of the manuscript.</p><p>NA: Discussed and approved the primary text of the manuscript as prepared by the team of the Centre for Arab Genomic Studies in Dubai.</p><p>HAH: Enriched the primary content of the paper co-authored in Dubai with extensively detailed data (Table <xref ref-type="table" rid="T1">1</xref> and additional file <xref ref-type="supplementary-material" rid="S1">1</xref>), and modified, revised, and added text content in different sections of the manuscript and made it reach to the present 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