Genome-wide genotype and sequence-based reconstruction of the 140,000 year history of modern human ancestry
Identifieur interne : 000170 ( Ncbi/Checkpoint ); précédent : 000169; suivant : 000171Genome-wide genotype and sequence-based reconstruction of the 140,000 year history of modern human ancestry
Auteurs : Daniel Shriner [États-Unis] ; Fasil Tekola-Ayele [États-Unis] ; Adebowale Adeyemo [États-Unis] ; Charles N. Rotimi [États-Unis]Source :
- Scientific Reports [ 2045-2322 ] ; 2014.
Abstract
We investigated ancestry of 3,528 modern humans from 163 samples. We identified 19 ancestral components, with 94.4% of individuals showing mixed ancestry. After using whole genome sequences to correct for ascertainment biases in genome-wide genotype data, we dated the oldest divergence event to 140,000 years ago. We detected an Out-of-Africa migration 100,000–87,000 years ago, leading to peoples of the Americas, east and north Asia, and Oceania, followed by another migration 61,000–44,000 years ago, leading to peoples of the Caucasus, Europe, the Middle East, and south Asia. We dated eight divergence events to 33,000–20,000 years ago, coincident with the Last Glacial Maximum. We refined understanding of the ancestry of several ethno-linguistic groups, including African Americans, Ethiopians, the Kalash, Latin Americans, Mozabites, Pygmies, and Uygurs, as well as the CEU sample. Ubiquity of mixed ancestry emphasizes the importance of accounting for ancestry in history, forensics, and health.
Url:
DOI: 10.1038/srep06055
PubMed: 25116736
PubMed Central: 4131216
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Rotimi</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Center for Research on Genomics and Global Health, National Human Genome Research Institute</institution>, Building 12A, Room 4047, 12 South Drive, Bethesda, Maryland 20892<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We investigated ancestry of 3,528 modern humans from 163 samples. We identified 19 ancestral components, with 94.4% of individuals showing mixed ancestry. After using whole genome sequences to correct for ascertainment biases in genome-wide genotype data, we dated the oldest divergence event to 140,000 years ago. We detected an Out-of-Africa migration 100,000–87,000 years ago, leading to peoples of the Americas, east and north Asia, and Oceania, followed by another migration 61,000–44,000 years ago, leading to peoples of the Caucasus, Europe, the Middle East, and south Asia. We dated eight divergence events to 33,000–20,000 years ago, coincident with the Last Glacial Maximum. We refined understanding of the ancestry of several ethno-linguistic groups, including African Americans, Ethiopians, the Kalash, Latin Americans, Mozabites, Pygmies, and Uygurs, as well as the CEU sample. Ubiquity of mixed ancestry emphasizes the importance of accounting for ancestry in history, forensics, and health.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Li, H" uniqKey="Li H">H. 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Loh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clark, P U" uniqKey="Clark P">P. U. Clark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arredi, B" uniqKey="Arredi B">B. Arredi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cruciani, F" uniqKey="Cruciani F">F. Cruciani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Price, A L" uniqKey="Price A">A. L. Price</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raghavan, M" uniqKey="Raghavan M">M. Raghavan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wangkumhang, P" uniqKey="Wangkumhang P">P. Wangkumhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moreno Estrada, A" uniqKey="Moreno Estrada A">A. Moreno-Estrada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Botigue, L R" uniqKey="Botigue L">L. R. Botigué</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elhaik, E" uniqKey="Elhaik E">E. Elhaik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Purcell, S" uniqKey="Purcell S">S. Purcell</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Shriner, D" uniqKey="Shriner D">D. Shriner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alexander, D H" uniqKey="Alexander D">D. H. Alexander</name></author><author><name sortKey="Novembre, J" uniqKey="Novembre J">J. Novembre</name></author><author><name sortKey="Lange, K" uniqKey="Lange K">K. Lange</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hartl, D L" uniqKey="Hartl D">D. L. Hartl</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Shriner, Daniel" sort="Shriner, Daniel" uniqKey="Shriner D" first="Daniel" last="Shriner">Daniel Shriner</name></noRegion><name sortKey="Adeyemo, Adebowale" sort="Adeyemo, Adebowale" uniqKey="Adeyemo A" first="Adebowale" last="Adeyemo">Adebowale Adeyemo</name><name sortKey="Rotimi, Charles N" sort="Rotimi, Charles N" uniqKey="Rotimi C" first="Charles N." last="Rotimi">Charles N. Rotimi</name><name sortKey="Tekola Ayele, Fasil" sort="Tekola Ayele, Fasil" uniqKey="Tekola Ayele F" first="Fasil" last="Tekola-Ayele">Fasil Tekola-Ayele</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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