Definitive radiotherapy for early stage glottic cancer by 6 MV photons
Identifieur interne : 000296 ( Pmc/Curation ); précédent : 000295; suivant : 000297Definitive radiotherapy for early stage glottic cancer by 6 MV photons
Auteurs : Chi-Chung Tong [Hong Kong] ; Kwok-Hung Au [Hong Kong] ; Roger Kai-Cheong Ngan [Hong Kong] ; Foon-Yiu Cheung [Hong Kong] ; Sin-Ming Chow [Hong Kong] ; Yiu-Tung Fu [Hong Kong] ; Joseph Siu-Kei Au [Hong Kong] ; Stephen Chun-Key Law [Hong Kong]Source :
- Head & Neck Oncology [ 1758-3284 ] ; 2012.
Abstract
To evaluate the clinical outcome of early glottic cancer (GC) treated by primary radiotherapy (RT) with 6 MV photons.
We retrospectively reviewed the medical records of 695 consecutive patients with T1N0 and T2N0 GC treated between 1983 and 2005 by RT in our institution. Clinical outcome in terms of local control (LC), overall survival (OS) and cause- specific survival (CSS) rate were evaluated.
The median follow-up time was 10.5 years. The 10-year actuarial LC rates were as follows: T1A, 91%; T1B, 87%; T2, 77%. The 10-year OS were as follows: T1, 74.2%; T2, 70.7%. The 10-year CSS were as follows: T1, 97.7%; T2, 97.1%.
Poorly differentiated histology and tumor biologically effective dose < 65 Gy15 were adverse factors in both LC of T1 and T2 disease. Involvement of anterior commissure was an adverse factor in both LC and CSS of T1 disease. Subglottic extension was associated with poor LC in T2 disease whereas hemoglobin <13.0 was associated with poor LC and CSS of T2 disease.
Primary RT remains an option among the various standard treatments for early GC. Clinical treatment outcome by 6MV photons is similar and comparable to historic data of Cobalt-60 and 2 MV photons.
Url:
DOI: 10.1186/1758-3284-4-23
PubMed: 22607730
PubMed Central: 3448507
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<author><name sortKey="Tong, Chi Chung" sort="Tong, Chi Chung" uniqKey="Tong C" first="Chi-Chung" last="Tong">Chi-Chung Tong</name>
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<author><name sortKey="Au, Kwok Hung" sort="Au, Kwok Hung" uniqKey="Au K" first="Kwok-Hung" last="Au">Kwok-Hung Au</name>
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<author><name sortKey="Ngan, Roger Kai Cheong" sort="Ngan, Roger Kai Cheong" uniqKey="Ngan R" first="Roger Kai-Cheong" last="Ngan">Roger Kai-Cheong Ngan</name>
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<author><name sortKey="Chow, Sin Ming" sort="Chow, Sin Ming" uniqKey="Chow S" first="Sin-Ming" last="Chow">Sin-Ming Chow</name>
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<author><name sortKey="Fu, Yiu Tung" sort="Fu, Yiu Tung" uniqKey="Fu Y" first="Yiu-Tung" last="Fu">Yiu-Tung Fu</name>
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<author><name sortKey="Law, Stephen Chun Key" sort="Law, Stephen Chun Key" uniqKey="Law S" first="Stephen Chun-Key" last="Law">Stephen Chun-Key Law</name>
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<front><div type="abstract" xml:lang="en"><sec><title>Purpose</title>
<p>To evaluate the clinical outcome of early glottic cancer (GC) treated by primary radiotherapy (RT) with 6 MV photons.</p>
</sec>
<sec><title>Methods and materials</title>
<p>We retrospectively reviewed the medical records of 695 consecutive patients with T1N0 and T2N0 GC treated between 1983 and 2005 by RT in our institution. Clinical outcome in terms of local control (LC), overall survival (OS) and cause- specific survival (CSS) rate were evaluated.</p>
</sec>
<sec><title>Results</title>
<p>The median follow-up time was 10.5 years. The 10-year actuarial LC rates were as follows: T1A, 91%; T1B, 87%; T2, 77%. The 10-year OS were as follows: T1, 74.2%; T2, 70.7%. The 10-year CSS were as follows: T1, 97.7%; T2, 97.1%.</p>
<p>Poorly differentiated histology and tumor biologically effective dose < 65 Gy<sub>15</sub>
were adverse factors in both LC of T1 and T2 disease. Involvement of anterior commissure was an adverse factor in both LC and CSS of T1 disease. Subglottic extension was associated with poor LC in T2 disease whereas hemoglobin <13.0 was associated with poor LC and CSS of T2 disease.</p>
</sec>
<sec><title>Conclusion</title>
<p>Primary RT remains an option among the various standard treatments for early GC. Clinical treatment outcome by 6MV photons is similar and comparable to historic data of Cobalt-60 and 2 MV photons.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Pfister, Dg" uniqKey="Pfister D">DG Pfister</name>
</author>
<author><name sortKey="Laurie, Sa" uniqKey="Laurie S">SA Laurie</name>
</author>
<author><name sortKey="Weinstein, Gs" uniqKey="Weinstein G">GS Weinstein</name>
</author>
<author><name sortKey="Mendenhall, Wm" uniqKey="Mendenhall W">WM Mendenhall</name>
</author>
<author><name sortKey="Adelstein, Dj" uniqKey="Adelstein D">DJ Adelstein</name>
</author>
<author><name sortKey="Ang, Kk" uniqKey="Ang K">KK Ang</name>
</author>
<author><name sortKey="Clayman, Gl" uniqKey="Clayman G">GL Clayman</name>
</author>
<author><name sortKey="Fisher, Sg" uniqKey="Fisher S">SG Fisher</name>
</author>
<author><name sortKey="Forastiere, Aa" uniqKey="Forastiere A">AA Forastiere</name>
</author>
<author><name sortKey="Harrison, Lb" uniqKey="Harrison L">LB Harrison</name>
</author>
<author><name sortKey="Lefebvre, Jl" uniqKey="Lefebvre J">JL Lefebvre</name>
</author>
<author><name sortKey="Leupold, N" uniqKey="Leupold N">N Leupold</name>
</author>
<author><name sortKey="List, Ma" uniqKey="List M">MA List</name>
</author>
<author><name sortKey="O Malley, Bo" uniqKey="O Malley B">BO O'Malley</name>
</author>
<author><name sortKey="Patel, S" uniqKey="Patel S">S Patel</name>
</author>
<author><name sortKey="Posner, Mr" uniqKey="Posner M">MR Posner</name>
</author>
<author><name sortKey="Schwartz, Ma" uniqKey="Schwartz M">MA Schwartz</name>
</author>
<author><name sortKey="Wolf, Gt" uniqKey="Wolf G">GT Wolf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaanders, Jh" uniqKey="Kaanders J">JH Kaanders</name>
</author>
<author><name sortKey="Hordijk, Gj" uniqKey="Hordijk G">GJ Hordijk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wei, W" uniqKey="Wei W">W Wei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Warde, P" uniqKey="Warde P">P Warde</name>
</author>
<author><name sortKey="O Sullivan, B" uniqKey="O Sullivan B">B O'Sullivan</name>
</author>
<author><name sortKey="Bristow, Rg" uniqKey="Bristow R">RG Bristow</name>
</author>
<author><name sortKey="Panzarella, T" uniqKey="Panzarella T">T Panzarella</name>
</author>
<author><name sortKey="Keane, Tj" uniqKey="Keane T">TJ Keane</name>
</author>
<author><name sortKey="Gullane, Pj" uniqKey="Gullane P">PJ Gullane</name>
</author>
<author><name sortKey="Witterick, Ip" uniqKey="Witterick I">IP Witterick</name>
</author>
<author><name sortKey="Payne, D" uniqKey="Payne D">D Payne</name>
</author>
<author><name sortKey="Liu, Ff" uniqKey="Liu F">FF Liu</name>
</author>
<author><name sortKey="Mclean, M" uniqKey="Mclean M">M McLean</name>
</author>
<author><name sortKey="Waldron, J" uniqKey="Waldron J">J Waldron</name>
</author>
<author><name sortKey="Cummings, Bj" uniqKey="Cummings B">BJ Cummings</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cellai, E" uniqKey="Cellai E">E Cellai</name>
</author>
<author><name sortKey="Frata, P" uniqKey="Frata P">P Frata</name>
</author>
<author><name sortKey="Magrini, Sm" uniqKey="Magrini S">SM Magrini</name>
</author>
<author><name sortKey="Palar, F" uniqKey="Palar F">F Palar</name>
</author>
<author><name sortKey="Barca, R" uniqKey="Barca R">R Barca</name>
</author>
<author><name sortKey="Fondelli, S" uniqKey="Fondelli S">S Fondelli</name>
</author>
<author><name sortKey="Polli, C" uniqKey="Polli C">C Polli</name>
</author>
<author><name sortKey="Livi, L" uniqKey="Livi L">L Livi</name>
</author>
<author><name sortKey="Bonetti, B" uniqKey="Bonetti B">B Bonetti</name>
</author>
<author><name sortKey="Vitali, E" uniqKey="Vitali E">E Vitali</name>
</author>
<author><name sortKey="De Stefani, A" uniqKey="De Stefani A">A De Stefani</name>
</author>
<author><name sortKey="Buglion, M" uniqKey="Buglion M">M Buglion</name>
</author>
<author><name sortKey="Biti, G" uniqKey="Biti G">G Biti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chera, Bs" uniqKey="Chera B">BS Chera</name>
</author>
<author><name sortKey="Amdur, Rj" uniqKey="Amdur R">RJ Amdur</name>
</author>
<author><name sortKey="Morris, Cg" uniqKey="Morris C">CG Morris</name>
</author>
<author><name sortKey="Kirwan, Jm" uniqKey="Kirwan J">JM Kirwan</name>
</author>
<author><name sortKey="Mendenhall, Wm" uniqKey="Mendenhall W">WM Mendenhall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Frata, P" uniqKey="Frata P">P Frata</name>
</author>
<author><name sortKey="Cellai, E" uniqKey="Cellai E">E Cellai</name>
</author>
<author><name sortKey="Magrini, Sm" uniqKey="Magrini S">SM Magrini</name>
</author>
<author><name sortKey="Bonetti, B" uniqKey="Bonetti B">B Bonetti</name>
</author>
<author><name sortKey="Vitali, E" uniqKey="Vitali E">E Vitali</name>
</author>
<author><name sortKey="Tonoli, S" uniqKey="Tonoli S">S Tonoli</name>
</author>
<author><name sortKey="Buglione, M" uniqKey="Buglione M">M Buglione</name>
</author>
<author><name sortKey="Palar, F" uniqKey="Palar F">F Palar</name>
</author>
<author><name sortKey="Barca, R" uniqKey="Barca R">R Barca</name>
</author>
<author><name sortKey="Fodelli, S" uniqKey="Fodelli S">S Fodelli</name>
</author>
<author><name sortKey="Polli, C" uniqKey="Polli C">C Polli</name>
</author>
<author><name sortKey="Livi, L" uniqKey="Livi L">L Livi</name>
</author>
<author><name sortKey="Biti, G" uniqKey="Biti G">G Biti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sobin, Lh" uniqKey="Sobin L">LH Sobin</name>
</author>
<author><name sortKey="Wittekind, Ch" uniqKey="Wittekind C">CH Wittekind</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fowler, Jf" uniqKey="Fowler J">JF Fowler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Robertson, Ag" uniqKey="Robertson A">AG Robertson</name>
</author>
<author><name sortKey="Robertson, C" uniqKey="Robertson C">C Robertson</name>
</author>
<author><name sortKey="Boyle, P" uniqKey="Boyle P">P Boyle</name>
</author>
<author><name sortKey="Symonds, Rp" uniqKey="Symonds R">RP Symonds</name>
</author>
<author><name sortKey="Wheldon, Te" uniqKey="Wheldon T">TE Wheldon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Skladowski, K" uniqKey="Skladowski K">K Skladowski</name>
</author>
<author><name sortKey="Law, Mg" uniqKey="Law M">MG Law</name>
</author>
<author><name sortKey="Maciejewski, B" uniqKey="Maciejewski B">B Maciejewski</name>
</author>
<author><name sortKey="Steel, Gg" uniqKey="Steel G">GG Steel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fowler, Jf" uniqKey="Fowler J">JF Fowler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Trotti, A" uniqKey="Trotti A">A Trotti</name>
</author>
<author><name sortKey="Colevas, Ad" uniqKey="Colevas A">AD Colevas</name>
</author>
<author><name sortKey="Setser, A" uniqKey="Setser A">A Setser</name>
</author>
<author><name sortKey="Rusch, V" uniqKey="Rusch V">V Rusch</name>
</author>
<author><name sortKey="Jaques, D" uniqKey="Jaques D">D Jaques</name>
</author>
<author><name sortKey="Budach, V" uniqKey="Budach V">V Budach</name>
</author>
<author><name sortKey="Langer, C" uniqKey="Langer C">C Langer</name>
</author>
<author><name sortKey="Murphy, B" uniqKey="Murphy B">B Murphy</name>
</author>
<author><name sortKey="Cumberlin, R" uniqKey="Cumberlin R">R Cumberlin</name>
</author>
<author><name sortKey="Coleman, Cn" uniqKey="Coleman C">CN Coleman</name>
</author>
<author><name sortKey="Rubin, P" uniqKey="Rubin P">P Rubin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dey, P" uniqKey="Dey P">P Dey</name>
</author>
<author><name sortKey="Arnold, D" uniqKey="Arnold D">D Arnold</name>
</author>
<author><name sortKey="Wight, R" uniqKey="Wight R">R Wight</name>
</author>
<author><name sortKey="Mackenzie, K" uniqKey="Mackenzie K">K MacKenzie</name>
</author>
<author><name sortKey="Kelly, C" uniqKey="Kelly C">C Kelly</name>
</author>
<author><name sortKey="Wilson, J" uniqKey="Wilson J">J Wilson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vlantis, Ac" uniqKey="Vlantis A">AC Vlantis</name>
</author>
<author><name sortKey="Yu, Bk" uniqKey="Yu B">BK Yu</name>
</author>
<author><name sortKey="Tsang, Rk" uniqKey="Tsang R">RK Tsang</name>
</author>
<author><name sortKey="Kam, Mk" uniqKey="Kam M">MK Kam</name>
</author>
<author><name sortKey="Lo, Ps" uniqKey="Lo P">PS Lo</name>
</author>
<author><name sortKey="Van Hasselt, Ca" uniqKey="Van Hasselt C">CA van Hasselt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steiner, W" uniqKey="Steiner W">W Steiner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name>
</author>
<author><name sortKey="Machtay, M" uniqKey="Machtay M">M Machtay</name>
</author>
<author><name sortKey="Mckenna, Mg" uniqKey="Mckenna M">MG McKenna</name>
</author>
<author><name sortKey="Weinstein, Gs" uniqKey="Weinstein G">GS Weinstein</name>
</author>
<author><name sortKey="Markiewicz, Da" uniqKey="Markiewicz D">DA Markiewicz</name>
</author>
<author><name sortKey="Krisch, Re" uniqKey="Krisch R">RE Krisch</name>
</author>
<author><name sortKey="Kligerman, Wm" uniqKey="Kligerman W">WM Kligerman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Epp, Er" uniqKey="Epp E">ER Epp</name>
</author>
<author><name sortKey="Boyer, Al" uniqKey="Boyer A">AL Boyer</name>
</author>
<author><name sortKey="Doppke, Kp" uniqKey="Doppke K">KP Doppke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klein, Ee" uniqKey="Klein E">EE Klein</name>
</author>
<author><name sortKey="Chin, Lm" uniqKey="Chin L">LM Chin</name>
</author>
<author><name sortKey="Rice, Rk" uniqKey="Rice R">RK Rice</name>
</author>
<author><name sortKey="Mijnheer, Bj" uniqKey="Mijnheer B">BJ Mijnheer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Izuno, I" uniqKey="Izuno I">I Izuno</name>
</author>
<author><name sortKey="Sone, S" uniqKey="Sone S">S Sone</name>
</author>
<author><name sortKey="Oguchi, M" uniqKey="Oguchi M">M Oguchi</name>
</author>
<author><name sortKey="Kiyono, K" uniqKey="Kiyono K">K Kiyono</name>
</author>
<author><name sortKey="Takei, K" uniqKey="Takei K">K Takei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tong, Cc" uniqKey="Tong C">CC Tong</name>
</author>
<author><name sortKey="Au, Kh" uniqKey="Au K">KH Au</name>
</author>
<author><name sortKey="Ngan, Rk" uniqKey="Ngan R">RK Ngan</name>
</author>
<author><name sortKey="Chow, Sm" uniqKey="Chow S">SM Chow</name>
</author>
<author><name sortKey="Cheung Fy, Fyt" uniqKey="Cheung Fy F">FYT Cheung FY</name>
</author>
<author><name sortKey="Au, Js" uniqKey="Au J">JS Au</name>
</author>
<author><name sortKey="Law, Sc" uniqKey="Law S">SC Law</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Franchin, G" uniqKey="Franchin G">G Franchin</name>
</author>
<author><name sortKey="Minatel, E" uniqKey="Minatel E">E Minatel</name>
</author>
<author><name sortKey="Gobitti, C" uniqKey="Gobitti C">C Gobitti</name>
</author>
<author><name sortKey="Talamini, R" uniqKey="Talamini R">R Talamini</name>
</author>
<author><name sortKey="Vaccher, E" uniqKey="Vaccher E">E Vaccher</name>
</author>
<author><name sortKey="Sartor, G" uniqKey="Sartor G">G Sartor</name>
</author>
<author><name sortKey="Politi, D" uniqKey="Politi D">D Politi</name>
</author>
<author><name sortKey="Trovo, Mg" uniqKey="Trovo M">MG Trovö</name>
</author>
<author><name sortKey="Barzan, L" uniqKey="Barzan L">L Barzan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garden, As" uniqKey="Garden A">AS Garden</name>
</author>
<author><name sortKey="Forster, K" uniqKey="Forster K">K Forster</name>
</author>
<author><name sortKey="Wong, Pf" uniqKey="Wong P">PF Wong</name>
</author>
<author><name sortKey="Morrison, Wh" uniqKey="Morrison W">WH Morrison</name>
</author>
<author><name sortKey="Schechter, Nr" uniqKey="Schechter N">NR Schechter</name>
</author>
<author><name sortKey="Ang, Kk" uniqKey="Ang K">KK Ang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mccoul, Ed" uniqKey="Mccoul E">ED McCoul</name>
</author>
<author><name sortKey="Har El, G" uniqKey="Har El G">G Har-El</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smee, Ri" uniqKey="Smee R">RI Smee</name>
</author>
<author><name sortKey="Meagher, Ns" uniqKey="Meagher N">NS Meagher</name>
</author>
<author><name sortKey="Williams, Jr" uniqKey="Williams J">JR Williams</name>
</author>
<author><name sortKey="Broadley, K" uniqKey="Broadley K">K Broadley</name>
</author>
<author><name sortKey="Bridger, Gp" uniqKey="Bridger G">GP Bridger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Akimoto, T" uniqKey="Akimoto T">T Akimoto</name>
</author>
<author><name sortKey="Nonaka, T" uniqKey="Nonaka T">T Nonaka</name>
</author>
<author><name sortKey="Kitamoto, Y" uniqKey="Kitamoto Y">Y Kitamoto</name>
</author>
<author><name sortKey="Ishikawa, H" uniqKey="Ishikawa H">H Ishikawa</name>
</author>
<author><name sortKey="Ninomiya, H" uniqKey="Ninomiya H">H Ninomiya</name>
</author>
<author><name sortKey="Chikamatsu, K" uniqKey="Chikamatsu K">K Chikamatsu</name>
</author>
<author><name sortKey="Furuya, N" uniqKey="Furuya N">N Furuya</name>
</author>
<author><name sortKey="Hayakawa, K" uniqKey="Hayakawa K">K Hayakawa</name>
</author>
<author><name sortKey="Mitsuhashi, N" uniqKey="Mitsuhashi N">N Mitsuhashi</name>
</author>
<author><name sortKey="Nakano, T" uniqKey="Nakano T">T Nakano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nishimura, G" uniqKey="Nishimura G">G Nishimura</name>
</author>
<author><name sortKey="Tsukuda, M" uniqKey="Tsukuda M">M Tsukuda</name>
</author>
<author><name sortKey="Mikami, Y" uniqKey="Mikami Y">Y Mikami</name>
</author>
<author><name sortKey="Matsuda, H" uniqKey="Matsuda H">H Matsuda</name>
</author>
<author><name sortKey="Horiuchi, C" uniqKey="Horiuchi C">C Horiuchi</name>
</author>
<author><name sortKey="Taguchi, T" uniqKey="Taguchi T">T Taguchi</name>
</author>
<author><name sortKey="Takahashi, M" uniqKey="Takahashi M">M Takahashi</name>
</author>
<author><name sortKey="Kawakami, M" uniqKey="Kawakami M">M Kawakami</name>
</author>
<author><name sortKey="Watanabe, M" uniqKey="Watanabe M">M Watanabe</name>
</author>
<author><name sortKey="Niho, T" uniqKey="Niho T">T Niho</name>
</author>
<author><name sortKey="Abo, H" uniqKey="Abo H">H Abo</name>
</author>
<author><name sortKey="Yamomoto, S" uniqKey="Yamomoto S">S Yamomoto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murakami, R" uniqKey="Murakami R">R Murakami</name>
</author>
<author><name sortKey="Nishimura, R" uniqKey="Nishimura R">R Nishimura</name>
</author>
<author><name sortKey="Baba, Y" uniqKey="Baba Y">Y Baba</name>
</author>
<author><name sortKey="Yumoto, E" uniqKey="Yumoto E">E Yumoto</name>
</author>
<author><name sortKey="Oya, N" uniqKey="Oya N">N Oya</name>
</author>
<author><name sortKey="Ymashita, Y" uniqKey="Ymashita Y">Y Ymashita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hirasawa, N" uniqKey="Hirasawa N">N Hirasawa</name>
</author>
<author><name sortKey="Itoh, Y" uniqKey="Itoh Y">Y Itoh</name>
</author>
<author><name sortKey="Ishihara, S" uniqKey="Ishihara S">S Ishihara</name>
</author>
<author><name sortKey="Kubota, S" uniqKey="Kubota S">S Kubota</name>
</author>
<author><name sortKey="Itoh, J" uniqKey="Itoh J">J Itoh</name>
</author>
<author><name sortKey="Fujimoto, Y" uniqKey="Fujimoto Y">Y Fujimoto</name>
</author>
<author><name sortKey="Nakashima, T" uniqKey="Nakashima T">T Nakashima</name>
</author>
<author><name sortKey="Naganawa, S" uniqKey="Naganawa S">S Naganawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Feigenberg, Sj" uniqKey="Feigenberg S">SJ Feigenberg</name>
</author>
<author><name sortKey="Lango, M" uniqKey="Lango M">M Lango</name>
</author>
<author><name sortKey="Nicolaou, N" uniqKey="Nicolaou N">N Nicolaou</name>
</author>
<author><name sortKey="Ridge, Ja" uniqKey="Ridge J">JA Ridge</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gomez, D" uniqKey="Gomez D">D Gomez</name>
</author>
<author><name sortKey="Cahlon, O" uniqKey="Cahlon O">O Cahlon</name>
</author>
<author><name sortKey="Mechalakos, J" uniqKey="Mechalakos J">J Mechalakos</name>
</author>
<author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rosenthal, Di" uniqKey="Rosenthal D">DI Rosenthal</name>
</author>
<author><name sortKey="Fuller, Cd" uniqKey="Fuller C">CD Fuller</name>
</author>
<author><name sortKey="Barker, Jl" uniqKey="Barker J">JL Barker</name>
</author>
<author><name sortKey="Mason, B" uniqKey="Mason B">B Mason</name>
</author>
<author><name sortKey="Garcia, Ja" uniqKey="Garcia J">JA Garcia</name>
</author>
<author><name sortKey="Lewin, Js" uniqKey="Lewin J">JS Lewin</name>
</author>
<author><name sortKey="Holsinger, Fc" uniqKey="Holsinger F">FC Holsinger</name>
</author>
<author><name sortKey="Stasney, Cr" uniqKey="Stasney C">CR Stasney</name>
</author>
<author><name sortKey="Frank, Sj" uniqKey="Frank S">SJ Frank</name>
</author>
<author><name sortKey="Schwartz, Dl" uniqKey="Schwartz D">DL Schwartz</name>
</author>
<author><name sortKey="Morrison, Wh" uniqKey="Morrison W">WH Morrison</name>
</author>
<author><name sortKey="Garden, As" uniqKey="Garden A">AS Garden</name>
</author>
<author><name sortKey="Ang, Kk" uniqKey="Ang K">KK Ang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chera, Bs" uniqKey="Chera B">BS Chera</name>
</author>
<author><name sortKey="Amdur, Rj" uniqKey="Amdur R">RJ Amdur</name>
</author>
<author><name sortKey="Morris, Cg" uniqKey="Morris C">CG Morris</name>
</author>
<author><name sortKey="Mendenhall, Wm" uniqKey="Mendenhall W">WM Mendenhall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tiong, Ac" uniqKey="Tiong A">AC Tiong</name>
</author>
<author><name sortKey="Huang, S" uniqKey="Huang S">S Huang</name>
</author>
<author><name sortKey="O Sullivan, B" uniqKey="O Sullivan B">B O'Sullivan</name>
</author>
<author><name sortKey="Xu, W" uniqKey="Xu W">W Xu</name>
</author>
<author><name sortKey="Kim, J" uniqKey="Kim J">J Kim</name>
</author>
<author><name sortKey="Dawson, La" uniqKey="Dawson L">LA Dawson</name>
</author>
<author><name sortKey="Cho, J" uniqKey="Cho J">J Cho</name>
</author>
<author><name sortKey="Gilbert, R" uniqKey="Gilbert R">R Gilbert</name>
</author>
<author><name sortKey="Breen, S" uniqKey="Breen S">S Breen</name>
</author>
<author><name sortKey="Waldron, Jn" uniqKey="Waldron J">JN Waldron</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
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<pmc article-type="research-article" xml:lang="en"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Head Neck Oncol</journal-id>
<journal-id journal-id-type="iso-abbrev">Head Neck Oncol</journal-id>
<journal-title-group><journal-title>Head & Neck Oncology</journal-title>
</journal-title-group>
<issn pub-type="epub">1758-3284</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22607730</article-id>
<article-id pub-id-type="pmc">3448507</article-id>
<article-id pub-id-type="publisher-id">1758-3284-4-23</article-id>
<article-id pub-id-type="doi">10.1186/1758-3284-4-23</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>Definitive radiotherapy for early stage glottic cancer by 6 MV photons</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Tong</surname>
<given-names>Chi-Chung</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>chichungtong@hkcr.org</email>
</contrib>
<contrib contrib-type="author" id="A2"><name><surname>Au</surname>
<given-names>Kwok-Hung</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>akhz01@ha.org.hk</email>
</contrib>
<contrib contrib-type="author" id="A3"><name><surname>Ngan</surname>
<given-names>Roger Kai-Cheong</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>ngankc@ha.org.hk</email>
</contrib>
<contrib contrib-type="author" id="A4"><name><surname>Cheung</surname>
<given-names>Foon-Yiu</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>cheungfy@ha.org.hk</email>
</contrib>
<contrib contrib-type="author" id="A5"><name><surname>Chow</surname>
<given-names>Sin-Ming</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>sinmingchow@hkcr.org</email>
</contrib>
<contrib contrib-type="author" id="A6"><name><surname>Fu</surname>
<given-names>Yiu-Tung</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>fuyt@ha.org.hk</email>
</contrib>
<contrib contrib-type="author" id="A7"><name><surname>Au</surname>
<given-names>Joseph Siu-Kei</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>ausk@ha.org.hk</email>
</contrib>
<contrib contrib-type="author" id="A8"><name><surname>Law</surname>
<given-names>Stephen Chun-Key</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>lawck@ha.org.hk</email>
</contrib>
</contrib-group>
<aff id="I1"><label>1</label>
Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong</aff>
<pub-date pub-type="collection"><year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>18</day>
<month>5</month>
<year>2012</year>
</pub-date>
<volume>4</volume>
<fpage>23</fpage>
<lpage>23</lpage>
<history><date date-type="received"><day>22</day>
<month>4</month>
<year>2012</year>
</date>
<date date-type="accepted"><day>29</day>
<month>4</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2012 Tong et al.; licensee BioMed Central Ltd.</copyright-statement>
<copyright-year>2012</copyright-year>
<copyright-holder>Tong et al.; licensee BioMed Central Ltd.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri xlink:href="http://www.headandneckoncology.org/content/4/1/23"></self-uri>
<abstract><sec><title>Purpose</title>
<p>To evaluate the clinical outcome of early glottic cancer (GC) treated by primary radiotherapy (RT) with 6 MV photons.</p>
</sec>
<sec><title>Methods and materials</title>
<p>We retrospectively reviewed the medical records of 695 consecutive patients with T1N0 and T2N0 GC treated between 1983 and 2005 by RT in our institution. Clinical outcome in terms of local control (LC), overall survival (OS) and cause- specific survival (CSS) rate were evaluated.</p>
</sec>
<sec><title>Results</title>
<p>The median follow-up time was 10.5 years. The 10-year actuarial LC rates were as follows: T1A, 91%; T1B, 87%; T2, 77%. The 10-year OS were as follows: T1, 74.2%; T2, 70.7%. The 10-year CSS were as follows: T1, 97.7%; T2, 97.1%.</p>
<p>Poorly differentiated histology and tumor biologically effective dose < 65 Gy<sub>15</sub>
were adverse factors in both LC of T1 and T2 disease. Involvement of anterior commissure was an adverse factor in both LC and CSS of T1 disease. Subglottic extension was associated with poor LC in T2 disease whereas hemoglobin <13.0 was associated with poor LC and CSS of T2 disease.</p>
</sec>
<sec><title>Conclusion</title>
<p>Primary RT remains an option among the various standard treatments for early GC. Clinical treatment outcome by 6MV photons is similar and comparable to historic data of Cobalt-60 and 2 MV photons.</p>
</sec>
</abstract>
<kwd-group><kwd>T1/T2N0 glottic cancer</kwd>
<kwd>Radiotherapy</kwd>
<kwd>6MV photons</kwd>
<kwd>Biologically effective dose</kwd>
</kwd-group>
</article-meta>
<notes><p>PUBLISHER'S NOTE: Based on the information available to BioMed Central, this article was apparently handled and peer reviewed only by Waseem Jerjes, an Editor-in-Chief of the journal at that time. There were no other peer reviewers.</p>
</notes>
</front>
</pmc>
</record>
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