CobaltMaghrebV1, Main, Exploration, bibRecord, 000884

[Preoperative concurrent chemotherapy and radiation therapy in cervix cancer: preliminary results].

Identifieur interne : 000884 ( Main/Exploration ); précédent : 000883; suivant : 000885

[Preoperative concurrent chemotherapy and radiation therapy in cervix cancer: preliminary results].

Auteurs : Lotfi Kochbati [Tunisie] ; Chiraz Nasr Ben Ammar ; Farouk Benna ; Monia Hechiche ; Hamouda Boussen ; Mounir Besbes ; Mansour Ben Abdallah ; Khaled Rahal ; Farhat Ben Ayed ; Khaked Ben Romdhane ; Mongi Maalej

Source :

La Tunisie medicale [ 0041-4131 ] ; 2005.

RBID : pubmed:15929442

Descripteurs français

English descriptors

KwdEn :
- Adenocarcinoma (drug therapy), Adenocarcinoma (pathology), Adenocarcinoma (radiotherapy), Adenocarcinoma (surgery), Adenocarcinoma (therapy), Adult, Aged, Antineoplastic Agents (therapeutic use), Brachytherapy, Carcinoma, Squamous Cell (drug therapy), Carcinoma, Squamous Cell (pathology), Carcinoma, Squamous Cell (radiotherapy), Carcinoma, Squamous Cell (surgery), Carcinoma, Squamous Cell (therapy), Cervix Uteri (pathology), Cisplatin (therapeutic use), Cobalt Radioisotopes (therapeutic use), Combined Modality Therapy, Female, Humans, Hysterectomy, Lymph Node Excision, Middle Aged, Neoplasm Staging, Preoperative Care, Radiotherapy Dosage, Retrospective Studies, Treatment Outcome, Uterine Cervical Neoplasms (drug therapy), Uterine Cervical Neoplasms (pathology), Uterine Cervical Neoplasms (radiotherapy), Uterine Cervical Neoplasms (surgery), Uterine Cervical Neoplasms (therapy).
MESH :
- chemical , therapeutic use : Antineoplastic Agents, Cisplatin, Cobalt Radioisotopes.
- drug therapy : Adenocarcinoma, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms.
- pathology : Adenocarcinoma, Carcinoma, Squamous Cell, Cervix Uteri, Uterine Cervical Neoplasms.
- radiotherapy : Adenocarcinoma, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms.
- surgery : Adenocarcinoma, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms.
- therapy : Adenocarcinoma, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms.
- Adult, Aged, Brachytherapy, Combined Modality Therapy, Female, Humans, Hysterectomy, Lymph Node Excision, Middle Aged, Neoplasm Staging, Preoperative Care, Radiotherapy Dosage, Retrospective Studies, Treatment Outcome.

Abstract

This is a retrospective study of patients treated for cervix cancer staged IB2, IIA or IIB with bulky tumor (> 4cm). Treatment was concurrent radiotherapy (45Gy with 1,8Gy daily fraction) and chemotherapy (5 cycles of Platinum 40mg/m2/week). All patients underwent Brachytherapy (15Gy on the reference isodose according to Paris system) followed by surgery (radical abdominal hysterectomy and bilateral pelvic lymphadenectomy: Piver 3) Between October 1999 and December 2002, forty five patients were treated in this protocol. Median age was 46 years (21- 68). Histology was squamous cell carcinoma in 93% and glandular carcinoma in 7%. Average external radiation dose was 44Gy (20-50). Ninety three percent of patients had at least 3 cycles of chemotherapy and 46,5% received the planned 5 cycles. On the operative specimens, there was 62,5% complete response and only 7 pelvic node involvement (17,5%). Four postoperative complications were noted (one vascular injury, one urinary fistula, one phlebitis and one lymph collection). Preoperative combined radiotherapy and chemotherapy in the early bulky stages of uterine cervix cancer is well tolerated and "gives" a high rate of sterilisation. There was no increase in surgical morbidity.

PubMed: 15929442

Affiliations:

Le document en format XML

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<author><name sortKey="Ben Ammar, Chiraz Nasr" sort="Ben Ammar, Chiraz Nasr" uniqKey="Ben Ammar C" first="Chiraz Nasr" last="Ben Ammar">Chiraz Nasr Ben Ammar</name>
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<author><name sortKey="Boussen, Hamouda" sort="Boussen, Hamouda" uniqKey="Boussen H" first="Hamouda" last="Boussen">Hamouda Boussen</name>
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<author><name sortKey="Besbes, Mounir" sort="Besbes, Mounir" uniqKey="Besbes M" first="Mounir" last="Besbes">Mounir Besbes</name>
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<author><name sortKey="Ben Abdallah, Mansour" sort="Ben Abdallah, Mansour" uniqKey="Ben Abdallah M" first="Mansour" last="Ben Abdallah">Mansour Ben Abdallah</name>
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<series><title level="j">La Tunisie medicale</title>
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<imprint><date when="2005" type="published">2005</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma (drug therapy)</term>
<term>Adenocarcinoma (pathology)</term>
<term>Adenocarcinoma (radiotherapy)</term>
<term>Adenocarcinoma (surgery)</term>
<term>Adenocarcinoma (therapy)</term>
<term>Adult</term>
<term>Aged</term>
<term>Antineoplastic Agents (therapeutic use)</term>
<term>Brachytherapy</term>
<term>Carcinoma, Squamous Cell (drug therapy)</term>
<term>Carcinoma, Squamous Cell (pathology)</term>
<term>Carcinoma, Squamous Cell (radiotherapy)</term>
<term>Carcinoma, Squamous Cell (surgery)</term>
<term>Carcinoma, Squamous Cell (therapy)</term>
<term>Cervix Uteri (pathology)</term>
<term>Cisplatin (therapeutic use)</term>
<term>Cobalt Radioisotopes (therapeutic use)</term>
<term>Combined Modality Therapy</term>
<term>Female</term>
<term>Humans</term>
<term>Hysterectomy</term>
<term>Lymph Node Excision</term>
<term>Middle Aged</term>
<term>Neoplasm Staging</term>
<term>Preoperative Care</term>
<term>Radiotherapy Dosage</term>
<term>Retrospective Studies</term>
<term>Treatment Outcome</term>
<term>Uterine Cervical Neoplasms (drug therapy)</term>
<term>Uterine Cervical Neoplasms (pathology)</term>
<term>Uterine Cervical Neoplasms (radiotherapy)</term>
<term>Uterine Cervical Neoplasms (surgery)</term>
<term>Uterine Cervical Neoplasms (therapy)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Adénocarcinome ()</term>
<term>Adénocarcinome (anatomopathologie)</term>
<term>Adénocarcinome (radiothérapie)</term>
<term>Adénocarcinome (traitement médicamenteux)</term>
<term>Antinéoplasiques (usage thérapeutique)</term>
<term>Association thérapeutique</term>
<term>Carcinome épidermoïde ()</term>
<term>Carcinome épidermoïde (anatomopathologie)</term>
<term>Carcinome épidermoïde (radiothérapie)</term>
<term>Carcinome épidermoïde (traitement médicamenteux)</term>
<term>Cisplatine (usage thérapeutique)</term>
<term>Col de l'utérus (anatomopathologie)</term>
<term>Curiethérapie</term>
<term>Dosimétrie en radiothérapie</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hystérectomie</term>
<term>Lymphadénectomie</term>
<term>Radio-isotopes du cobalt (usage thérapeutique)</term>
<term>Résultat thérapeutique</term>
<term>Soins préopératoires</term>
<term>Stade de la tumeur</term>
<term>Sujet âgé</term>
<term>Tumeurs du col de l'utérus ()</term>
<term>Tumeurs du col de l'utérus (anatomopathologie)</term>
<term>Tumeurs du col de l'utérus (radiothérapie)</term>
<term>Tumeurs du col de l'utérus (traitement médicamenteux)</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Agents</term>
<term>Cisplatin</term>
<term>Cobalt Radioisotopes</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Adénocarcinome</term>
<term>Carcinome épidermoïde</term>
<term>Col de l'utérus</term>
<term>Tumeurs du col de l'utérus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Adenocarcinoma</term>
<term>Carcinoma, Squamous Cell</term>
<term>Uterine Cervical Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Adenocarcinoma</term>
<term>Carcinoma, Squamous Cell</term>
<term>Cervix Uteri</term>
<term>Uterine Cervical Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Adenocarcinoma</term>
<term>Carcinoma, Squamous Cell</term>
<term>Uterine Cervical Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Adénocarcinome</term>
<term>Carcinome épidermoïde</term>
<term>Tumeurs du col de l'utérus</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Adenocarcinoma</term>
<term>Carcinoma, Squamous Cell</term>
<term>Uterine Cervical Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Adenocarcinoma</term>
<term>Carcinoma, Squamous Cell</term>
<term>Uterine Cervical Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Adénocarcinome</term>
<term>Carcinome épidermoïde</term>
<term>Tumeurs du col de l'utérus</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antinéoplasiques</term>
<term>Cisplatine</term>
<term>Radio-isotopes du cobalt</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Brachytherapy</term>
<term>Combined Modality Therapy</term>
<term>Female</term>
<term>Humans</term>
<term>Hysterectomy</term>
<term>Lymph Node Excision</term>
<term>Middle Aged</term>
<term>Neoplasm Staging</term>
<term>Preoperative Care</term>
<term>Radiotherapy Dosage</term>
<term>Retrospective Studies</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Adénocarcinome</term>
<term>Association thérapeutique</term>
<term>Carcinome épidermoïde</term>
<term>Curiethérapie</term>
<term>Dosimétrie en radiothérapie</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hystérectomie</term>
<term>Lymphadénectomie</term>
<term>Résultat thérapeutique</term>
<term>Soins préopératoires</term>
<term>Stade de la tumeur</term>
<term>Sujet âgé</term>
<term>Tumeurs du col de l'utérus</term>
<term>Études rétrospectives</term>
</keywords>
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<front><div type="abstract" xml:lang="en">This is a retrospective study of patients treated for cervix cancer staged IB2, IIA or IIB with bulky tumor (> 4cm). Treatment was concurrent radiotherapy (45Gy with 1,8Gy daily fraction) and chemotherapy (5 cycles of Platinum 40mg/m2/week). All patients underwent Brachytherapy (15Gy on the reference isodose according to Paris system) followed by surgery (radical abdominal hysterectomy and bilateral pelvic lymphadenectomy: Piver 3) Between October 1999 and December 2002, forty five patients were treated in this protocol. Median age was 46 years (21- 68). Histology was squamous cell carcinoma in 93% and glandular carcinoma in 7%. Average external radiation dose was 44Gy (20-50). Ninety three percent of patients had at least 3 cycles of chemotherapy and 46,5% received the planned 5 cycles. On the operative specimens, there was 62,5% complete response and only 7 pelvic node involvement (17,5%). Four postoperative complications were noted (one vascular injury, one urinary fistula, one phlebitis and one lymph collection). Preoperative combined radiotherapy and chemotherapy in the early bulky stages of uterine cervix cancer is well tolerated and "gives" a high rate of sterilisation. There was no increase in surgical morbidity.</div>
</front>
</TEI>
<affiliations><list><country><li>Tunisie</li>
</country>
<region><li>Gouvernorat de Tunis</li>
</region>
<settlement><li>Tunis</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Ben Abdallah, Mansour" sort="Ben Abdallah, Mansour" uniqKey="Ben Abdallah M" first="Mansour" last="Ben Abdallah">Mansour Ben Abdallah</name>
<name sortKey="Ben Ammar, Chiraz Nasr" sort="Ben Ammar, Chiraz Nasr" uniqKey="Ben Ammar C" first="Chiraz Nasr" last="Ben Ammar">Chiraz Nasr Ben Ammar</name>
<name sortKey="Ben Ayed, Farhat" sort="Ben Ayed, Farhat" uniqKey="Ben Ayed F" first="Farhat" last="Ben Ayed">Farhat Ben Ayed</name>
<name sortKey="Ben Romdhane, Khaked" sort="Ben Romdhane, Khaked" uniqKey="Ben Romdhane K" first="Khaked" last="Ben Romdhane">Khaked Ben Romdhane</name>
<name sortKey="Benna, Farouk" sort="Benna, Farouk" uniqKey="Benna F" first="Farouk" last="Benna">Farouk Benna</name>
<name sortKey="Besbes, Mounir" sort="Besbes, Mounir" uniqKey="Besbes M" first="Mounir" last="Besbes">Mounir Besbes</name>
<name sortKey="Boussen, Hamouda" sort="Boussen, Hamouda" uniqKey="Boussen H" first="Hamouda" last="Boussen">Hamouda Boussen</name>
<name sortKey="Hechiche, Monia" sort="Hechiche, Monia" uniqKey="Hechiche M" first="Monia" last="Hechiche">Monia Hechiche</name>
<name sortKey="Maalej, Mongi" sort="Maalej, Mongi" uniqKey="Maalej M" first="Mongi" last="Maalej">Mongi Maalej</name>
<name sortKey="Rahal, Khaled" sort="Rahal, Khaled" uniqKey="Rahal K" first="Khaled" last="Rahal">Khaled Rahal</name>
</noCountry>
<country name="Tunisie"><region name="Gouvernorat de Tunis"><name sortKey="Kochbati, Lotfi" sort="Kochbati, Lotfi" uniqKey="Kochbati L" first="Lotfi" last="Kochbati">Lotfi Kochbati</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur le cobalt au Maghreb

[Preoperative concurrent chemotherapy and radiation therapy in cervix cancer: preliminary results].

[Preoperative concurrent chemotherapy and radiation therapy in cervix cancer: preliminary results].

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le cobalt au Maghreb
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